Patents by Inventor Philip Wilson

Philip Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140120118
    Abstract: A compound which is selected from A: B: and C: and salts and solvates thereof, as well as conjugates thereof with cell binding agent.
    Type: Application
    Filed: October 11, 2013
    Publication date: May 1, 2014
    Applicant: Spirogen Sàrl
    Inventor: Philip Wilson HOWARD
  • Patent number: 8697688
    Abstract: Pyrrolobenzodiazepine dimers I having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: April 15, 2014
    Assignees: Seattle Genetics Inc., Spirogen Sarl
    Inventors: Philip Wilson Howard, Luke Masterson, Arnaud Tiberghien, Scott Jeffrey, Patrick Burke, Peter Senter
  • Publication number: 20140066435
    Abstract: Pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds.
    Type: Application
    Filed: November 6, 2013
    Publication date: March 6, 2014
    Applicant: SPIROGEN SARL
    Inventors: Philip Wilson HOWARD, Luke MASTERSON, Arnaud TIBERGHIEN, Scott JEFFREY, Patrick BURKE, Peter SENTER
  • Publication number: 20140030279
    Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.
    Type: Application
    Filed: July 8, 2013
    Publication date: January 30, 2014
    Applicants: Spirogen Sarl, Genentech, Inc.
    Inventors: Paul Polakis, Andrew Polson, Susan Diane Spencer, Shang-Fan Yu, John A. Flygare, Janet L. Gunzner-Toste, Thomas Harden Pillow, Philip Wilson Howard, Luke Masterson
  • Patent number: 8637664
    Abstract: A compound of formula (I); or a salt or solvate thereof, wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R2 is selected from —H, —OH, =0, ?CH2, —CN, —R, OR, halo, ?CH—R, O—SO2—R, CO2R and COR; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, nitro, Me3Sn and halo, where R and R? are independently selected from optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R10 and R11 either together form a double bond, or are selected from H and YRY, where Y is selected from O, S and NH and R is H or C1-7 alkyl or H and SOxM, where x is 2 or 3 and M is a monovalent pharmaceutically acceptable cation; each X is independently a heteroarylene group; n is from 1 to 6; and RE is C1-4 alkyl. The compound is useful for the treatment of proliferative diseases.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: January 28, 2014
    Assignee: Spirogen SARL
    Inventors: Philip Wilson Howard, David Edwin Thurston, Geoffrey Wells
  • Patent number: 8633185
    Abstract: Compounds of the formula I: or solvate thereof, wherein: R2 is an optionally substituted C5-20 aryl group; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, nitro, Me3Sn and halo; where R and R? are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NHRR?, nitro, Me3Sn and halo; R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms and/or aromatic rings; X is selected from O, S, or NH; z is 2 or 3; M is a monovalent pharmaceutically acceptable cation; R2?, R6?, R7?, R9?, X? and M? are selected from the same groups as R2, R6, R7, R9, X and M respectively, or M and M? may together represent a divalent pharmaceutically acceptable cation.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: January 21, 2014
    Assignee: Spirogen Sarl
    Inventors: Philip Wilson Howard, Zhizhi Chen, Stephen John Gregson
  • Patent number: 8592576
    Abstract: Claimed are unsymmetrical Pyrrolobenzodiazepine-dimers (PBD-dimers) of formula (I), that are unsymmetrical due at least to the values that the variables R12 and R2 represent. Formula (I), wherein: R2 is of formula (II), where A is a C5-7 aryl group, X is selected from the group comprising: OH, SH, CO2H, COH, N?C?O, NHRN, wherein RN is selected from the group comprising H and C1-4 alkyl, and (OC2H4)mOCH3, where m is 1 to 3, and either: (i) Q1 is a single bond, and Q2 is selected from a single bond and —Z—(CH2)n—, where Z is selected from a single bond, O, S and NH and n is from 1 to 3; or (ii) Q1 is —CH?CH—, and Q2 is a single bond; R12 is a C5-10 aryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, C1-7 alkyl, C3-7 heterocyclyl and bis-oxy-C1-3 alkylene. The other variables are as defined in the claims. The compounds are useful for the treatment of proliferative diseases.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: November 26, 2013
    Assignee: Spirogen Sarl
    Inventors: Philip Wilson Howard, Stephen John Gregson, Luke Masterson
  • Patent number: 8572631
    Abstract: Systems and methods are provided for controlling a device. In one aspect, a method for controlling a device includes exposing a plurality of virtual device interfaces (13) for a device (11), wherein each virtual device interface (13) enables client control of a discrete function of the device, and controlling concurrent communication between the device (11) and two or more virtual device interfaces (13) operating on a single shared I/O connection (15) using a shared I/O port controlled by a device I/O module (12). The device I/O module (12) enables independent development of multiple device interfaces (13) that can seamlessly and independently operate on a single (physical) device communication connection (15), wherein the device shared I/O (input/output) module (12) implements functions to arbitrate and coordinate I/O activity between the device interfaces (13) and target device (11).
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: October 29, 2013
    Assignee: GVBB Holdings S.A.R.L.
    Inventor: Gerald Philip Wilson
  • Publication number: 20130266595
    Abstract: A conjugate of formula (A): where Y is selected from a single bond, and a group of formulae A1 or A2: where N shows where the group binds to the N10 of the PBD moiety; RL1 and RL2 are independently selected from H and methyl, or together with the carbon atom to which they are bound form a cyclopropylene group; CBA represents a cell binding agent; Q is independently selected from O, S and NH; R11 is either H, or R or, where Q is O, SO3M, where M is a metal cation.
    Type: Application
    Filed: October 12, 2012
    Publication date: October 10, 2013
    Inventors: John A. Flygare, Janet L. Gunzner-Toste, Thomas Pillow, Philip Wilson Howard, Luke Masterson
  • Patent number: 8501934
    Abstract: Methods of preparing ZC-423 (I) which result in varying enantiomeric ratios.
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: August 6, 2013
    Assignee: Spirogen SARL
    Inventors: Philip Wilson Howard, Stephen John Gregson, Zhizhi Chen, Arnaud Charles Tiberghien, Luke Masterson
  • Patent number: 8502436
    Abstract: An electro-dynamic machine including a rotor shaft extending along an axis and a bearing rotatably supporting the rotor shaft for rotation about the axis. An inner housing has an outer surface and defines a bearing bore. The bearing bore receives and supports the bearing. An outer housing surrounds the inner housing. A plurality of non-radial ribs extends from the outer housing to the inner housing. The non-radial ribs are coupled to the inner housing substantially tangential to the outer surface.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: August 6, 2013
    Assignee: Regal Beloit America, Inc.
    Inventors: Philip A. Wilson, Jr., Edward Drye
  • Patent number: 8487092
    Abstract: The invention relates to certain pyrrolobenzodiazepines (PBDs), and in particular pyrrolobenzodiazepine dimers bearing C2 substitutions, including compounds of formula (T): wherein: R2 is CHR2A, and R2A is independently selected from H, R, CO2R, COR, CHO, CO2H, and halo; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R7 is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R8 is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R is independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; or the compound is a dimer with each monomer being of formula (M), where the R7 groups or R8 groups of each monomer form together a dimer bridge having the formula —X—R?—X— linking the monomers; wherein R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms, e.g. O, S, N(H), and/or aromatic rings, e.g.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: July 16, 2013
    Assignee: Spirogen Developments SARL
    Inventors: Philip Wilson Howard, Stephen John Gregson, ZhiZhi Chen, Arnaud Charles Tiberghien, Luke Masterson
  • Publication number: 20130059800
    Abstract: Pyrrolobenzodiazepine dimers I having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds.
    Type: Application
    Filed: April 15, 2011
    Publication date: March 7, 2013
    Applicants: SEATTLE GENETICS INC., SPIROGEN DEVELOPMENTS SÀRL
    Inventors: Philip Wilson Howard, Luke Masterson, Arnaud Tiberghien, Scott Jeffrey, Patrick Burke, Peter Senter
  • Publication number: 20130035484
    Abstract: A compound of formula (I): which is substantially free of any of the corresponding compound of formula (IB): methods of making such compounds, and the further transformation of such compounds.
    Type: Application
    Filed: April 15, 2011
    Publication date: February 7, 2013
    Applicant: SPIROGEN DEVELOPMENTS SÀRL
    Inventors: Philip Wilson Howard, Luke Masterson, Arnaud Tiberghien
  • Publication number: 20130028919
    Abstract: Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs.
    Type: Application
    Filed: April 15, 2011
    Publication date: January 31, 2013
    Applicants: SPIROGEN DEVELOPMENTS SÀRL, SEATTLE GENETICS, INC.
    Inventors: Philip Wilson Howard, Scott Jeffrey, Patrick Burke, Peter Senter
  • Publication number: 20130028917
    Abstract: Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
    Type: Application
    Filed: April 15, 2011
    Publication date: January 31, 2013
    Applicant: SPIROGEN DEVELOPMENTS SÀRL
    Inventors: Philip Wilson Howard, Luke Masterson, Arnaud Tiberghien, John A. Flygare, Janet L. Gunzner, Paul Polakis, Andrew Polson, Helga E. Raab, Susan D. Spencer
  • Publication number: 20120206022
    Abstract: An electro-dynamic machine including a rotor shaft extending along an axis and a bearing rotatably supporting the rotor shaft for rotation about the axis. An inner housing has an outer surface and defines a bearing bore. The bearing bore receives and supports the bearing. An outer housing surrounds the inner housing. A plurality of non-radial ribs extends from the outer housing to the inner housing. The non-radial ribs are coupled to the inner housing substantially tangential to the outer surface.
    Type: Application
    Filed: February 14, 2011
    Publication date: August 16, 2012
    Inventors: Philip A. Wilson, JR., Edward Drye
  • Publication number: 20120205999
    Abstract: An end frame for an electro-dynamic machine. The end frame includes a radial bearing support surface disposed concentrically about the axis and an axial bearing support surface substantially perpendicular to the axis. A base wall is substantially perpendicular to the axis. A first annular wall is disposed concentrically about the axis and extends from the base wall to the axial bearing support surface. A second annular wall is disposed radially outward of the first annular wall and cooperates therewith to define an annular space that extends from the base wall to the axial bearing support surface. A first boundary wall extends across the annular space from the base wall to the axial bearing support surface. A metering wall extends across the annular space a portion of a distance from the base wall to the axial bearing support surface.
    Type: Application
    Filed: February 14, 2011
    Publication date: August 16, 2012
    Inventor: Philip A. Wilson, JR.
  • Publication number: 20110256157
    Abstract: Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.
    Type: Application
    Filed: April 15, 2011
    Publication date: October 20, 2011
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Luke Masterson, Arnaud Tiberghien, John A. Flygare, Janet L. Gunzner, Paul Polakis, Andrew Polson, Helga E. Raab, Susan D. Spencer
  • Publication number: 20110201803
    Abstract: The invention relates to certain pyrrolobenzodiazepines (PBDs), and in particular pyrrolobenzodiazepine dimers bearing C2 substitutions, including compounds of formula (T): wherein: R2 is CHR2A, and R2A is independently selected from H, R, CO2R, COR, CHO, CO2H, and halo; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R7 is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R8 is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, NO2, Me3Sn and halo; R is independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; or the compound is a dimer with each monomer being of formula (M), where the R7 groups or R8 groups of each monomer form together a dimer bridge having the formula —X—R?—X— linking the monomers; wherein R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms, e.g. O, S, N(H), and/or aromatic rings, e.g.
    Type: Application
    Filed: October 16, 2009
    Publication date: August 18, 2011
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Stephen John Gregson, Zhizhi Chen, Arnaud Charles Tiberghien, Luke Masterson