Abstract: A power management device and microprocessor within a System-in-Package (SiP) are provided with communication signals externally available as outputs from the SiP so that they can be reconfigured by an external device. Methods for the configuration of SiPs and Power Management Integrated Circuits (PMICs) packaged within a SiP are also provided.

Abstract: The embodiments herein provide a secure computing resource set identification, evaluation, and management arrangement, employing in various embodiments some or all of the following highly reliable identity related means to establish, register, publish and securely employ user computing arrangement resources in satisfaction of user set target contextual purposes.

Abstract: Systems and methods of identifying reagents loaded into a fluid handling system can comprise programming a protocol for preparing a sample into a controller of the fluid handling system, loading multiple reagent vessels into a carousel of the fluid handling system, imaging individual labels of the multiple reagent vessels with an imaging device to produce label images, comparing information in the label images to identification information located in a database in communication with the controller, and determining if appropriate reagents have been loaded into the carousel to perform the protocol. A fluid handling system can include a deck, a tube holder, an imaging device, a pipettor, a non-transitory computer-readable storage medium and a processor configured to perform the method.

Abstract: The embodiments herein provide a secure computing resource set identification, evaluation, and management arrangement, employing in various embodiments some or all of the following highly reliable identity related means to establish, register, publish and securely employ user computing arrangement resources in satisfaction of user set target contextual purposes.

Abstract: Amino-pyrazinecarboxamide compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGF?R2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.

Abstract: The present invention provides an article inverting and displacing apparatus and a machine for making sandwiches comprising the apparatus, wherein the apparatus comprises an engagement member (12) adapted to engage a lateral edge portion of a sandwich element; a drive unit (14) configured to drive the engagement member (12) to lift and turn the sandwich element engaged thereby about is opposite lateral edge to invert it; and a control unit configured to control the drive unit (14); wherein the control unit is configured to control the drive unit (14) to drive the engagement member (12) so that the opposite lateral edge of the sandwich element is caused to be raised to approximately at or above the level or height of the engaged lateral edge portion during the inverting step, and, optionally subsequently the sandwich element is caused to lie in a generally horizontal plane. The present invention also provides a process of automatically inverting and displacing articles.

Abstract: A server stores a set of laboratory applications to process batches of samples. The server receives, from a first lab administrator, a selection of a subset of the laboratory applications to process the batches of samples and an admin configuration for a laboratory application in the subset. The server receives configuration(s) of batch(es) to be used for running at least a portion of the subset of laboratory applications configured according to the admin configuration. The server receives, from a first scientific device, a request to run a laboratory application form the first subset to process a batch. The server provides the laboratory application(s) that are capable of being executed using the first scientific device. The server receives, from the first scientific device, a selected laboratory application. The server transmits, to the first scientific device, a signal for executing a first part of the selected laboratory application.

Abstract: The embodiments herein provide a secure computing resource set identification, evaluation, and management arrangement, employing in various embodiments some or all of the following highly reliable identity related means to establish, register, publish and securely employ user computing arrangement resources in satisfaction of user set target contextual purposes.

Abstract: A laboratory workstation for preparing a sample according to a programmed protocol. The laboratory workstation may include a display device configured to display an instruction for loading a first item of labware onto a deck of the laboratory workstation at a position on the deck specified by the programmed protocol; an imaging device configured to monitor the deck of the laboratory workstation by creating one or more images of the deck; and a processor configured to recognize, in the one or more images created by the imaging device, an item of labware loaded onto the deck by an operator. In some embodiments, the processor may be configured to indicate on the display device whether the recognized item of labware loaded by the operator is arranged on the deck in accordance with the programmed protocol.

Abstract: An apparatus for cleaning a surface includes a body defining a cavity and terminating in a distal end that is adapted, in use, to be in the vicinity of a surface to be cleaned such that the surface forms an end wall of a chamber including the cavity; at least one cleaning liquid inlet for flow of a cleaning liquid into the chamber; a divider located in or at the end of the cavity that divides the chamber into first and second portions, the second portion, in use, being in fluid communication with the surface to be cleaned; and an acoustic transducer associated with the first portion to introduce acoustic energy into the chamber; wherein the divider is adapted to permit the passage of acoustic energy therethrough from the first portion to the second portion of the chamber to thereby allow pressure fluctuations to be generated at the surface.

Abstract: A power management device and microprocessor within a System-in-Package (SiP) are provided with communication signals externally available as outputs from the SiP so that they can be configured by an external device. Methods for the configuration of SiPs and Power Management Integrated Circuits (PMICs) packaged within a SiP are also provided.

Abstract: Anti-mesothelin antibodies and conjugates comprising such antibodies are disclosed herein as well as the use of such conjugates in the treatment of disease, such as cancer.

Abstract: A system includes at least partially autonomous vehicles, at least partially separated interconnected roadways, and a management system. Each of the vehicles is configured to cooperate with another vehicle or an area controller. The management system is configured to receive requests to transport, which may have respective start points and respective destinations. Additionally, the management system is configured, responsive to receiving the request, to assign a vehicle to fulfill the request. The assigned vehicle is configured to transport a person from the respective start point, at least in part via the interconnected roadways, to the respective destination.

Abstract: A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form and at least one liquid fill phase. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. Method and apparatus for manufacturing the multi phase soft gelatin dosage forms are also described. The solid phase, liquid phase or coatings may comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, therapeutic substances, functional excipients or combinations thereof.

Abstract: The disclosure relates generally to methods for treating or slowing progression of a tumor, a neurodegenerative disease or a cognitive impairment, and for improving cognition, comprising administration of light therapy. The disclosure also relates to methods for activating oral stem cells, comprising administration of light therapy. Further provided herein are methods for improving cognition, comprising administering to the oral cavity of a subject in need thereof an effective amount of light. Additionally provided herein are methods for treating autism or Asperger's syndrome, comprising administering to the oral cavity of a subject in need thereof an effective amount of light.

Abstract: This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base hydrate (Form 24). This invention also relates to pharmaceutical compositions comprising Form 24, and to methods of using Form 24 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.

Abstract: Electromagnetic interference (EMI) shielding structures for use inside an electronic system are provided, which allow access for mold compound or cables by using baffle-like features on the shield's sides and/or top, as well as methods for shielding components from EMI, or for containing EMI. The structures block external RF from sensitive components and reduce EMI emission from internal, RF generating components.

Abstract: Methods are provided for regulating tooth movement and for maintaining or improving tissue health using heavy forces. Such methods comprise allowing a heavy force to be exerted on one or more teeth of a patient in need thereof; and administering an effective amount of light to the maxillary or mandibular alveolar bone of the patient, wherein the light is administered before, during, or after the heavy force is exerted. The light can have a wavelength in the range of about 585 nm to about 665 nm, or about 815 nm to about 895 nm. An apparatus useful for providing light therapy is also provided.

Abstract: A method of inspecting a pipe joint for use in a subsea pipeline and a method of manufacturing a pipe joint for use in a subsea pipeline employing said inspection method are disclosed, the inspection method comprising the steps of: receiving a pipe joint; measuring the ovality of the pipe joint to obtain ovality data; determining that the ovality data does not exceed a predetermined maximum pipe joint ovality value; and carrying out external pressure collapse tests on a ring cut from one end of the received pipe joint, resulting in data representative of the hydrostatic collapse pressure of said pipe joint for use in confirming that the pipe joint is suitable for its intended use.

Abstract: Systems and methods for purposeful computing are disclosed that, among other things, include enabling an operating system for connected computing configured for identification, evaluation, selection, and/or use of suitable to user purposes' resources to produce outcomes optimized to such purposes' fulfillment. Such resources populate a distributed resource ecosphere and have associated attributes that inform regarding resource suitability.