Abstract: The present invention related to a method of assaying ubiquitination in a sample by combining ubiquitin and two or more of E1, E2, E3 and a substrate protein in a sample under conditions suitable for ubiquitination to take place, exposing the sample with a labelled binding partner which is specific for the ubiquitin and measuring the amount of labelled ubiquitin bound to any one of the components in the sample, wherein one or more of the components in the sample comprises an immobilisation tag which facilitates its immobilisation onto a solid surface.

Abstract: A method for producing oil from an underground formation comprising providing a first well in one or more formations, the first well comprising a plurality of sections along a length of the well; providing a second well in the formation; injecting an enhanced oil recovery formulation into at least a first section and a second section of the first well and into the formation; flowing the formulation and/or oil towards the second well in one or more formations; producing the formulation and/or oil from the second well; and then modifying the injecting into the second section, while continuing the injecting into the first section.

Abstract: The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently —C(H)? or —N?, provided that at least one of A and B is —N?, n is 1-3, m is 0-3, and R1-4 are as defined herein.

Abstract: A tablet electronic device is disclosed. The tablet electronic device includes a first side, a second side and an electronic component. The first side has a first thickness. The second side is opposite to the first side and has a second thickness. The second thickness is larger than the first thickness. The second side has a recess. The electronic component is accommodated in the recess such that a gravity center of the tablet electronic device is adjusted towards the second side. The tablet electronic device has a holding portion and the center of gravity of the tablet electronic device is arranged in a suitable position, thus the tablet electronic device disclosed herein can be comfortably operated while being held in a user's hand. Furthermore, the tablet electronic device can be set in various ways for comfortable usage.

Abstract: An electrically controllable optical lens apparatus makes use of fixed lenses and an active optical element together in a lens enclosure. The enclosure may be a barrel structure that is easily mounted to a camera device having an image sensor. The active optical element, such as a tunable liquid crystal lens, receives an electrical signal from the camera device via electrical conductors integral with the lens enclosure that provide electrical pathways between the active element on the interior of the enclosure and surface contacts on the camera device. The enclosure may be a two-piece structure, and the electrical conductors may be attached to either piece of the structure. The lens enclosure may also be threaded for attachment to the camera device. The electrical conductors may also use spring loaded contact portions or molded interconnect devices.

Abstract: A rail car collision system is disclosed that includes a front face and an underframe having a first anticlimber. The first anticlimber protrudes from and extends across at least a portion of the front face at a first position. At least one second anticlimber extends along at least a portion of the front face at a second position that is vertically different than the first position.

Abstract: Liquid crystal optoelectronic devices are produced by fabricating a wafer-level component structure and affixing a plurality of discrete components to a surface structure prior to singulating the individual devices therefrom. After singulation, the individual devices include a portion of the wafer-level fabricated structure and at least of the discrete components. The wafer-level structure may include a liquid crystal and controlling electrodes, and the discrete components may include fixed lenses or image sensors. The discrete components may be located on either or both of two sides of the wafer-level structure. Multiple liquid crystal layers may be used to reduce nonuniformities in the interaction with light from different angles, and to control light of different polarizations. The liquid crystal devices may function as optoelectronic devices such as tunable lenses, shutters or diaphragms.

Abstract: An electrical connector system may include multiple wafer assemblies configured to engage with a substrate. A ground strip of the electrical connector system may be coupled with a first wafer assembly and a second wafer assembly. The ground strip is configured to engage with the substrate and provide a common ground potential between the first wafer assembly, the second wafer assembly, and the substrate.

Abstract: A rail car collision system is disclosed that includes a front face and an underframe having a first anticlimber. The first anticlimber protrudes from and extends across at least a portion of the front face at a first position. At least one second anticlimber extends along at least a portion of the front face at a second position that is vertically different than the first position.

Abstract: An electrical connector system may include multiple wafer assemblies configured to engage with a substrate. A ground strip of the electrical connector system may be coupled with a first wafer assembly and a second wafer assembly. The ground strip is configured to engage with the substrate and provide a common ground potential between the first wafer assembly, the second wafer assembly, and the substrate.

Abstract: The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)? or N?, provided that at least one of A and B is —N?, n is 1-3, m is 0-3, and R14 are as defined herein.

Abstract: A rail car collision system is disclosed that includes a front face and an underframe having a first anticlimber. The first anticlimber protrudes from and extends across at least a portion of the front face at a first position. At least one second anticlimber extends along at least a portion of the front face at a second position that is vertically different than the first position.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).

Abstract: The present invention provides compounds of formula (I) wherein A is (1), (2), (3), (4), (5), (6) or (7) and wherein R1, R7, y and Ar1 are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.

Abstract: The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected from serotonin, norepinephrine and dopamine and, as such, may be useful in the treatment of disorders of the central and/or peripheral nervous system.

Abstract: The invention relates to compounds of formula (I): wherein R, R1, R2 and X are defined herein, their preparation, and their use as pharmaceuticals.

Abstract: A rail car collision system is disclosed that includes a front face and an underframe having a first anticlimber. The first anticlimber protrudes from and extends across at least a portion of the front face at a first position. At least one second anticlimber extends along at least a portion of the front face at a second position that is vertically different than the first position.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active monoamines (serotonin, norepinephrine, and dopamine).

Abstract: Compounds of formula (I): wherein A is S or O; R is H; Ar is an optionally substituted phenyl group; X is an optionally substituted phenyl group, a C1-C4 alkyl, a C3-C6 cycloalkyl group or a CH2(C3-C6 cycloalkyl) group; R? is H or C1-C4 alkyl; and each R1 is independently H or C1-C4 alkyl; and pharmaceutically acceptable salts thereof are selective inhibitors of norepinephrine reuptake.