Abstract: The present invention relates to novel compositions comprising mixtures of cis and trans isomers of retinol, particularly with a cis/trans ratio of less than 1:100, as well as the use of said compositions for preservation.

Abstract: The present invention relates to novel compositions comprising a retinoid mixture of cis and trans isomers of a retinyl ester, particularly retinyl acetate, with a cis/trans ratio of less than 0.03 as well as the use thereof for the treatment, prevention and lessening of the symptoms of diseases and conditions which can be treated with 5-HT2B serotonin receptor antagonists, including but not limited to diseases or conditions selected from migraine headaches, anxiety, ocular hypotension, heart valve disease, irritable bowel syndrome, and MDMA (commonly called “ecstasy”) abuse.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.

Abstract: Suture passer systems for tissue suspension and tissue compression, and more particularly for tongue suspension, are described. The system can include at least a first elongate tubular body or shaft, a needle having a lateral bias carried by the elongate body, and a retrieval element operably connected to the elongate tubular body. The needle can have a substantially straight configuration when located within the elongate tubular body, and be configured to exit an opening at or near a distal end of the elongate tubular body and assume a laterally biased or curved shape to form a path through tissue. The needle is configured to carry a suture. The retrieval element can be configured to retrieve the suture carried by the needle after the needle has formed a curved or otherwise angled path through tissue. The system can also include one or more bone anchors to secure the suture loops. Methods of placing one or more suture loops into tissue, such as the base of the tongue, are also described.

Abstract: The systems and methods of the disclosure can rapidly and automatically determine and monitor tracking events by generating event codes using messages from multiple source systems within the healthcare ecosystem. The method may include detecting one or more healthcare data messages of a plurality of types of healthcare data messages associated with healthcare of a patient. The method may include extracting text of each message of the first type and processing the extracted text of each message to determine one or more units of text. The method may include determining one or more tracking events by applying one or more trained models to each unit of text of each message. The method may include storing one or more event codes corresponding to the one or more tracking events and its associated deadline in a record for the patient of the tracking event database.

Abstract: Methods, compositions of matter, and devices for delivering a therapeutic composition to a heart of a subject using a biopolymer scaffold material are described. In some embodiments, the biopolymer scaffold material including the therapeutic composition may be attached to a first cardiac tissue of a subject. The therapeutic composition is delivered from the biopolymer scaffold material to the heart of the subject.

Abstract: Devices and methods for forming guided angiogenesis and enhanced vascularization in ischemic heart tissue are described. In some embodiments, a biopolymer scaffold material may comprise a plurality of through holes (e.g., slits, cutouts, and/or other appropriate types of through holes) that may guide angiogenesis and promote enhanced revascularization in ischemic heart tissue. In some embodiments, microneedles may be used to form a plurality of microchannels in ischemic heart tissue. The plurality of microchannels may be patterned to form guided vascularization such that vascularization may be directed from non-ischemic heart tissue to the ischemic heart tissue. In some embodiments, a biopolymer scaffold material including through holes formed therein applied to ischemic heart tissue may be combined with a plurality of microchannels formed in the ischemic heart tissue to improve microvascularization of the ischemic heart.

Abstract: A method, system, and computer program product for identifying a malicious user obtain a plurality of service requests for a service provided by a processing system, each service request of the plurality of service requests being associated with a requesting user and a requesting system, and a plurality of service responses associated with the plurality of service requests, each service response of the plurality of service responses being associated with the processing system; and identify the requesting user as malicious based on the plurality of service requests and the plurality of service responses.

Abstract: Systems and methods are provided for searching one or more sources of digital assets in dependence on one or more keywords. The server node includes logic to identify initial results from the searching of one or more sources of digital assets. The initial search results are accessible by any client node participating in a collaboration session. The server node includes logic to receive an identification of a particular digital asset from the initial results. The server node includes logic to further search the one or more sources of digital assets in dependence on the identified particular digital asset to obtain further results. The server node includes logic to curate the further results as digital assets in a workspace that is accessible in the collaboration session. The digital assets can be curated into separate canvases within the workspace in dependence on at least one criterion.

Abstract: Systems and methods are provided for operating a server node for performing collaborative search and curation of digital assets from sources of digital assets. The method includes, searching, by the server node, one or more sources of digital assets in dependence on one or more keywords received from a client node participating in a collaboration session. The method includes, curating, by the server node, results of the searching as digital assets in a workspace. The digital assets being curated into separate canvases within the workspace in dependence on at least one criterion. The digital assets are identified in data that is accessible by client nodes participating in the collaboration session. The method includes providing to the client node, the data identifying curated digital assets.

Abstract: Articles of manufacture, machines, processes for using the articles and machines, processes for making the articles and machines, and products produced by the process of making, along with necessary intermediates, directed to mixed nuclear power conversion.

Abstract: A method for protecting data within a storage system includes receiving one or more user objects from a user into the storage system, the user objects including user data that includes user metadata and raw data; deduplicating the raw data; copying the user metadata and system metadata to provide copied metadata; and storing the copied metadata in a metadata storage area within the storage system so that the copied metadata stored in the metadata storage area is not modifiable by the user. The method can further include storing the copied metadata in a separate, second metadata storage area within the storage system that is user modifiable. At least a portion of the copied metadata stored in the user modifiable metadata storage area and copied to the unmodifiable metadata storage area includes a reference that points to sub-objects in the data storage area that allows the system to rehydrate the raw data for the user objects.

Abstract: Method and system are provided for storage optimization for event streaming for multiple consumers. The method provides an entire event stream for storage in a first tier storage and dynamically determines advance portions of the event stream for at least some of the consumers based on a consumer's position index in the event stream. The advance portions are portions of the event stream that will be consumed next by the consumer and the method provides the advance portions of the event stream for storage in second tier storage that has a higher performance than the first tier storage.

Abstract: A machine, article, process of using, process of making, products produced thereby and necessary intermediates.

Abstract: A method, system, and computer program product for identifying a malicious user obtain a plurality of service requests for a service provided by a processing system, each service request of the plurality of service requests being associated with a requesting user and a requesting system, and a plurality of service responses associated with the plurality of service requests, each service response of the plurality of service responses being associated with the processing system; and identify the requesting user as malicious based on the plurality of service requests and the plurality of service responses.

Abstract: Method and system are provided for storage optimization for event streaming for multiple consumers. The method provides an entire event stream for storage in a first tier storage and dynamically determines advance portions of the event stream for at least some of the consumers based on a consumer's position index in the event stream. The advance portions are portions of the event stream that will be consumed next by the consumer and the method provides the advance portions of the event stream for storage in second tier storage that has a higher performance than the first tier storage.

Abstract: Methods and compositions for modulating shoot apical meristem size are provided. Methods are provided for modulating the expression of fea3 sequence in a host plant or plant cell to modulate agronomic characteristics such as altered size and number of organs, including plant seeds.

Abstract: A machine, article, process of using, process of making, products produced thereby and necessary intermediates. Illustratively, there can be a process that includes: ionizing at least some injected gas to form ions; confining, without using magnetic fields, at least some of said ions to produce confined ions; accumulating at least some of said confined ions to produce accumulated ions; cooling at least some of said accumulated ions to produce cooled ions; compressing, without using magnetic fields, at least some of said accumulated ions to produce compressed ions; accelerating at least some of said compressed ions to produce accelerated ions; ejecting at least some of said accelerated ions; and measuring at least one property of said ejected ions.

Abstract: Methods, compositions of matter, and devices for delivering a therapeutic composition to a heart of a subject using a biopolymer scaffold material are described. In some embodiments, the biopolymer scaffold material including the therapeutic composition may be attached to a first cardiac tissue of a subject. The therapeutic composition is delivered from the biopolymer scaffold material to the heart of the subject.