Abstract: The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit.

Abstract: The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit.

Abstract: Flexible data center systems and methods of deployment are provided. A flexible data center (100, 200) including T rows of server racks (106, 206, 306) can be deployed by constructing a number B of blocks (101, 201). Constructing each block (101, 201) can include constructing from one to a number P of perimeter structures (104, 204, 304) each housing up to a number R of rows of server racks (106, 206, 306). Constructing each block (102, 201) can include constructing a connecting structure (102, 202) connected to the perimeter structures (104, 204, 304), the connecting structure (102, 202) housing operations monitoring equipment (108, 208) for the server racks (106, 206, 306). A total integer number T/R of perimeter structures (104, 204, 304) can be constructed for the flexible data center (100, 200). At most one perimeter structure (10, 204, 304) houses less than R rows of server racks (106, 206, 306). B is equal to an integer number (T/R)/P.

Abstract: A connection switching device for an aircraft network includes a switching network and a second identification device. The switching network connects input/output devices, such that applications may be interconnected or such that an application may be connected to a peripheral device. The second identification device detects an input/output device that is connected to the connection switching device.

Abstract: The oral hygiene device, particularly a toothbrush, has in the neck part, a cavity, which is closed off from the surroundings and in which a snap dome is arranged. This snap dome produces an acoustic warning signal when a limiting bending of the neck part is exceeded as a result of a limiting pressing force with which the head part is pressed, for example, against the teeth and gums is exceeded. On the one hand, this has the effect of protecting the snap dome, usually produced from metal, from corrosion and, on the other hand, the cavity serves as a resonance chamber to amplify the warning signal.

Abstract: Methods and apparatus are described for an aircraft network that permits an automatic configuring and/or repairing of the network.

Abstract: The structural element of an aircraft fuselage, with stringers running in the longitudinal direction of the aircraft fuselage and ribs running transversely to the stringers in the circumferential direction of the fuselage. According to the invention, at least one of the stringers running in the longitudinal direction of the aircraft fuselage is designed as a fastening rail for elements to be installed in the aircraft fuselage.

Abstract: The invention relates to a brush, specifically a toothbrush, a head part with a cleaning structure that includes bristles, a hand part and a neck part, a cavity of at least one outlet opening for an active substance being located in the head or neck part. In one embodiment, the cavity incorporates an active substance element, which contains the active substance in a carrier material and releases said substance in a controlled manner when it comes into contact with water. In another embodiment, the cavity is adapted to the shape of an active substance element by means of defined external contours. Volume of the cavity is 1-2 times and no more than 4 times greater than the volume of the active substance element, ensuring that the latter is surrounded by water during use. This allows the active substance to be metered and ensures that the brush is easy to use.

Abstract: An active biological substance is disclosed for use in abnormal cellular and viral membrane physiologies in human and mammal organisms. The active substance has diagnostic and/or therapeutic properties and contains or consists of at least one component selected from the group of substances including: histones, covalently modified histones, histone-like polypeptides, biologically active histone sequences and histone-like polypeptides as agents for stopping the supply to solid tumours over their blood vessels, for killing cells infected by virus and for killing tumour cells with disturbed lipid asymmetry.

Abstract: A brush, in particular a toothbrush, comprising a head part with a cleaning structure featuring bristles, a hand part and a neck part, and a cavity located in the head or neck part comprising at least one outlet opening for an active substance. In one embodiment, the cavity incorporates an active substance element, which contains the active substance in a carrier material and releases said substance in a controlled manner when it comes into contact with water. In another embodiment, the cavity is adapted to the shape of an active substance element by means of defined external contours. The volume of the cavity is preferably 1-2 times and no more than 4 times greater than the volume of the active substance element, ensuring that the latter is preferably surrounded by water during use. This allows the active substance to be effectively metered and ensures the brush is easy to use.

Abstract: A battery module is described. The battery module includes a plurality of battery cells; a plurality of cooling fin assemblies, each cooling fin assembly positioned between two battery cells, the cooling fin assemblies comprising at least one cooling fin and a foot on at least one side of the cooling fin assemblies, the foot having a bottom and interlocking profiles on each end, the interlocking profiles on adjacent feet of the cooling fin assemblies interlocking the feet and forming a surface; and a heat sink contacting the surface of the interlocked feet. A method of cooling a battery module is also described.

Abstract: An active biological substance is disclosed for use in abnormal cellular and viral membrane physiologies in human and mammal organisms. The active substance has diagnostic and/or therapeutic properties and contains or consists of at least one component selected from the group of substances including: histones, covalently modified histones, histone-like polypeptides, biologically active histone sequences and histone-like polypeptides as agents for stopping the supply to solid tumors over their blood vessels, for killing cells infected by virus and for killing tumour cells with disturbed lipid asymmetry.

Abstract: In the case of a structural component of an aircraft or spacecraft comprising a fuselage portion connection region for connecting to an associated fuselage portion and having a thermal expansion coefficient which is approximately matched to the associated fuselage portion; an inner connection region for connecting to an associated installation element and having a thermal expansion coefficient which is approximately matched to the associated installation element; and a separation region for connecting the fuselage portion connection region and the inner connection region, at least one of the regions has a high heat conduction resistance.

Abstract: The brush head of the toothbrush has filaments that are pointed at one end and led through clearances in the bristle carrier. These filaments have a length of about 10-20 mm. The tips of the pointed filaments produce a height profile other than that of a plane and the ends of the pointed filaments that are remote from the tips are melted.

Abstract: The brush head of the toothbrush has filaments that are pointed at one end and led through clearances in the bristle carrier. These filaments have a length of about 10-20 mm. The tips of the pointed filaments produce a height profile other than that of a plane and the ends of the pointed filaments that are remote from the tips are melted.

Abstract: Systems and methods include a power module comprising at least one fuel cell generator for powering a load, and a bypass mechanism having a first, normally-open fast-acting switch that closes in 1-250 msec, and a second, normally-open switch in parallel with the first switch, the bypass mechanism being electrically connected between the load and a second power source, such as a grid source, where the first switch is configured to close in response to a fault event such that when the first switch is closed power to the load is provided from the second power source through the first switch, and the second switch closes after a predetermined time such that power to the load from the second source is provided through the second switch. Additional methods and systems include providing power to a plurality of loads using fuel cell power generators.

Abstract: An exemplary embodiment of the present invention indicates an installation system for an airplane for securing interior equipment, which exhibits longitudinal and transverse rails. The transverse rails are designed as peripheral rails, and exhibit perforations to which the interior equipment can be secured.

Abstract: The toothbrush according to the invention is equipped with a handle of which the surface is formed, at least in certain sections, in a facet-like manner by way of multiplicity of planar surface-area elements. The surface-area elements are arranged directly adjacent to one another and form a network of element edges. The multiplicity of surface-area elements reproduce, more or less, an essentially rounded handle form, this ensuring comfortable use of the toothbrush in different rotary positions in relation to its longitudinal axis.

Abstract: Flexible data center systems and methods of deployment are provided. A flexible data center (100, 200) including T rows of server racks (106, 206, 306) can be deployed by constructing a number B of blocks (101, 201). Constructing each block (101, 201) can include constructing from one to a number P of perimeter structures (104, 204, 304) each housing up to a number R of rows of server racks (106, 206, 306). Constructing each block (102, 201) can include constructing a connecting structure (102, 202) connected to the perimeter structures (104, 204, 304), the connecting structure (102, 202) housing operations monitoring equipment (108, 208) for the server racks (106, 206, 306). A total integer number T/R of perimeter structures (104, 204, 304) can be constructed for the flexible data center (100, 200). At most one perimeter structure (10, 204, 304) houses less than R rows of server racks (106, 206, 306). B is equal to an integer number (T/R)/P.

Abstract: A brush, in particular a toothbrush, including a head part with a cleaning structure with bristles, a handle part and a neck part, a cavity with at least one outlet opening for an active substance being located in the head or neck part. In one embodiment, the cavity incorporates an active substance element, which contains the active substance in a carrier material and releases the substance in a controlled manner when it comes into contact with water. The cavity may be adapted to the shape of an active substance element by means of defined external contours. The volume of the cavity is preferably 1-2 times and no more than 4 times greater than the volume of the active substance element, ensuring that the latter is preferably surrounded by water during use. This allows the active substance to be effectively metered and ensures the brush is easy to use.