Patents by Inventor Peter Ma
Peter Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200069933Abstract: A device for coupling to a fluid connector of an IV administration set to resist contamination of the fluid connector and IV administration set and permit priming of the IV administration set. The device including a cover body having a cavity for receiving the fluid connector, a priming passage for priming fluid from the IV administration set through the fluid connector, and a coupling tab extending from the cover body, the coupling tab permitting the cover body to be coupled to a length of an IV line or other portion of the IV administration set to resist contamination and permit priming of the IV administration set.Type: ApplicationFiled: August 31, 2018Publication date: March 5, 2020Inventors: Soon PARK, Siddarth K. SHEVGOOR, Peter MA, Jiagui LI
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Publication number: 20190211373Abstract: A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: ApplicationFiled: January 14, 2019Publication date: July 11, 2019Inventors: Linda Lee, Sam Woo, Peter Ma
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Patent number: 9708650Abstract: A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: GrantFiled: March 5, 2014Date of Patent: July 18, 2017Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Linda Lee, Sam Woo, Peter Ma
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Publication number: 20170051344Abstract: According to various embodiments described herein, a microfiuidics-chip based purification device and system for Sanger-sequencing reactions is provided. The device and system allow for the introduction into a sequencing system of a cartridge containing purification technologies specific to the sequencing contaminants or sequencing method where the simplified purification solution of a cartridge allows automation of the sample purification process, reduced consumption of purification reagents, and consistency in sampling by reducing the sampling errors and artifacts. These various embodiments therefore solve the need for a microfiuidics-chip-based, Sanger-sequencing reaction purification system for CE devices. The microfiuidic chips described can be used as a PCR chip by reorganizing the on-chip reagents, reaction wells and work flow steps.Type: ApplicationFiled: January 23, 2015Publication date: February 23, 2017Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Swati Goyal, Achim Karger, Peter Ma, S. Jeffrey Rosner, Ian Walton, Jonathan Wang, Michael Wenz
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Publication number: 20170051342Abstract: A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a chemically-enhanced primer. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the primer as well as a method of preparing DNA for sequencing and a method of sequencing DNA and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: ApplicationFiled: August 8, 2016Publication date: February 23, 2017Inventors: LINDA LEE, Sam WOO, Peter MA
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Publication number: 20160321690Abstract: A method of providing advertising on a mobile device is provided. The method provides an advertising control interface area as a top layer on an application interface layer of an application executing on the mobile device. The user launches full advertisements which generally consume more display space than the advertising control interface area by performing an advertising control interface area selection gesture. A user advertisement queue is dynamically updated as the user views full advertisements. Once the user views all of the advertisements in the queue, the advertisement control interface area is removed from the display for a selected period of time, providing full access to the entirety of the application interface area, which incentivizes mobile device users to view the full advertisements in their queue.Type: ApplicationFiled: April 30, 2015Publication date: November 3, 2016Inventor: Peter Ma
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Patent number: 9410192Abstract: A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a chemically-enhanced primer. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the primer as well as a method of preparing DNA for sequencing and a method of sequencing DNA and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: GrantFiled: October 14, 2013Date of Patent: August 9, 2016Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Linda Lee, Sam Woo, Peter Ma
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Publication number: 20160096153Abstract: Systems and methods of manipulating discrete volumes of a first fluid in a second fluid are provided. In some embodiments, discrete volumes can be formed in a conduit. In other embodiments, addition fluid can be added to a discrete volume in a first conduit by injecting the addition fluid at a relatively higher pressure. In some embodiments, discrete volumes that normally would not coalesce can be manipulated to be merged together.Type: ApplicationFiled: September 11, 2015Publication date: April 7, 2016Inventors: Linda G. Lee, Mark F. Oldham, Sam L. Woo, David M. Cox, Richard T. Reel, Peter Ma, Ben Johnson, Dennis Lehto
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Patent number: 9292264Abstract: A software development kit for providing advertising in a mobile device user interface is provided. The software development kit includes computer executable program instructions for generating a wrapper view object that wraps an advertising corner control view object. The kit allows an application developer to create an application interface and wrap it in the wrapper view object. When the resulting computer executable instructions are executed, a user interface is displayed with an advertising corner control interface area and an application interface area. The user can select the advertising corner control interface area using a first selection technique to display an advertising interface area and remove the advertising control interface area and the application interface area. The user can select the advertising corner control interface area using a second technique to remove the application corner control interface area while continuing to display the application interface area.Type: GrantFiled: March 15, 2013Date of Patent: March 22, 2016Assignee: Paschar LLCInventor: Peter Ma
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Publication number: 20150095160Abstract: A method of providing advertising on a mobile device having a plurality of applications is provided by executing a set of computer executable advertising instructions stored on the mobile device. The instructions are stored as part of an operating system or a secondary application that can run in the background and are capable of identifying an application executing in the foreground. The instructions are stored separately from the executable code for the applications on which advertising is displayed. As a result, application developers can subscribe to an advertising service that displays advertising on their application interfaces without creating any code.Type: ApplicationFiled: October 1, 2013Publication date: April 2, 2015Applicant: Paschar LLCInventor: Peter Ma
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Publication number: 20140377747Abstract: A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: ApplicationFiled: March 5, 2014Publication date: December 25, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Linda LEE, Sam Woo, Peter Ma
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Publication number: 20140279029Abstract: A software development kit for providing advertising in a mobile device user interface is provided. The software development kit includes computer executable program instructions for generating a wrapper view object that wraps an advertising corner control view object. The kit allows an application developer to create an application interface and wrap it in the wrapper view object. When the resulting computer executable instructions are executed, a user interface is displayed with an advertising corner control interface area and an application interface area. The user can select the advertising corner control interface area using a first selection technique to display an advertising interface area and remove the advertising control interface area and the application interface area. The user can select the advertising corner control interface area using a second technique to remove the application corner control interface area while continuing to display the application interface area.Type: ApplicationFiled: May 3, 2013Publication date: September 18, 2014Applicant: Paschar LLCInventor: Peter Ma
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Publication number: 20140282126Abstract: A software development kit for providing advertising in a mobile device user interface is provided. The software development kit includes computer executable program instructions for generating a wrapper view object that wraps an advertising corner control view object. The kit allows an application developer to create an application interface and wrap it in the wrapper view object. When the resulting computer executable instructions are executed, a user interface is displayed with an advertising corner control interface area and an application interface area. The user can select the advertising corner control interface area using a first selection technique to display an advertising interface area and remove the advertising control interface area and the application interface area. The user can select the advertising corner control interface area using a second technique to remove the application corner control interface area while continuing to display the application interface area.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Applicant: PASCHAR LLCInventor: Peter Ma
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Patent number: 8703925Abstract: A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: GrantFiled: February 15, 2012Date of Patent: April 22, 2014Assignee: Life Technologies CorporationInventors: Linda Lee, Sam Woo, Peter Ma
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Publication number: 20140099645Abstract: A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a chemically-enhanced primer. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the primer as well as a method of preparing DNA for sequencing and a method of sequencing DNA and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: ApplicationFiled: October 14, 2013Publication date: April 10, 2014Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Linda LEE, Sam WOO, Peter MA
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Publication number: 20130344492Abstract: In one aspect, there are provided methods of amplifying and sequencing a polynucleotide. In some embodiments, the method includes (a) amplifying the polynucleotide with at least one amplification primer, a processive amplification polymerase, a sequencing primer, a sequencing polymerase, deoxynucleoside triphosphates suitable for template-dependent primer extension, and one or more terminating nucleotides, the incubation being carried out at a first temperature suitable for amplifying the polynucleotide with the processive amplification polymerase; (b) incubating the product of step (a) at a second temperature suitable for forming a plurality of differently-sized extended sequencing primers with the sequencing polymerase; (c) evaluating the extended sequencing primers in order to determine the sequence of the polynucleotide. The reactions at the first and second temperatures can be carried out in a single reaction vessel. In other aspects, compositions and kits for carrying out the methods are also provided.Type: ApplicationFiled: June 12, 2013Publication date: December 26, 2013Inventor: Peter MA
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Publication number: 20120270211Abstract: A chemically-enhanced primer is provided comprising a negatively charged moiety (NCM), an oligonucleotide sequence having a) non-nuclease resistant inter-nucleotide linkages or b) at least one nuclease resistance inter-nucleotide linkage. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the chemically-enhanced primer as well as a method of preparing DNA for sequencing, a method of sequencing DNA, and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition wherein excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: ApplicationFiled: February 15, 2012Publication date: October 25, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Linda LEE, Sam WOO, Peter MA
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Publication number: 20120135414Abstract: A composition is provided comprising a negatively charged group, an oligonucleotide sequence and at least none or one nuclease-resistant linkage group to form a chemically-enhanced primer. The chemically-enhanced primer can be used for sequencing and fragment analysis. Methods for synthesizing the primer as well as a method of preparing DNA for sequencing and a method of sequencing DNA and kits containing the chemically-enhanced primer are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which excess amplification primer is degraded by the nuclease and the chemically-enhanced primer is essentially non-degraded.Type: ApplicationFiled: October 28, 2011Publication date: May 31, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Linda LEE, Sam Lee Woo, Peter Ma
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Publication number: 20110070580Abstract: In one aspect, there are provided methods of amplifying and sequencing a polynucleotide. In some embodiments, the method includes (a) amplifying the polynucleotide with at least one amplification primer, a processive amplification polymerase, a sequencing primer, a sequencing polymerase, deoxynucleoside triphosphates suitable for template-dependent primer extension, and one or more terminating nucleotides, the incubation being carried out at a first temperature suitable for amplifying the polynucleotide with the processive amplification polymerase; (b) incubating the product of step (a) at a second temperature suitable for forming a plurality of differently-sized extended sequencing primers with the sequencing polymerase; (c) evaluating the extended sequencing primers in order to determine the sequence of the polynucleotide. The reactions at the first and second temperatures can be carried out in a single reaction vessel. In other aspects, compositions and kits for carrying out the methods are also provided.Type: ApplicationFiled: January 7, 2010Publication date: March 24, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventor: Peter Ma
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Patent number: D892319Type: GrantFiled: August 31, 2018Date of Patent: August 4, 2020Assignee: CareFusion 303, Inc.Inventors: Soon Park, Siddarth K. Shevgoor, Peter Ma, Jiagui Li