Abstract: An apparatus includes a first electromagnetic sensor configured to generate a first sensed signal based at least in part on detection of a first signal having a first wavelength. The apparatus includes a second electromagnetic sensor configured to generate a second sensed signal based at least in part on detection of a second signal having a second wavelength different from the first wavelength. The apparatus includes a processing circuit configured to generate a plethysmogram based at least in part on the first sensed signal and the second sensed signal. The apparatus may include a first emitter configured to emit an optical signal having the first wavelength. The apparatus may include a second emitter configured to emit a reference signal. The first wavelength may be a human-blood-sensitive and human-skin-penetrable wavelength and the second wavelength may be at least one of a human-blood-insensitive wavelength and a human-skin-impenetrable wavelength.

Abstract: An image sensor includes a plurality of photodiodes disposed in a semiconductor material to convert image light into image charge, and a metal grid, including a metal shield that is coplanar with the metal grid, disposed proximate to a backside of the semiconductor material. The metal grid is optically aligned with the plurality of photodiodes to direct the image light into the plurality of photodiodes, and a contact pad is disposed in a trench in the semiconductor material. The contact pad is coupled to the metal shield to ground the metal shield.

Abstract: An electrical assembly includes mated plug connector and receptacle connector. The plug connector includes an insulative main body, a flat flexible cable attached upon the main body, a rotatable presser assembled upon the main body and retaining the flat flexible cable in position, and a metallic unitary latch assembled upon the main body with pair of resilient latches on two opposite lateral sides.

Abstract: An image sensor includes a substrate, a plurality of light sensitive pixels, a first plurality of color filters, a plurality of reflective sidewalls, and a second plurality of color filters. The light sensitive pixels are formed on said substrate. The first plurality of color filters is disposed over a first group of the light sensitive pixels. The reflective sidewalls are formed on each side of each of the first plurality of color filters. The second plurality of color filters are disposed over a second group of light sensitive pixels and each color filter of the second plurality of color filters is separated from each adjacent filter of said first plurality of color filters by one of the reflective sidewalls. In a particular embodiment an etch-resistant layer is disposed over the first plurality of color filters and the second group of light sensitive pixels.

Abstract: The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt thereof, and (b) at least one c-Met receptor tyrosine kinase inhibitor or pharmaceutically acceptable salt thereof, for simultaneous, separate or sequential administration for the treatment of a proliferative disease, particularly a c-Met dependent proliferative disease; a pharmaceutical composition comprising such combination; a method of treating a subject having a proliferative disease comprising administration of said combination to a subject in need thereof; use of such combination for the treatment of proliferative disease; and a commercial package comprising such combination.

Abstract: Disclosed herein are methods and thermoplastic compositions of blended polycarbonate thermoplastic compositions with improved heat resistance. The resulting blended polymer thermoplastic compositions, comprising at least one aromatic polycarbonate; at least one high heat PPPBP-polycarbonate copolymer; at least one polycarbonate-siloxane copolymer; and at least one copper salt based laser direct structuring additive; wherein the composition is capable of being plated after being activated using a laser; and wherein the composition has a heat distortion temperature higher than 150° C., as determined by ASTM D 648.

Abstract: A pharmaceutical combination comprising an ALK inhibitor, in free form or a pharmaceutically acceptable salt thereof, and a SHP2 inhibitor, in free form or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

Abstract: A thermoplastic composition includes a polymeric base resin, a glass fiber component, and a laser direct structuring additive. The laser direct structuring additive includes copper chromite black, copper hydroxide phosphate, tin-antimony cassiterite grey or a combination thereof. In some aspects the polymeric base resin includes polybutylene terephthalate (PBT), polyamide (PA), polycarbonate (PC), poly(p-phenylene oxide) (PPO), or combinations thereof. In certain aspects the thermoplastic composition has a nano molding technology (NMT) bonding strength of at least about 20 MPa when bonded to aluminum alloy. In further aspects the thermoplastic composition includes a plating index of at least a about 0.25. The disclosed thermoplastic compositions can be used to form articles such as NMT bonded covers of consumer electronics devices.

Abstract: The invention includes methods for modulating a reaction dependent on a blue light-dependent protein interaction between a CRY protein and a CRY-signaling protein. The method comprises combining a CRY protein and a CRY-signaling protein with a BIC protein, wherein the BIC protein modulates the blue light-dependent interaction between the CRY protein and the CRY-signaling protein. Embodiments of the invention include compositions of matter comprising a CRY gene or protein, a CRY-signaling gene or protein, and a BIC gene or protein (optionally linked to a heterologous nucleic acid or amino acid sequence), wherein the BIC protein modulates a blue light-dependent interaction between the CRY protein and the CRY-signaling protein.

Abstract: A brake cylinder dust cover is installed on a waterproof brake cylinder. The brake cylinder includes a brake cylinder body and a front cover. A waterproof dust cover assembly is arranged on the front cover. The waterproof dust cover assembly includes a dust cover fixedly connected to the front cover, and a filter felt support and a filter felt pad which are arranged in the dust cover. The filter felt support is connected with the dust cover, and the filter felt pad is fixed on the filter felt support. An outwards extending skirt is arranged at the edge of the dust cover in the axial direction thereof.

Abstract: A vehicle position detecting method comprises: continuously detecting a detection region and generating a sensing signal by a sensor (S100); continuously determining whether a sudden change exists in the sensing signal, and starting timing when the sensing signal suddenly changes (S200); terminating timing after a preset time, if the sensing signal received at an end of timing does not restore to the sensing signal prior to the sudden change, confirming a vehicle is or is not in the detection region (S300); the sudden change is defined as a variation of the sensing signal per unit time exceeding a preset range. A vehicle position detecting system is also provided.

Abstract: An air-tight door system and a control method therefor. The air-tight door comprises a first door (M1), a second door (M2), a first door detection module (S1, S2, P1), a second door detection module (S3, S4, P2) and a controller (K). The air-tight door control method comprises: the first and second detection modules (S1, S2, P1, S3, S4, P2) detect whether the first door (M1) and the second door (M2) are completely closed; and the controller (K) controls opening and closing of the first door (M1) and the second door (M2) according to whether the first and second doors (M1, M2) are completely closed. The air-tight door system and the control method therefor ensure that at least one door is in the closed state at any time, thereby further improving air-tightness and device safety.

Abstract: A needle groove body, a puncture frame body and a puncture frame, wherein the needle groove body is a hollow cylindrical structure, and comprises a first baffle, a first fixing plate, a limiting plate, and a second fixing plate which are connected in sequence. The needle groove body has multiple specifications and can adapt to puncture needles of different specifications in puncture operations; a u-shaped needle groove can be formed between the first baffle of the needle groove body and a second baffle as well as an inclined mounting plate of the puncture frame body so as to accommodate free movement of a puncture needle in the u-shaped needle groove; and the u-shaped needle groove, which is semi-open, can implement a function of needle-frame separation (separation of the puncture needle from the puncture frame) in puncture operations.

Abstract: A reaming device connects to downhole motor with paralleled driving structure. The downhole motor contains power section assembly, sleeve and connection pad. The power section assembly has a rotor and a stator in which the stator covers the rotor. The sleeve is located inside the rotor that drives the sleeve to make rotation. The connection pad which is fixed and rotates with the sleeve is on the one end of the extended part of rotor from the bottom of sleeve. The reamer is set on the stator of power section assembly or on the cover connecting to the stator from power section assembly. The rotor drives the reamer to rotate on the stator or on the cover connecting to the stator through the sleeve and the connection pad.

Abstract: A thermoplastic composition includes from about 50 wt. % to about 90 wt. % of a polymeric base resin and from about 10 wt. % to about 50 wt. % of a low dielectric constant (Dk)/low dissipation factor (Df) glass fiber component. The low Dk/low Df glass fiber component has a Dk of less than about 5.0 at a frequency of from 1 MHz to 1 GHz and a Df of less than about 0.002 at a frequency of from 1 MHz to 1 GHz. In certain aspects the thermoplastic composition has a Dk that is at least about 0.1 lower than a substantially identical reference composition that does not include the low Dk/low Df glass fiber component.

Abstract: A probe sleeve (1), a pipe socket (2), a pipe socket assembly, and a method for wrapping the probe sleeve (1) around the pipe socket (2), wherein the probe sleeve (1) comprises a large diameter section (11) and a small diameter section (12); the free end of the large diameter section (11) is an open end (111), and the free end of the small diameter section (12) is a closed end (121). The probe sleeve (1), which is an intracavitary probe sleeve/transesophageal probe sleeve, can be used with the pipe socket (2) and as a surrogate of a condom, and can achieve an aseptic operation in an operative process. The method for wrapping the probe sleeve (1) around the pipe socket (2), which wraps the probe sleeve (1) around the pipe socket (2), is used for an ultrasonic B-ultrasound operation, and can meet the requirements of an aseptic operation.

Abstract: An image sensor includes a plurality of photodiodes disposed in a semiconductor material to convert image light into image charge, and a metal grid, including a metal shield that is coplanar with the metal grid, disposed proximate to a backside of the semiconductor material. The metal grid is optically aligned with the plurality of photodiodes to direct the image light into the plurality of photodiodes, and a contact pad is disposed in a trench in the semiconductor material. The contact pad is coupled to the metal shield to ground the metal shield.

Abstract: The disclosure relates to a pharmaceutical combination of a mdm2/4 inhibitor, namely (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4-methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4-dihydro-2H-isoquinolin-3-one or (S)-5-(5-Chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-6-(4-chloro-phenyl)-2-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one, and a cyclin dependent kinase 4/6 (CDK4/6) inhibitor 7-Cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide. In addition, the disclosure relates to a pharmaceutical combination product. The disclosure also relates to corresponding pharmaceutical formulations, uses and treatment methods comprising said mdm2/4 inhibitor or a cyclin dependent kinase 4/6 (CDK4/6) inhibitor.

Abstract: An image sensor includes a semiconductor material including a plurality of photodiodes disposed in the semiconductor material. The image sensor also includes a first insulating material disposed proximate to a frontside of the semiconductor material, and an interconnect disposed in the first insulating material proximate to the frontside of the semiconductor material. A metal pad extends from a backside of the semiconductor material through the first insulating material and contacts the interconnect. A metal grid is disposed proximate to the backside of the semiconductor material, and the semiconductor material is disposed between the metal grid and the first insulating material disposed proximate to the frontside.

Abstract: A double-sided needle groove, a frame body and a puncture frame, wherein the double-sided needle groove has an axisymmetric outer contour, and is provided at one side with at least one needle slot a (1) and at the other side with at least one needle slot b (2); and the needle slot b (2) is fan-shaped. The double-sided needle groove is provided with one or more needle slots a (1) having a fixed needle insertion angle and a needle slot b (2) having an adjustable needle insertion angle, and the needle slot a (1) and the needle slot b (2) respectively correspond to the diameters of puncture needles and may be designed to meet multiple width specifications. During the performance of a B-ultrasound puncture operation, based on operation requirements of a surgeon for a fixed or adjustable angle, there is only a need to switch front and back sides of the double-sided needle groove, thus avoiding the need for an additional puncture frame, and switch the needle slots according to the diameters of the puncture needles.