Abstract: A method of prilling or spray drying comprising calculating and controlling the viscosity of a shear-thinnable fluid stream at a particle-forming section of a dispersion device. The method comprises measuring the static head of fluid in the dispersion device, providing a pressurized blanket of inert gas over the fluid, mechanically agitating the fluid in the dispersion device, calculating the viscosity at the particle-forming section and controlling the viscosity by adjusting the speed of mechanical agitation.

Abstract: The present invention provides novel glycoconjugates such as glycopeptides, as well as convergent methods for the synthesis thereof. An exemplary preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the glycoconjugates of the invention.

Abstract: A method of prilling or spray drying comprising calculating and controlling the viscosity of a shear-thinnable fluid stream at a particle-forming section of a dispersion device. The method comprises measuring the static head of fluid in the dispersion device, providing a pressurized blanket of inert gas over the fluid, mechanically agitating the fluid in the dispersion device, calculating the viscosity at the particle-forming section and controlling the viscosity by adjusting the speed of mechanical agitation.

Abstract: The present invention relates to chemical processes useful in the manufacture of the compound 4-(6-chloro-2,3-methylenedioxyanilino)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-tetrahydropyran-4-yloxyquinazoline (the active entity within AZD0530), to intermediates useful in the manufacture of that compound and to processes for the manufacture of those intermediates. The invention also relates to particular crystalline forms of that compound such as a difumarate salt and a trihydrate and to pharmaceutical compositions containing such crystalline forms.

Abstract: Catalytic compositions for conversion of substituted aromatic feed materials to oxidized products comprising aromatic carboxylic acid derivatives of the substituted aromatic feed materials comprise a combination comprising a palladium component, an antimony component and/or a bismuth component, and one or more Group 4, 5, 6 or 14 metal or metalloid components. A process for oxidizing substituted aromatic feed materials comprises contacting the feed material with oxygen in the presence of such a catalytic composition in a liquid reaction mixture.

Abstract: A single-mode optical waveguide with a core, surrounded by a cladding consisting of an inner soft layer and an outer harder layer is described. The outer layer has a grating structure on its inner surface, whose spatial frequency is the same as that of the guided mode. The thickness of the inner cladding is sufficient to keep the grating outside the mode field in undeformed regions of the waveguide, so that normally no out-coupling of the light results. Connections are made by crossing two such waveguides at an angle and pressing them together. This results in deformation of the two waveguides such that the gratings are brought into proximity with the cores. Light is coupled out of one waveguide and into the other in the deformed region, resulting in a self-aligning optical connection. The out-coupled light propagates normal to the waveguide axis, so errors in the crossing angle cause little change in efficiency.

Abstract: A method and a system for using a modular signal device for a room occupancy management system are disclosed here. The method includes the steps of determining the occupancy status of a room associated with the device and generating a signal in the device in response to the determination of the status of the room. The device may be a light bar displaying different color patterns in response to the occupancy status of the room. A room occupancy management system is also disclosed. The system includes a signal device for generating a signal displaying the occupancy status of an associated room and a control unit for controlling the device.

Abstract: Catalytic compositions for conversion of substituted aromatic feed materials to oxidized products comprising aromatic carboxylic acid derivatives of the substituted aromatic feed materials comprise at least two metal or metalloid elements, at least one of which is palladium, platinum, vanadium or titanium, and at least one of which is a Group 5, 6, 14 or 15 metal or metalloid. A process for oxidizing substituted aromatic feed materials comprises contacting the feed material with oxygen in the presence of such a catalytic composition in a liquid reaction mixture.

Abstract: This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant. This invention also provides a multivalent vaccine comprising at least two of the following: glycosylated MUC-1-32mer, Globo H, GM2, Ley, Tn(c), sTN(c), and TF(c). This invention provides the vaccine above, wherein the adjuvant is saponin-based adjuvant. This invention provides a method for inducing immune response in a subject comprising administering an effective amount of the vaccine above to the subject. Finally, this invention provides a method for treating cancer in a subject comprising administering an appropriate amount of the vaccine above to the subject.

Abstract: This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant. This invention also provides a multivalent vaccine comprising at least two of the following: glycosylated MUC-1-32mer, Globo H, GM2, Ley, Tn(c), sTN(c), and TF(c). This invention provides the vaccine above, wherein the adjuvant is saponin-based adjuvant. This invention provides a method for inducing immune response in a subject comprising administering an effective amount of the vaccine above to the subject. Finally, this invention provides a method for treating cancer in a subject comprising administering an appropriate amount of the vaccine above to the subject.

Abstract: A cargo roller tray shear fitting that may be used to fasten a cargo roller tray to a floor beam. The shear fitting may include a back plate having at least one slot. A lug extends from the back plate and has a lug opening.

Abstract: A system, method, and computer program for component scattering from a bill of material, comprising selecting a plurality of components from a list; calculating a bounding box for each of said plurality of components; calculating a centroid corresponding to each of said bounding boxes; calculating a scatter circle for placement of said plurality of components; and calculating a number of locations to place said plurality of components on said scatter circle; whereby said plurality of components are added to an assembly view in a single operation such that a largest of said plurality of components is at a start point and appropriate means and computer-readable instructions.

Abstract: A method for radar protection. The method includes recording energy events and calculating differences in recorded energy events to determine pulses. The method further includes sorting intervals between pulses into histogram bins, each bin representing a range of time intervals between two pulses, each pulse indicative of a radar frequency and limiting network traffic on a frequency based on a selected bin count.

Abstract: This invention provides a method for identification of the optimal combination of a polyvalent vaccine against a cancer comprising steps of: a) selection of an appropriate cancer cell line; and b) detection of the expression of antigens on the surface of said cell line of the cancer, wherein the antigens expressed will be used in the polyvalent vaccine. This invention also provides a method for identification of the optimal combination of a polyvalent vaccine against a cancer comprising steps of : a) selection of an appropriate cancer cell line and b) detection of the immunogenicity will be used in the polyvalent vaccine. This invention provides various uses of the identified polyvalent vaccine.

Abstract: A medical device configured to be temporarily secured at a tissue field, such as a fetal skull, via a spiral probe. The spiral probe functions to both secure the sensor in place and provide an electrode for ECG purposes. The spiral probe is non-uniform and includes one or more of a stop element, a cross bar element and a collapsed portion adapted to engage tissue after a predetermined rotation of the probe into the tissue field. The probe diameter can expand with an increase in torque applied to a drive rod, leading to disengagement of the drive rod from the probe. The spiral probe and drive rod may define a detent mechanism whereby upon reaching a predetermined torque the drive rod is disengaged from the probe and freely rotates without further entry of the spiral probe into the tissue field.

Abstract: The invention relates to apparatuses for moving cargo. In one embodiment, such an apparatus may have a plurality of torque tubes. Each of the torque tubes may comprise a member in the shape of a continuous, closed loop defining a hole extending along the member. Rollers may be attached between torque tubes to move cargo disposed on the rollers. The apparatus may be used in the cargo hold of an aircraft.

Abstract: A method of using an oximeter sensor assembly including the steps of detecting light from a light emitting element and storing digital data in a memory associated with the sensor assembly. The stored digital data includes coefficients for use by an oximeter monitor coupled to the sensor assembly to calculate data from the detected light, wherein the coefficients represent a combination of different sensor-specific characteristics, application-specific characteristics, and patient-specific characteristics. Control means including means for processing received information signals in accordance with the equation in response to received coefficients to determine blood oxygen levels is provided.

Abstract: An apparatus and methods for forming a composite part are provided. A method for forming a composite part may include placing initial composite material on a base tool, placing a tooling mandrel on the composite material, placing additional composite material over the tooling mandrel, covering at least a portion of the composite material that overlays the tooling mandrel with a composite forming tool, heating the composite material to at least partially cure the composite material, and permitting a first portion of the composite forming tool to change size during the heating of the composite material to a greater degree than a second portion of the composite forming tool. In this regard, the second portion of the composite forming tool is closer to the base tool than the first portion of the composite forming tool. A composite forming tool is also provided that permits differential expansion of different portions of the tool.

Abstract: Impure aromatic carboxylic acids such as are obtained by liquid phase oxidation of feed materials comprising aromatic compounds with substituent groups oxidizable to carboxylic acid groups, or comprising aromatic carboxylic acid and one or more aromatic carbonyl impurities that form hydrogenated species more soluble in aqueous solvents or with less color or color-forming tendencies than the aromatic carbonyl impurity, are purified to an aromatic carboxylic acid product with lower levels of impurities by a process comprising contacting an aqueous solution comprising the impure aromatic carboxylic acid with hydrogen at elevated temperature and pressure with an attrition-resistance, acid stable catalyst composition comprising at least one hydrogenation catalyst metal and a support comprising relatively high surface area silicon carbide.

Abstract: A flexible finger sensor having a finger entrance, a sensor holder at a distal end of the assembly, and a fenestrated region disposed between the finger entrance and the sensor holder. A displacement resistant finger sensor and method of use for reducing motion-related artifacts by mechanical isolation from external forces by providing a resilient sensor body having a digit entrance, a sensor holder, and a fenestrated region between the digit entrance and the sensor holder. The sensor holder maintains sensing elements relative to a user's finger, with said sensing elements being in communication with a monitoring device via a lead wire. The lead wire may extend at a lateral edge of the sensor body. A force to the lead wire may be applied so as to distort the fenestrated region without substantially disturbing the sensing elements relative to the finger surface.