Abstract: A phone managing method is implemented within an electronic communication device installed with a location system and having several preset regions stored with sorted received calls in different groups. The managing method includes the steps of (a) receiving a communication signal so that a phone number corresponding to the communication signal is obtained; (b) detecting the location of the electronic communication device receiving the communication signal; (c) comparing the phone number with the received calls in the preset regions; and (d) rejecting the phone number in case the phone number is excluded from anyone of the received calls in the preset regions.

Abstract: Provided is a method for enhancing the activity of a protein, which protein when mutated, folds in an incorrect conformation in the endoplasmic reticulum, by contacting the protein with an effective amount of a compound which specifically binds to the protein and induces the protein to fold into a proper conformation (a specific chaperone). Also provided are methods for enhancing the stability and preventing the degradation of a protein by contacting the protein with an effective amount of a specific chaperone for the protein which stabilizes the protein in a proper conformation.

Abstract: A digital toy kit includes a picture book and a digital printing toy. At least one of the pages on the picture book includes one or more pictures and words. The digital printing toy includes a frame member that has a cavity, an ink jet printing head that has one or more nozzles, a memory storing a plurality of objects, a display area, a selection button operative to select an object, and a printing control circuit. The ink jet printing head can be activated to move inside the cavity of the frame member when it is pressed against a chosen page on the picture book. The printing control circuit controls the nozzles on ink jet printing head to project an ink pattern on the chosen page on the picture book when the ink jet printing head moves inside the cavity of the frame member.

Abstract: This application provides methods of improving gene therapy by combining gene therapy with active site-specific chaperones (ASSCs). The ASSC increases the stability and efficiency of the protein encoded by the recombinant gene that is administered.

Abstract: The present invention provides compositions and methods for alleviating physical discomfort and/or pain-related conditions in a subject, comprising one or more ingredients that improve blood circulation, one or more ingredients that reduce pain and one or more ingredients that enhance bone health. The ingredients are selected from synthetic compounds, natural products, natural ingredients, extracts from natural ingredients, or combinations thereof. The compositions of the invention are particularly useful in alleviating musculoskeletal pain and nerve related pain.

Abstract: This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides stable compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.

Abstract: The invention relates to methods of enhancing normal melanocortin-4 receptor (MC4R) activity, and to enhancing activity of an MC4R having a mutation which affects protein folding and/or processing of the MC4R. The invention provides a method of treating an individual having a condition in which increased activity of an MC4R at the cell surface would be beneficial, for example in obesity, by administering an effective amount of a pharmacological chaperone for the MC4R. The invention provides MC4R pharmacological chaperones which enhance the activity of MC4R. The invention further provides a method of screening to identify pharmacological chaperones which enhance folding of an MC4R in the endoplasmic reticulum (ER), in order to enhance the activity of the MC4R at the cell surface.

Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compoiunds are effective to enhance glucocerebrosidase activity.

Abstract: A digital toy kit includes a picture book and a digital printing toy. At least one of the pages on the picture book includes one or more pictures and words. The digital printing toy includes a frame member that has a cavity, an ink jet printing head that has one or more nozzles, a memory storing a plurality of objects, a display area, a selection button operative to select an object, and a printing control circuit. The ink jet printing head can be activated to move inside the cavity of the frame member when it is pressed against a chosen page on the picture book. The printing control circuit controls the nozzles on ink jet printing head to project an ink pattern on the chosen page on the picture book when the ink jet printing head moves inside the cavity of the frame member.

Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8–12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.

Abstract: This application provides methods of improving protein replacement therapy by combining protein replacement therapy with active site-specific chaperones (ASSC) to increase the stability and efficiency of the protein being administered. The application further provides stable compositions comprising the purified protein and an ASSC, and methods of treatment by administering the compositions.

Abstract: The present invention is to provide a method of carrying out call forwarding realized in a dual-mode mobile phone having setting options including a setting of a specific incoming call and a setting of a specific call forwarding target number, which comprises the steps of receiving an incoming call by the mobile phone from a mobile communication system (such as GSM); determining whether the phone number of the incoming call matches the target number; and if yes, using a specific call forwarding setting software installed therein to automatically transfer the incoming call to a low power communication system (such as PHS), enabling a user to receive a desired incoming call in low power communication system for free.

Abstract: A pixel element in the matrix of pixel elements includes a light emitting diode, a resistor electrically connecting to the light emitting diode, a data input, and a sensing output. The data input receives a data signal that changes a current flowing through the light emitting diode when the data input is enabled. The sensing output generates a sensing signal when the sensing output is enabled. The sensing output generates substantially no sensing signal when the sensing output is disabled. A change in a current flowing through both the light emitting diode and the resistor induces a change in the sensing signal.

Abstract: A remote control for controlling a computer using a screen of a television is disclosed. The television receives a video signal from the computer, and a remote control receiver is connecting to the computer. The remote control includes a body member, a light-scope, a photo detector, an electromagnetic emitter, and a mouse button. The light-scope includes a lens system defining a narrow field of view and receives a light signal emitted from an aiming point on the screen of the television as pointed by the light-scope. The photo detector detects the light signal received by the light-scope. The electromagnetic emitter sends back to the remote control receiver a communicating electromagnetic signal communicating the timing that a light signal is emitted from the aiming point. The computer can display a cursor at the aiming point.

Abstract: Provided is a method for enhancing the activity of a protein, which protein when mutated, folds in an incorrect conformation in the endoplasmic reticulum, by contacting the protein with an effective amount compound which specifically binds to the protein and induces the protein to fold into a proper conformation (a specific chaperone). Also provided are methods for enhancing the stability and preventing the degradation of a protein by contacting the protein with an effective amount of a specific chaperone for the protein which stabilizes the protein in a proper conformation.

Abstract: A method of automatically switching in an on-hook state suitable for a telephone system is provided. The method automatically switches a spring circuit from an off-hook state to the on-hook state when the telephone system operates in an abnormal use state for a unreasonably long period of time. Therefore, the telephone system can be switched back to the on-hook state when the mouthpiece is unintentionally off the hook so the missing of the phone call can be effectively avoided.

Abstract: A digital hand stamp that can print multiple images on a supporting surface. The digital hand stamp includes a frame member, an ink jet printing head, a non-volatile memory, an image selection button, a display area, and a printing control circuit. The frame member has a cavity. The ink jet printing head has one or more nozzles. The ink jet printing head can be activated to slide inside the cavity of the frame member when the digital hand stamp is pressed against the supporting surface. The non-volatile memory can store a plurality of images. The image selection button can select an image from the plurality of images stored in the non-volatile memory. The display area can display the image selected by the selection button. The printing control circuit controls the nozzles on the ink jet printing head to project an ink pattern on the supporting surface when the ink jet printing head slides inside the cavity of the frame member.

Abstract: A primary object of the present invention is to provide a method of automatically changing a calling mode of a telephone having a program timer installed therein as a timer setting changes, wherein the program timer comprising an on/off item responsible for controlling an on/off of the program timer, a timer setting item responsible for setting a time slot of an activation of the program timer, and a calling mode item responsible for setting a plurality of ring types, so that when the program timer is on and the time slot has been set by the timer setting item, a microprocessor of the telephone will activate the ring type set by the calling mode item for informing of an incoming call within the time slot.

Abstract: Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compoiunds are effective to enhance glucocerebrosidase activity.

Abstract: The present invention provides glucoimidazole (GIZ) and polyhydroxycyclohexenyl amine (PHCA) derivatives, methods of making them, and methods of use where the GIZ and PHCA derivatives have a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. More particularly, the present invention further provides a method for treating individuals having Gaucher disease by administering the novel GIZ or PHCA derivatives as “active-site specific chaperones” for the mutant glucocerebrosidase associated with the disease.