Abstract: The present technology relates to commercial-scale methods for purifying botulinum toxin compositions obtained from cell cultures. Purification methods according to the present disclosure are based on a series of filtration and chromatographic separation steps that produce a high-purity botulinum toxin composition, which comprises botulinum toxin protein molecules (˜150 kDa) in solution, which is free, essentially free, or substantially free of botulinum toxin complexes and animal products, and without precipitating or lyophilizing botulinum toxin protein molecules. The purification method according to the present disclosure uses no precipitation, lyophilization, or centrifugation steps, permitting production of highly pure, highly active, free botulinum toxin protein molecules (˜150 kDa) in solution, without the need for reconstitution by the end user.

Abstract: The present technology relates to commercial-scale methods for purifying botulinum toxin compositions obtained from cell cultures. Purification methods according to the present disclosure are based on a series of filtration and chromatographic separation steps that produce a high-purity botulinum toxin composition, which comprises botulinum toxin protein molecules (˜150 kDa) in solution, which is free, essentially free, or substantially free of botulinum toxin complexes and animal products, and without precipitating or lyophilizing botulinum toxin protein molecules. The purification method according to the present disclosure uses no precipitation, lyophilization, or centrifugation steps, permitting production of highly pure, highly active, free botulinum toxin protein molecules (˜150 kDa) in solution, without the need for reconstitution by the end user.

Abstract: A system for operating a driverless utility vehicle in a restricted area, including: a transfer module for transferring control of the utility vehicle at an entrance: from the driver of the utility vehicle to the system, and at an exit: from the system to the driver of the utility vehicle, wherein the restricted area has the entrance, the exit and a predetermined target point; a movement module for autonomously moving the utility vehicle from the entrance to the predetermined target point and from the predetermined target point to the exit; and a performance module for autonomously performing an action on the utility vehicle while the utility vehicle is situated at the predetermined target point, so as to change a state of the utility vehicle by the action. Also described are a related management system, a method, and a computer readable medium.

Abstract: A machining tool for chip-removing machining includes a tool body and a generator assembly for harvesting electric energy to be used in the tool. At least one first component is secured to the tool body and a second component is movably connected to the tool body so as to, by moving with respect to the first component through interaction therewith, generate electric energy in the first component. The generator assembly includes an arrangement for conducting a medium flow to hit and act upon the second component for moving it with respect to the first component.

Abstract: A boring tool has a slider member connected to a cutting insert seat, the slider member is arranged movably inside a tool body of the boring tool along a path extending transversely to a rotation axis of the boring tool for adjusting the distance of the of the cutting insert seat in relation to the rotation axis. A wedge-shaped clamping member is connected to a drive unit and arranged inside the tool body. The wedge-shaped clamping member is in contact with the slider member for clamping the slider member into a locked position, in which locked position, the wedge-shaped clamping member is pre-loaded to passively lock the slider member. The drive unit is controllable such that the wedge-shaped clamping member is actively releasable when adjusting the distance of the cutting insert seat.

Abstract: The present technology relates to commercial-scale methods for purifying botulinum toxin compositions obtained from cell cultures. Purification methods according to the present disclosure are based on a series of filtration and chromatographic separation steps that produce a high-purity botulinum toxin composition, which comprises botulinum toxin protein molecules (˜150 kDa) in solution, which is free, essentially free, or substantially free of botulinum toxin complexes and animal products, and without precipitating or lyophilizing botulinum toxin protein molecules. The purification method according to the present disclosure uses no precipitation, lyophilization, or centrifugation steps, permitting production of highly pure, highly active, free botulinum toxin protein molecules (˜150 kDa) in solution, without the need for reconstitution by the end user.

Abstract: The present disclosure relates generally to the field of producing botulinum toxin. More specifically, the present disclosure relates to a method for producing botulinum toxin in a culture medium free or substantially free of animal product. The present disclosure also relates to the culture medium for producing botulinum toxin that is free or substantially free of animal product.

Abstract: A system for operating a driverless utility vehicle in a restricted area, including: a transfer module for transferring control of the utility vehicle at an entrance: from the driver of the utility vehicle to the system, and at an exit: from the system to the driver of the utility vehicle, wherein the restricted area has the entrance, the exit and a predetermined target point; a movement module for autonomously moving the utility vehicle from the entrance to the predetermined target point and from the predetermined target point to the exit; and a performance module for autonomously performing an action on the utility vehicle while the utility vehicle is situated at the predetermined target point, so as to change a state of the utility vehicle by the action. Also described are a related management system, a method, and a computer readable medium.

Abstract: A system for operating a driverless utility vehicle in a restricted area, including: a transfer module for transferring control of the utility vehicle at an entrance: from the driver of the utility vehicle to the system, and at an exit: from the system to the driver of the utility vehicle, wherein the restricted area has the entrance, the exit and a predetermined target point; a movement module for autonomously moving the utility vehicle from the entrance to the predetermined target point and from the predetermined target point to the exit; and a performance module for autonomously performing an action on the utility vehicle while the utility vehicle is situated at the predetermined target point, so as to change a state of the utility vehicle by the action. Also described are a related management system, a method, and a computer readable medium.

Abstract: A boring tool has a slider member connected to a cutting insert seat, the slider member is arranged movably inside a tool body of the boring tool along a path extending transversely to a rotation axis of the boring tool for adjusting the distance of the of the cutting insert seat in relation to the rotation axis. A wedge-shaped clamping member is connected to a drive unit and arranged inside the tool body. The wedge-shaped clamping member is in contact with the slider member for clamping the slider member into a locked position, in which locked position, the wedge-shaped clamping member is pre-loaded to passively lock the slider member. The drive unit is controllable such that the wedge-shaped clamping member is actively releasable when adjusting the distance of the cutting insert seat.

Abstract: A machining tool for chip-removing machining includes a tool body and a generator assembly for harvesting electric energy to be used in the tool. At least one first component is secured to the tool body and a second component is movably connected to the tool body so as to, by moving with respect to the first component through interaction therewith, generate electric energy in the first component. The generator assembly includes an arrangement for conducting a medium flow to hit and act upon the second component for moving it with respect to the first component.

Abstract: A high-frequency testing probe is disclosed. The probe includes a layered probe substrate having a first and second PCB, as well as first and second conducting traces disposed on opposite sides of the substrate. The probe substrate has an ungrounded differential region including two probe tips coupled to the traces, a grounded differential region, and a decoupled differential region including two probe connectors coupled to the traces. The probe also includes a ground plane between the two PCBs and between the two traces in the decoupled and grounded differential regions. In the ungrounded differential region, the first and second traces form a first differential transmission pair having a differential impedance. In the grounded differential region, the first and second traces form a second differential transmission pair having the differential impedance. The probe connectors are configured to couple to one of a vector network analyzer and a time domain reflectometer.

Abstract: A metal cutting tool includes a main tool body and a slider element received at least partially in the main tool body and arranged movably relative. The slider element has a cutting edge or supports a cutting insert having a cutting edge. An internal coolant supply is arranged to supply coolant from the main tool body to the cutting edge and has a coolant channel running within the main tool body and within the slider element. The main tool body, or a transfer element that has the coolant channel being part of the internal coolant supply and connected with the main tool body, includes a first sealing surface on which an outlet of the coolant channel of the main tool body is arranged. The slider element, or the transfer element, includes a second sealing surface on which an inlet of the coolant channel of the slider element is arranged.

Abstract: A system for providing driverless operation of a utility vehicle in a limited area, including: a control module to output a valid autonomous control signal to an electropneumatic parking brake system and to control the utility vehicle in a driverless manner, wherein the utility vehicle allows an autonomous operating mode and includes the electropneumatic parking brake system which is configured to release the parking brake system when the valid autonomous control signal is present and to initiate automatic emergency braking when no valid autonomous control signal is applied; and a transfer module to transfer control of the utility vehicle from the driver to the control module. Also described are a related method and computer readable medium.

Abstract: A method and system for providing a switchable waveguide are provided. According to some aspects, a switched waveguide has a waveguide structure having a reflector located within the waveguide structure. The switched waveguide also includes a radio frequency (RF) switch configured to connect and disconnect the reflector to the waveguide structure.

Abstract: A system for providing driverless operation of a utility vehicle in a limited area, including: a control module to output a valid autonomous control signal to an electropneumatic parking brake system and to control the utility vehicle in a driverless manner, wherein the utility vehicle allows an autonomous operating mode and includes the electropneumatic parking brake system which is configured to release the parking brake system when the valid autonomous control signal is present and to initiate automatic emergency braking when no valid autonomous control signal is applied; and a transfer module to transfer control of the utility vehicle from the driver to the control module. Also described are a related method and computer readable medium.

Abstract: A system for operating a driverless utility vehicle in a restricted area, including: a transfer module for transferring control of the utility vehicle at an entrance: from the driver of the utility vehicle to the system, and at an exit: from the system to the driver of the utility vehicle, wherein the restricted area has the entrance, the exit and a predetermined target point; a movement module for autonomously moving the utility vehicle from the entrance to the predetermined target point and from the predetermined target point to the exit; and a performance module for autonomously performing an action on the utility vehicle while the utility vehicle is situated at the predetermined target point, so as to change a state of the utility vehicle by the action. Also described are a related management system, a method, and a computer readable medium.

Abstract: A microfiber nonwoven composite includes: at least one layer S that contains a first fiber component; and at least one layer M that contains a second fiber component. The second fiber component is forced at least in part into the layer S. Fibers of the first fiber component comprise melt-spun include filaments deposited as a nonwoven fabric, and which are at least partially split and solidified to form elementary filaments having an average titer of less than 1 dtex. Fibers of the second fiber component include melt-blown fibers.

Abstract: A metal cutting tool includes a main tool body and a slider element received at least partially in the main tool body and arranged movably relative. The slider element has a cutting edge or supports a cutting insert having a cutting edge. An internal coolant supply is arranged to supply coolant from the main tool body to the cutting edge and has a coolant channel running within the main tool body and within the slider element. The main tool body, or a transfer element that has the coolant channel being part of the internal coolant supply and connected with the main tool body, includes a first sealing surface on which an outlet of the coolant channel of the main tool body is arranged. The slider element, or the transfer element, includes a second sealing surface on which an inlet of the coolant channel of the slider element is arranged.

Abstract: A method and system for providing a switchable waveguide are provided. According to some aspects, a switched waveguide has a waveguide structure having a reflector located within the waveguide structure. The switched waveguide also includes a radio frequency (RF) switch configured to connect and disconnect the reflector to the waveguide structure.