Patents by Inventor Qiao Lin

Qiao Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200196925
    Abstract: A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 25, 2020
    Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, DEPARTMENT OF ANATOMY AND CELL BIOLOGY - UNIVERSITY OF IOWA
    Inventors: Qiao Lin, Yibo Zhu, Junyi Shang, Zhixing Zhang, Xuejun Wang, Jaeyoung Yang, Cheng Wang, Pavana G. Rotti, John F. Engelhardt, Zhuang Hao
  • Patent number: 10667634
    Abstract: An article of tableware has a container portion defining a well, and a base portion coupled to the container portion. The base portion includes a foot portion and a hinge portion. The hinge portion includes a first hinge line and a second hinge line, and the foot portion is coupled to the hinge portion at the first hinge line. The hinge portion is pivotable about the first and second hinge lines such that the foot portion is movable between an extended position and a retracted position to adjust a height of the tableware article.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: June 2, 2020
    Assignee: Olababy, Inc.
    Inventors: Paul Wang, Qiao Lin, Benny Sun
  • Patent number: 10429328
    Abstract: A microelectromechanical systems-based calorimetric device includes first and second micromixers and first and second thermally-isolated microchambers. A first solution including a sample and a reagent is introduced to the first microchamber via the first micromixer, and a second solution including a sample and a buffer is introduced to the second microchamber via the second micromixer. A thermopile measures the differential temperature between the first microchamber and the second microchamber and outputs a voltage representative of the difference. The output voltage can be used to calculate reaction parameters.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: October 1, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Qiao Lin, Bin Wang
  • Patent number: 10295490
    Abstract: A MEMS-based calorimeter includes a reference channel, a sample channel, and a thermopile configured to measure a temperature differential between the reference channel and a sample channel. The reference channel and the sample channel each include a passive mixer such as a splitting-and-recombination micromixer. The passive mixer can be formed by a first set of channels in a first layer and a second set of channels in a second layer. Methods for fabricating the MEMS-based calorimeter and methods of using the calorimeter to measure thermodynamic properties of chemical reactions are also provided.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: May 21, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Yuan Jia, Zhixing Zhang, Qiao Lin
  • Patent number: 10294471
    Abstract: A method for selecting and isolating aptamers that target M-Ig proteins with a microdevice including at least a first selection chamber is provided. The method includes preparing a first sample of M-Ig proteins from a serum; placing the M-Ig proteins in the first selection chamber; introducing a first group of oligomers including at least an M-Ig targeting oligomer into the first selection chamber, whereby the M-Ig targeting oligomer binds to the first sample of M-Ig proteins. The method further includes removing unbound oligomers of the first sample from the first selection chamber to isolate the M-Ig targeting oligomer.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: May 21, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Qiao Lin, Milan N. Stojanovic, Timothy R. Olsen, Tilla S. Worgall
  • Patent number: 10175123
    Abstract: MEMS-based calorimeter including two microchambers supported in a thin film substrate formed on a polymeric layer is provided. The thin film substrate includes a thermoelectric sensor configured to measure temperature differential between the two microchambers, and also includes a thermally stable and high strength polymeric diaphragm. Methods for fabricating the MEMS-based calorimeter, as well as methods of using the calorimeter to measure thermal properties of materials, such as biomolecules, or thermodynamic properties of chemical reactions or physical interactions, are also provided.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: January 8, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Qiao Lin, Bin Wang, Yuan Jia
  • Publication number: 20180368743
    Abstract: A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.
    Type: Application
    Filed: June 19, 2018
    Publication date: December 27, 2018
    Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW NEW YORK, Department of Anatomy and Cell Biology - Universit y of Iowa
    Inventors: Qiao Lin, Yibo Zhu, Junyi Shang, Zhixing Zhang, Xuejun Wang, Jaeyoung Yang, Cheng Wang, Pavana G. Rotti, John F. Engelhardt, Zhuang Hao
  • Publication number: 20180332984
    Abstract: An article of tableware has a container portion defining a well, and a base portion coupled to the container portion. The base portion includes a foot portion and a hinge portion. The hinge portion includes a first hinge line and a second hinge line, and the foot portion is coupled to the hinge portion at the first hinge line. The hinge portion is pivotable about the first and second hinge lines such that the foot portion is movable between an extended position and a retracted position to adjust a height of the tableware article.
    Type: Application
    Filed: May 17, 2017
    Publication date: November 22, 2018
    Inventors: Paul Wang, Qiao Lin, Benny Sun
  • Patent number: 10058276
    Abstract: Techniques for monitoring a target analyte in a sample using a polymer capable of binding to the target analyte are disclosed. An implantable monitor useful for the disclosed techniques includes a microdevice coupled with a wireless interface. The wireless interface can comprise a capacitance digital converter coupled with the microdevice and can be adapted to produce a digital signal representing a measurement of the target analyte. A microcontroller can be coupled with the capacitance digital converter and a transponder can be coupled with the microcontroller to transmit the digital signal received from the capacitance digital converter to an external reader.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: August 28, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Qiao Lin, Xian Huang
  • Patent number: 9928334
    Abstract: A method for redistribution layer routing is proposed. The method at least comprises inputting information regarding a redistribution layer layout, at least one netlist, and a constraint file. Next, it is creating a concentric-circle model based on the information, the netlist and the constraint file. Subsequently, it is assigning at least one pre-assignment net to at least one redistribution layer according to the concentric-circle model. Finally, the redistribution layer routing is performed.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: March 27, 2018
    Inventors: Bo-Qiao Lin, Ting-Chou Lin, Chun-Yi Yang, Yao-Wen Chang
  • Publication number: 20180032660
    Abstract: A method for redistribution layer routing is proposed. The method at least comprises inputting information regarding a redistribution layer layout, at least one netlist, and a constraint file. Next, it is creating a concentric-circle model based on the information, the netlist and the constraint file. Subsequently, it is assigning at least one pre-assignment net to at least one redistribution layer according to the concentric-circle model. Finally, the redistribution layer routing is performed.
    Type: Application
    Filed: July 29, 2016
    Publication date: February 1, 2018
    Applicant: AnaGlobe Technology, Inc.
    Inventors: Bo-Qiao Lin, Ting-Chou Lin, Chun-Yi Yang, Yao-Wen Chang
  • Publication number: 20170350882
    Abstract: A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.
    Type: Application
    Filed: August 21, 2017
    Publication date: December 7, 2017
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: QIAO Lin, Yibo Zhu, Junyi Shang, Zhixing Zhang, Xuejun Wang, Jaeyoung Yang, Cheng Wang
  • Publication number: 20170307553
    Abstract: A MEMS-based calorimeter includes a reference channel, a sample channel, and a thermopile configured to measure a temperature differential between the reference channel and a sample channel. The reference channel and the sample channel each include a passive mixer such as a splitting-and-recombination micromixer. The passive mixer can be formed by a first set of channels in a first layer and a second set of channels in a second layer. Methods for fabricating the MEMS-based calorimeter and methods of using the calorimeter to measure thermodynamic properties of chemical reactions are also provided.
    Type: Application
    Filed: April 24, 2017
    Publication date: October 26, 2017
    Applicant: The Trustees Of Columbia University in the City of New York
    Inventors: Yuan Jia, Zhixing Zhang, Qiao Lin
  • Publication number: 20170283859
    Abstract: The disclosed subject matter provides a microdevice and techniques for single-cell gene expression profiling using a microfluidic device capable of cell-trapping, cell lysis, bead-based gene analysis. The microdevice can be capable of independent or parallelized, simultaneous quantitative genetic assays of single cells.
    Type: Application
    Filed: April 20, 2017
    Publication date: October 5, 2017
    Applicant: The Trustees Of Columbia University In the City of New York
    Inventors: Qiao Lin, Jing Zhu, Timothy R. Olsen, Hao Sun, Brian Ponnaiya, Sally A. Amundson, David J. Brenner
  • Publication number: 20170181669
    Abstract: A receptor capable of binding to the target analyte can be used in monitoring a target analyte in a bodily fluid or a sample. A microdevice in accordance with the disclosed subject matter can include a substrate and a conductance elements with receptors grafted on the surface of the conductance element. A microdevice in accordance with the disclosed subject matter can also include a substrate, a first and second conductance elements, and synthetic polymers grafted on the surface of the first and second conductance elements. The first conductance element can be grafted with a sensing polymer that binds the target analyte, and the second conductance element can be grafted with a reference polymer that is insensitive to the target analyte. Differential measurement of the graphene conductance can allow determination of target analyte concentration in a bodily fluid.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 29, 2017
    Inventors: Qiao Lin, Yibo Zhu, Junyi Shang, Zhixing Zhang, Xuejun Wang, Jaeyoung Yang, Cheng Wang
  • Publication number: 20170130218
    Abstract: A method for selecting and isolating aptamers that target M-Ig proteins with a microdevice including at least a first selection chamber is provided. The method includes preparing a first sample of M-Ig proteins from a serum; placing the M-Ig proteins in the first selection chamber; introducing a first group of oligomers including at least an M-Ig targeting oligomer into the first selection chamber, whereby the M-Ig targeting oligomer binds to the first sample of M-Ig proteins. The method further includes removing unbound oligomers of the first sample from the first selection chamber to isolate the M-Ig targeting oligomer.
    Type: Application
    Filed: January 24, 2017
    Publication date: May 11, 2017
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Qiao Lin
  • Publication number: 20170067091
    Abstract: A microdevice for isolating and amplifying aptamers includes a selection microchamber and an amplification microchamber. The selection microchamber can include a plurality of cultured cells immobilized therein. A first microchannel connecting the selection microchamber to the amplification microchamber can be configured to hydrodynamically transfer oligomers from the selection microchamber to the amplification chamber. A second microchannel connecting the selection microchamber to the amplification microchamber can be configured to hydrodynamically transfer oligomers from the amplification chamber to the selection chamber.
    Type: Application
    Filed: September 19, 2016
    Publication date: March 9, 2017
    Inventors: Qiao Lin, Jing Zhu, Timothy Olsen
  • Publication number: 20160370362
    Abstract: The disclosed subject matter relates to a sensor or system for monitoring a target analyte by using a polymer solution that is capable of binding to the analyte. The sensor of the disclosed subject matter includes a viscosity-based sensor or a permittivity-based sensor. The viscosity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber including a vibrational element. The permittivity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber. The sensor discussed herein provides excellent reversibility and stability as highly desired for long-term analyte monitoring.
    Type: Application
    Filed: June 22, 2016
    Publication date: December 22, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Qiao Lin, Xian Huang
  • Patent number: D778690
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: February 14, 2017
    Inventors: Paul Wang, Qiao Lin, Pengcheng Gao
  • Patent number: D808231
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: January 23, 2018
    Inventors: Paul Wang, Qiao Lin, Pengcheng Gao