Abstract: Provided are an optimized CPY4V2 gene and an application thereof. The gene relates to a polynucleotide for coding a CYP4V2 protein, and comprises a nucleotide sequence having 90% or over 90% of identity with a nucleotide sequence as shown in SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 or SEQ ID NO: 9. Also provided is an expression vector comprising the gene. The expression vector can realize lasting and stable expression in retinal pigment epithelium of eyes, can effectively reduce the dosage and possible side effects of a gene therapy drug for treating BCD, and improves the therapeutic effect.

Abstract: Embodiments of the invention are directed to a system for detecting neurotransmitters. A non-limiting example of the system includes a porous electrode. A system can also include a pH sensor attached to the porous electrode, wherein the pH sensor includes a sensing electrode and a reference electrode. The system can also include electronic circuitry in communication with the pH sensor.

Abstract: Provided are an optimized CPY4V2 gene and an application thereof. The gene relates to a polynucleotide for coding a CYP4V2 protein, and comprises a nucleotide sequence having 90% or over 90% of identity with a nucleotide sequence as shown in SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 or SEQ ID NO: 9. Also provided is an expression vector comprising the gene. The expression vector can realize lasting and stable expression in retinal pigment epithelium of eyes, can effectively reduce the dosage and possible side effects of a gene therapy drug for treating BCD, and improves the therapeutic effect.

Abstract: A curable composition contains: (A) a polydiorganosiloxane component including: (A1) greater than 3.1 wt % to 20 wt % of an aliphatically unsaturated polydiorganosiloxane polymer and (A3) a hydroxyl-terminated polydiorganosiloxane gum of unit formula (A-III); (B) a polyorganosilicate resin component including (B1) a capped resin, (B2) >18.53 wt % to 54.3 wt % of an uncapped resin; where the weight ratio of the uncapped resin (B2) to the capped resin (B1) is greater than 0.51 to 58.82; where component (A) and component (B) are present in amounts to provide a weight ratio of (B):(A) of 1.2:1 to less than 1.62:1; (C) a polyorganohydrogensiloxane that is present in an amount to provide a molar ratio of silicon bonded hydrogen atoms to alkenyl groups for the curable composition of 5 to 50; (D) a hydrosilylation reaction catalyst in an amount sufficient to provide 1 to 1000 ppm of platinum group metal; and (E) a condensation reaction catalyst; where the content of alkenyl groups in the curable composition is 0.

Abstract: Disclosed is a silicone pressure sensitive adhesive which is prepared by curing a hydrosilylation reaction curable composition. The silicone pressure sensitive adhesive is useful in preparation of components of flexible display devices.

Abstract: A curable composition contains: (A) a polydiorganosiloxane component including: (A1) greater than 3.1 wt % to 20 wt % of an aliphatically unsaturated polydiorganosiloxane polymer and (A3) a hydroxyl-terminated polydiorganosiloxane gum of unit formula (A-III); (B) a polyorganosilicate resin component including (B1) a capped resin, (B2) >18.53 wt % to 54.3 wt % of an uncapped resin; where the weight ratio of the uncapped resin (B2) to the capped resin (B1) is greater than 0.51 to 58.82; where component (A) and component (B) are present in amounts to provide a weight ratio of (B):(A) of 1.2:1 to less than 1.62:1; (C) a polyorganohydrogensiloxane that is present in an amount to provide a molar ratio of silicon bonded hydrogen atoms to alkenyl groups for the curable composition of 5 to 50; (D) a hydrosilylation reaction catalyst in an amount sufficient to provide 1 to 1000 ppm of platinum group metal; and (E) a condensation reaction catalyst; where the content of alkenyl groups in the curable composition is 0.

Abstract: A silicone pressure sensitive adhesive composition is curable to form a silicone pressure sensitive adhesive. The silicone pressure sensitive adhesive composition can be coated on a substrate and cured to form a topside protective film. The topside protective film can be used to protect an anti-fingerprint hard coating in a screen protective film on cover glass for a display device, such as a smartphone.

Abstract: The present invention provides a method for promoting functional cure of AIDS by reducing HIV reservoir with lenalidomide, the method including administering a therapeutically effective amount of lenalidomide to a patient. Also provided is a method for reducing intracellular P24 and cell-related HIV RNA in PBMCs derived from HIV patients in vitro with lenalidomide, including orally administering lenalidomide at 25 mg/d at days 1 to 21 in a 28-day cycle, and continuing ART for 48 weeks. Further provided is a method for inhibiting latent activator-induced activation of latent HIV cell line U1 with lenalidomide, including orally administering lenalidomide at 25 mg/d at days 1 to 21 in a 28-day cycle, and continuing ART for 48 weeks.

Abstract: A system and method authenticate payment transactions using risk based analysis modeling when multiple payment accounts are identified by input biometric data. An authentication request includes the biometric data associated with a user. Multiple user payment accounts associated with the biometric data are identified. A confidence score is generated for each of the multiple user payment accounts based on context data associated with the payment transaction. The payment account with the highest confidence score is selected. The selected payment account is authenticated for use in processing the payment transaction to ensure payment transactions are performed on the correct payment account.

Abstract: A silicone pressure sensitive adhesive composition is curable to form a silicone pressure sensitive adhesive. The silicone pressure sensitive adhesive composition can be coated on a substrate and cured to form a topside protective film. The topside protective film can be used to protect an anti-fingerprint hard coating in a screen protective film on cover glass for a display device, such as a smartphone.

Abstract: A silicone pressure sensitive adhesive composition is curable to form a silicone pressure sensitive adhesive. The silicone pressure sensitive adhesive composition can be coated on a substrate and cured to form a topside protective film. The topside protective film can be used to protect an anti-fingerprint hard coating in a screen protective film on cover glass for a display device, such as a smartphone.

Abstract: The present disclosure provides an ultrasound imaging method, comprising acquiring an ultrasound echo signal of a subject to be scanned, and generating an ultrasound image on the basis of the ultrasonic echo signal; identifying a section of the subject to be scanned that corresponds to the ultrasound image; determining a first anatomical feature in the ultrasound image; and determining a second anatomical feature in the ultrasound image, the determination of the second anatomical feature being at least partially based on the positional relationship between the first anatomical feature and the second anatomical feature in the section. The present disclosure also provides an ultrasound imaging system and a non-transitory computer-readable medium.

Abstract: This disclosure relates to a fluorosilicone release coating composition. The fluorosilicone release coating composition comprises: (A) a linear organopolysiloxane having at least two alkenyl groups and at least one fluoroalkyl group per molecule, and not having a silicon atom-bonded hydrogen atom; (B) a branched organopolysiloxane having at least one fluoroalkyl group per molecule, and not having a silicon atom-bonded hydrogen atom; (C) a linear organopolysiloxane having at least one fluoroalkyl group per molecule, and having neither an aliphatic unsaturated group nor a silicon atom-bonded hydrogen atom; (D) an organohydrogenpolysiloxane having at least two silicon atom-bonded hydrogen atoms and at least one fluoroalkyl group per molecule; and (E) a hydrosilylation reaction catalyst. The fluorosilicone release coating composition can form a release coating exhibiting a stable and low release force with respect to a silicone pressure-sensitive adhesive having a low glass transition temperature.

Abstract: The present invention discloses a method for constructing and optimizing a molecular structure model of lignite, comprising: collecting and processing a lignite sample, analyzing a lignite experimental sample, calculating the number of carbon atoms in lignite and the number of carbon atoms in other parameters, obtaining the sizes of aromatic clusters, and determining the composition features and number of aromatic structural units in lignite; calculating the total number of carbon atoms and the number of aliphatic carbon atoms in lignite; obtaining the categories and number of oxygen-containing functional groups in lignite based on the contents of aromatic hydrocarbon, aliphatic hydrocarbon and various oxygen-containing functional groups, and designing the structural forms of nitrogen and sulfur; constructing a molecular structure model of lignite.

Abstract: A process for preparing a solventless pressure sensitive adhesive composition comprising mixing (A) a solid poly-organosilicate resin component with (B) an aliphatically unsaturated polydiorganosiloxane (B-1), a branched polyorganosiloxane (B-2), or a mixture of (B-1) and (B-2), at certain temperatures, followed by cooling. The solventless pressure sensitive adhesive composition prepared by the process has a low viscosity and can be cured to form pressure sensitive adhesives. The pressure sensitive adhesives are suitable for protective film applications.

Abstract: A silicone pressure sensitive adhesive composition is curable to form a silicone pressure sensitive adhesive. The silicone pressure sensitive adhesive composition can be coated on a substrate and cured to form a protective film. The protective film can be adhered to an anti-fingerprint coating on display glass, such as cover glass for a smartphone.

Abstract: The present disclosure provides for methods of treating or preventing a headache disorder in a subject including administering to the subject a CCL2-CCR2 signaling inhibiting agent.

Abstract: A silicone pressure sensitive adhesive is prepared by curing a radical reaction curable composition. The silicone pressure sensitive adhesive adheres to various silicone elastomers and is useful in preparation of components of flexible display devices.

Abstract: Systems and methods are provided for facilitating voice authentication of a user in connection with a network transaction. One example method includes capturing, by a voice interactive device, a voice command from a user to initiate a transaction with a third party and determining content of the voice command. The method then includes authenticating the user, based on the captured voice command and a voice biometric reference associated with an identifier for at least one of the user and/or the voice interactive device, and transmitting, by the voice interactive device, a purchase request for the transaction consistent with the content of the voice command to the third party. The purchase request includes an indication of biometric authentication for the user, whereby the third party is permitted to initiate an enhanced authentication of the user in connection with the transaction.

Abstract: The present application relates to a field of image processing and discloses an ECG image processing method, device, medium, and an electrocardiograph. The ECG image processing method of the present application includes: receiving the ECG image; extracting a feature map of the ECG image, and reducing the feature map to obtain an attention map; extracting a feature matrix from the feature map and the attention map using a bilinear attention pooling; obtaining an expression matrix using an adaptive weight learning and a weighted fusion of the feature matrix by a multi-headed self-attention processing; and classifying the ECG image with a plurality of labels. This application allows direct interpretation of ECG images without limiting to a use of conventional digital signals, while capturing subtle discrepancies in the ECG image for classifying ECG abnormalities with high noise immunity.