Abstract: Medical devices for accessing the central nervous system, as well as making and using medical devices, are disclosed. An example medical device may include an expandable access sheath having a proximal end region and a distal end region. The expandable access sheath may be designed to shift between a first configuration and an expanded configuration. The expandable access sheath may include a tubular body having one or more axial support members disposed along the tubular body. The medical device may include an expansion member designed to shift the expandable access sheath between the first configuration and the expanded configuration.

Abstract: Bras for high impact, high support activities are provided. A bra comprises a band that wraps around a torso. The band includes first and second cup regions, and a channel that runs below the collective cup regions. A gore is formed above the channel and between the respective cup regions, adjoining the respective cup regions. A molded cradle is fitted into the channel. For each cup region, a tessellated encapsulating bra cup is fitted therein. Each tessellated encapsulating bra cup includes a plurality of tiles. Respective tiles in the plurality of tiles that are further away from the cradle are larger in size than respective tiles in the plurality of tiles that are closer to the cradle. Each tessellated encapsulating bra cup has a generally concave first inner face and a generally convex first outer face. The tessellated encapsulating bra cups collectively contribute cantilevered support to the bra.

Abstract: A fabric control protocol is described for use within a data center in which a switch fabric provides full mesh interconnectivity such that any of the servers may communicate packet data for a given packet flow to any other of the servers using any of a number of parallel data paths within the data center switch fabric. The fabric control protocol enables spraying of individual packets for a given packet flow across some or all of the multiple parallel data paths in the data center switch fabric and, optionally, reordering of the packets for delivery to the destination. The fabric control protocol may provide end-to-end bandwidth scaling and flow fairness within a single tunnel based on endpoint-controlled requests and grants for flows. In some examples, the fabric control protocol packet structure is carried over an underlying protocol, such as the User Datagram Protocol (UDP).

Abstract: A breathing assistance apparatus has a housing with an engagement feature and an electrical component in the housing and a removable component. The electrical component has a receptacle. The removable component has an electrical connector that is a close or tight fit in the receptacle of the electrical component to assist with holding the removable component in connection with the electrical component. The removable component has a tab with a terminal end portion that can be flexed relative to the rest of the removable component. An engagement feature is provided on the terminal end portion of the tab and engages with the engagement feature of the housing to inhibit disconnection of the removable component from the housing in the absence of actuating the terminal end portion of the removable component to flex the tab.

Abstract: The disclosure provides for an oral composition, the oral composition including at least one active agent, at least one filler component, and water in an amount sufficient such that the oral composition has a total moisture content of about 15% to about 30% by weight or greater based on the total weight of the oral composition.

Abstract: A mountable bracket includes a first leg and a second leg configured to be coupled to a mounting surface, a first sub-leg coupled to the first leg, and a second sub-leg coupled to the second leg. The first leg projects from the mounting surface to define a first engagement surface. The first sub-leg projects from the first leg to define a second engagement surface. The second leg projects from the mounting surface to define a third engagement surface. The second sub-leg projects from the second leg to define a fourth engagement surface. The second engagement surface and the first engagement surface form a first mounting rail having a first rail width. The fourth engagement surface and the third engagement surface form a second mounting rail having the first rail width. The first engagement surface and the third engagement surface form a third mounting rail having a second rail width.

Abstract: Data is received that specifies a bound for an adversarial posterior belief pc that corresponds to a likelihood to re-identify data points from the dataset based on a differentially private function output. Privacy parameters ?, ? are then calculated based on the received data that govern a differential privacy (DP) algorithm to be applied to a function to be evaluated over a dataset. The calculating is based on a ratio of probabilities distributions of different observations, which are bound by the posterior belief pc as applied to a dataset. The calculated privacy parameters are then used to apply the DP algorithm to the function over the dataset. Related apparatus, systems, techniques and articles are also described.

Abstract: The invention relates to a breathing assistance apparatus that may be configured to reduce the risk of damage to electronics within the apparatus as a result of liquid leaks within the apparatus or impacts to the apparatus. In other forms, the apparatus may be configured to allow for easy assembly and/or safe operation.

Abstract: A method includes determining a cluster reliability of a computing cluster including a maximum computing capacity and representative of a reliability of the computing cluster when utilizing an entirety of the maximum computing capacity. The operations include receiving a provisioning request of the computing cluster including a threshold reliability of the computing cluster. In response to the provisioning request, determining, using the cluster reliability, a reserved computing capacity of the computing cluster based on the threshold reliability. The reserved computing capacity is less than the maximum computing capacity. Based on the reserved computing capacity and the maximum computing capacity, the operations include determining an unreserved computing capacity of the computing cluster. The operations include provisioning the computing cluster for execution of a user workload. The user workload executes on the unreserved computing capacity.

Abstract: The present disclosure relates to compounds of Formula I, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for treatment of viral infections, for example for treatment of paramyxoviridae, pneumoviridae, picornaviridae, flaviviridae, filoviridae, arenaviridae, orthomyxovirus, and coronaviridae infections.

Abstract: An electrical machine may include a rotor rotatable about an axis of rotation, by way of which an axial direction of the electrical machine may be defined, a stator having electrically conductive stator windings, and at least one cooling channel through which a coolant may be flowable for cooling the stator windings. The stator may have stator teeth extending along the axial direction, arranged spaced apart from another along a circumferential direction of the rotor, and bearing the stator windings. The at least one cooling channel and at least one stator winding may be arranged in at least one intermediate space formed between two stator teeth adjacent in the circumferential direction. A plastic for transferring heat from the at least one stator winding to the at least one cooling channel may be arranged in the at least one intermediate space.

Abstract: The invention relates to a method for the operational analysis of an engine and/or for calibrating a controller of the engine, in particular an internal combustion engine, wherein run-up occurs of test points defined by values of a plurality of predetermined operating parameters and selected from a multidimensional test space using a statistical experiment design, whereby at least one operating parameter is in each case changed from one test point to the next test point in a plurality of steps in the run-up of the test points, wherein operational measurements are performed at measurement points resulting from a respective increment and at the actual test points, whereby measurement data from the operational measurements for the analysis and calibration of the controller are output and continuously stored, as well as a corresponding system.

Abstract: Data is received that specifies a bound for an adversarial posterior belief ?c that corresponds to a likelihood to re-identify data points from the dataset based on a differentially private function output. Privacy parameters ?, ? are then calculated based on the received data that govern a differential privacy (DP) algorithm to be applied to a function to be evaluated over a dataset. The calculating is based on a ratio of probabilities distributions of different observations, which are bound by the posterior belief ?c as applied to a dataset. The calculated privacy parameters are then used to apply the DP algorithm to the function over the dataset. Related apparatus, systems, techniques and articles are also described.

Abstract: The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: A method includes determining a cluster reliability of a computing cluster including a maximum computing capacity and representative of a reliability of the computing cluster when utilizing an entirety of the maximum computing capacity. The operations include receiving a provisioning request of the computing cluster including a threshold reliability of the computing cluster. In response to the provisioning request, determining, using the cluster reliability, a reserved computing capacity of the computing cluster based on the threshold reliability. The reserved computing capacity is less than the maximum computing capacity. Based on the reserved computing capacity and the maximum computing capacity, the operations include determining an unreserved computing capacity of the computing cluster. The operations include provisioning the computing cluster for execution of a user workload. The user workload executes on the unreserved computing capacity.

Abstract: A vehicle includes first and second drive units, such as drive units that each include an electric motor and a gear train coupling the electric motor to one or more wheels. A first drive unit may be idled while the second drive unit continues to induce movement of the vehicle. Losses within the first drive unit while idled may be reduced by heating the first drive unit, such as with heat generated by the second drive unit. A cooling system is present and may be used to heat the first drive unit by directing fluid exiting the second drive unit into the first drive unit before entering the cooling system or bypassing the cooling system entirely. Oil circulation within the first drive unit may facilitate heating of the gear train by bypassing a heat exchanger receiving the oil and the fluid.

Abstract: Data is received that specifies a bound for an adversarial posterior belief ?c that corresponds to a likelihood to re-identify data points from the dataset based on a differentially private function output. Privacy parameters ?, ? are then calculated based on the received data that govern a differential privacy (DP) algorithm to be applied to a function to be evaluated over a dataset. The calculating is based on a ratio of probabilities distributions of different observations, which are bound by the posterior belief ?c as applied to a dataset. The calculated privacy parameters are then used to apply the DP algorithm to the function over the dataset. Related apparatus, systems, techniques and articles are also described.

Abstract: The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: Data is received that specifies a bound for an adversarial posterior belief ?c that corresponds to a likelihood to re-identify data points from the dataset based on a differentially private function output. Privacy parameters ?, ? are then calculated based on the received data that govern a differential privacy (DP) algorithm to be applied to a function to be evaluated over a dataset. The calculating is based on a ratio of probabilities distributions of different observations, which are bound by the posterior belief ?c as applied to a dataset. The calculated privacy parameters are then used to apply the DP algorithm to the function over the dataset. Related apparatus, systems, techniques and articles are also described.

Abstract: An apparatus for manufacturing a composite article from a composite material. The apparatus comprising: a pulsed broadband radiation source comprising a flashlamp and a light guide adapted to guide light emitted by the pulsed broadband radiation source to a target area. The light guide comprises at least a portion ahead of the pulsed broadband radiation source, relative to the target area, comprising a light transmitting material.