Abstract: The invention relates to a virus particle comprising a lymphocytic choriomeningitis virus (LCMV) S segment and an LCMV L segment, wherein the S segment comprises an open reading frame encoding a glycoprotein derived from LCMV strain WE, and wherein the L segment comprises an open reading frame encoding an L protein derived from LCMV strain Clone13. The invention also relates to related host cells, methods of producing such virus particles, pharmaceutical compositions comprising such virus particles, and medical uses of such virus particles.

Abstract: Methods and devices are disclosed relating improved articular models, implant components, and related guide tools and procedures. In addition, methods and devices are disclosed relating articular models, implant components, and/or related guide tools and procedures that include one or more features derived from patient-data, for example, images of the patient's joint. The data can be used to create a model for analyzing a patient's joint and to devise and evaluate a course of corrective action. The data also can be used to create patient-adapted implant components and related tools and procedures.

Abstract: Provided is a Coriolis flow sensor assembly that includes a flow tube configured to provide a flow path through the flow tube. Further, the Coriolis flow sensor assembly includes a mechanical drive assembly configured to drive an oscillation of the flow tube while fluid is flowing via an oscillation surface. The Coriolis flow sensor assembly includes an interface fixedly coupled to the oscillation surface of the mechanical drive assembly and configured to receive the flow tube.

Abstract: A blank for use in manufacturing a surgical implant is provided. The blank includes a shape based, at least in part, on one or more features common to a specific type of patient-adapted implants. The blank has dimensions that are equal to or larger than corresponding dimensions of each patient-adapted implant included in the specific type of patient-adapted implants.

Abstract: An arrangement includes a structure affixed to a housing, a planetary carrier mounted rotatably in the structure affixed to the housing, an oil bushing ring, and a first means and a second means for contactless power transmission. The oil bushing ring forms a lubricant-conducting joint between the structure affixed to the housing and the planetary carrier. The structure affixed to the housing has the first means and the oil bushing ring has the second means.

Abstract: The invention relates to a clamping device and is designed for releasably clamping a supporting body on which a workpiece can be arranged. The clamping device has a main body with receiving bores each for receiving a clamping bolt of the supporting body. Each clamping body can be moved linearly along the longitudinal axis thereof between a clamping position and a release position. The movement from the release position into the clamping position and/or conversely from the clamping position into the release position can be effected by means of an actuation device. Each clamping body has a clamping end which protrudes into an associated receiving bore in the clamping position. The longitudinal axes of the clamping bodies form a plurality of intersection points in a common projection plane parallel to which the longitudinal axes extend. In a preferred embodiment, at least three or four intersection points are formed.

Abstract: A clamping means system including a bearing device and clamping vices, which fit into the bearing device and respectively have on their base area machine coupling system and on their side faces and flanks a bearing receiving contour and a gripping receiving contour. The bearing receiving contour has the greatest play; the fit between the gripper and the gripper receiving contour is of moderate precision, while the precision of the machine coupling system is the greatest. The clear functional separation between the machine coupling system and the bearing receiving contour or gripper receiving contour allows a reliable low-cost system to be constructed. Furthermore, in the case of mixed partly automated systems, in which parts of the handling tasks are performed by the operator and other parts are performed by gripping robots, the handling is possible in an easy and intuitive way.

Abstract: Methods and devices are disclosed relating improved articular models, implant components, and related guide tools and procedures. In addition, methods and devices are disclosed relating articular models, implant components, and/or related guide tools and procedures that include one or more features derived from patient-data, for example, images of the patient's joint. The data can be used to create a model for analyzing a patient's joint and to devise and evaluate a course of corrective action. The data also can be used to create patient-adapted implant components and related tools and procedures.

Abstract: The present invention describes methods, devices and instruments for resurfacing or replacing facet joints, uncovertebral joints and costovertebral joints. The joints can be prepared by smoothing the articular surface on one side, by distracting the joint and by implant insertion. Implants can be stabilized against a first articular surface by creating a high level of conformance with said first articular surface, while smoothing the second articular surface with a surgical instrument with a smooth mating implant surface.

Abstract: Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Abstract: A method detects a fault, in particular coking, in the intake tract of an internal combustion engine with direct fuel injection, a throttle valve, and a variable intake valve lift controller.

Abstract: Improved systems, methods, and devices for performing joint arthroplasty, including patient-adapted implant components and tools, as well as intraoperative measurement and optimization of joint kinematics are disclosed herein.

Abstract: Disclosed herein are methods, compositions and tools for repairing articular surfaces repair materials and for repairing an articular surface. The articular surface repairs are customizable or highly selectable by patient and geared toward providing optimal fit and function. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Abstract: An embossing device that serves for preparation of a combined form-fit and friction-fit clamping of a workpiece in a respective clamping chuck. The embossing device includes jaws having embossing teeth that are formed on insertion bodies. The insertion bodies include a penetration edge respectively with which they penetrate into the workpiece surface in order to create a depression with defined dimensions. For this a workpiece contact surface is formed on the insertion body, preferably in the proximity to the bar-like projection that stops the penetration process of the bar-like projection as soon as the workpiece contact surface gets in contact with the workpiece surface during the execution of the embossing process. Then the force required for movement of the jaw increases considerably from which a control device generates a switch-off signal for the operation device.

Abstract: A workpiece clamping device having a first base body on which a first clamping body is slidably supported in a clamping direction, as well as a second base body on which a second clamping body is slidably supported in the clamping direction. The two clamping bodies are in engagement with a threaded spindle. A contact surface is provided on each base body on the side that faces the other base body respectively. The contact surfaces are arranged with base body distance in the clamping direction. A centering body of the threaded spindle has centering surfaces that abut at one assigned contact surface respectively in order to position the threaded spindle in clamping direction without clearance as far as possible.

Abstract: A workpiece clamping device having at least one base body. A first clamping body and a second clamping body are movably supported on the at least one base body in a clamping direction. A threaded spindle extends along a spindle longitudinal axis. The spindle longitudinal axis is orientated in clamping direction. It has a first thread section for the first clamping body and a second thread section for the second clamping body. A first coupling body has a first counter thread portion and a second coupling body has a second counter thread portion. In a coupling position the counter thread portions are in engagement with the assigned thread section respectively. In a decoupling position the counter thread portion is disengaged from the assigned thread section. In this decoupling position a movement of the clamping bodies is possible without rotation of the threaded spindle.

Abstract: Provided is a Coriolis flow sensor assembly that includes a flow tube configured to provide a flow path through the flow tube. Further, the Coriolis flow sensor assembly includes a mechanical drive assembly configured to drive an oscillation of the flow tube while fluid is flowing via an oscillation surface. The Coriolis flow sensor assembly includes an interface fixedly coupled to the oscillation surface of the mechanical drive assembly and configured to receive the flow tube.

Abstract: Provided is a Coriolis flow sensor assembly that includes a fluid flow assembly, including a flow tube, wherein the fluid flow assembly is configured to provide a flow path through the flow tube. The flow tube has at least one region of increased stiffness, which may be a result of a structural support component coupled to the flow tube. In another embodiment, the increased stiffness is caused by integral properties of the flow tube.

Abstract: Methods and devices for correcting wear pattern defects in joints. The methods and devices described herein allow for the restoration of correcting abnormal biomechanical loading conditions in a joint brought on by wear pattern defects, and also can, in embodiments, permit correction of proper kinematic movement.

Abstract: In a first aspect, the present invention relates to new recombinant artificial polypeptides allowing cytoplasmic signaling in cells containing the same. In particular, the present invention relates to a system for transmitting signals containing a recombinant polypeptide containing a domain with a first binding partner selected from an artificial ligand and a receptor binding an artificial ligand, a transmembrane domain and a cytoplasmic signaling domain whereby the domain with the binding partner and the cytoplasmic signaling domain are a combination of domains not naturally occurring in an organism and the second binding partner for specific forming of the binding pair. In a further aspect, a nucleic acid molecule comprising a nucleic acid sequence encoding the polypeptide according to the present invention as well as a vector, cell, cell line or host cell containing said vector are provided.