Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: The present invention relates to the use of molecular markers and related signaling mechanisms for the preclinical and clinical profiling of inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of such markers as diagnostic and/or prognostic tools for the treatment of tumor patients with such inhibitors.

Abstract: The present invention relates to an automatic dishwashing composition including from about 0.1 to 5 weight, percent cross-linked anionic polyacrylate polymer, from about 0.1 to 40 weight percent alkali metal citrate chelating agent and from about 1 to 40 weight percent alkali metal sulfate, with from about 0.1 to 20 weight percent nonionic surfactant and from about 0.05 to 8.0 weight percent bleaching agent as optional components.

Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: The present invention is directed towards cleaning composition and/or formulations of commercial cleaning products containing beneficial metallocarbene activators for peroxygen species. The cleaning compositions and/or formulations include a bleaching component comprising a peroxy compound and one or more activators present in an effective amount to activate the peroxy compound to accomplish bleaching or cleaning or oxidation. The activator is a metallocarbene of the general structure (XX?C)yMLn? where M represents a metal center, C represents the carbene carbon bound to the metal center, X and X? may be the same or different and may furthermore be part of a cyclic structure, Ln? represents one or more other ligands which may or may not include one or more metal centers, and where y greater than equal to I.

Abstract: A novel glycosyl hydrolase with activities of beta-xylosidase and beta-glucosidase is provided. Said glycosyl hydrolase can convert 7-xylosyltaxane compounds to 7-hydroxyltaxane compounds.

Abstract: The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2?,3?,5?-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.

Abstract: Disinfectant compositions include 0.001 to 10% by weight of hydrogen peroxide or a hydrogen peroxide source based on the total weight of the composition; 0.001 to 20% by weight of at least one amphoteric surfactant based on the total weight of the composition; and 0.001 to 0.8% by weight of at least one alkali metal or alkaline earth metal salt of a cyclic or heterocyclic aromatic compound comprising at least one hydroxyl group, carboxylic group, or combination thereof based on the total weight of the composition. The disinfectant compositions are particularly effective at treating surfaces contaminated with resistant bacteria, such as Staphylococcus aureus at a fast killing rate.

Abstract: Disinfectant compositions include 0.001 to 10% by weight of hydrogen peroxide or a hydrogen peroxide source based on the total weight of the composition; 0.001 to 20% by weight of at least one amphoteric surfactant based on the total weight of the composition; and 0.001 to 15% by weight of at least one alkali metal or alkaline earth metal salt of a cyclic or heterocyclic aromatic compound comprising at least one hydroxyl group, carboxylic group, or combination thereof based on the total weight of the composition. The disinfectant compositions are particularly effective at treating surfaces contaminated with resistant bacteria, such as Staphylococcus aureus at a fast killing rate.

Abstract: A crystal, a preparation method and 3D structure of CD147 extracellular region are provided. Such 3D structure is useful in the determination of the active site of CD147 extracellular region by computer modeling or molecular docking method. The crystal and/or 3D structure are useful in a structure-based drug design and the selection of an antibody, a ligand or an interacting molecule of CD 147 extracellular region.

Abstract: A hydrogen peroxide composition comprises hydrogen peroxide, a stabilizer system comprising a colloidal stannate, at least one acidifying agent or a salt thereof selected from the group consisting of sulfur-containing acidifying agents, nitric acid, and mixtures and salts thereof. Optionally, the hydrogen peroxide composition comprises an organic phosphonic acid or a salt thereof, such as amino-phosphonate, and/or a free radical scavenger, such as salicylic acid. A cleaning formulation comprises the hydrogen peroxide composition, a pH adjusting agent, and optionally other additives, such as surfactants. The cleaning formulation may be made by mixing the hydrogen peroxide or a precursor thereof, water, colloidal stannate, and at least one acidifying agent, and optionally, adjusting the pH to achieve an alkaline pH.

Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: A method and a device for file transfer protocol (FTP) deadlock detection and self recovery are provided by the disclosure in order to solve the sudden deadlock problem in the FTP upload operation. The method includes: if a daemon determines that a deadlock occurs in an FTP upload task by a heartbeat detection mechanism, the socket resources used by the FTP upload operation is recorded at the storage location in a socket resource cycle queue, and an FTP upload task end process is started; determining whether the socket resource cycle queue is full, if it is not full, the socket resource information occupied by the current deadlock is put into the socket resource cycle queue, otherwise, the earliest socket resources in the socket resource cycle queue are released, and the socket resource information occupied by the current deadlock is put into the socket resource cycle queue.

Abstract: Cutting fluids for brittle materials, e.g., silicon ingot, comprise, in weight percent: A. 70-99% polyalkylene glycol (PAG), e.g., polyethylene glycol; B. 0.01-10% PAG-grafted polycarboxylate; and C. 0-30% water. These cutting fluids are used with abrasive materials, e.g., silicon carbide (SiC), to form cutting slurries. The slurry is sprayed on the cutting tool, e.g., a wire saw, to cut a brittle work piece, e.g., a silicon ingot.

Abstract: The cutting of semi-conducting crystals with a wire saw is facilitated with a cutting fluid comprising a polyalkylene glycol neutralized with an un-neutralized or partially neutralized polymeric acid that has a molecular weight of 500 to 1,000,000 and contains more than three acid groups per molecule.

Abstract: Water-based cutting fluids for use with diamond wiresaws that are used for cutting or otherwise treating hard brittle materials, e.g., silicon ingots, comprise: A. Water-soluble, polymeric dispersing agent, typically a polycarboxylate; B. Optionally wetting agent; C. Optionally defoamer; B. Optionally corrosion inhibitor; E. Optionally chelant; F. Optionally biocide; and G. Water. Typically water comprises at least 50 weight percent of the fluid, and the polycarboxylate is grafted with a polyalkylene glycol, e.g., polyethylene glycol.

Abstract: A gap protection device for an examining table includes a guide rail, a protecting chain and a rigid rope. The guide rail is fixed onto the non-moving part of the examining table. One end of the protecting chain is fixed onto the body of the examining table and is movable along the guide rail so as to cover the gap between the body and the non-moving part of the examining table. The two ends of the rigid rope are respectively connected to the two ends of the protecting chain. When the examining table is moved, the closed loop formed by the protecting chain and the rigid rope circulates synchronously under the drive of the examining table, such that the protecting chain covers the gap between the body and the non-moving part of the examining table.

Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.

Abstract: The present invention relates to a liquid cleaning composition comprising a peroxygen bleach, a sulfonated anionic surfactant and an amphoteric/zwitterionic surfactant where the sulfonated anionic surfactant and the amphoteric/zwitterionic surfactants are in a ratio of from 0.1:1 to 13:1. The combination of the sulfonated anionic surfactant and the amphoteric/zwitterionic surfactants provides for high viscosities and improved cleaning performance.

Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.