Abstract: Embodiments of the present invention relate to use of a GP73 inhibitor in preparation of a drug for treating diabetes. In the embodiments of the present invention, the inventor finds that GP73 plays a key role in blood glucose regulation, and in particular, finds that soluble GP73 can specifically bind to glucagon to form a complex, enhances the blood glucose-rising function and gluconeogenesis function of glucagon and prolongs the half-life of glucagon; and finds soluble GP73 can activate the glucose production in liver and/or kidney and a gluconeogenesis signaling pathway in a glucagon-independent manner. Based on the blood glucose regulation effect of the GP73 described above, the inventor also proves through animal experiments: the GP73 inhibitor can reduce the blood glucose level and glycated hemoglobin level of diabetic mice and have a protective effect on islet ? cells, and thereby having the effect of treating diabetes.

Abstract: A bendable fill light lamp comprises a plurality of segments of a lamp body assembly connected in a series or a sequence, wherein the lamp body assembly comprises a body for connecting the plurality of segments. Any two adjacent segments of the plurality of the segments are rotatably connected. Each of the plurality of the segments comprises a light-emitting surface as a fill light source. The body comprises a connecting member passing among the plurality of the segments. The connecting member comprises a bendable elastic body. In this way, during the use of the fill light, the bending of the intermediary segments may drive the sequential adjustment of the illumination angles of the light emitting parts on the intermediary segments. In one aspect, the light angle of the fill light may be adjusted and avoid phenomenon of multiple lights on the object to be photographed, which improves the shooting effect.

Abstract: Provided herein, inter alia, are polymeric compositions and systems useful for maintaining particle dispersions for extended periods of time. Also provided are dry polymeric compositions and systems that are able to undergo fast hydration. Methods for using such compositions and systems are also provided.

Abstract: A transceiver architecture supports high-speed communication over a signal lane that extends between a high-performance integrated circuit (IC) and one or more relatively low-performance ICs employing less sophisticated transmitters and receivers. The architecture compensates for performance asymmetry between ICs communicating over a bidirectional lane by instantiating relatively complex transmit and receive equalization circuitry on the higher-performance side of the lane. Both the transmit and receive equalization filter coefficients in the higher-performance IC may be adaptively updated based upon the signal response at the receiver of the higher-performance IC.

Abstract: A chip matching system and a corresponding method are provided. The method defines a plurality of first electronic components in a first wafer as various grades of chips and defines a plurality of second electronic components in a second wafer as various grades of chips, and then grades of the first electronic components and the second electronic components are matched to generate target information, and finally the first and second electronic components are integrated in the same position according to the target information. Therefore, the highest-grade chips can be arranged in a multi-chip module to optimize the quality of the multi-chip module.

Abstract: A substrate structure has an obtuse portion formed between a side surface and a bottom surface of a substrate body. The obtuse portion includes a plurality of turning surfaces to disperse the stress of the substrate body generated in the packaging process. Therefore, the substrate body is prevented from being cracked. A method for fabricating the substrate structure and an electronic package including the substrate structure are also provided.

Abstract: Systems and methods are disclosed for collecting driving data from simulated autonomous driving vehicle (ADV) driving sessions and real-world ADV driving sessions. The driving data is processed to exclude manual (human) driving data and to exclude data corresponding to the ADV being stationary (not driving). Data can further be filtered based on driving direction: forward or reverse driving. Driving data records are time stamped. The driving data can be aligned according to the timestamp, then a standardized set of metrics is generated from the collected, filtered, and time-aligned data. The standardized set of metrics are used to grade the performance the control system of the ADV, and to generate an updated ADV controller, based on the standardized set of metrics.

Abstract: Disclosed is a dual-robot position/force multivariate-data-driven method using reinforcement learning. A master robot adopts an ideal position meta-control strategy, learns a desired position by a reinforcement learning algorithm, and feeds back an actual position to a desired position, and a goal is to generate an optimal force while the robot interacts with the environment, as to minimize a position error; and a slave robot, based on a force meta-control strategy of position deviation of the master robot, adopts a damping proportional-derivative (PD) control strategy suitable for an unknown environment, and learns a desired acting force by the reinforcement learning algorithm, namely a minimum force for driving the slave robot to approach a desired reference point. The present invention may improve the dexterity of dual-robot collaboration, solve a parameter optimization problem in position/force control.

Abstract: The present invention provides a lectin-magnetic carrier coupling complex for separating glycosylated exosomes from a clinical sample. The lectin-magnetic carrier coupling complex comprises a magnetic carrier and lectins coupled to the outer side of the magnetic carrier. The lectin-magnetic carrier coupling complex provided by the present invention may rapidly, accurately, and automatically separate glycosylated exosomes from a clinical sample with a high separation efficiency; and the separated exosomes are intact in morphology without rupturing or cracking, may be directly used for liquid detection of glycosylated exosomes, or directly used for immunology-related detection, or directly used for nucleotide sequence detection and analysis after extracting nucleic acids from the exosomes.

Abstract: A method, computer program product, and computer system for processing instances of message sequences. Two or more instances are received. Each instance has an instance number and an associated instance Id. Each instance includes a stream of one or more messages. Each message in each stream is associated with a respective task. All messages in the two or more instances whose respective tasks have been completed are distributed into partitions in the broker. Different messages in each instance of at least one instance are distributed into different partitions. The messages distributed in the partitions include parallel task messages. The parallel task messages are sequenced by being grouped by the instance number or instance Id and are sequentially ordered in each group in an ascending order of a timestamp of arrival of each parallel task message at the broker. The parallel task messages in each instance are dispatched to a service.

Abstract: The present disclosure provides antibodies that bind to OX40 and antigen binding fragments thereof, and use of the antibodies and the antigen binding fragments in the treatment of diseases for example cancers. The antibodies or the antigen binding fragments include a heavy chain variable region including one or more CDRs having an amino acid sequence selected from amino acid sequences as set forth in SEQ ID NOs: 1-12.

Abstract: The present invention relates to a lectin-macromolecular carrier coupling complex for separating glycosylated exosomes from a clinical sample, which comprises a macromolecular carrier and lectins coupled to the outer side of the macromolecular carrier. The complex may simply, conveniently, rapidly, and accurately separate glycosylated exosomes from a clinical sample with a high separation efficiency and a good repeatability; and the separated exosomes are intact in morphology without rupturing or cracking, may be directly used for liquid detection of glycosylated exosomes, or directly used for immunology-related detection, or directly used for gene detection or analysis after extracting related nucleic acids from the exosomes.

Abstract: A motor driving method includes steps of: at an open loop phase and in response to a motor being operated under a steady-state, calculating an angle difference between an estimation coordinate axis of the motor and an actual coordinate axis by a controller, according to an estimation voltage value, an estimation current value and at least one electrical parameter feedback from the motor and in reference with the estimation coordinate axis of the motor; calculating an actual current value in reference with the actual coordinate axis according to the angle difference by the controller; calculating a load torque estimation value associated with the motor according to the actual current value by the controller; and, in response to the open loop phase being switched to a close loop phase, compensating an output torque of the motor according to the load torque estimation value by the controller.

Abstract: Sensor-integrated prosthetic valves that can comprise a variety of features, including a plurality of valve leaflets, a frame assembly configured to support the plurality of valve leaflets and define a plurality of commissure supports terminating at an outflow end of the prosthetic valve, a sensor device associated with the frame assembly and configured to generate a sensor signal, for example, a sensor signal indicating deflection of one or more of the plurality of commissure supports, and a transmitter assembly configured to receive the sensor signal from the sensor device and wirelessly transmit a transmission signal that is based at least in part on the sensor signal.

Abstract: An autonomous driving vehicle (ADV) receives instructions for a human test driver to drive the ADV in manual mode and to collect a specified amount of driving data for one or more specified driving categories. As the user drivers the ADV in manual mode, driving data corresponding to the one or more driving categories is logged. A user interface of the ADV displays the one or more driving categories that the human driver is instructed collect data upon, and a progress indicator for each of these categories as the human driving progresses. The driving data is uploaded to a server for machine learning. If the server machine learning achieves a threshold grading amount of the uploaded data to variables of a dynamic self-driving model, then the server generates an ADV self-driving model, and distributes the model to one or more ADVs that are navigated in the self-driving mode.

Abstract: Single loop inductive sensors are widely deployed in infrastructure for traffic data collection, however, these loops currently provide little more than vehicle detection. A system and method are provided that enable single loop inductive sensors to be used for vehicle classification (e.g., identification as motorcycle, passenger car, bus, etc.). Classification may be done using the Federal Highway Administration's 13 class system. Initially a signature library is built from vehicle signatures with known classifications. Vehicle signature waveforms of unknown classification obtained from inductive loop sensors are analyzed to identify specific features in the waveform including the number of “peaks”, the first peak location and its magnitude. A classifier (e.g., K-nearest neighbor) uses a representation of the vehicle signature and the features to determine from the signature library the classification of the vehicle.

Abstract: The disclosure provides a spintronic device, a SOT-MRAM storage cell, a storage array and a in-memory computing circuit. The spintronic device includes a ferroelectric/ferromagnetic heterostructure, a magnetic tunnel junction, and a heavy metal layer between the ferroelectric/ferromagnetic heterostructure and the magnetic tunnel junction; the ferroelectric/ferromagnetic heterostructure includes a multiferroic material layer and a ferromagnetic layer arranged in a stacked manner, and the magnetic tunnel junction includes a free layer, an insulating layer and a reference layer arranged in a stacked manner, and the heavy metal layer is disposed between the ferromagnetic layer and the free layer. According to one or more embodiments of the disclosure, the spintronic device, the SOT-MRAM storage cell, the storage array and the in-memory computing circuit can realize deterministic magnetization inversion under the condition of no applied field assistance.

Abstract: An operating method for improving the performance of a selector device is provided, including: determining and applying a direct current (DC) or alternating current (AC) operating voltage and a limit current of the selector device, so that the selector device circulates until a off-state resistance is reduced; continuously applying the operating voltage and the limit current to the selector device, so that the selector device circulates until the off-state resistance is reduced to a minimum value; continuously applying the operating voltage and the limit current to the selector device, so that the selector device circulates until the off-state resistance is increased; continuously applying the operating voltage and the limit current to the selector device, so that the selector device circulates until the off-state resistance is increased to a maximum value; and adjusting the operating voltage and the limit current, and performing DC or AC operation pulsed operation on a selector.

Abstract: Systems and methods for sound source detection and localization utilizing an autonomous driving vehicle (ADV) are disclosed. The method includes receiving audio data from a number of audio sensors mounted on the ADV. The audio data comprises sounds captured by the audio sensors and emitted by one or more sound sources. Based on the received audio data, the method further includes determining a number of sound source information. Each sound source information comprises a confidence score associated with an existence of a specific sound. The method further includes generating a data representation to report whether there exists the specific sound within the driving environment of the ADV. The data representation comprises the determined sound source information. The received audio data and the generated data representation are utilized to subsequently train a machine learning algorithm to recognize the specific sound source during autonomous driving of the ADV in real-time.

Abstract: A method for displaying a virtual object is disclosed, applied to an electronic device (10) having a display component (323) and a camera (324). The method includes: detecting an operation of starting an application by a user; in response to the operation, downloading a global submap and storing the global submap in a simultaneous localization and mapping SLAM system of the electronic device (10), where the global submap (123) is a submap corresponding to a location of the electronic device (10) in a global map; and displaying a location and a posture of the virtual object on the display component (323), where the location and the posture of the virtual object are obtained by performing pose calculation based on at least a video image collected by the camera (324) and the global submap (123).