Abstract: A method of preparing an interpositional implant suitable for a knee. The method includes determining a three-dimensional shape of a tibial surface of the knee. An implant is produced having a superior surface and an inferior surface, with the superior surface adapted to be positioned against a femoral condyle of the knee, and the inferior surface adapted to be positioned upon the tibial surface of the knee. The inferior surface conforms to the three-dimensional shape of the tibial surface. The implant may be inserted into the knee without making surgical cuts on the tibial surface. The tibial surface may include cartilage, or cartilage and bone.

Abstract: A medical device for measuring blood flow through a blood vessel of a mammal includes a conductive elastomer having a variable resistance. A frame is at least partially surrounding at least a portion of the conductive elastomer, the conductive elastomer is suspended within the frame. A mechanical amplification element is slidably engaged to the conductive elastomer, the mechanical amplification element being configured to slide within the frame and to contact skin of the mammal over the blood vessel when the frame is positioned over the blood vessel, the mechanical amplification element being configured to be displaced when the artery pulsates and changes the resistance of the elastomer.

Abstract: A medical device for measuring blood flow through a blood vessel of a mammal includes a conductive elastomer having a variable resistance. A frame is at least partially surrounding at least a portion of the conductive elastomer, the conductive elastomer is suspended within the frame. A mechanical amplification element is slidably engaged to the conductive elastomer, the mechanical amplification element being configured to slide within the frame and to contact skin of the mammal over the blood vessel when the frame is positioned over the blood vessel, the mechanical amplification element being configured to be displaced when the artery pulsates and changes the resistance of the elastomer.

Abstract: Disclosed herein are tools for repairing articular surfaces repair materials and for repairing an articular surface. The surgical tools are designed to be customizable or highly selectable by patient to increase the speed, accuracy and simplicity of performing total or partial arthroplasty.

Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.

Abstract: The invention relates to a protective helmet, comprising an outer shell (1) for distributing impact forces and an antenna (2) for transferring a radio signal, which antenna is arranged at least partially inside the outer shell (1). The outer shell (1) consists of a main material in a main region (5). The protective helmet is characterized in that the outer shell (1) consists of a cut-out material in a cut-out region (6), the cut-out material having a lesser damping effect on the radio signal in comparison with the main material. The invention further relates to a method for producing a protective helmet.

Abstract: Methods and devices for correcting wear pattern defects in joints. The methods and devices described herein allow for the restoration of correcting abnormal biomechanical loading conditions in a joint brought on by wear pattern defects, and also can, in embodiments, permit correction of proper kinematic movement.

Abstract: A method of joint arthroplasty includes obtaining an image of at least a portion of the tibial plateau. An outer periphery of at least a portion of the tibial plateau is derived based, at least in part, on the image. An implant is provided for the tibial plateau, the implant having a periphery that includes an outer edge that substantially matches the derived outer periphery of the tibial plateau.

Abstract: This application relates to hip replacement systems and methods. Disclosed include patient-adapted (patient-specific or patient-engineered) hip replacement systems including patient-adapted implants and patient-adapted surgical instrumentation. Related methods of making and using the systems are also disclosed.

Abstract: A Coriolis flow meter for measuring one or more properties of a fluid is described herein which involves a modular configuration, and includes a fluid flow sub-system and a mechanical oscillator sub-system, both functionally separate, and are coupled in a closed loop arrangement, such that the flow conduit is not directly vibrated, and instead receives induced oscillations from the mechanical oscillator sub-system. The Coriolis flow meter is useful for high purity applications, as well as for the bioprocessing applications. Bioprocessing systems incorporating the Coriolis flow meter are also described herein. Method for measuring one or more properties of a fluid using the disclosed Coriolis flow meter are also described herein.

Abstract: Disclosed are designs, methods and systems for manufacturing implants, implant components, features of implant components, and/or related tools using solid freeform fabrication or additive metals technologies.

Abstract: A system that includes a flow tube configured to provide a flow path through the flow tube. The system also includes a plurality of actuators distributed radially about the flow tube, wherein a first actuator of the plurality of actuators is configured to drive a first oscillation in a first plane and a second actuator of the plurality of actuators is configured to drive a second oscillation in a second plane. Further, the system includes a plurality of sensor sets disposed on the flow tube, wherein each sensor set comprises two or more sensors configured to sense the first oscillation, the second oscillation, or both.

Abstract: Methods, system, devices, processes and techniques are disclosed for manufacturing orthopedic implants utilizing blanks and/or fixtures.

Abstract: The invention relates to an outer shell for a safety helmet (1), in particular for a motorcycle safety helmet, for distributing impact forces, said outer shell having an outer shell material (2). The outer shell is characterized in that, on a side (3) having the outer shell material (2) of the outer shell, the outer shell has a cover (4) having the outer shell material (2) in order to hold an antenna (5) between the cover (4) and the side (3). The invention further relates to a safety helmet (1) having such an outer shell and to a method for producing such an outer shell.

Abstract: Methods of predicting bone or joint disease in a subject are disclosed. Methods of determining the effect of a candidate agent on any subject's risk of developing bone or joint disease are also disclosed. A method for generating a parameter map from a bone image of a subject includes obtaining the bone image of the subject, defining two or more regions of interest (ROIs) in the image, analyzing a plurality of positions in the ROIs to obtain measurements for one or more bone microarchitecture parameters and one or more bone macro-anatomy parameters, and generating the parameter map from the measurements.

Abstract: Patient-adapted articular repair systems, including implants, instruments, and surgical plans, and methods of making and using such systems, are disclosed herein. In particular, various embodiments include knee joint articular repair systems designed for posterior stabilization, including patient-adapted posterior-stabilizing features.

Abstract: Disclosed are designs, methods and systems for manufacturing implants, implant components, features of implant components, and/or related tools using solid freeform fabrication or additive metals technologies.

Abstract: Methods and devices are disclosed relating improved articular models, implant components, and related guide tools and procedures. In addition, methods and devices are disclosed relating articular models, implant components, and/or related guide tools and procedures that include one or more features derived from patient-data, for example, images of the patient's joint. The data can be used to create a model for analyzing a patient's joint and to devise and evaluate a course of corrective action. The data also can be used to create patient-adapted implant components and related tools and procedures.

Abstract: Methods, system, devices, processes and techniques are disclosed for manufacturing orthopedic implants utilizing blanks and/or fixtures.

Abstract: A system comprising that includes a flow tube configured to provide a flow path through the flow tube. The system also includes a plurality of actuators distributed radially about the flow tube, wherein a first actuator of the plurality of actuators is configured to drive a first oscillation in a first plane and a second actuator of the plurality of actuators is configured to drive a second oscillation in a second plane. Further, the system includes a plurality of sensor sets disposed on the flow tube, wherein each sensor set comprises two or more sensors configured to sense the first oscillation, the second oscillation, or both.