Abstract: Wireless receivers are described for receiving signals from a transmitter. A receiver can include a plurality of antennas each for receiving a version of a signal via a different propagation channel and providing that version to a respective input. Signal processing means can be included and configured to operate diversity processing of a supplied number of said inputs for use in performing detection of said signal. The receiver can include channel parameter estimation means, configured to estimate one or more channel parameters on the propagation channels. The receiver can also include selection means configured to select only a subset of said inputs to implement a specific dimensionality of the receiver diversity processing, in dependence on the one or more channel parameters indicative of channel conditions on said propagation channels. The diversity processing can be linear or non-linear. Related methods and software implementations and computer program products are also described.

Abstract: The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent cancer and other hypoxia-mediated diseases.

Abstract: The invention relates to an antigen binding site for binding to a P2X7 receptor, the antigen binding site being defined by general formula 1: FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4.

Abstract: Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

Abstract: The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent cancer and other hypoxia-mediated diseases.

Abstract: Storage-stable compositions comprising soil release polymers. Compositions are described comprising *A) of from 45 to 55% by weight of one or more polyesters according to the following formula (I) wherein * R and R2 independently of one another are X—(OC2H4)n—(OC3H6)m wherein X is C1-4alkyl, the —(OC2H4) groups and the —(OC3H6) groups are arranged block-wise and the block consisting of the —(OC3H6) groups is bound to a COO group or are HO—(C3H6), *n is based on a molar average a number of from 12 to 120, * m is based on a molar average a number of from 1 to 10, and *a is based on a molar average a number of from 4 to 9, and * B) of from 10 to 30% by weight of one or more alcohols selected from the group consisting of ethylene glycol, 1,2-propylene glycol, 1,3 -propylene glycol, 1,2 -butylene glycol, 1,3 -butylene glycol, 1,4 -butylene glycol and butyl glycol and *C) of from 24 to 42% by weight of water, the amounts in each case being based on the total weight of the composition.

Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: The present invention relates to compounds and methods which may be useful as inhibitors of HIF pathway activity for the treatment or prevention of cancer and other hypoxia-mediated diseases.

Abstract: A method of processing digital samples of a signal received at a receiver of a wireless communication system includes monitoring channel conditions and generating a channel indicator including at least one channel parameter by performing at least one of: estimating a channel mobility parameter and comparing it with a threshold; estimating a channel parameter of the energy of the channel outside a predefined temporal window, and comparing it with a threshold; estimating a channel temporal duration parameter and establishing if it meets predetermined criteria; estimating a channel-zero location parameter and establishing if it meets predetermined criteria; estimating a received-signal signal-to-disturbance power ratio, and comparing it to a threshold; estimating an estimated-channel-response signal-to-disturbance power ratio; estimating the degree of non-stationarity of the disturbance at the receiver input; and selecting one of a plurality of processing routines for processing the digital samples based on said

Abstract: At least one message flow file that stores a message flow is read by a processor. The message flow stored within the at least one message flow file is parsed. The message flow is organized within a memory as a message flow database structure. Entries within the message flow database structure represent nodes, connections, and properties used by the message flow. The message flow database structure is edited in response to receipt of a structured query language (SQL) statement that specifies a change to the message flow database structure.

Abstract: Techniques are described for optimizing the processing facilities of a receiver in a wireless communication environment, taking into account processing performance set against the computing resources and/or power consumption required to obtain that processing performance. A radio receiver for a wireless communications system can include channel equalization means arranged to receive samples of an incoming signal and to generate an equalized output, said channel equalization means including means for processing said digital samples in accordance with an equalizer algorithm. The receiver includes means for estimating parameters of a channel over which the incoming signal has been transmitted. The receiver can also include means for selecting from a plurality of equalizer algorithms an equalizer algorithm for execution by the processing means based on at least one said estimated channel parameter. Related methods and algorithms are described. Related computer program products are also described.

Abstract: At least one message flow file that stores a message flow is read by a processor. The message flow stored within the at least one message flow file is parsed. The message flow is organized within a memory as a message flow database structure. Entries within the message flow database structure represent nodes, connections, and properties used by the message flow. The message flow database structure is edited in response to receipt of a structured query language (SQL) statement that specifies a change to the message flow database structure.

Abstract: Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

Abstract: An aerial delivery platform comprises first and second modules (10a, 10b) each having a respective load-bearing surface (14). The modules (10a, 10b) are hinged together for relative flexing movement about an axis (24) between the modules (10a, 10b). A superstructure of interconnected struts (25, 26, 27, 28, 29) is connected to, and is upstanding from, the modules (10a, 10b) to hold the modules (10a, 10b) with the load bearing surfaces (14) co-planar when loaded and during descent but being elastically deformable to permit limited relative flexing movement between the modules (10a, 10b) under the loads applied by parachute opening and on landing to assist in the absorption the energy transferred to the platform.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of bromodomain-containing protein-mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibiting activity of a bromodomain-containing protein in a human or animal subject are also provided.

Abstract: A method, apparatus and computer program is disclosed for managing a user interface (UI) for an application program in which a plurality of user interface methods are provided for a given application program function, one or more of the more frequently used UI options being maintained in the UI while one or more of the less frequently used UI options are removed.

Abstract: Provided herein are compounds of formula A-L-B, and pharmaceutically acceptable salts and stereoisomers thereof, wherein A is ?wherein L, B and R3 are defined herein, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds and compositions provided herein are PDE-10 inhibitors and useful, e.g., for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.