Abstract: Disclosed is a cardio-pulmonary health monitoring apparatus. The apparatus comprises a contactless motion sensor configured to generate one or more movement signals representing bodily movement of a patient during a monitoring session; a processor; and a memory storing program instructions configured to cause the processor to carry out a method of processing the one or more movement signals. The method comprises extracting one or more sleep disordered breathing features from the one or more movement signals, and predicting whether a clinical event is likely to occur during a predetermined prediction horizon based on the one or more sleep disordered breathing features.

Abstract: The invention relates to the soybean variety designated 01094730. Provided by the invention are the seeds, plants and derivatives of the soybean variety 01094730. Also provided by the invention are tissue cultures of the soybean variety 01094730 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 01094730 with itself or another soybean variety and plants produced by such methods.

Abstract: Systems and methods for managing sleep quality of a patient, comprising: collecting physiological signal data of the patient using a data acquisition unit electrically coupled to at least one sensor affixed to the patient that generates the physiologic signal data; using one or more hardware processors executing instructions stored in a storage device: filtering the physiological signal data into a plurality of frequency bands corresponding to a plurality of power spectra waveforms; and characterizing an etiology of sleep quality of the patient based on a comparison of at least a first power spectra waveform of the plurality of power spectra waveforms against at least a second power spectra waveform of the plurality of power spectra waveforms, wherein the sleep quality of the patient is managed based on the characterized etiology of sleep.

Abstract: A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.

Abstract: A pulmonary treatment system for treatment of target tissue in an airway of a subject, including a catheter assembly comprising an ablation assembly or tip including an expandable member, at least one energy emitter, and a cooling member, wherein the ablation tip is configured to be positioned within the airway of the subject such that expansion of the expandable member enables the at least one energy emitter and cooling member to engage a wall of the airway, the cooling member configured to cool a portion of the surface of the wall of the airway to reduce damage to the airway disposed between the at least one energy emitter and the target tissue, while the at least one energy emitter delivers energy to the target tissue to create one or more nerve attenuating lesions, and a control assembly including a display configured to depict a three-dimensional graphical rendering of the airway of the subject for preplanning prior to the procedure, with real-time tracking of the ablation tip during the treatment of the

Abstract: Psilocin formulations of psilocin mucate with improved stability, physical properties and/or handling characteristics, as well as enhanced pharmacologic activity, pharmacokinetic parameters and safety characteristics as compared to psilocin or psilocybin and methods for their use are provided.

Abstract: Provided herein are methods of treating and/or managing cancers, which comprise administering to a patient Compound A. Provided herein are also methods of treating and/or managing cancers, which comprise administering to a patient Compound A in combination with nivolumab. Additionally, provided herein are methods of treating and/or managing cancers, which comprise administering to a patient Compound A in combination with chemotherapy.

Abstract: A pivotable junction box and driver housing unit includes a junction box having a junction box cavity, and a driver housing having a driver housing cavity to contain a light fixture driver. The junction box and the driver housing are attached to each other. The junction box and the driver housing are rotatable with respect to each other.

Abstract: Excessive deposition of extracellular matrix is a hallmark of Idiopathic pulmonary fibrosis (IPF); it is advantageous to target the cells and the mechanisms associated with this process. By targeting myofibroblasts (specialized contractile fibroblasts) that are key for the development of IPF with drugs conjugated with fibroblast activation protein (FAP), this technology helps minimize the production of extracellular matrix in the lungs and provides a new treatment option for patients diagnosed with IPF.

Abstract: The present invention relates to compounds that bind to prostate-specific membrane antigen (PSMA) comprising a PSMA binding moiety, a linker group comprising a silicon-fluoride acceptor (SIFA) moiety and a chelator moiety, optionally containing a chelated nonradioactive or radioactive cation, wherein the SIFA moiety comprises a covalent bond between a silicon and a fluorine atom which can be 18F. The disclosure includes compounds of Formula (1) or a pharmaceutically acceptable salt or any individual isomer thereof, wherein CM is defined herein, and their use as cancer diagnostic or imaging agents.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: Fabric and home care compositions including a surfactant and a protease. The automatic dishwashing composition is in the form of a water-soluble unit-dose pouch including a compartment. The compartment includes both a powder component and a gel component. The protease is a subtilisin variant that includes: (i) a mutation at position 122; and (ii) one or more mutations at positions 126, 127, 128, 211 and 212, with reference to SEQ ID NO: 1. The variant has at least about 80% identity to the amino acid sequence of SEQ ID NO: 1.

Abstract: A battery-powered tool equipped with damping to reduce vibration, noise and heat generated by drive components and high oscillation rates of components and mating accessories mounted to those tools. Some versions of the tool may include elastomeric damping pads, rings, strips, blocks, threaded mounts or co-molded elements. Other versions may include shrouded components or shrouds comprising elastomeric materials.

Abstract: A desmodromic mechanism exhibits reciprocating motion of a pair of cam followers driven by a single cam. The mechanism is useful in a fuel pump that pressurizes a liquid for delivery to a fuel rail of a combustion engine. A desmodromic lever is symmetric about its rotational axis and maintains continuous contact between cam lobes and cam followers for the entirety of each rotational cycle. The mechanism is particularly useful in multi-piston pumps required to deliver higher than normal volumes of liquid fuel, as is the case with low energy density alternatives to diesel fuel.

Abstract: A method of controlling an adjustable chair comprising the steps of measuring the height of a person, entering the height of the person into a software application on a mobile device, taking a photograph of the person with a mobile device, analyzing the photograph to determine physical measurements of the person, storing the measurements in the mobile device; calculating optimum ergonomic adjustment of the chair based upon the stored measurements; and, transmitting signals to a controller in the chair to control actuators and adjust various components in the chair to achieve optimum ergonomic adjustment. The technology also includes the ergonomic task chair adjusted by the aforementioned method.

Abstract: Described is a track assembly for a tracked vehicle that comprises a track support beam configured to support road wheels, a drive wheel member, and a drive arrangement for drive wheel member operation and an endless track disposed around said road wheels and drive wheel member. Said drive arrangement comprises a motor device for driving said drive wheel member, a transmission device for transferring torque from said motor device to said drive wheel member and a brake arrangement for braking the drive wheel member. Said drive arrangement is configured to be coaxially arranged relative to a centre axis of said drive wheel member. A bearing configuration is arranged in said track support beam, said drive arrangement configured to be journaled in bearings to said bearing configuration for allowing rotation of said drive wheel member relative to said track support beam and for supporting said drive arrangement.

Abstract: An attachment mechanism configured to couple to a receiving port of a bronchoscope, the attachment mechanism including an adapter segment having a tubular body having an inner lumen and distal end, where the distal end includes a plurality of axial slits positioned circumferentially around the distal end to define a flexible tab section, where the flexible tab section defined a recess within the inner lumen configured to receive and mechanically interlock with the receiving port of the bronchoscope; and a slide lock positioned over the tubular body configured to slide over the tubular body between a first position that allows flexible tab section to flex radially outward to receive the receiving port within the recess, and a second position where slide lock restrains the radial expansion of flexible tab section.

Abstract: A retort system includes a vessel defining an interior volume, and a product holding structure received within the interior volume. The product holding structure includes: one or more inlet openings that together define a first flow area for receiving heat exchange liquid and one or more outlet openings that together define a second flow area for outflow of heat exchange liquid, the second flow area being smaller than the first flow area for limiting flow of heat exchange liquid out of the product holding structure. A heat exchange liquid flow system that is configured to direct heat exchange liquid into the product holding structure causing the product holding structure to fill with heat exchange liquid to at least a submersion level above products within the product holding structure while a level of heat exchange liquid outside the product holding structure and within the interior volume remains below the submersion level.

Abstract: Apparatus and methods for charging and specifying a capacitor for storing charge in a wearable cardioverter defibrillator (“WCD”). In one aspect the WCD circuitry includes a power source such as a battery coupled to a charger that provides charge energy to an energy storage module including an energy storage capacitor having a rated voltage. Control circuitry is configured to implement a multi-stage charging scheme under which the energy storage capacitor is charged to a first intermediate voltage below its rated voltage during a first charging stage and charged to a second voltage above the rated voltage for a limited time during a second charging stage. In response to detection of potential shockable rhythms the capacitor is charged to an intermediate voltage, while upon confirmation of shockable rhythms the capacitor may be charged to the second voltage, which is then used to deliver a shock to a patient.

Abstract: The invention relates to the soybean variety designated 01094729. Provided by the invention are the seeds, plants and derivatives of the soybean variety 01094729. Also provided by the invention are tissue cultures of the soybean variety 01094729 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 01094729 with itself or another soybean variety and plants produced by such methods.