Patents by Inventor Philip Wilson

Philip Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110196148
    Abstract: Claimed are unsymmetrical Pyrrolobenzodiazepine-dimers (PBD-dimers) of formula (I), that are unsymmetrical due at least to the values that the variables R12 and R2 represent. Formula (I), wherein: R2 is of formula (II), where A is a C5-7 aryl group, X is selected from the group comprising: OH, SH, CO2H, COH, N?C?O, NHRN, wherein RN is selected from the group comprising H and C1-4 alkyl, and (OC2H4)mOCH3, where m is 1 to 3, and either: (i) Q1 is a single bond, and Q2 is selected from a single bond and —Z—(CH2)m—, where Z is selected from a single bond, O, S and NH and n is from 1 to 3; or (ii) Q1 is —CH?CH—, and Q2 is a single bond; R12 is a C5-10 aryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, C1-7 alkyl, C3-7 heterocyclyl and bis-oxy-C1-3 alkylene. The other variables are as defined in the claims. The compounds are useful for the treatment of proliferative diseases.
    Type: Application
    Filed: October 16, 2009
    Publication date: August 11, 2011
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Stephen John Gregson, Luke Masterson
  • Publication number: 20110162227
    Abstract: Methods of preparing ZC-423 (I) which result in varying enantiomeric ratios.
    Type: Application
    Filed: July 22, 2009
    Publication date: July 7, 2011
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Stephen John Gregson, Zhizhi Chen, Arnaud Charles Tiberghien, Luke Masterson
  • Publication number: 20110160192
    Abstract: Compounds of formula (I): Z?-CO-A-B—NH-Z (I) wherein: Z is H or an amino protecting group; Z? is OH, a protected or activated hydroxyl group or Cl; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.
    Type: Application
    Filed: March 7, 2011
    Publication date: June 30, 2011
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Geoffrey Wells
  • Publication number: 20110099557
    Abstract: Systems and methods are provided for controlling a device. In one aspect, a method for controlling a device includes exposing a plurality of virtual device interfaces (13) for a device (11), wherein each virtual device interface (13) enables client control of a discrete function of the device, and controlling concurrent communication between the device (11) and two or more virtual device interfaces (13) operating on a single shared I/O connection (15) using a shared I/O port controlled by a device I/O module (12). The device I/O module (12) enables independent development of multiple device interfaces (13) that can seamlessly and independently operate on a single (physical) device communication connection (15), wherein the device shared I/O (input/output) module (12) implements functions to arbitrate and coordinate I/O activity between the device interfaces (13) and target device (11).
    Type: Application
    Filed: June 25, 2008
    Publication date: April 28, 2011
    Applicant: Thomson Licensing
    Inventor: Gerald Philip Wilson
  • Patent number: 7876779
    Abstract: A device that schedules the transmission of information between system components, paired with different data adapters, allows for a system that can transmit data between unlike devices. The system focuses on allowing electronic devices to be used in more facets than the intended application. A user is able to hook up multiple source devices including computers, cable boxes, heating systems, et. al. and interact with them on different output devices. Based on the output device television, speakers, monitors, et. al. and the control device, i.e. a remote, keyboard, Wii Mote™, et. al. the interaction with the source device will be tailored to provide the most natural interaction. This will also allow unlike devices to be used together in order to create a synergistic effect.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: January 25, 2011
    Assignee: Ayaion, Inc.
    Inventor: Mathew Philip Wilson
  • Patent number: 7758961
    Abstract: A process for creating readily or highly dispersible nanoparticles on which chemically reactive functional groups or ligands have been placed. An ultra-high shear fluidic processor is used to change the size distribution of nanoparticle agglomerations and facilitate the formation of stable dispersions of such nanoparticles, as well as the placement of various chemically reactive functional groups or ligands on exposed surface areas of such nanoparticles. Such functionalized nanoparticle agglomerations have a broader size distribution (with a substantial increase in the proportion of smaller agglomerations), can exhibit enhanced dispersion characteristics and, when dispersed in various bulk materials, can impart to such bulk materials the desirable physical or chemical properties associated with the selected chemically active functional groups that have been attached to the surface areas of such agglomerations.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: July 20, 2010
    Assignee: Milliken & Company
    Inventors: Jamie N. Jones, F. Brent Neal, Hao Zhou, Philip Wilson
  • Patent number: 7741319
    Abstract: The present inventors have developed a key intermediate for the production of C2 substituted PBDs, which has a leaving group at the C2 position, a carbamate protecting group at the N10 position and a protected hydroxy group at the C11 position. In a first aspect, the present invention comprises a compound with a the formula (I), wherein: R10 is a carbamate-based nitrogen protecting group; R11 is an oxygen protecting group; and R2 is a labile leaving group. In a further aspect, the present invention comprises a method of synthesising a compound of formula (III), or a solvate thereof, from a compound of formula (I) as defined in the first aspect, R16 is either O—R11, wherein R11 is as defined in the first aspect, or OH, or R10 and R16 together form a double bond between N10 and C11; and R15 is R. The other substituents are defined in the claims.
    Type: Grant
    Filed: March 1, 2005
    Date of Patent: June 22, 2010
    Assignee: Spirogen Limited
    Inventors: Philip Wilson Howard, Stephen John Gregson
  • Publication number: 20100113425
    Abstract: Compounds of the formula I: or solvate thereof, wherein: R2 is an optionally substituted C5-20 aryl group; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, nitro, Me3Sn and halo; where R and R? are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NHRR?, nitro, Me3Sn and halo; R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms and/or aromatic rings; X is selected from O, S, or NH; z is 2 or 3; M is a monovalent pharmaceutically acceptable cation; R2?, R6?, R7?, R9?, X? and M? are selected from the same groups as R2, R6, R7, R9, X and M respectively, or M and M? may together represent a divalent pharmaceutically acceptable cation.
    Type: Application
    Filed: November 2, 2009
    Publication date: May 6, 2010
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, Zhizhi Chen, Stephen John Gregson
  • Patent number: 7704924
    Abstract: A compound of formula (IV): O is a solid support; L is a linking group or a single bond; X? is selected from CO, NH, S, or O; A is O, S, NH, or a single bond; R2 and R3 are independently selected from: H, R, OH, OR, ?O, ?CH—R, ?CH2, CH2—CO2R, CH2—CO2H, CH2—SO2R, O—SO2R, CO2R, COR, CN and there is optionally a double bond between C1 and C2 or C2 and C3; R6, R7, and R9 are independently selected from H, R, OH, OR, halo, nitro, amino, Me3Sn; R11 is either H or R; Q is S, O or NH; R10 is a nitrogen protecting group; and Y is a divalent group such that HY?R, and other related compounds and collections of compounds.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: April 27, 2010
    Assignee: Spirogen Limited
    Inventors: David Edwin Thurston, Philip Wilson Howard
  • Publication number: 20090316720
    Abstract: A device that schedules the transmission of information between system components, paired with different data adapters, allows for a system that can transmit data between unlike devices. The system focuses on allowing electronic devices to be used in more facets than the intended application. A user is able to hook up multiple source devices including computers, cable boxes, heating systems, et. al. and interact with them on different output devices. Based on the output device television, speakers, monitors, et. al. and the control device, i.e. a remote, keyboard, Wii Mote™, et. al. the interaction with the source device will be tailored to provide the most natural interaction. This will also allow unlike devices to be used together in order to create a synergistic effect.
    Type: Application
    Filed: February 11, 2009
    Publication date: December 24, 2009
    Inventor: Mathew Philip Wilson
  • Patent number: 7612062
    Abstract: Compounds of the formula: (I) or solvate thereof, wherein: R2 is an optionally substituted C5-20 aryl group; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, nitro, Me3Sn and halo; where R and R? are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NHRR?, nitro, Me3Sn and halo; R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms and/or aromatic rings; X is selected from O, S, or NH; z is 2 or 3; M is a monovalent pharmaceutically acceptable cation; R2?, R6?, R7?, R9?, X? and M? are selected from the same groups as R2, R6, R7, R9, X and M respectively, or M and M? may together represent a divalent pharmaceutically acceptable cation.
    Type: Grant
    Filed: April 21, 2006
    Date of Patent: November 3, 2009
    Assignee: Spirogen Limited
    Inventors: Stephen John Gregson, Philip Wilson Howard, Zhizhi Chen
  • Patent number: 7557099
    Abstract: Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R2 and R3 are independently selected from —H, ?O, ?CH2, —CN, —R, OR, halo, ?CH—R, O—SO2—R, CO2R and COR; R10 is a carbamate-based nitrogen protecting group; and R11 is an oxygen protecting group.
    Type: Grant
    Filed: March 1, 2005
    Date of Patent: July 7, 2009
    Assignee: Spirogen Limited
    Inventors: Philip Wilson Howard, Gyoung-Dong Kang
  • Patent number: 7528126
    Abstract: A compound of formula (I) and salts and solvates thereof, wherein: R10 is a nitrogen protecting group and R11 is either OH or O—R12, wherein R12 is an oxygen protecting group, or R10 and R11 together form a double bond between N10 and C11; and R10? and R11? are selected from the same options as R10 and R11 respectively.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: May 5, 2009
    Assignee: Spirogen Limited
    Inventors: Philip Wilson Howard, Stephen John Gregson, Peter William Taylor, David Edwin Thurston, Tsveta Stefanova Hadjivassileva
  • Publication number: 20080287586
    Abstract: A process for creating readily or highly dispersible nanoparticles on which chemically reactive functional groups or ligands have been placed. An ultra-high shear fluidic processor is used to change the size distribution of nanoparticle agglomerations and facilitate the formation of stable dispersions of such nanoparticles, as well as the placement of various chemically reactive functional groups or ligands on exposed surface areas of such nanoparticles. Such functionalized nanoparticle agglomerations have a broader size distribution (with a substantial increase in the proportion of smaller agglomerations), can exhibit enhanced dispersion characteristics and, when dispersed in various bulk materials, can impart to such bulk materials the desirable physical or chemical properties associated with the selected chemically active functional groups that have been attached to the surface areas of such agglomerations.
    Type: Application
    Filed: March 22, 2007
    Publication date: November 20, 2008
    Inventors: Jamie N. Jones, F. Brent Neal, Hao Zhou, Philip Wilson
  • Publication number: 20080274356
    Abstract: A process for creating readily or highly dispersible nanoparticles on which chemically reactive functional groups or ligands have been placed. An ultra-high shear fluidic processor is used to change the size distribution of nanoparticle agglomerations and facilitate the formation of stable dispersions of such nanoparticles, as well as the placement of various chemically reactive functional groups or ligands on exposed surface areas of such nanoparticles. Such functionalized nanoparticle agglomerations have a broader size distribution (with a substantial increase in the proportion of smaller agglomerations), can exhibit enhanced dispersion characteristics and, when dispersed in various bulk materials, can impart to such bulk materials the desirable physical or chemical properties associated with the selected chemically active functional groups that have been attached to the surface areas of such agglomerations.
    Type: Application
    Filed: February 28, 2008
    Publication date: November 6, 2008
    Inventors: Jamie N. Jones, F. Brent Neal, Hao Zhou, Philip Wilson
  • Publication number: 20080257880
    Abstract: A method of disseminating to where it is required a substance that is advantageously disseminated after undergoing a heat-induced change of state or heat-induced fluidification, comprising the provision of the substance in a container that comprises a secondary induction coil, the container being adapted to be used in association with an apparatus provided with a primary induction coil, the coils being in a heat-providing relationship when the container is in association with the apparatus, and providing to the primary induction coil sufficient electricity to generate the necessary heat in the secondary induction coil. An apparatus to achieve this is also provided. Control of the temperature attained in the container may be regulated by choice of coil construction and positioning, thus permitting many different applications (air freshening, skin and hair care materials, cleaning and polishing materials) from a single base unit with a primary coil.
    Type: Application
    Filed: May 13, 2005
    Publication date: October 23, 2008
    Applicant: GIVAUDAN SA
    Inventors: Colin Brown, Guy Edward Naish, Andrew Philip Wilson Stedman
  • Publication number: 20080214525
    Abstract: A compound of formula (I); or a salt or solvate thereof, wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R2 is selected from —H, —OH, =0, ?CH2, —CN, —R, OR, halo, ?CH—R, O—SO2—R, CO2R and COR; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, nitro, Me3Sn and halo, where R and R? are independently selected from optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R10 and R11 either together form a double bond, or are selected from H and YRY, where Y is selected from O, S and NH and R is H or C1-7 alkyl or H and SOxM, where x is 2 or 3 and M is a monovalent pharmaceutically acceptable cation; each X is independently a heteroarylene group; n is from 1 to 6; and RE is C1-4 alkyl. The compound is useful for the treatment of proliferative diseases.
    Type: Application
    Filed: October 5, 2006
    Publication date: September 4, 2008
    Applicant: SPIROGEN LIMITED
    Inventors: Philip Wilson Howard, David Edwin Thurston, Geoffrey Wells
  • Patent number: 7407951
    Abstract: Compounds of formula (I): formula (I) and salts, solvates, chemically protected forms, and prodrugs thereof, are disclosed wherein R2 is selected from: an optionally substituted napthyl group; an optionally substituted thiophenyl or furanyl group; and a phenyl group substituted by: one or more chloro or fluoro groups; an ethyl or propyl group; a 4-t-butyl group; a 2-methyl group; or two methyl groups in the 2- and 6-positions.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: August 5, 2008
    Assignee: Spirogen Limited
    Inventors: David Edwin Thurston, Philip Wilson Howard
  • Publication number: 20080167293
    Abstract: Compounds of the formula: (I) or solvate thereof, wherein: R2 is an optionally substituted C5-20 aryl group; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR?, nitro, Me3Sn and halo; where R and R? are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NHRR?, nitro, Me3Sn and halo; R? is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms and/or aromatic rings; X is selected from O, S, or NH; z is 2 or 3; M is a monovalent pharmaceutically acceptable cation; R2?, R6?, R7?, R9?, X? and M? are selected from the same groups as R2, R6, R7, R9, X and M respectively, or M and M? may together represent a divalent pharmaceutically acceptable cation.
    Type: Application
    Filed: April 21, 2006
    Publication date: July 10, 2008
    Applicant: Spirogen Limited
    Inventors: Philip Wilson Howard, Zhizhi Chen, Stephen John Gregson
  • Patent number: D595140
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: June 30, 2009
    Assignee: JohnsonDiversey, Inc.
    Inventors: Kirk M. Reimann, Daniel Newman, Philip Wilson, Rajnikant Desai, Darold Faurot, Eric Weldzius