Abstract: The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15R?) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15R? domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.

Abstract: The present invention relates to a low loss antenna switch. The antenna switch comprises a plurality of switch module and a plurality of transmitting/receiving terminals, wherein one end of each switch module is connected to an antenna unit and the other end of each switch module is connected to each transmitting and receiving end respectively. Further, each switch module comprises a plurality of switch units in series, wherein the width of at least one switch unit is smaller than other switch units of each switch module. Thus, the parasitic capacitance of the off-stage switch modules can be reduced, and VSWR (Voltage Standing Wave Ratio) of the antenna switch also can be improved.

Abstract: The reflecting structure includes at least one light source; and at least one reflector in which the light source is disposed to emit light, wherein the reflector includes a light intercepting plate and a main body joined to the light intercepting plate; the light intercepting plate includes at least one light intercepting surface, at least one reflecting surface extending from the light intercepting plane perpendicularly toward an outer surface of the light intercepting plate and a first positioning structure; the main body is joined to the light intercepting surface and includes a second positioning structure and a plurality of reflecting inner surfaces reflecting light direct from the light source and light reflected by the reflecting surface, and each of the reflecting inner surfaces has an inclined angle different from the inclined angle of other of the reflecting inner surfaces.

Abstract: A reflecting structure of the invention includes at least one light source emitting light; and at least one reflector having an inner surface comprising a plurality of strip reflecting surfaces connected to each other, and each of the strip reflecting surfaces having an inclined angle different from the inclined angles of other strip reflecting surfaces, wherein the reflector has an inward reflecting region and an outward reflecting region, wherein the light source is disposed in the inward reflecting region, and the inward reflecting region locates on an upper portion of the reflector and the outward reflecting surface locates on an lower portion of the reflector; light from the light source is reflected by the inward reflecting region at least once to reach the outward reflecting region and reflected by the outward reflecting region at least once to reach an object.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: This disclosure provides a composite beam generator and a method of performing powder melting or sintering in additive manufacturing process using the same. The composite beam generator comprises: a beam splitter for splitting a beam into a first directed beam and a second directed beam; a beam shaper for shaping a transverse energy distribution profile of the second directed beam to non-circular; at least one beam delivery unit for guiding the first directed beam or the second directed beam; and a beam combiner for receiving the first directed beam and the second directed beam, and respectively generating a first output beam and a second output beam, and combining them into the composite beam.

Abstract: A voice coil motor (VCM) includes a fastening portion, a moving portion, a magnet assembly, a coil, an elastic sheet, and glue. The lower plate seals the fastening portion. The lower plate includes a first surface and a second surface opposite to the first surface, the lower plate defines a through hole penetrating the first surface and the second surface, the low plate defines a first glue recess around the through hole and a second glue recess along an edge of the low plate in the first surface. The fastening portion is positioned on the first surface of the lower plate via glue received in the first glue recess.

Abstract: A linker polynucleotide for attaching a nanomaterial to a polynucleotidic platform and related nanoassemblies, arrangements, structures, methods and systems.

Abstract: Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: Semiconductor devices and methods of manufacture thereof are disclosed. In a preferred embodiment, a method of manufacturing a semiconductor device includes providing a semiconductor wafer, forming a gate dielectric over the semiconductor wafer, and forming a gate over the gate dielectric. At least one recess is formed in the semiconductor wafer proximate the gate and the gate dielectric, at least a portion of the at least one recess extending beneath the gate. The at least one recess in the semiconductor wafer is filled with a semiconductive material.

Abstract: The present invention provides a method for removing burrs of battery electrode plates using inductively coupled plasma (ICP) dry etching, in which an induction coil is used for ionizing reaction gas. A DC bias is applied to accelerate the ionized reaction gas to bombard the burrs of electrode plate, removing burrs that formed in machining processes using physical bombardment. The equipment used in the present invention is an ICP etch system. The method according to the present invention can completely remove the burrs of electrode plate, thereby effectively preventing short circuits caused by burrs penetrating the membrane separator in the battery.

Abstract: The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize diseased states of the cell. The interaction between the subject polynucleotides and the signals is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a substrate that can be processed by proteins of the RNAi pathway (such as Dicer). The input and output of multiple different polynucleotides of the invention can form an in vivo signaling network. In addition, the multiple input signals can be integrated to modulate the activity of the subject polynucleotides.

Abstract: The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor ?/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).

Abstract: A voice coil motor (VCM) includes a fixing portion, a moving portion, a magnet assembly, a coil, and an elastic sheet. The fixing portion includes an upper plate and a sidewall extending from edges of the upper plate. The moving portion is received in the fixing portion, and includes a top surface and an outer surface connected to the top surface. The moving portion defines a plurality of glue receiving recesses in the top surface and a plurality of second connecting portions each extending from a bottom surface of each glue receiving recess. The magnet assembly is fixed on the inner surface. The coil is circled around the outer surface of the moving portion, and is opposite to the magnet assembly. The elastic sheet is connected between the first connecting portions and the second connecting portions.

Abstract: A method and apparatus for conditioning an oxide surface during a semiconductor device formation process is provided herein. One or more plasma processing operations are performed on a substrate having a fin structure and shallow trench isolation structure (STI) formed thereon. An oxygen containing plasma process may modify surfaces of the STI structure in preparation for an argon containing plasma process. The argon containing plasma process may form a first layer on the fin structure and STI structure and an ammonia fluoride containing plasma process may form a second layer on the first layer. The first and second layers may be removed from the substrate during a subsequent heating process to provide a cleaned fin structure suitable for subsequent processing operations.

Abstract: Methods of fabricating semiconductor devices and structures thereof are disclosed. In one embodiment, a method of manufacturing a semiconductor device includes forming a gate material stack over a substrate having a first region and a second region. The gate material stack includes a semiconductive gate material. A thickness is altered or a substance is introduced to the semiconductive gate material in the first region or the second region of the substrate. The gate material stack is patterned in the first region and the second region resulting in a first transistor in the first region of the substrate comprising an NMOS FET of a CMOS device and a second transistor in the second region of the substrate comprising an NMOS FET of the CMOS device. The first transistor has a first threshold voltage and the second transistor has a second threshold voltage different than the first threshold voltage.

Abstract: Semiconductor devices and methods of manufacture thereof are disclosed. In a preferred embodiment, a method of manufacturing a semiconductor device includes providing a semiconductor wafer, forming a gate dielectric over the semiconductor wafer, and forming a gate over the gate dielectric. At least one recess is formed in the semiconductor wafer proximate the gate and the gate dielectric, at least a portion of the at least one recess extending beneath the gate. The at least one recess in the semiconductor wafer is filled with a semiconductive material.

Abstract: Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.

Abstract: Provided herein are signal activatable molecular constructs for delivery of molecules and related components, compositions, methods, and systems, having a 17 to 30 by targeting domain duplex RNA, at least one protection strand having a protection segment and linker segment and a sensor strand having a displacement segment and a toehold segment, in which in an inactive conformation the protection segment and the displacement segment form a sensor domain duplex polynucleotide covalently attached to the targeting domain and presenting the toehold segment for binding to a signal molecule. In an active conformation the sensor strand is bound to the signal molecule and is detached from the at least one protection strand and from the targeting domain; and the targeting domain attaches the at least one protection strand in a configuration allowing processing by Dicer and/or an Argonaute enzyme.