Abstract: The present disclosure relates to the involvement of HSA-miR-6891-5p in immune and/or inflammatory disorders, as well as the use of agonists/antagonists thereof to treat the same.

Abstract: Accurate mapping of RNA-Seq reads to the reference genome is critical for accurate identification and quantification of miRNA transcripts. The miRNA transcriptome of two homozygous lymphoblastoic cell lines with completely characterized MHC haplotypes (PGF and COX) was analyzed and revealed 89 novel mature miRNA transcripts originating from within the MHC, including three mature miRNA that are haplotype specific, one of which originates from within intron 5 of HLA-DRB5. This is a novel way to identify miRNA transcripts originating from the MHC in a variety of tissue types and disease states, and can be utilized to prepare personal genome assemblies.

Abstract: A bit for drilling a wellbore includes: a shank having a coupling formed at an upper end thereof; a body mounted to a lower end of the shank; and a cutting face forming a lower end of the bit. The cutting face includes: a blade protruding from the body; a leading cutter including: a substrate mounted in a pocket formed in a leading edge of the blade; and a cutting table made from a superhard material, mounted to the substrate, and having a non-planar working face with a cutting feature; and a backup cutter mounted in a lower face of the blade at a position trailing the leading cutter and made from a composite material including a ceramic or cermet matrix impregnated with a superhard material.

Abstract: A liquid crystal optical device is provided including at least two LC cells. A first LC cell layer has a predominant director orientation imparting a transversally non-uniform phase delay to a first polarization of an unpolarized incident light field passing therethrough while incident light of a second polarization orthogonal to the first light polarization passes therethrough undergoing transversally uniform phase delay. The first LC cell is configured to project a center extraordinary ray onto an optical axis of the device at the image surface. A second LC cell layer has a predominant director oriented orthogonally to the other predominant director in a plane perpendicular to the optical axis. The second LC layer imparts a transversally non-uniform phase delay to the second polarization of the incident light passing therethrough, the second LC cell being configured to project a center ordinary ray onto the optical axis at the image surface.

Abstract: A composition comprising: (a) an acyl isethionate surfactant; (b) a cationic polymer; and (c) a water insoluble benefit agent: wherein the composition comprises less than 3 wt % amphoteric or zwitterionic surfactants.

Abstract: Disclosed in some examples are methods, systems, and machine readable mediums which monitor, archive, and version file system elements stored in one or more different network based file storage systems for one or more different users. Any changes to file system elements stored in the network based file storage systems are recorded and versioned. The system may allow users to revert to a previous version of a file system element, recover a deleted file system element, and the system allows for audits to determine which users placed a file system element in which network based file storage systems and determine which users had access to the file system element in the network based file storage systems. As a result, the disclosed system improves the end-user experience by providing versioning and auditing capabilities as well as allowing organizations to monitor and control their digital property in network based file storage systems.

Abstract: A bit for drilling a wellbore includes: a shank having a coupling formed at an upper end thereof; a body mounted to a lower end of the shank; and a cutting face forming a lower end of the bit. The cutting face includes: a blade protruding from the body; a leading cutter including: a substrate mounted in a pocket formed in a leading edge of the blade; and a cutting table made from a superhard material, mounted to the substrate, and having a non-planar working face with a cutting feature; and a backup cutter mounted in a lower face of the blade at a position trailing the leading cutter and made from a composite material including a ceramic or cermet matrix impregnated with a superhard material.

Abstract: The present application relates to a method of assaying ubiquitination in a sample by combining ubiquitin together with a substrate in a sample containing UBE1, UbcH3, Skp2-isoform 1, Skp1, Cull, Rbx1, Cks1, CDK2 and Cyclin E1 under conditions suitable for ubiquitination to take place, exposing the sample to a labelled binding partner which is specific for the ubiquitin, and measuring the amount of ubiquitin bound to the substrate.

Abstract: The present invention related to a method of assaying ubiquitination in a sample by combining ubiquitin and two or more of E1, E2, E3 and a substrate protein in a sample under conditions suitable for ubiquitination to take place, exposing the sample with a labelled binding partner which is specific for the ubiquitin and measuring the amount of labelled ubiquitin bound to any one of the components in the sample, wherein one or more of the components in the sample comprises an immobilization tag which facilitates its immobilization onto a solid surface.

Abstract: An autofocus camera assembly is described. The camera assembly includes an electrically controllable optical power lens and a lens assembly having a frame supporting at least one lens element near the electrically controllable optical power lens. The electrically controllable optical power lens is mounted to an object end of the frame. An aperture stop is provided located either at or within the electrically controllable optical power lens or on an external surface of the frame next to the electrically controllable optical power lens. The aperture stop can include an opaque mask and optionally alignment marks.

Abstract: A liquid crystal optical device is provided including at least two LC cells. A first LC cell layer has a predominant director orientation imparting a transversally non-uniform phase delay to a first polarization of an unpolarized incident light field passing therethrough while incident light of a second polarization orthogonal to the first light polarization passes therethrough undergoing transversally uniform phase delay. The first LC cell is configured to project a center extraordinary ray onto an optical axis of the device at the image surface. A second LC cell layer has a predominant director oriented orthogonally to the other predominant director in a plane perpendicular to the optical axis. The second LC layer imparts a transversally non-uniform phase delay to the second polarization of the incident light passing therethrough, the second LC cell being configured to project a center ordinary ray onto the optical axis at the image surface.

Abstract: A measuring instrument, such as a coating thickness measuring instrument, comprises a reader (6) arranged to read information provided on a calibration piece article (7), such as a calibration foil. The reader (6) can be an RFID reader and the information provided in a RFID tag. The information may be used to calibrate the instrument when the instrument is used to measure a property of the calibration piece. The reader (6) may also be used to read information provided on an article to be measured, to identify the article or a location on the article, or on a detachable probe of the instrument.

Abstract: A closed loop refrigeration system comprises an ice slurry mixture which comprises ice, water, and a freezing point depressant. The system also comprises a first storage device for storing the ice slurry mixture, and an agitator disposed in the first storage device. The agitator agitates the ice slurry mixture in at least an intermittent manner. The system further comprises a first conduit connecting the first storage device and a heat load, and a first pump disposed on the first conduit for pumping the ice slurry mixture through the first conduit from the first storage device to the heat load. At least some of the ice melts in the heat load. The system also comprises a second conduit connecting the heat load and a second storage device. The second storage device is connected to the first storage device.

Abstract: Implementations described and claimed herein provide systems and methods for processing telecommunication orders taking advantage of the infrastructure and capabilities of a plurality of different providers. In one implementation, one or more databases store provider data received from a plurality of provider members. The provider data is aggregated based on at least one of a plurality of attributes associated with one or more telecommunication packages. The plurality of attributes include infrastructure information, location information, and pricing information. At least one server is in communication with the one or more databases. The at least one server is configured to generate a design for a customer order based on the aggregated provider data. The design uses at least one of the plurality of provider members to provide a customer telecommunication package at one or more customer sites. The customer telecommunication package is selected from the one or more telecommunication packages.

Abstract: An electrically controllable optical lens apparatus makes use of fixed lenses and an active optical element together in a lens enclosure. The enclosure may be a barrel structure that is easily mounted to a camera device having an image sensor. The active optical element, such as a tunable liquid crystal lens, receives an electrical signal from the camera device via electrical conductors integral with the lens enclosure that provide electrical pathways between the active element on the interior of the enclosure and surface contacts on the camera device. The enclosure may be a two-piece structure, and the electrical conductors may be attached to either piece of the structure. The lens enclosure may also be threaded for attachment to the camera device. The electrical conductors may also use spring loaded contact portions or molded interconnect devices.

Abstract: A tablet electronic device is disclosed. The tablet electronic device includes a first side, a second side and an electronic component. The first side has a first thickness. The second side is opposite to the first side and has a second thickness. The second thickness is larger than the first thickness. The second side has a recess. The electronic component is accommodated in the recess such that a gravity center of the tablet electronic device is adjusted towards the second side. The tablet electronic device has a holding portion and the center of gravity of the tablet electronic device is arranged in a suitable position, thus the tablet electronic device disclosed herein can be comfortably operated while being held in a user's hand. Furthermore, the tablet electronic device can be set in various ways for comfortable usage.

Abstract: The present invention provides for a proteomic approach to predicting, diagnosing and staging invasive bladder cancer, and for predicting patient survival and therapeutic efficacy. More specifically, the target being analyzed for reduced expression is FOXA1, and optionally including analysis of increased FOXA2 expression.

Abstract: The present invention provides novel mGlu2/3 agonists of the formula wherein R1, R2, and R3 are as defined herein, for use in the treatment of neurological or psychiatric disorders.

Abstract: The electron emission portion of a cathode for an electron gun has layers of substrate material formed from a ceramic powder such as Aluminum nitride. The substrate layers have conductive traces formed on them, the conductive traces made from sintered tungsten or alternatively a refractory foil. When current is passed through the conductive traces, heat is coupled to a cathode which is thermally coupled to the heater assembly. In another embodiment of the invention, one of the layers of the heater includes a thermionic emission material and optionally a work function lowering material such as BaO, which allows the outer layer of the multi-layer heater to directly emit electrons. In another embodiment of the invention, a control grid is formed on a layer above the thermionic cathode layer, which provides for a complete electron gun assembly having a heater, cathode with a reduced work function material, and control grid to be fabricated as a single unit at the same time.

Abstract: The present application relates to a method of assaying ubiquitination in a sample by combining ubiquitin together with a substrate in a sample containing UBE1, UbcH3, Skp2-isoform 1, Skp1, Cul1, Rbx1, Cks1, CDK2 and Cyclin E1 under conditions suitable for ubiquitination to take place, exposing the sample to a labelled binding partner which is specific for the ubiquitin, and measuring the amount of ubiquitin bound to the substrate.