Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a toothed belt (10a, 10b) with two mutually oppositely arranged running surfaces (2, 4), wherein, on the running surfaces (2, 4), there are arranged toothings (12, 14) arranged obliquely with respect to the axial direction (X), wherein the obliquity is defined in each case by helix angles (16, 18) between the axial direction (X) and the direction of the tooth flanks of the respective toothings (12, 14). It is provided that the helix angle (16) of the first toothing (12) is oriented oppositely to the helix angle (18) of the second toothing (14).

Abstract: An apparatus is provided for measuring a torque in a force-feedback actuator for a steer-by-wire steering system has a housing element, a control unit, a drive apparatus, and a transmission apparatus to be coupled to a steering device. At least one motion sensor detects a motion of the transmission apparatus relative to the housing element and provide a motion signal resulting from the motion to the control unit. The transmission apparatus is coupled to the housing element by way of at least one reset-reversible adjusting device which has at least one mechanical property. A torque of the transmission apparatus, and thus of a connectable steering device, may be ascertained by the control unit using the at least one mechanical property, which has at least one changing state value during the movement of the transmission apparatus, in combination with the motion signal.

Abstract: The invention relates to a toothed belt (10a, 10b) with two mutually oppositely arranged running surfaces (2, 4), wherein, on the running surfaces (2, 4), there are arranged toothings (12, 14) arranged obliquely with respect to the axial direction (X), wherein the obliquity is defined in each case by helix angles (16, 18) between the axial direction (X) and the direction of the tooth flanks of the respective toothings (12, 14). It is provided that the helix angle (16) of the first toothing (12) is oriented oppositely to the helix angle (18) of the second toothing (14).

Abstract: An apparatus is provided for measuring a torque in a force-feedback actuator for a steer-by-wire steering system has a housing element, a control unit, a drive apparatus, and a transmission apparatus to be coupled to a steering device. At least one motion sensor detects a motion of the transmission apparatus relative to the housing element and provide a motion signal resulting from the motion to the control unit. The transmission apparatus is coupled to the housing element by way of at least one reset-reversible adjusting device which has at least one mechanical property. A torque of the transmission apparatus, and thus of a connectable steering device, may be ascertained by the control unit using the at least one mechanical property, which has at least one changing state value during the movement of the transmission apparatus, in combination with the motion signal.

Abstract: A medical device and/or a method are used by a rescuer who is caring for a patient. The depth of CPR chest compressions is determined, by detecting magnetic fields. An interference is sensed, which is not associated with the CPR chest compressions, but which is superimposed on the detected magnetic fields. Appropriate countermeasures may be taken, if the sensed interference is larger than a threshold.

Abstract: The method for adjusting a natural gas temperature for a fuel supply line of a gas turbine engine includes measuring by infrared analysis the natural gas percentage content of methane (CH4), ethane (C2H6), propane (C3H8), butane (C4H10), carbon dioxide (CO2), calculating the nitrogen (N2) percentage content as the complement to 100 of the measured percentage content of methane (CH4), ethane (C2H6), propane (C3H8), butane (C4H10), carbon dioxide (CO2), calculating an index indicative of the natural gas energy content and adjusting the natural gas temperature on the basis of the index.

Abstract: The method for adjusting a natural gas temperature for a fuel supply line of a gas turbine engine includes measuring by infrared analysis the natural gas percentage content of methane (CH4), ethane (C2H6), propane (C3H8), butane (C4H10), carbon dioxide (CO2), calculating the nitrogen (N2) percentage content as the complement to 100 of the measured percentage content of methane (CH4), ethane (C2H6), propane (C3H8), butane (C4H10), carbon dioxide (CO2), calculating an index indicative of the natural gas energy content and adjusting the natural gas temperature on the basis of the index.

Abstract: The method for adjusting a natural gas temperature for a fuel supply line of a gas turbine engine includes measuring by infrared analysis the natural gas percentage content of methane (CH4), ethane (C2H6), propane (C3H8), butane (C4H10), carbon dioxide (CO2), calculating the nitrogen (N2) percentage content as the complement to 100 of the measured percentage content of methane (CH4), ethane (C2H6), propane (C3H8), butane (C4H10), carbon dioxide (CO2), calculating an index indicative of the natural gas energy content and adjusting the natural gas temperature on the basis of the index.

Abstract: A control system is provided for a power generating system having a gas turbine, a flue gas exhaust stage and a blow-off valve assembly. The gas turbine includes a compression stage, a combustion stage and a driveshaft. The blow-off valve assembly is configured to selectively provide fluid communication between the combustion stage and the flue gas exhaust stage. The control system includes a controller configured to output a signal causing the blow-off valve assembly to provide the fluid communication in response to a sudden de-loading of the gas turbine.

Abstract: In order to improve the cooling of an air-cooled gas turbine in the partial load operating mode it is proposed to provide a connecting line between two cooling air lines with different pressure levels, which connecting line leads from the second cooling air line at a relative high pressure level to the first cooling air line at a relative low pressure level. In this context, a cooling device for cooling an auxiliary cooling air stream, flowing from the second cooling air line into the first cooling air line, and an adjustment element are arranged in the connecting line. In addition to a gas turbine, a method for operating such a gas turbine is the subject matter of the disclosure.

Abstract: The method for adjusting a natural gas temperature for a fuel supply line of a gas turbine engine includes measuring by infrared analysis the natural gas percentage content of methane (CH4), ethane (C2H6), propane (C3H8), butane (C4H10), carbon dioxide (CO2), calculating the nitrogen (N2) percentage content as the complement to 100 of the measured percentage content of methane (CH4), ethane (C2H6), propane (C3H8), butane (C4H10), carbon dioxide (CO2), calculating an index indicative of the natural gas energy content and adjusting the natural gas temperature on the basis of the index.

Abstract: A medical device and/or a method are used by a rescuer who is caring for a patient. The depth of CPR chest compressions is determined, by detecting magnetic fields. An interference is sensed, which is not associated with the CPR chest compressions, but which is superimposed on the detected magnetic fields. Appropriate countermeasures may be taken, if the sensed interference is larger than a threshold.

Abstract: A control system is provided for a power generating system having a gas turbine, a flue gas exhaust stage and a blow-off valve assembly. The gas turbine includes a compression stage, a combustion stage and a driveshaft. The blow-off valve assembly is configured to selectively provide fluid communication between the combustion stage and the flue gas exhaust stage. The control system includes a controller configured to output a signal causing the blow-off valve assembly to provide the fluid communication in response to a sudden de-loading of the gas turbine.

Abstract: Systems, methods, and computer program products for assisting play are disclosed. In some examples, the system may include a portable computer including a user interface configured to receive input from a user, and a computer communication mechanism configured to transmit computer data based, at least in part, on the received user input; and a plurality of portable devices each including an enclosure, a device communication mechanism within the enclosure and configured to receive the computer data, a proximity sensor mechanism configured to detect proximity of one or more other portable devices of the plurality of portable devices, and an audiovisual output mechanism configured to generate at least one of an audio output and a visual output based on at least one of (1) the received computer data and (2) the detected proximity of the one or more other portable devices.

Abstract: In a method of operating a gas turbine during shut down, the gas turbine is decelerated and closure of compressor inlet guide vanes (1) is initiated at a shaft speed at least 5% above the shaft speed where a vibration peak occurs. The compressor inlet guide vanes (1) are closed by an angle in the range from 15°-35°, preferably at a rate between 5° and 10° per second. The method effects a reduction of the risk of rotational stall.

Abstract: A business object model, which reflects data that is used during a given business transaction, is utilized to generate interfaces. This business object model facilitates commercial transactions by providing consistent interfaces that are suitable for use across industries, across businesses, and across different departments within a business during a business transaction. In some operations, software creates, updates, or otherwise processes information related to a campaign and/or a price specification template business object.

Abstract: Methods and apparatus, including systems and computer program products, for a services architecture design that provides enterprise services having customer relationship management functionality at the level of an enterprise application. The design includes a set of service operations, process components, and optionally deployment units. Suitable business objects are also described.

Abstract: In a method of operating a gas turbine during shut down, the gas turbine is decelerated and closure of compressor inlet guide vanes (1) is initiated at a shaft speed at least 5% above the shaft speed where a vibration peak occurs. The compressor inlet guide vanes (1) are closed by an angle in the range from 15°-35°, preferably at a rate between 5° and 10° per second. The method effects a reduction of the risk of rotational stall.

Abstract: In a guide vane element for a gas turbine with a vane blade extending between a platform that is located radially inward in relation to the main housing of the gas turbine and a radially outward platform, a flange is provided on at least one edge of the platforms adjoining an adjacent second guide vane element in the circumferential direction and on the side of the platform facing away from the vane blade. The second guide vane element can be attached, via a second flange provided on a second platform on the second guide vane element. The connection of the platforms forms a cover band, or a connection between the guide vane elements that is tight, flush, and stress-free at different temperatures.