Patents by Inventor Qiao Lin
Qiao Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9513240Abstract: MEMS-based calorimeter including two microchambers supported in a thin film substrate is provided. The thin film substrate includes a thermoelectric sensor configured to measure temperature differential between the two microchambers, and also includes a thermally stable and high strength polymeric diaphragm. Methods for fabricating the MEMS-based calorimeter, as well as methods of using the calorimeter to measure thermal properties of materials, such as biomolecules, or thermodynamic properties of chemical reactions or physical interactions, are also provided.Type: GrantFiled: August 21, 2013Date of Patent: December 6, 2016Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Qiao Lin, Bin Wang
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Publication number: 20160249837Abstract: Techniques for monitoring a target analyte in a sample using a polymer capable of binding to the target analyte are disclosed. An implantable monitor useful for the disclosed techniques includes a microdevice coupled with a wireless interface. The wireless interface can comprise a capacitance digital converter coupled with the microdevice and can be adapted to produce a digital signal representing a measurement of the target analyte. A microcontroller can be coupled with the capacitance digital converter and a transponder can be coupled with the microcontroller to transmit the digital signal received from the capacitance digital converter to an external reader.Type: ApplicationFiled: May 13, 2016Publication date: September 1, 2016Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Qiao Lin, Xian Huang
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Publication number: 20160216163Abstract: MEMS-based calorimeter including two microchambers supported in a thin film substrate formed on a polymeric layer is provided. The thin film substrate includes a thermoelectric sensor configured to measure temperature differential between the two microchambers, and also includes a thermally stable and high strength polymeric diaphragm. Methods for fabricating the MEMS-based calorimeter, as well as methods of using the calorimeter to measure thermal properties of materials, such as biomolecules, or thermodynamic properties of chemical reactions or physical interactions, are also provided.Type: ApplicationFiled: December 3, 2015Publication date: July 28, 2016Inventors: Qiao Lin, Bin Wang, Yuan Jia
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Patent number: 9400233Abstract: The disclosed subject matter relates to a sensor or system for monitoring a target analyte by using a polymer solution that is capable of binding to the analyte. The sensor of the disclosed subject matter includes a viscosity-based sensor or a permittivity-based sensor. The viscosity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber including a vibrational element. The permittivity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber. The sensor discussed herein provides excellent reversibility and stability as highly desired for long-term analyte monitoring.Type: GrantFiled: September 27, 2011Date of Patent: July 26, 2016Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Qiao Lin, Xian Huang
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Publication number: 20160169780Abstract: The described subject matter includes techniques and components for minimally invasive, selective capture and release of analytes. An aptamer is selected for its binding affinity with a particular analyte(s). The aptamer is functionalized on a solid phase, for example, microbeads, polymer monolith, microfabricated solid phase, etc. The analyte is allowed to bind to the aptamer, for example, in a microchamber. Once the analyte has been bound, a temperature control sets the temperature to an appropriate temperature at which the captured analyte is released.Type: ApplicationFiled: December 22, 2015Publication date: June 16, 2016Inventors: Jingyue Ju, Donald W. Landry, Qiao Lin, ThaiHuu Nguyen, Renjun Pei, Chunmei Qiu, Milan N. Stojanovic
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Patent number: 9364174Abstract: Techniques for monitoring a target analyte in a sample using a polymer capable of binding to the target analyte are disclosed. A microdevice useful for the disclosed techniques includes a semi-permeable membrane structure, a substrate, a first and second microchambers formed between the membrane structure and the substrate. The first microchamber can be adapted to receive a solution including the polymer, and the second microchamber can be adapted to receive a reference solution. Environmental target analyte can permeate the semi-permeable membrane structure and enters the first microchamber and the second microchamber. Based on the difference in a property associated with the polymer solution that is responsive to the target analyte-polymer binding, and the corresponding property associated with reference solution, the presence and/or concentration of the target analyte can be determined.Type: GrantFiled: January 21, 2014Date of Patent: June 14, 2016Assignee: The Trustees of Columbia University in the City of New YorkInventors: Qiao Lin, Xian Huang
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Publication number: 20160146797Abstract: Systems and methods are provided for capturing and/or isolating target microparticles. In one aspect, a method for capturing target microparticles is disclosed. The method includes: forming a fluid including the target microparticles, non-target microparticles, and magnetic beads, the magnetic beads having a stronger affinity with the target microparticles than with the non-target microparticles; flowing the fluid through a multidirectional microchannel; and applying a magnetic field to the fluid while the fluid is flowing through at least a portion of the microchannel to effect capture of at least a portion of the target microparticles onto the magnetic beads. Such a method can further includes passing the fluid having exited from the microchannel through a separator while subjecting the fluid to a second magnetic field so as to isolate the target microparticles. In addition, devices and systems are disclosed for capturing and/or isolating target microparticles based on magnetic manipulation.Type: ApplicationFiled: June 18, 2015Publication date: May 26, 2016Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Qiao Lin, Yao Zhou
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Patent number: 9250169Abstract: The described subject matter includes techniques and components for minimally invasive, selective capture and release of analytes. An aptamer is selected for its binding affinity with a particular analyte(s). The aptamer is functionalized on a solid phase, for example, microbeads, polymer monolith, microfabricated solid phase, etc. The analyte is allowed to bind to the aptamer, for example, in a microchamber. Once the analyte has been bound, a temperature control sets the temperature to an appropriate temperature at which the captured analyte is released.Type: GrantFiled: October 15, 2012Date of Patent: February 2, 2016Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Jingyue Ju, Donald W. Landry, Qiao Lin, ThaiHuu Nguyen, Renjun Pei, Chunmei Oiu, Milan N. Stojanovic
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Publication number: 20150285751Abstract: A microelectromechanical systems-based calorimetric device includes first and second micromixers and first and second thermally-isolated microchambers. A first solution including a sample and a reagent is introduced to the first microchamber via the first micromixer, and a second solution including a sample and a buffer is introduced to the second microchamber via the second micromixer. A thermopile measures the differential temperature between the first microchamber and the second microchamber and outputs a voltage representative of the difference. The output voltage can be used to calculate reaction parameters.Type: ApplicationFiled: January 23, 2015Publication date: October 8, 2015Applicant: The Trustees of Columbia University in the City of New YorkInventors: Qiao Lin, Bin Wang
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Patent number: 9090663Abstract: Systems and methods are provided for capturing and/or isolating target microparticles. In one aspect, a method for capturing target microparticles is disclosed. The method includes: forming a fluid including the target microparticles, non-target microparticles, and magnetic beads, the magnetic beads having a stronger affinity with the target microparticles than with the non-target microparticles; flowing the fluid through a multidirectional microchannel; and applying a magnetic field to the fluid while the fluid is flowing through at least a portion of the microchannel to effect capture of at least a portion of the target microparticles onto the magnetic beads. Such a method can further includes passing the fluid having exited from the microchannel through a separator while subjecting the fluid to a second magnetic field so as to isolate the target microparticles. In addition, devices and systems are disclosed for capturing and/or isolating target microparticles based on magnetic manipulation.Type: GrantFiled: April 21, 2010Date of Patent: July 28, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventors: Qiao Lin, Yao Zhou
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Publication number: 20150004494Abstract: The present invention discloses a high electrochemical performance silicon/graphene composite anode structure. The electrochemical properties of silicon in the composite anode structure can be improved by graphene thin films. The thickness of the silicon thin film and the graphene thin films is less than 50 nm to prevent the composite anode structure from any volumetric change during the charge/discharge process. The manufacturing procedure starts with the formation of a Si/graphene unit layer, which includes an amorphous phase upper silicon thin film and a lower graphene thin film, on a copper foil current collector, so as to decrease the difference of conductivity between the silicon thin film and the copper foil current collector. Finally, the deposition is concluded with the formation of a graphene thin film on the topmost surface of the silicon thin film to prevent the surface of the anode structure from oxidation.Type: ApplicationFiled: June 25, 2014Publication date: January 1, 2015Inventors: Mori Tatsuhiro, Chih-Jung Chen, Tai-Feng Hung, Saad G. Mohamed, Ru-Shi Liu, Shu-Fen Hu, Hong-Zheng Lin, Yi-Qiao Lin, Chien-Ming Sung, Bing-Joe Hwang
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Publication number: 20140296095Abstract: Methods and systems are provided for capturing and releasing target cells. The system includes a microdevice having a microchamber including surface-patterned aptamers capable of binding with the target cells. A sample including target cells is introduced to the microchamber, where the target cells bind to the aptamers at locally regulated temperatures. The captured target cells can be selectively released when the temperature of a region is changed to a second temperature.Type: ApplicationFiled: March 24, 2014Publication date: October 2, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Qiao Lin, Jing Zhu, Milan N. Stojanovic, Renjun Pei
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Publication number: 20140295424Abstract: Techniques for isolating, enriching, and/or amplifying target DNA molecules using MEMS-based microdevices are disclosed. The techniques can be used for detecting single nucleotide polymorphism, and for isolating and enriching desired DNA molecules, such as aptamers.Type: ApplicationFiled: March 21, 2014Publication date: October 2, 2014Applicant: The Tustees of Columbia University in the City of New YorkInventors: Qiao Lin, Jing Zhu, Jinho Kim, John Paul Hilton, Renjun Pei, Milan N. Stojanovic
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Publication number: 20140134607Abstract: Techniques for monitoring a target analyte in a sample using a polymer capable of binding to the target analyte are disclosed. A microdevice useful for the disclosed techniques includes a semi-permeable membrane structure, a substrate, a first and second microchambers formed between the membrane structure and the substrate. The first microchamber can be adapted to receive a solution including the polymer, and the second microchamber can be adapted to receive a reference solution. Environmental target analyte can permeate the semi-permeable membrane structure and enters the first microchamber and the second microchamber. Based on the difference in a property associated with the polymer solution that is responsive to the target analyte-polymer binding, and the corresponding property associated with reference solution, the presence and/or concentration of the target analyte can be determined.Type: ApplicationFiled: January 21, 2014Publication date: May 15, 2014Inventors: Qiao LIN, Xian HUANG
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Publication number: 20140092935Abstract: MEMS-based calorimeter including two microchambers supported in a thin film substrate is provided. The thin film substrate includes a thermoelectric sensor configured to measure temperature differential between the two microchambers, and also includes a thermally stable and high strength polymeric diaphragm. Methods for fabricating the MEMS-based calorimeter, as well as methods of using the calorimeter to measure thermal properties of materials, such as biomolecules, or thermodynamic properties of chemical reactions or physical interactions, are also provided.Type: ApplicationFiled: August 21, 2013Publication date: April 3, 2014Inventors: Qiao Lin, Bin Wang
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Patent number: 8310371Abstract: A power supply protection device for an electric appliance includes a switching circuit for establishing an electrical connection to receive an external voltage from the external power supply and output the external voltage to the electric appliance, a detecting circuit for disabling the switch circuit to break the electrical connection when determining the external voltage is equal to or higher than a predetermined value, and an alert circuit for generating an alert signal when the electrical connection is broken and outputting the alert signal to a user.Type: GrantFiled: December 31, 2008Date of Patent: November 13, 2012Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.Inventors: Lung Dai, Yong-Song Shi, Qiao-Lin Deng, Yong Xiong
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Publication number: 20120043203Abstract: The disclosed subject matter relates to a sensor or system for monitoring a target analyte by using a polymer solution that is capable of binding to the analyte. The sensor of the disclosed subject matter includes a viscosity-based sensor or a permittivity-based sensor. The viscosity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber including a vibrational element. The permittivity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber. The sensor discussed herein provides excellent reversibility and stability as highly desired for long-term analyte monitoring.Type: ApplicationFiled: September 27, 2011Publication date: February 23, 2012Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Qiao Lin, Xian Huang
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Patent number: 7990107Abstract: An exemplary charging control circuit includes a signal shaping unit, a first switch unit, and a second switch unit. The signal shaping unit receives a control signal, and is capable of reshaping the received control signal to have a time interval transited from a first state to a second state. The first switch unit receives the shaped control signal, and generates a first switching signal. The second switch unit receives the first switching signal, and is capable of being turned on based on the first switching signal for allowing electrical power to be outputted to a battery.Type: GrantFiled: July 14, 2008Date of Patent: August 2, 2011Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.Inventors: Lung Dai, Qiao-Lin Deng, Yong-Song Shi, Wang-Chang Duan
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Publication number: 20100297733Abstract: Systems and methods are provided for capturing and/or isolating target microparticles. In one aspect, a method for capturing target microparticles is disclosed. The method includes: forming a fluid including the target microparticles, non-target microparticles, and magnetic beads, the magnetic beads having a stronger affinity with the target microparticles than with the non-target microparticles; flowing the fluid through a multidirectional microchannel; and applying a magnetic field to the fluid while the fluid is flowing through at least a portion of the microchannel to effect capture of at least a portion of the target microparticles onto the magnetic beads. Such a method can further includes passing the fluid having exited from the microchannel through a separator while subjecting the fluid to a second magnetic field so as to isolate the target microparticles. In addition, devices and systems are disclosed for capturing and/or isolating target microparticles based on magnetic manipulation.Type: ApplicationFiled: April 21, 2010Publication date: November 25, 2010Inventors: Qiao Lin, Yao Zhou
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Publication number: 20100151465Abstract: The described subject matter includes techniques and components for minimally invasive, selective capture and release of analytes. An aptamer is selected for its binding affinity with a particular analyte(s). The aptamer is functionalized on a solid phase, for example, microbeads, polymer monolith, microfabricated solid phase, etc. The analyte is allowed to bind to the aptamer, for example, in a microchamber. Once the analyte has been bound, a temperature control sets the temperature to an appropriate temperature at which the captured analyte is released.Type: ApplicationFiled: September 28, 2009Publication date: June 17, 2010Inventors: Jingyue Ju, Donald W. Landry, Qiao Lin, ThaiHuu Nguyen, Renjun Pei, Chunmei Qiu, Milan N. Stojanovic