Abstract: The invention relates to an optical element for guiding and forming a laser beam, and to a method for recording beam parameters, particularly in a laser system, comprising a carrier substrate (40) and a coating (39), which is applied to at least one side of the carrier substrate (40), and comprising at least one temperature sensor (38). The temperature sensor (38) is comprised of a number of pixels arranged in a matrix, and each respective pixel has at least one temperature-sensitive element (39). The at least one temperature-sensitive element (39) of the pixel is constructed inside the carrier substrate (40) made of silicon.

Abstract: The present invention relates to compounds of formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly asthma and COPD.

Abstract: This disclosure relates to systems and methods for managing documents and other electronic works. Certain embodiments relate to enabling secure, governed, and/or audited collaboration and/or document management over cloud storage platforms (e.g., third-party cloud storage platforms). Further embodiments relate to providing key and rights management as well as collaboration services in conjunction with cloud storage services.

Abstract: A construction equipment machine includes an operator station equipped with a driver seat which is rotatable around a vertical axis at least from a first operating position to a second operating position through an intermediate position, wherein the machine includes at least a first hand controller which the operator may use at least for some operations and at least in one position of the seat for operating a hydraulic implement. When the seat moves between the first position up to at least the intermediate position, the first hand controller is in a first configuration with respect the seat so as to be in a manipulatable position with respect to the seat, and, when the seat is in its second position, the controller is shifted to a second configuration where it is displaced to a non manipulatable position with respect to the seat.

Abstract: The path selection and wavelength assignment to a selected path are performed by mapping the wavelength reach to the demand distribution (agile reach) resulting in a 50-60% increase in the network reach. The network reach is further increased (about 2.2 times) when on-line measured performance data are used for path selection and wavelength assignment. The connections may be engineered/upgraded individually, by optimizing the parameters of the entire path or of a regenerator section of the respective path. The upgrades include changing the wavelength, adjusting the parameters of the regenerator section, controlling the launch powers, mapping a certain transmitter and/or receiver to the respective wavelength, selecting the wavelengths on a certain link so as to reduce cross-talk, increasing wavelength spacing, etc.

Abstract: Novel imidazolopyridines according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. Wherein R1, L1, R3, R4, Cy, L2 and R5 are as defined herein.

Abstract: A measurement circuit measures a first power consumption value corresponding to a first configuration of a component of a computing device and a second power consumption value corresponding to a second configuration of the component. A user interface module provides a the first power consumption value for the first configuration and the second power consumption value for the second configuration. A user selection indicating one of the first configuration and the second configuration is received and a configuration module implements the configuration indicated by the user selection in the component.

Abstract: Embodiments of the invention are generally directed to adaptive interconnection for multimedia devices. An embodiment of an apparatus includes an apparatus that includes one or more ports, the one or more ports including one or more adaptable ports, where each adaptable port includes a receptacle to accept a plug of a connector element, the receptacle including multiple electrical contacts. The apparatus further includes an adaptable port device to process data including multimedia data received at the one or more adaptable ports, where the adaptable port device is to detect a multimedia signal format for multimedia data received at each of the adaptable ports, and adapt each of the adaptable ports to be compatible with the detected multimedia signal format for the adaptable port.

Abstract: In a method of treating a gas stream, an aqueous scrubbing liquor is circulated through an essentially closed loop (20) comprising an electrochemical unit (48) for reducing the acidity of the liquor. A portion of the circulating liquor is diverted away from the closed loop (20) to a gas scrubbing unit (10). The gas stream enters the scrubbing unit (10), wherein an acid, for example HF and solid particulates, for example SiO2 particulates, within the gas stream dissolve in the diverted liquor. The diverted liquor is subsequently returned to the closed loop (20), and is replenished in the scrubbing unit (10) by fresh liquor diverted from the closed loop (20). A device (46) is provided for monitoring the acidity of the liquor at a location within the closed loop (20). The reduction in the acidity of the liquor by the electrochemical cell (48) is controlled depending on the monitored concentration.

Abstract: Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home.

Abstract: Particular embodiments provide novel and clinically useful DNA methylation predictors of hormone receptor status, and predictors of response to endocrine (e.g., hormonal) and non-endocrine breast cancer therapy. The ESR1 gene, encoding the estrogen receptor (ER) alpha proved to be the preferred predictor of progesterone receptor (PR) status, while methylation of the PGR gene, encoding PR, was the preferred predictor of ER status. ESR1 methylation outperformed hormone receptor status as a predictor of clinical response in patients treated with antiestroges (e.g., tamoxifen), while promoter methylation of the CYP1B1 gene, encoding a tamoxifen and estradiol metabolizing cytochrome P450, predicted response differentially in tamoxifen-treated and non-treated patients. High levels of promoter methylation of the ARH1 gene, encoding a RAS-related small G-protein, were shown to be preferred predictors of better survival in patients who had not received tamoxifen therapy.

Abstract: The present invention relates to compounds of formula (I): to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts, wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly asthma and COPD.

Abstract: Apparatus and method for forming beverages using a beverage cartridge and sonic energy. A cartridge may include a sonic receiver, such as a feature that extends into an interior space of the cartridge and is arranged to receive a sonic emitter that introduces sonic energy into the interior space. The sonic receiver may be excited by sonic energy, which causes the sonic receiver to itself introduce sonic energy into the cartridge.

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-IV) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

Abstract: A rack for carrying skis and snowboards on top of a vehicle includes a pair of clamp devices equipped for mounting on a pair of crossbars. Each clamp device has a collapsible position which reduces its forward facing profile when not being used to carry cargo items.

Abstract: The path selection and wavelength assignment to a selected path are performed by mapping the wavelength reach to the demand distribution (agile reach) resulting in a 50-60% increase in the network reach. The network reach is further increased (about 2.2 times) when on-line measured performance data are used for path selection and wavelength assignment. The connections may be engineered/upgraded individually, by optimizing the parameters of the entire path or of a regenerator section of the respective path. The upgrades include changing the wavelength, adjusting the parameters of the regenerator section, controlling the launch powers, mapping a certain transmitter and/or receiver to the respective wavelength, selecting the wavelengths on a certain link so as to reduce cross-talk, increasing wavelength spacing, etc.

Abstract: The path selection and wavelength assignment to a selected path are performed by mapping the wavelength reach to the demand distribution (agile reach) resulting in a 50-60% increase in the network reach. The network reach is further increased (about 2.2 times) when on-line measured performance data are used for path selection and wavelength assignment. The connections may be engineered/upgraded individually, by optimizing the parameters of the entire path or of a regenerator section of the respective path. The upgrades include changing the wavelength, adjusting the parameters of the regenerator section, controlling the launch powers, mapping a certain transmitter and/or receiver to the respective wavelength, selecting the wavelengths on a certain link so as to reduce cross-talk, increasing wavelength spacing, etc.

Abstract: A power inverter is provided for converting DC power into AC power. The inverter may be operable to couple to two or more transformer modules each operable to convert at least a portion of the DC power to at least a portion of the AC power. In one embodiment, two or more transformer modules are removably coupled to the inverter. In an alternative embodiment, the inverter is capable of electrically coupling to an externally-housed transformer module. In an alternative embodiment, the inverter may include two or more transformer modules hard-wired into the device. The inverter may include an AC safety plug for releasably connecting to an AC power network and outputting AC power. The inverter may include one or more sensors configured to detect one or more properties of the AC power network for the purposes of determining whether a connection to the power network should be established.

Abstract: A method for the treatment of an aqueous stream containing both anionic and cationic species is provided. The method comprises the following steps. Circulating water continuously through an essentially closed loop, the loop incorporating an ion adsorption unit which, in turn, comprises a water permeable layer of an ion adsorbing material. Feeding an aqueous solution containing the anionic and the cationic species to the essentially closed loop. Passing the circulating water, including the aqueous solution containing the ionic and the cationic species, through the ion adsorbing material in the ion adsorption unit in a continuous manner. While at the same time applying an electric potential across the thickness of the layer of ion adsorbing material and removing from the ion adsorption unit more concentrated aqueous solutions of the separate ionic species. Discharging each of the aqueous solutions from the ion adsorption unit.

Abstract: The present invention relates in general to microRNAs (miRNAs). More specifically, the invention relates to expression vectors comprising multiple miRNAs or families and, clusters capable of targeting multiple oncogenic pathways.