Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.

Abstract: Meta-data (tags) for an audiovisual file can be generated by producing an initial estimate of the tags and then revising the estimate (notably to expand it and/or render it more precise) based on the assumption that the relationships which hold between the different tags for a set of manually-tagged training examples will also hold for the tags of the input file now being tagged. A fully-automatic method and system is a hybrid between signal-based and machine-learning approaches, because the initial tag estimate is based on the physical properties of the signal representing the audiovisual file. The initial tag estimate may be produced by inferring that the input content will have the same tags as those files of the same kind, in the training database, which have a global similarity to the input audiovisual file in terms of signal properties.

Abstract: The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to receive a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis.

Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.

Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.

Abstract: A method and a system for generating sequencing information representing a sequence of items selected in a database. Similarity relation techniques are applied between the items.

Abstract: The feed connector (270) capable of interacting with a device for delivering active principles comprising a reservoir delimited by at least two lateral walls of substantially cylindrical shape and extending opposite one another, is characterized in that it includes means (202, 203, 204, 205) for dispensing active principles into the reservoir that are arranged such that said reservoir is filled substantially uniformly between the two lateral walls.

Abstract: Device for delivering active principles to the eye, comprising a reservoir able to contain the active principles, and means for releasing the active principles contained in the reservoir towards the vicinity of a site intended to receive the active principles, characterized in that the device also comprises means for distributing the active principles which can be driven by iontophoresis or electroporation.

Abstract: The invention relates to a device for ocular delivery of active principle(s) (1) comprising a first outer layer (2) which is essentially non-leaking, and a second inner layer (3) which has a surface (7) able to come into contact with at least one eyelid. characterized in that the second layer comprises at least one active principle intended to be delivered to the patient through the eyelid.

Abstract: The invention relates to a connector assembly (10) for the transfer of fluids, particularly fluids comprising an active agent from a reservoir to a medical device for dosage, comprising: a first connector element (20), pertaining to the reservoir with first fixing means (23), a second connector element (10), pertaining to the medical dosage device with second fixing means (12), cooperating with the first fixing means to give an irreversible connection between the two elements. The first and second elements are embodied such as to cooperate with other by clipping on a single translational movement of a connector element relative to the other to produce the irreversible connection, characterised in that at least one of the connection elements is embodied with means to render the same breakable.

Abstract: The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.

Abstract: The invention concerns a device for ocular delivery of an active principle by peroperative intraocular iontophoresis or electroporation comprising a reservoir (7) for receiving a solution comprising the active principle, means for diffusing (8, 6) the active principle connected to the reservoir, means for injecting (4) the solution into the reservoir, and means (5) for exerting suction of the content of the reservoir during an injection of the solution therein by the injection means.

Abstract: The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

Abstract: A communications apparatus has an interface unit, interface unit with at least one input/output device and a computer. The input/output device is responsive to the computer to present clinical information to a care giver and non-clinical information to a patient. At least one server operatively connected to the interface unit provides customer services to assist the care giver and patient to use the apparatus. The system automatically guides the user through the process required to accomplish the desired result. Where the user prefers, as indicated by the user's activation of a “operator assist” feature or where the system cannot resolve the user's inquiry in the absence of operator assistance, the user is connected to a live operator. Such a connection is made using voice over internet or other techniques, so that it is not necessary to provide a separate telephone connection.

Abstract: A method and system for automatic generation of sequences (notably temporal or spatial sequences) from items in a database involves the organisation of the data in a generic format, and the formulation of the problem as a Constraint Satisfaction Problem using special constraint classes. The database format includes attribute values referring to a predetermined taxonomy allowing similarity and difference between the respective values to be evaluated.

Abstract: The invention relates to a method of generating sequencing information representing a sequence of items selected in a database. Each of the items comprises a set of descriptors. The method is characterised by comprising the steps of: a) specifying a length of items and at least one of the descriptors; b) performing similarity relation techniques between the items; and c) generating a fixed-length sequence having a morphological continuity. Each of the items is represented by a series of constraint variables having a domain in the database, and modelling each of the values of descriptors in a desired sequence as a constrained variable. The similarity relation performing step may comprise performing global similarity techniques by combining individual similarity measures on all of the descriptors. The sequence-generating step comprises transforming at least one of the values into unary constraints in terms of constraint satisfaction programming techniques.

Abstract: A swivelling wheel assembly containing a wheel whose swivelling action around a vertical axle may be locked or unlocked by rotating the wheel in one direction or the other. A curved double control lever is housed in a space between the thrust bearing and the tread of the wheel in the area of the lateral extensions of the fork joint. A lower lever arm holds a friction device engaging the tread of the wheel. An upper lever arm contains a locking means which can be received in a locking slot constructed in a housing component which is fixed relative to the pivot axle. A circular cover of the fork joint contains a tracking groove to guide the upper lever arm.