Abstract: A wire bonding method, comprising the steps of: extending a length of bonding wire from a capillary to form a wire tail; deforming a point on the wire tail to form a weakened portion between the wire tail and a remainder of the bonding wire retained within the capillary; and retracting at least a portion of the wire tail including the weakened portion into the capillary prior to bonding the wire tail to at least one of a bonding pad and a substrate.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: A disinfectant composition that is effective against tuberculosis-causing bacteria is disclosed. The composition contains a disinfectant agent that is a combination of biocidal quaternary ammonium compound and an N,N-di-substituted alkylamide water insoluble solvent. The composition can be a concentrated formulation or a ready-to-use formulation. Methods of disinfecting surfaces containing tuberculosis-causing bacteria are also disclosed.

Abstract: The present disclosure relates to a display panel and a display device. The display panel includes a display substrate and an encapsulating unit. The encapsulating unit is disposed on the display substrate, and the encapsulating unit includes at least one buffer layer. The buffer layer includes a buffer body and first buffer particles. The buffer body is deformable under an action of an external force thereby compressing the first buffer particles, and the first buffer particles are elastically deformable or capable of being crushed by compression.

Abstract: Methods and systems for operating an engine having at least first and second variable geometry mechanisms are provided. A spool-specific ratio for at least one spool of the engine is determined, wherein the spool-specific ratio relates to an aerodynamic parameter. The spool-specific ratio is compared to a reference to determine a ratio discrepancy for the at least one spool. An engine-specific ratio relating to the aerodynamic parameter is determined. At least one of a position of the first variable geometry mechanism and a position of the second variable geometry mechanism is adjusted based on the engine-specific ratio and the ratio discrepancy to reduce the ratio discrepancy.

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A system for reducing a resonant oscillation on a direct current bus is disclosed. The system includes a battery, a first capacitor connected in parallel with the battery, and an inductor connected in series with the first capacitor. The system also includes a first element connected in series with the inductor, a second element connected in parallel with the inductor and the first element, and a second capacitor connected in series with the first element. The system also includes an electric machine connected to the second capacitor. During a re-generation mode for charging the battery, a re-generation current flows from the electric machine to the battery, passing through the first element and the inductor and bypassing the second element. Additionally, during a motor mode, a motor current flows from the battery to the electric machine, passing through the second element and bypassing the first element and the inductor.

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: The present disclosure provides pharmaceutical combinations comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors. Also provided are methods of treating cancer comprising administering a therapeutically effective amount of at least one spliceosome modulator and a therapeutically effective amount of at least one inhibitor chosen from BCL2, BCL2/BCLxL, and BCLxL inhibitors.

Abstract: A display panel, a manufacturing method thereof, and a display device. The manufacturing method includes: providing a pretreatment solution containing a water-soluble organic protective agent, and forming, on an anode, a solution layer covering the anode; drying the solution layer to form an adhesive layer; removing the adhesive layer; and drying the anode; where the pretreatment solution contains 10-30% by weight of propylene glycol methyl ether and 70-90% by weight of water.

Abstract: A height of a vertical wire interconnection bonded onto a substrate is measured by first capturing a top view of the vertical wire interconnection and identifying a position of a tip end of the vertical wire interconnection from the top view. A conductive probe is located over the tip end of the vertical wire interconnection, and is lowered towards the vertical wire interconnection until an electrical connection is made between the conductive probe and the tip end of the vertical wire interconnection. A contact height at which the electrical connection is made may thus be determined, wherein the contact height corresponds to the height of the vertical wire interconnection.

Abstract: An image processing method performed by a terminal is provided. A molybdenum target image is obtained, and a plurality of candidate regions are extracted from the molybdenum target image. In the molybdenum target image, a target region is marked in the plurality of candidate regions by using a neural network model obtained by deep learning training, a probability that a lump comprised in the target region is a target lump being greater than a first threshold, a probability that the target lump is a malignant tumor being greater than a second threshold, and the neural network model being used for indicating a mapping relationship between a candidate region and a probability that a lump comprised in the candidate region is the target lump.

Abstract: Display panel, manufacturing method thereof, and display device are provided. As an example, the display panel includes a substrate, a TFT layer formed on the substrate, and an encapsulation layer formed on the TFT layer. The TFT layer includes a thin film transistor with a source electrode, a drain electrode and a gate electrode, and further includes a first metal layer, a first inorganic layer on the first metal layer, and a second metal layer on the first inorganic layer. The second metal layer includes a first region and a second region, a hollowed-out region is formed between the first region and the second region, and the first region and the second region are electrically connected via the first metal layer. A portion of the encapsulation layer that is located in the hollowed-out region is in contact with the first inorganic layer.

Abstract: A method of preparing a semiconductor nanocrystal-silicate composite without significantly reducing the quantum yield of the semiconductor nanocrystal, a composite prepared from the method, and a film and an electronic device comprising the composite.

Abstract: A wire bonding method, comprising the steps of: extending a length of bonding wire from a capillary to form a wire tail; deforming a point on the wire tail to form a weakened portion between the wire tail and a remainder of the bonding wire retained within the capillary; and retracting at least a portion of the wire tail including the weakened portion into the capillary prior to bonding the wire tail to at least one of a bonding pad and a substrate.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: The present disclosure provides a display panel, manufacturing method thereof, and a display device. The display panel includes a substrate, a functional layer formed on the substrate, and an encapsulation layer formed on the functional layer. The encapsulation layer includes an inorganic layer on the functional layer, the inorganic layer includes a first oxide layer and a second oxide layer, and a ratio of the number of atomic layers of the first oxide layer to the number of atomic layers of the second oxide layer ranges from 1:4 to 3:1.