Patents by Inventor Ping Dai

Ping Dai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136941
    Abstract: The present disclosure provides a method for producing growth factor-producing cells by inducing differentiation directly from somatic cells, and a composition for producing growth factor-producing cells by inducing differentiation directly from somatic cells.
    Type: Application
    Filed: February 27, 2023
    Publication date: May 1, 2025
    Applicants: KATAOKA CORPORATION, Kyoto Prefectural Public University Corporation
    Inventors: Ping DAI, Yoshinori HARADA, Toshihiro KURAHASHI, Hiroko NAMBA, Junichi MATSUMOTO
  • Publication number: 20240385177
    Abstract: The present disclosure relates to a new screening method to search for compounds that have browning-promoting or browning-inhibiting effects on brown adipocytes and that target cell membrane receptors.
    Type: Application
    Filed: September 15, 2022
    Publication date: November 21, 2024
    Applicants: KATAOKA CORPORATION, Kyoto Prefectural Public University Corporation
    Inventors: Ping DAI, Yukimasa TAKEDA, Yoshinori HARADA, Junichi MATSUMOTO
  • Publication number: 20240270851
    Abstract: Single-domain shark variable new antigen receptor (VNAR) monoclonal antibodies that specifically bind programmed death-ligand 1 (PD-L1) are described. The PD-L1-specific VNAR antibodies are capable of binding PD-L1-expressing tumor cells from human, mouse and canine origin. Immune cells expressing chimeric antigen receptors (CARs) developed using the VNAR antibodies can be used to kill PD-L1-positive tumor cells, for example in animal models of liver cancer and breast cancer.
    Type: Application
    Filed: June 6, 2022
    Publication date: August 15, 2024
    Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services
    Inventors: Mitchell Ho, Glenn Merlino, Dan Li, Hejiao English, Chi-Ping Day
  • Patent number: 12018283
    Abstract: The present invention chiefly aims to provide a process for directly inducing insulin-producing cells from somatic cells without performing artificial gene transfer. The present invention can include a process for producing an insulin-producing cell by inducing differentiation directly from a somatic cell, the process comprising a step of culturing the somatic cell in the presence of a cAMP inducer, and six members selected from the group consisting of a GSK3 inhibitor, a TGF-? inhibitor, a BMP inhibitor, a p53 inhibitor, a PI3K inhibitor, a Notch inhibitor and a RAR agonist, or all members thereof. The insulin-producing cells obtained by the present invention are useful in regenerative medicine and the like.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: June 25, 2024
    Assignees: KATAOKA CORPORATION, KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
    Inventors: Ping Dai, Yukimasa Takeda, Yoshinori Harada, Junichi Matsumoto, Ayumi Kusaka
  • Patent number: 11834679
    Abstract: The present invention chiefly aims to provide a process for directly inducing cardiomyocytes from somatic cells without performing artificial gene transfer, a cardiomyocyte obtained thereby, and a composition comprising a combination of chemical compounds capable of using for the said process. The present invention can include a process for producing a cardiomyocyte by inducing differentiation directly from a somatic cell, the process comprising a step of culturing the somatic cell in the presence of a MEK inhibitor and a cAMP inducer, and a cardiomyocyte obtained thereby, and then a composition for producing a cardiomyocyte by inducing differentiation directly from a somatic cell, the composition comprising a MEK inhibitor and a cAMP inducer. The cardiomyocytes obtained according to the present invention are useful in regenerative medicine and the like.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: December 5, 2023
    Assignees: Kataoka Corporation, Kyoto Prefectural Public University Corporation
    Inventors: Ping Dai, Yukimasa Takeda, Yoshinori Harada, Junichi Matsumoto, Ayumi Kusaka
  • Patent number: 11781108
    Abstract: The present invention provides a method with which it is possible to directly induce nervous system cells efficiently and in a short amount of time. Because the method is easy to scale up and is not affected by the characteristics or background of the somatic cells used as material, the method enables the stable supply of nervous system cells. The nervous system cells obtained by the method are useful in various fields of research and healthcare.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: October 10, 2023
    Assignees: KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, KATAOKA CORPORATION
    Inventors: Ping Dai, Tetsuro Takamatsu
  • Patent number: 11726968
    Abstract: Embodiments of the present specification disclose methods, apparatuses, and devices for transferring data assets based on a blockchain. One method includes: obtaining usage demand information of a data requestor for using original data, wherein the usage demand information indicates a demand of the data requestor for performing computations based on the original data; sending a usage authorization request for the original data to a data owner of the original data based on a decentralized identifier (DID) corresponding to the original data; receiving confirmation information of the usage authorization request from the data owner; processing the original data based on the usage demand information to obtain a processing result; transmitting the processing result to the data requestor; and generating a verifiable claim (VC) for recording usage information of the original data.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: August 15, 2023
    Assignee: Alipay (Hangzhou) Information Technology Co., Ltd.
    Inventors: Shubo Li, Wenyu Yang, Shanlu Sun, Ping Dai, Renhui Yang, Qin Liu
  • Publication number: 20230082555
    Abstract: The present invention is primarily directed to provide a new composition for a medium which can be used for differentiation induction from somatic cells to brown adipocytes. The present invention can include, for example, a composition for a medium used in differentiation induction from somatic cells to brown adipocytes, wherein the composition comprises the following seven components: a thyroid hormone receptor agonist, a glucocorticoid receptor agonist, a phosphodiesterase inhibitor, insulin, an ascorbic acid derivative, albumin, and an antibiotic. According to the present invention, direct differentiation induction from somatic cells to brown adipocytes can be effectively performed. In addition, according to the present invention, it is possible to effectively maintain brown adipocytes.
    Type: Application
    Filed: November 18, 2020
    Publication date: March 16, 2023
    Applicants: Kataoka Corporation, Kyoto Prefectural Public University Corporation
    Inventors: Ping Dai, Yukimasa Takeda, Yoshinori Harada, Junichi Matsumoto
  • Publication number: 20230059404
    Abstract: The present invention is primarily directed to provide a new process capable of performing direct conversion of or induction from a somatic cell to brown adipocytes with low molecular weight compounds, without performing artificial gene transfer. The present invention includes, for example, a process for producing brown adipocytes by direct differentiation induction from somatic cells, comprising a step of culturing a somatic cell in a serum-free differentiation induction medium in the presence of a selective PPAR? agonist and a cAMP inducer. According to the present invention, direct conversion of or induction from somatic cells to brown adipocytes can be effectively performed without gene transfer. The brown adipocytes obtained by the present invention are useful as regenerative medicine, models of human brown adipocytes and human beige cells, and the like.
    Type: Application
    Filed: November 18, 2020
    Publication date: February 23, 2023
    Applicants: Kataoka Corporation, Kyoto Prefectural Public University Corporation
    Inventors: Ping Dai, Yukimasa Takeda, Yoshinori Harada, Junichi Matsumoto
  • Patent number: 11546333
    Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for blockchain-based service processing. One of the methods includes receiving a service processing request by a first service processing platform from a first user. The first service processing platform is one of a plurality of service processing platforms that access a blockchain network, and service data of the first user is shared between the plurality of service processing platforms over the blockchain network. In response to a determination that the service processing request involves a second service processing platform of the plurality of service processing platforms, it is determined whether the service processing request is permitted to be executed. In response to determining that the service processing request is permitted to be executed, the service processing request is executed over the blockchain network.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: January 3, 2023
    Assignee: Alipay (Hangzhou) Information Technology Co., Ltd.
    Inventors: Diaolong Tang, Shanlu Sun, Xiao Wu, Ping Dai, Shengdong Pang
  • Patent number: 11516217
    Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on computer storage media, for blockchain-based service processing. One of the methods includes receiving a service processing request by a first service processing platform from a first user. The first service processing platform is one of a plurality of service processing platforms that access a blockchain network, and service data of the first user is shared between the plurality of service processing platforms over the blockchain network. In response to a determination that the service processing request involves a second service processing platform of the plurality of service processing platforms, it is determined whether the service processing request is permitted to be executed. In response to determining that the service processing request is permitted to be executed, the service processing request is executed over the blockchain network.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: November 29, 2022
    Assignee: Alipay (Hangzhou) Information Technology Co., Ltd.
    Inventors: Diaolong Tang, Shanlu Sun, Xiao Wu, Ping Dai, Shengdong Pang
  • Patent number: 11459546
    Abstract: The present invention addresses the problem of providing: a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells from somatic cells without performing artificial gene transfer; brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells; or a composition including a combination of chemical substances that can be used for the aforementioned production method. An example of the present invention is a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells including a step for culturing somatic cells in the presence or absence of an inhibitor or activator selected from the group consisting of an ALK5 inhibitor, an ALK6 inhibitor, an AMPK inhibitor, a cAMP activator, an ALK2 inhibitor, an ALK3 inhibitor, a GSK3 inhibitor, and an Erk inhibitor.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: October 4, 2022
    Assignees: Kyoto Prefectural Public University Corporation, Kataoka Corporation
    Inventors: Yuta Murakami, Yasuhiro Yoshioka, Ping Dai, Toshikazu Yoshikawa, Yoshinori Harada
  • Patent number: 11363696
    Abstract: The application relates to an over-temperature protection circuit of an LED driving power supply. The over-temperature protection circuit comprises a temperature detection circuit for sensing a temperature change; a switch control circuit connected to the output end of the temperature detection circuit and controlling the on-off of the circuit according to the output signal of the temperature detection circuit; a shunt circuit connected to an output end of the switch control circuit and shunting current when the switch control circuit is in an on state; a current detection circuit connected to an output end of the shunt circuit and changing a current detection signal according to an output current of the shunt circuit; the output end of the current detection circuit is connected with the feedback loop. The application has the advantages of low cost, stable performance, little environmental influence and high precision.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: June 14, 2022
    Assignee: SHENZHEN SOSEN ELECTRONICS CO., LTD
    Inventors: Jiansheng Chen, Ping Dai, Chaoyang Zou
  • Patent number: 11362840
    Abstract: Disclosed herein are methods, systems, and media for backtracking a user's operation of services. One method comprises: receiving an authorization request from a service device, the authorization request based on a service processing request from a client device, and comprises: data corresponding to a user's operation related to a service, authorization information for accessing the data granted to the service device; a first digital identity of the user; and a second digital identity of the service device; in response to determining that the authorization information satisfies a condition, generating a claim based on the data, the authorization information, the first digital identity, and the second digital identity; recording the claim to a blockchain; and in response to determining that a supervising user has permission to access the claim, granting permission to the supervising user to backtrack the user's operation corresponding to the service based on the claim in the blockchain.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: June 14, 2022
    Assignee: Alipay (Hangzhou) Information Technology Co., Ltd.
    Inventors: Shanlu Sun, Ping Dai, Xiuying Dai, Shubo Li
  • Publication number: 20220039238
    Abstract: The application relates to an over-temperature protection circuit of an LED driving power supply. The over-temperature protection circuit comprises a temperature detection circuit for sensing a temperature change; a switch control circuit connected to the output end of the temperature detection circuit and controlling the on-off of the circuit according to the output signal of the temperature detection circuit; a shunt circuit connected to an output end of the switch control circuit and shunting current when the switch control circuit is in an on state; a current detection circuit connected to an output end of the shunt circuit and changing a current detection signal according to an output current of the shunt circuit; the output end of the current detection circuit is connected with the feedback loop. The application has the advantages of low cost, stable performance, little environmental influence and high precision.
    Type: Application
    Filed: April 1, 2019
    Publication date: February 3, 2022
    Inventors: Jiansheng Chen, Ping Dai, Chaoyang Zou
  • Publication number: 20220025336
    Abstract: It is a main object of the present invention to provide a new producing method capable of efficiently performing direct conversion or induction from a somatic cell to an insulin-producing cell. The present invention can include, for example, a process for producing an insulin-producing cell by direct differentiation induction from a somatic cell, comprising a step of culturing a somatic cell in a serum-free differentiation induction medium, or a step of culturing a somatic cell in a differentiation induction medium containing 5 ?g/mL or more of insulin. According to the present invention, insulin-producing cells having a high insulin secretion ability can be produced directly and efficiently from a somatic cell. The insulin-producing cells obtained according to the present invention are useful in regenerative medicine and the like.
    Type: Application
    Filed: November 11, 2019
    Publication date: January 27, 2022
    Applicants: KATAOKA CORPORATION, Kyoto Prefectural Public University Corporation
    Inventors: Ping DAI, Yukimasa TAKEDA, Yoshinori HARADA, Junichi MATSUMOTO, Ayumi KUSAKA
  • Publication number: 20220014384
    Abstract: Disclosed herein are methods, systems, and media for backtracking a user's operation of services. One method comprises: receiving an authorization request from a service device, the authorization request based on a service processing request from a client device, and comprises: data corresponding to a user's operation related to a service, authorization information for accessing the data granted to the service device; a first digital identity of the user; and a second digital identity of the service device; in response to determining that the authorization information satisfies a condition, generating a claim based on the data, the authorization information, the first digital identity, and the second digital identity; recording the claim to a blockchain; and in response to determining that a supervising user has permission to access the claim, granting permission to the supervising user to backtrack the user's operation corresponding to the service based on the claim in the blockchain.
    Type: Application
    Filed: June 15, 2021
    Publication date: January 13, 2022
    Applicant: ALIPAY (HANGZHOU) INFORMATION TECHNOLOGY CO., LTD.
    Inventors: Shanlu Sun, Ping Dai, Xiuying Dai, Shubo Li
  • Publication number: 20210395689
    Abstract: It is a main object of the present invention to provide a process for producing an insulin-producing cell from a somatic cell without performing artificial gene transfer, an insulin-producing cell obtained from the process, or a composition comprising a combination of chemical substances that can be used for the process. The present invention can include, for example: a process for producing an insulin-producing cell from a somatic cell by direct differentiation induction, comprising a step of culturing a somatic cell in the presence of an RSK inhibitor; an insulin-producing cell obtained from the process; and a composition for producing an insulin-producing cell from a somatic cell by directly inducing differentiation, comprising an RSK inhibitor. The insulin-producing cells obtained according to the present invention are useful in regenerative medicine and the like.
    Type: Application
    Filed: November 11, 2019
    Publication date: December 23, 2021
    Applicants: KATAOKA CORPORATION, Kyoto Prefectural Public University Corporation
    Inventors: Ping DAI, Yukimasa TAKEDA, Yoshinori HARADA, Junichi MATSUMOTO, Ayumi KUSAKA
  • Patent number: D1061032
    Type: Grant
    Filed: August 10, 2022
    Date of Patent: February 11, 2025
    Inventor: Ping Dai
  • Patent number: D1074254
    Type: Grant
    Filed: August 10, 2022
    Date of Patent: May 13, 2025
    Inventor: Ping Dai