Abstract: A low latency metadata subsystem for file systems in low latency (LL) mode in a distributed file storage service (DFSS). An LL server (LLS) may receive metadata requests from an access node of the DFSS. For read operations, the LLS may check a local cache of metadata and, for cache hits, retrieve the metadata from the cache. For cache misses, the metadata may be fetched from the storage subsystem of the DFSS and cached. For write operations, the LLS may write entries into a journal for the file system and notify the access node after the journal entries are committed to the journal; the journal entries are asynchronously committed in the storage subsystem. The access node may communicate with the storage subsystem to perform data reads and writes for the LL file system.

Abstract: This disclosure relates to systems and methods for managing documents and other electronic works. Certain embodiments relate to enabling secure, governed, and/or audited collaboration and/or document management over cloud storage platforms (e.g., third-party cloud storage platforms). Further embodiments relate to providing key and rights management as well as collaboration services in conjunction with cloud storage services.

Abstract: Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home.

Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.

Abstract: The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrro-lopyridines, pharmaceutical compositions thereof methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: In an automatically switched optical network operating according to a wavelength plan, the wavelengths are assigned to an optical path based on availability, performance and SRS wavelength coupling reduction. First, the wavelengths are grouped in static bins based on their reach versus cost performance, and each bin assumes a ?Q of a middle wavelength. Then, the bins are moved into subsets of dynamic bins, constructed using bin constraints that account for the particulars of the respective optical path. The path is characterized taking into account the wavelength currently accessing at the end nodes, and the wavelength tandeming through the end nodes. Wavelength selection starts with the bins that satisfy the maximum number of constraints, and the wavelengths are checked sequentially against wavelength constraints; relaxed constraints are also applied when it is not possible to exactly satisfy one or more constraints.

Abstract: A compound having the structure: or a pharmaceutically acceptable salt or solvate thereof, wherein A and A? are C or N, where C may be substituted by halo or C1-C6 alkyl; R and R0 are selected from the group consisting of H, C1-C6 alkyl, —(CH2)n—W, etc., where W is 5- or 6-membered heteroaryl or heterocyclic containing N, S and/or O atoms, —NR?SO2—R?, etc., where R? and R? are C1-C6 alkyl, etc.; wherein each alkyl, etc., may be substituted; or, R and Ro and the N atom to which they are bonded together to form a monocyclic or bicyclic heterocyclic ring, etc.; R1 is H, halo or cyano; R2 and R2? are H, C1-C6 alkyl, etc.; X is a bond, etc.; R3 is H, C1-C4 alkyl, etc.; Y is a bond, —(CH2)m—, etc. The invention also relates to compositions and uses in the treatment of various diseases.

Abstract: The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

Abstract: Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home.

Abstract: Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home.

Abstract: The present invention provides compounds, pharmaceutical compositions, methods of inhibiting ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.

Abstract: An inductive sensor device includes a scale unit (24) containing field elements (26) that cooperate with a transmit circuit (32) to create a field pattern (S(x)) in measuring direction (M). A sensor unit (25) contains at least one receive circuit (34) with at least one receive coil (35), respectively. The sensor unit (25) and the scale unit (24) can move relatively in measuring direction (M). The coil loops (37) of the at least one receive coil (35) and/or the scale loops (28) of the scale elements (26) are separated into a loop front (56) and a loop back (57), each containing a sectional portion that runs alternately with regard to the height direction. The alternating run can be obtained by combining linear and/or curved portions so that a meandering, zigzag, sinusoidal, or another arbitrary alternating run can be obtained.

Abstract: An inductive sensor device includes a scale unit (24) containing field elements (26) that cooperate with a transmit circuit (32) to create a field pattern (S(x)) in measuring direction (M). A sensor unit (25) contains at least one receive circuit (34) with at least one receive coil (35), respectively. The sensor unit (25) and the scale unit (24) can move relatively in measuring direction (M). The coil loops (37) of the at least one receive coil (35) and/or the scale loops (28) of the scale elements (26) are separated into a loop front (56) and a loop back (57), each containing a sectional portion that runs alternately with regard to the height direction. The alternating run can be obtained by combining linear and/or curved portions so that a meandering, zigzag, sinusoidal, or another arbitrary alternating run can be obtained.

Abstract: Provided is an abatement device that reduces an amount of drainage of circulating water. The abatement device lowers an average drainage flow of circulating water to a low flow, when a ratio of a concentration of silicon dioxide within the circulating water and a concentration of hydrogen fluoride within the circulating water is greater than or equal to a predetermined value at which hydrofluorosilicic acid can be produced, and raises the average drainage flow of the circulating water to a high flow higher than the low flow, when the ratio of the concentration of silicon dioxide within the circulating water and the concentration of hydrogen fluoride within the circulating water is less than the predetermined value.

Abstract: Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home.

Abstract: The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR? activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

Abstract: Apparatus and method for forming beverages using a beverage cartridge and sonic energy. A cartridge may include a sonic receiver, such as a feature that extends into an interior space of the cartridge and is arranged to receive a sonic emitter that introduces sonic energy into the interior space. The sonic receiver may be excited by sonic energy, which causes the sonic receiver to itself introduce sonic energy into the cartridge.

Abstract: Disclosed are methods and kits for genome-wide methylation of GpC sites and for genome-wide chromatin structural determination. Specifically, the methods and kits of the present invention make possible the simultaneous determination of endogenous DNA methylation state and chromatin architecture across the entire genome.

Abstract: A low latency metadata subsystem for file systems in low latency (LL) mode in a distributed file storage service (DFSS). An LL server (LLS) may receive metadata requests from an access node of the DFSS. For read operations, the LLS may check a local cache of metadata and, for cache hits, retrieve the metadata from the cache. For cache misses, the metadata may be fetched from the storage subsystem of the DFSS and cached. For write operations, the LLS may write entries into a journal for the file system and notify the access node after the journal entries are committed to the journal; the journal entries are asynchronously committed in the storage subsystem. The access node may communicate with the storage subsystem to perform data reads and writes for the LL file system.