Abstract: A device for automatically generating a real time accompaniment of input music data includes a music input that receives music data. A music analyzer analyzes received music data to obtain a music data description including one or more characteristics of the analyzed music data. A query generator generates a query to a music database including music patterns and associated metadata including one or more characteristics of the music patterns, the query being generated from the music data description and from an accompaniment description describing preferences of the real time accompaniment and/or music rules describing general rules of music. A query interface queries the music database using a generated query and receives a music pattern selected from the music database by use of the query. A music output outputs the received music pattern.

Abstract: A device for automatically generating a real time accompaniment of input music data includes a music input that receives music data. A music analyzer analyzes received music data to obtain a music data description including one or more characteristics of the analyzed music data. A query generator generates a query to a music database including music patterns and associated metadata including one or more characteristics of the music patterns, the query being generated from the music data description and from an accompaniment description describing preferences of the real time accompaniment and/or music rules describing general rules of music. A query interface queries the music database using a generated query and receives a music pattern selected from the music database by use of the query. A music output outputs the received music pattern.

Abstract: An ophthalmological device for the treatment of keratoconus includes a cylindrical reservoir made of a non-conductive material, open at the top and bottom, and formed by two telescopically engaged portions, a lower one open at the bottom and connected to a cylindrical chamber of smaller diameter, also open at the bottom and formed by an external annular chamber that is concentrically arranged around the chamber and is closed at the top, open at the bottom, and adapted to be placed on the eye; a first metallic conductor, housed in the container and connected to a terminal of a DC voltage generator, to the other terminal of which a second metallic conductor is connected; a first conduit provided with a closing device, one end of the first conduit flowing into the annular reservoir, the other end being located externally thereto, whereby vacuum may be applied through the first conduit; and a second conduit provided with a closing device, one end of the second conduit passing through the annular reservoir at its

Abstract: Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye; an active electrode disposed in or on the reservoir; and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body; elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery; wherein the reservoir and the active electrode are transparent to UV light and/or visible light and/or IR light. The method includes: positioning the iontophoretic device on the eye to be treated; driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA; and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW/cm2; thereby obtaining the corneal cross-linking of the solution.

Abstract: Compositions, devices, method of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides and electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least on buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multi-particulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including on or more layers and one or more concentric cylinders.

Abstract: The invention concerns an ocular iontophoresis device for delivering at least one active substance to an eyeball, comprising: a wall defining a tubular-shaped body delimitating laterally a reservoir configured for receiving the active substance(s), the wall comprising a circular distal end configured for being positioned on an ocular surface of the eyeball and surrounding the cornea and a part of the sclera of the eyeball, a first electrode configured to be positioned in front of the sclera, said first electrode being configured for delivering a first current density to the active substance(s) of the reservoir, the first electrode defining an annular-shaped first surface that is arranged in a peripheral part of the reservoir, a second electrode configured to be positioned in front of the cornea, said second electrode being configured for delivering a second current density to the active substance(s) of the reservoir, the second electrode defining a disk-shaped second surface that is arranged in a central part

Abstract: An improved formulation of an ophthalmic composition contains riboflavin, as cross-linking agent of corneal collagen, administered by corneal iontophoresis, able to guarantee an increased capacity of permeation of riboflavin of the corneal stroma and therefore greater therapeutic efficacy in the treatment of keratoconus.

Abstract: A device for generating a real time music accompaniment includes a music input interface, a music mode classifier that classifies pieces of music received at the music input interface into one of different music modes including at least a solo mode, a bass mode, and a harmony mode, a music storage, and a music output interface. A music selector selects one or more recorded pieces of music as real time music accompaniment to an actually played piece of music received at the music input interface, wherein the one or more selected pieces of music are selected to be in a different music mode than the actually played piece of music. A music output interface outputs the selected pieces of music.

Abstract: Iontophoresis, a minimally-invasive methodology that uses a weak electric current to enhance penetration of ionized molecules into tissues, was found to be an effective technique for the intraocular delivery of large bioactive molecules, specifically lutein.

Abstract: An ophthalmological device for the treatment of keratoconus includes a cylindrical reservoir made of a non-conductive material, open at the top and bottom, and formed by two telescopically engaged portions, a lower one open at the bottom and connected to a cylindrical chamber of smaller diameter, also open at the bottom and formed by an external annular chamber that is concentrically arranged around the chamber and is closed at the top, open at the bottom, and adapted to be placed on the eye; a first metallic conductor, housed in the container and connected to a terminal of a DC voltage generator, to the other terminal of which a second metallic conductor is connected; a first conduit provided with a closing device, one end of the first conduit flowing into the annular reservoir, the other end being located externally thereto, whereby vacuum may be applied through the first conduit; and a second conduit provided with a closing device, one end of the second conduit passing through the annular reservoir at its

Abstract: Compositions, devices, method of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides and electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least on buffer elementt, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multi-particulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including on or more layers and one or more concentric cylinders.

Abstract: The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer (1) of the eye over an underlying layer (2) of the eye as the plate is brought into contact with the eye before the needle is guided into the interior of the eye.

Abstract: The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.

Abstract: The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

Abstract: Compositions, devices, methods of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides an electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least one buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multiparticulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including one or more layers and one or more concentric cylinders.

Abstract: The present invention relates to a method for creating a Markov process that generates sequences. Each sequence has a finite length L, comprises items from a set of a specific number n of items, and satisfies one or more control constraints specifying one or more requirements on the sequence. The method comprises the steps of receiving data defining an initial Markov process of a specific order d and having an initial probability distribution and of receiving data defining one or more control constraints. The method further comprises the step of generating data defining intermediary matrices, each matrix being of dimension nd by n, by zeroing out transitions in the initial Markov process data that are forbidden by the one or more control constraints.

Abstract: A device for automatically generating a real time accompaniment of input music data includes a music input that receives music data. A music analyzer analyzes received music data to obtain a music data description including one or more characteristics of the analyzed music data. A query generator generates a query to a music database including music patterns and associated metadata including one or more characteristics of the music patterns, the query being generated from the music data description and from an accompaniment description describing preferences of the real time accompaniment and/or music rules describing general rules of music. A query interface queries the music database using a generated query and receives a music pattern selected from the music database by use of the query. A music output outputs the received music pattern.

Abstract: Device for packaging and dispensing drops of a substance for ophthalmic use, generally fluid, semi-fluid or in suspension, emulsion or oily solution, comprising a dispensing accessory (7) with a first valve (5) made of an elastomer material that allows the substance to pass through when the dispensing accessory (7) is stressed, without allowing outside air to pass through in the opposite direction when the dispensing accessory (7) is relaxed, characterized in that the first valve (5) is covered by a layer of Parylene.

Abstract: The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

Abstract: Device for sampling tear fluid that comprises: an extraction element (202) adapted to be applied on the eye to draw tear fluid therefrom, comprising at least one tube (209) and a distal portion (201) with at least one opening (207), a collection vessel (203), connected to said tube (209), suction means (210) adapted to continuously draw tear fluid from the eye to the collection vessel (203), through the extraction element (202) for a period higher than 10 minutes once the extraction element (202) is in place.