Abstract: An improved aluminum alloy fin stock is described having both a high strength and a high thermal conductivity. The fin stock contains 1.2-1.8% Fe, 0.7-0.95% Si, 0.3-0.5% Mn, 0.3-1.2% Zn and the balance Al, and is produced by continuously strip casting the alloy at a cooling rate greater than 10° C./sec. but less than 200° C./sec., hot rolling the strip to a re-roll sheet without homogenization, cold rolling the re-roll sheet to an intermediate gauge, annealing the sheet and cold rolling the sheet to final gauge. This fin stock has a conductivity after brazing of greater than 49.8% IACS.

Abstract: Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.

Abstract: The invention relates to a compound of formula (I) ##STR1## Wherein: B is adenine, guanine or hypoxanthineZ is hydrogen or a negative chargeR is --[CH.sub.2 CH(R.sup.1)--O].sub.n -R.sup.2, --CH.sub.2 CH.sub.2 X, in whichR.sup.1 is hydrogen or (C.sub.1 -.sub.6) alkylR.sup.2 is hydrogen or (C.sub.1 -.sub.6) alkyln is a number from 1 to 6X is OH, F, NR.sup.3 R.sup.4R.sup.3 and R.sup.4 are independently from each other hydrogen or (C.sub.1 -.sub.6) alkyland to methods of enzymatically treating these compounds with biocatalysts having cyclic phosphodiesterase activity.

Abstract: Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides contain a methoxyethoxy (2'-O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen or a protecting group, orR.sub.1 has those meanings andR.sub.2 is a radical forming a phosphorus-containing nucleotide bridge group;B is a purine or pyrimidine radical or an analogue thereof; andR.sub.3 is OH, or F, and oligonucleotides that comprise those nucleosides are described.

Abstract: Compounds of the formula ##STR1## are described wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen or a protecting group, orR.sub.1 has those definitions andR.sub.2 is a radical forming a phosphorus-containing nucleotide bridge group;B is a purine or pyrimidine radical or an analogue thereof; andR.sub.3 is a radical of formula Ia, Ib or Ic ##STR2## wherein R.sub.4 is hydrogen, C.sub.1 -C.sub.21 alkyl, C.sub.2 -C.sub.21 alkenyl, C.sub.2 -C.sub.21 alkynyl or --C(.dbd.O)-alkyl;R.sub.5 is hydrogen, C.sub.1 -C.sub.10 alkyl, --CH.sub.2 --O--R.sub.6 or a radical of formula Ib;R.sub.6 is hydrogen, C.sub.1 -C.sub.22 alkyl, C.sub.3 -C.sub.21 alkenyl, or partially or completely fluorine-substituted C.sub.1 -C.sub.10 alkyl or --[(CH.sub.2).sub.2 --O].sub.m --R.sub.7 ;R.sub.7 is hydrogen or C.sub.1 -C.sub.21 alkyl;Z is --(CH.sub.2).sub.p -- or --(CH.sub.2 --CH.sub.2 --O).sub.q --CH.sub.2 CH.sub.2 --, it being possible for Z in the case of --CH.sub.

Abstract: Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.

Abstract: Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides contain a methoxyethoxy (2'--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.

Abstract: A jointless artificial foot having a resilient foot insert. In order to improve comfort while walking, a tubular, cylindrical segment which is arranged lying and has a horizontal cylinder axis and an axial slot situated at the rear is provided for the foot insert, the lower C-limb being fastened on the rear end region of a leaf spring extending forward beyond the foot insert, while the upper C-limb is equipped with a foot adapter for releasable connection to a leg prosthesis.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen or a protecting group, orR.sub.1 has those meanings andR.sub.2 is a radical forming a phosphorus-containing nucleotide bridge group;B is a purine or pyrimidine radical or an analogue thereof; andR.sub.3 is OH, F or (CF.sub.2).sub.n CF.sub.3 wherein n is a number from 0 to 7, and oligonucleotides that comprise those nucleosides are described.

Abstract: Oligonucleotides are provided which are targeted to nucleic acids encoding human c-raf and capable of inhibiting raf expression. The oligonucleotides contain a methoxyethoxy (2'-O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting the expression of human raf using oligonucleotides of the invention are also provided. The present invention further comprises methods of inhibiting hyperproliferation of cells and methods of treating abnormal proliferative conditions which employ oligonucleotides of the invention.

Abstract: A method and the apparatus for in situ analysis of a rock formation that already contains fluid in its interstices an excitation device is provided for imparting motion to the fluid relative to the rock formation and the magnetic fields created by the relative motion of the fluid in the rock formation measured. The permeability of the rock formation are deduced from the measurement. The measurement system is particularly applicable to in situ measurement of the permeability of rocks, e.g. down an oil well.

Abstract: A cycle frame includes a top member having a front terminal portion and a rear assembly portion, a bottom member defining a rear fork and a sloping member that is upwardly inclined from the rear fork to a front terminal portion thereof, a tubular member constituting a front steering swivel socket, a pair of lugs for interconnecting the front terminal portions of the top and bottom members to the tubular member, a pair of stays interconnecting the rear assembly portion and the rear fork, and a spacer member extending between the rear assembly portion and the bottom member. The front terminal portions of the top and bottom members have constant, polygonal-shaped cross-sections. The length of the cycle frame can be readily set to a desired dimension by cutting the front terminal portions of the top and bottom member and the height of the cycle frame can be readily adjusted by cutting the tubular member, the pair of stays and the spacer member.

Abstract: The method of the invention consists in measuring remanent magnetization along a borehole drilled through a geological bed, in detecting the set of reversals in the remanent magnetization, in measuring the induced magnetization at the various levels in said bed, in detecting maxima in the induced magnetization, and in correlating these measurements with known dates, firstly of reversals in the earth's magnetic field and secondly of terrestrial phenomena that have given rise to concentrations of highly magnetic substances, thus making it possible to give dates to the various levels of the bed. The method is particularly applicable to oil prospecting.

Abstract: A cycle frame includes an upper tube joined at one end to a lower tube by a frontal part and joined at an opposing end to stays by a continuously formed connecting part. A front fork pivot housing is attached to a reduced thickness, core portion of the frontal part and a seat post housing, having a forked base, is secured to the connecting part. The core portion and the front fork pivot housing have complementary mating surfaces to enhance the structural integrity of the assembly. In a similar fashion, the connecting part includes a cut-out portion for receiving the forked base. The frame arrangement finds particular application in racing cycles and can be readily adapted for use with riders of varying sizes by utilizing front fork pivot and seat post housings of differing configurations.

Abstract: A wheel rim, made of composite materials, for cycles and the like, is disclosed, comprising at least two adjacent box-like structures presenting a common wall and each constituted by a core of a material of cellular structure and by an envelope of rigid character, based on composite textiles of impregnated and polymerized synthetic fibers closely surrounding the core to which it is bonded, one of the box structures constituting a rim body, while the other defines an outer peripheral rim section intended to mountably recline a tire. The invention is particularly applicable to racing cycle wheels.

Abstract: The invention provides a new method for the determination of the concentration of gas dissolved in a molten metal or metal matrix composite employing a new immersion head probe in apparatus employing the method. Such determinations are needed to facilitate removal of the gas, which can cause loss of desirable properties and/or bubbles in the solidified material and subsequent processing difficulties. This determination is particularly difficult with metals containing high concentrations of particulate additions, such as metal matrix composites, since it is necessary to avoid deposition of the particulates and consequent inaccurate readings. The method employs apparatus which circulates an inert carrier gas through the probe in gas exchange contact with the molten metal to entrain dissolved gas until an equilibrium mixture is obtained; the concentration of the dissolved gas in the mixture then is representative of its concentration in the molten metal.

Abstract: The invention relates to a process for the preparation of 4-phenylpyrrole derivatives of the formula I ##STR1## wherein R.sub.n, R.sub.1 and R.sub.2 are as defined in claim 1, which comprises reacting a phenacylamine of formula II ##STR2## with a compound of formula IIIT--CH.dbd.CH--R.sub.1 (III)to give an intermediate of formula IV ##STR3## and cyclizing said intermediate, in the presence of a base, to give the compound I.Important intermediates and novel final products are also described.

Abstract: The invention provides a new immersion head probe for use in apparatus for the determination of the concentration of gas dissolved in a molten metal. Such determinations are needed to facilitate removal of the gas, which can cause bubbles in the solidified metal and subsequent processing difficulties. The apparatus circulates an inert carrier gas through the probe in gas exchange contact with the molten metal to entrain dissolved gas until an equilibrium mixture is obtained; the concentration of the dissolved gas in the mixture then is representative of its concentration in the molten metal. The head consists of a monolithic or integral body of a porous gas-permeable material of sufficient mechanical strength at the temperature of the molten metal and of sufficient porosity, pore size and permeability to permit the necessary gas diffusion in a reasonable period of time.

Abstract: Novel 3-phenylpyrrole derivatives of the formula I ##STR1## wherein R.sup.1 is cyano, trifluoromethyl or C.sub.1 -C.sub.4 -alkoxycarbonyl, R.sup.2 is vinyl or a group --CH.sub.2 --CH.sub.2 --X, in which X is chlorine or bromine, or is cyano, C.sub.1 -C.sub.4 -alkoxycarbonyl, phenylsulfonyl, 4-bromophenylsulfonyl or 4-methylphenylsulfonyl, R is halogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -haloalkyl, and n is zero, one or two, have valuable microbicidal properties for controlling phytopathogenic plant pests, particularly phytopathogenic fungi.