Abstract: Antigen-binding proteins specific for HLA-A2-restricted Wilms tumor 1 peptide are disclosed. The antigen-binding proteins encompass antibodies in a variety of forms, including full-length antibodies, substantially intact antibodies, Fab fragments, F(ab?)2 fragments, and single chain Fv (scFv) fragments, as well as chimeric antigen receptors. Fusion proteins, such as scFv fusions with immunoglobulin or T-cell receptor domains, incorporating the antigen-binding proteins are provided. Methods of using the antigen-binding proteins in the treatment of hyperproliferative diseases such as cancer are also disclosed.

Abstract: In this application are described high affinity anti-GD2 antibody agents, and various methods and reagents related thereto, including for example for the detection, prevention, and/or therapeutical treatment of GD2-related diseases, in particular, neuroblastoma.

Abstract: Methods for joining dissimilar high-temperature alloys are provided, along with articles, such as turbine airfoils, formed by the method. The method comprises interposing a barrier material between a first segment and a second segment to form a segment assembly. The first segment comprises a titanium aluminide material, and the second segment comprises a nickel alloy. The barrier material comprises a primary constituent element present in the barrier material at a concentration of at least about 30 weight percent of the barrier material, and the primary constituent element is a transition metal element of Group 1B, Group 4B (excluding titanium and zirconium), Group 5B, Group 6B, Group 7B, or Group 8B (excluding nickel).

Abstract: Disclosed herein are human monoclonal antibodies that specifically bind both IGF-I and IGF-II with picomolar affinity and potently inhibit the IGF-IR signal transduction function. These antibodies are active in both an IgG and a scFv format. Bispecific forms of these antibodies are also disclosed. Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors are also disclosed herein. Also disclosed are pharmaceutical compositions including these antibodies. Methods are provided for treating a subject with cancer and for inhibiting phosphorylation of the insulin-like growth factor-I receptor. Methods are also provided for diagnosing cancer.

Abstract: A method for joining a filler material to a substrate material includes melting the filler material within a melting chamber of a crucible such that the filler material is molten. The crucible has an outlet fluidly connected to the melting chamber. The method also includes holding the filler material within the melting chamber of the crucible by applying a first pressure differential across the outlet of the crucible, and releasing the filler material from the melting chamber of the crucible by applying a second pressure differential across the outlet of the crucible to deliver the filler material to a target site of the substrate material. The second pressure differential has a different value than the first pressure differential.

Abstract: A shell mold is described. The shell mold includes a facecoat, a sealcoat, and a support disposed in between the facecoat and the sealcoat. The support includes a stucco in a concentration greater than about 40 volume percent of the support. The stucco includes a material that has a thermal conductivity greater than about 285 W/m-K.

Abstract: Disclosed herein are human monoclonal antibodies that specifically bind both IGF-I and IGF-II with picomolar affinity and potently inhibit the IGF-IR signal transduction function. These antibodies are active in both an IgG and a scFv format. Bispecific forms of these antibodies are also disclosed. Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors are also disclosed herein. Also disclosed are pharmaceutical compositions including these antibodies. Methods are provided for treating a subject with cancer and for inhibiting phosphorylation of the insulin-like growth factor-I receptor. Methods are also provided for diagnosing cancer.

Abstract: A method is provided for joining a filler material to a substrate material. The method includes melting the filler material within a melting chamber of a crucible such that the filler material is molten. The crucible has an outlet fluidly connected to the melting chamber. The method also includes holding the filler material within the melting chamber of the crucible by applying a first pressure differential across the outlet of the crucible, and releasing the filler material from the melting chamber of the crucible by applying a second pressure differential across the outlet of the crucible to deliver the filler material to a target site of the substrate material. The second pressure differential has a different value than the first pressure differential.

Abstract: A method of directionally solidifying a molten alloy is presented. The molten alloy is disposed in a shell mold that has a thermal conductivity value greater than about 2 W/m-K. During the direction solidification, heat is transferred from the shell mold to a cooling region with a heat extraction rate greater than about 120 W/m2.

Abstract: The present invention relates to compounds, compositions, methods, systems and kits for treating neuropathic pain regulated by SIP30. The present invention provides SIP30 antagonists for the treatment of neuropathic pain.

Abstract: A shell mold is described. The shell mold includes a facecoat, a sealcoat, and a support disposed in between the facecoat and the sealcoat. The support includes a stucco in a concentration greater than about 40 volume percent of the support. The stucco includes a material that has a thermal conductivity greater than about 285 W/m-K.

Abstract: A method of casting a low alloy steel using a mold is disclosed. The method includes receiving the mold having a foam pattern disposed within a sand casing. The received foam pattern is coated with a permeable refractory coating and is disposed between compacted sand and the sand casing. The method further includes pouring a molten metal comprising a low alloy steel having a carbon content in a range from about 0.1 to about 0.4 percent into the mold so as to vaporize the foam pattern and remove gasification products through the permeable refractory coating, to form a low alloy steel casting. Further, the method includes removing the low alloy steel casting from the mold.

Abstract: A container-based processing method includes: when a container state needs to be backed up, determining that content of a first control group file in at least one control group file of the container is modified; acquiring, a file name of the first control group file corresponding to the first flag bit; searching for, according to a correspondence between the file name of the at least one control group file and a storage location of the at least one control group file, a storage location of the first control group file corresponding to the file name of the first control group file, and extracting modified content of the first control group file from the first control group file stored in the storage location of the first control group file; and backing up the file name of the first control group file and the modified content of the first control group file.

Abstract: The subject application relates to a method and system for power delivery network analysis. The present disclosure is directed towards a computer-implemented method for analyzing a power delivery network (PDN) system. The method may include receiving at least one of a chip power model, a package power model and a board power model at the computing device and co-simulating at least two of the chip power model, the package power model, and the board power model. Numerous other features are also within the scope of the present disclosure.

Abstract: Embodiments of the present invention disclose a method for checkpointing and restarting a container status, including: at a checkpoint stage, acquiring and checkpointing configuration information of a first container, a control group status parameter of the first container, and an application program status parameter of the first container; and at a restart stage, reading the configuration information, the control group status parameter, and the application program status parameter, and configure a second container according to the read configuration information, the read control group status parameter, and the read application program status parameter. The embodiments of the present invention further disclose an apparatus for checkpointing and restarting a container status, so that an execution environment of a process in the container can be kept consistent before and after a checkpoint/restart operation.

Abstract: Refractory slurry for use in coating a foam cluster to provide a foam pattern for lost foam casting is provided. The slurry includes a catalyst capable of catalyzing reactions for vaporizing the foam cluster. A foam pattern with a refractory coating including the catalyst and processes for preparing the foam pattern and using the foam pattern are also provided.

Abstract: Systems and methods to model user activity information associated with a network system are provided. A particular method includes receiving, at a computing device, a request for user activity information associated with selected channels of a television access network that provides multimedia content to users. The method includes executing a model of user activity associated with the television access network at the computing device. The model estimates the user activity information as user multimedia access demands during particular time periods within a day. The method also includes storing the user activity information at a computer-readable non-transitory storage medium.

Abstract: A method predicts power flow in a distributed generation network of at least one distributed generator and at least one co-generator, where the network is defined by a plurality of network nonlinear equations. The method includes applying an iterative method to the plurality of network nonlinear equations to achieve a divergence from a power flow solution to the plurality of network nonlinear equations. The method also includes applying the iterative method to find a first solution to a plurality of simplified nonlinear equations homotopically related by parameterized power flow equations to the plurality of network nonlinear equations. The method further includes iteratively applying the iterative method to the parameterized power flow equations starting with the first solution to achieve the power flow solution to the plurality of network nonlinear equations.

Abstract: An example method for displaying clinical content includes monitoring user interaction with an image viewer displaying clinical content to a user according to a hanging protocol. The example method includes identifying a change in configuration of the hanging protocol and capturing, based on user input, criteria associated with the change. The example method includes saving the criteria in association with the hanging protocol and providing the saved hanging protocol and associated criteria for selection and application to clinical content to be displayed.

Abstract: A method is provided for joining a filler material to a substrate material. The method includes melting the filler material within a melting chamber of a crucible such that the filler material is molten. The crucible has an outlet fluidly connected to the melting chamber. The method also includes holding the filler material within the melting chamber of the crucible by applying a first pressure differential across the outlet of the crucible, and releasing the filler material from the melting chamber of the crucible by applying a second pressure differential across the outlet of the crucible to deliver the filler material to a target site of the substrate material. The second pressure differential has a different value than the first pressure differential.