Abstract: There is disclosed alighting device (8) comprising: at least one light-emitting filament comprising (12) a plurality of solid-state light sources (14); and an elongated reflector (9) arranged to reflect light emitted by the light-emitting filament (12), wherein the reflector (9) has a longitudinal groove (11) in which the light-emitting filament (12) is arranged such that the reflector (9) and the at least one light-emitting filament (12) extend longitudinally along a common path, and wherein said path is curved in three dimensions. A light bulb (5) comprising the lighting device (8) and a luminaire (1) comprising the lighting device (8) are also disclosed. The lighting device (8) can be produced cost-efficiently and adapted to conform well to a predetermined emission pattern.

Abstract: Provided is a connector assembly for optically connecting one or more optical fibers and an array of vertical coupling elements of a photonic integrated circuit (PIC). In various embodiments, the connector assembly is constructed to independently optically scale some feature sizes, such as, for example, the transverse mode size, the array size, the array geometry, and/or various incidence angles, the optical scaling being performed, e.g., from a fiber end face plane to a connector-mating plane and further to a PIC coupling plane. In some embodiments, the connector assembly may support a polarization (de)multiplexing functionality.

Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours and haematological malignancies expressing HER2, in particular breast cancer, gastric cancer, bladder cancer, ovarian cancer, lung cancer, prostate cancer, pancreatic cancer, colorectal cancer, head and neck squamous cell cancer or osteosarcoma, and acute lymphoblastic leukaemia. In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of human solid tumours with HER2 IHC 2+ or 1+ and HER2 FISH negative tissue status. Advantageously, the present invention relates to duocarmycin-containing ADCs for use in the treatment of triple negative breast cancer (TNBC).

Abstract: A WNT5A peptide or derivatives thereof in combination with one or more checkpoint inhibitors for use in treatment of cancer in a subject in need thereof. Furthermore, WNT5A peptides or derivatives thereof may be used in treatment of cancer in a subject, wherein the subject is responsive to immune checkpoint inhibitors.

Abstract: The invention provides nucleotide sequences and amino acid sequences of the Dip gene as well as (functional) homologues, fragments and variants thereof, which provides diplospory as a part of apomixis. Also diplospory plants and methods for making these are provided, as are methods of using these, and methods of making apomictic seed.

Abstract: A magnetic coupling assembly for coupling of a first rotary shaft and a second rotary shaft. The magnetic coupling assembly includes a first and second rotary hub, a sleeve, coaxial with the first rotary hub and arranged to be rotatable with respect to the first rotary hub, a first and second displacement element threadingly connected to the sleeve, and a first and a second rotatable inductor rotor arranged to co-rotate with the rotation of the first rotary hub. The first and second rotatable inductor rotors are connected to the first and second displacement element, respectively, and rotatable central magnet rotor. The sleeve includes threaded outer surfaces of opposite threading engaged by the first and second displacement elements so as to displace the first and second displacement elements in opposite directions.

Abstract: A system includes a housing and a first circuit board positioned inside the housing. The housing has a top panel, a bottom panel, a left side panel, a right side panel, a front panel, and a rear panel. The front panel is at an angle relative to the bottom panel in which the angle is in a range from 30 to 150°. The first circuit board has a length, a width, and a thickness, in which the length is at least twice the thickness, the width is at least twice the thickness, and the first circuit board has a first surface defined by the length and the width. The first surface of the first circuit board is at a first angle relative to the bottom panel in which the first angle is in a range from 30 to 150°. The first surface of the first circuit board is substantially parallel to the front panel or at a second angle relative to the front panel in which the second angle is less than 60°.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: The invention provides the nucleotide sequence and amino acid sequences of the parthenogenesis gene of Taraxacum as well as (functional) homologues, fragments and variants thereof, which provides parthenogenesis as a part of apomixis. Also parthenogenetic plants and methods for making these are provided, as are molecular markers and methods of using these.

Abstract: The invention relates to an antimicrobial peptide for use in a method of preventing or treating fungal nail infection (onychomycosis). The invention further relates to a composition comprising an antimicrobial peptide and a pharmaceutically acceptable diluent or excipient, for use in a method of preventing or treating onychomycosis. The invention also relates to a method of treating a patient suffering from onychomycosis, the method comprising administering a therapeutically effective amount of an antimicrobial peptide thereof to the cuticle of a nail affected by onychomycosis.

Abstract: The present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively linked to antigenic protein or peptide encoding sequences. The present vaccine stimulates an enhanced immune response.

Abstract: Provided is a connector assembly for optically connecting one or more optical fibers and an array of vertical coupling elements of a photonic integrated circuit (PIC). In various embodiments, the connector assembly is constructed to independently optically scale some feature sizes, such as, for example, the transverse mode size, the array size, the array geometry, and/or various incidence angles, the optical scaling being performed, e.g., from a fiber end face plane to a connector-mating plane and further to a PIC coupling plane. In some embodiments, the connector assembly may support a polarization (de)multiplexing functionality.

Abstract: A return air grille air purifier including an air filtration system including a media filter and a filter enhancement module. The filter enhancement module includes an ionization array configured to charge particles in an airstream passing through the filter enhancement module and towards the media filter. The return air grille air purifier also includes a first housing and a second housing configured to contain the air filtration system. The second housing contained within the first housing in a closed position and the second housing configured to move outward with the air filtration system at least partially out of the first housing in an open position. The media filter being removably accessible from the second housing in the open position.

Abstract: Provided are (i) a fiber-optic cable having a cable sheath that enables significant changes in the cable's cross-sectional shape when the cable is bent and (ii) a raceway that can be used to deploy such a fiber-optic cable.

Abstract: It was found that plants comprising modified CENPC protein comprising one or more active mutations which affect the functioning of CENPC protein yet allow plants expressing said modified CENPC protein to be viable, are able to induce haploid offspring after a cross to or with a wild type plant comprising a endogenous CENPC protein. The invention relates to generation of haploid and doubled haploid plants.

Abstract: A process for manufacturing a lysed cell in oil suspension and methods of applying thereof, the lysed cell in oil suspension including a solids content of at least 10 wt. % and a particle size Dv90 of 100 to 300 microns, including steps a) adding a first portion of microbial cell matter to an oil, b) subjecting the mixture of microbial cell matter and oil to one or more shear steps to effect lysis of at least part of the cells and produce a suspension including lysed cells in oil, c) adding a further portion of microbial cell matter to the suspension including lysed cells in oil, d) subjecting the mixture of microbial cell matter and the suspension including lysed cells in oil to one or more shear steps to effect lysis of at least part of the cells and produce a further suspension including lysed cells in oil.

Abstract: A method for improving the effectiveness of a building air circulation system having motorized blower and a contamination filter. The method including predicting a cost of operation of the system over an operational duration based on at least electricity consumption of the motor (115), and an operational cost to operate the filter (148), predicting a cost of maintenance of the system over the operational duration based on at least one of, a condition of the filter (148), a cost of a filter (148), a cost of labor to clean or replace the filter (148), and an effectiveness of the filter (148) over the operational duration, and balancing the cost of operation of the circulation system versus the cost of maintenance of the circulation system over the duration to recommend at least one of a filter use/bypass schedule, a filter maintenance schedule, and a fresh air input schedule satisfying an operation objective and an operational constraint.

Abstract: The invention provides nucleotide sequences and amino acid sequences of the Dipgene as well as (functional) homologues, fragments and variants thereof, which provides diplospory as a part of apomixis. Also diplospory plants and methods for making these are provided, as are methods of using these, and methods of making apomictic seed.

Abstract: The present invention relates to a technology and method of priming of an immune response using invariant chain linked antigen, when these are used to prime a subsequent booster immunization using any suitable vacci.

Abstract: Provided are (i) a fiber-optic cable having a cable sheath that enables significant changes in the cable's cross-sectional shape when the cable is bent and (ii) a raceway that can be used to deploy such a fiber-optic cable.