Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: A communication method and an apparatus are provided. The method includes: a first node receives a resource scheduling message transmitted by an upper-level node. The resource scheduling message carries template identification information indicating a target time slot allocation template to be used. The first node determines a transmission time slot of the first node based on indication information that is included in the target time slot allocation template and that is used for allocating time slots to a plurality of nodes. Because a byte length occupied by the template identification information is far less than a byte length occupied by time slot allocation information corresponding to each node, a length of the resource scheduling message can be greatly shortened, and even if a quantity of nodes in the communication system increases, the length of the resource scheduling message does not increase.

Abstract: Disclosed are a filter element for liquid filtration and a filter. The filter element includes a ring filter medium, first and second end caps connected to the ring filter medium, and a ventilation assembly, where the ring filter medium has a central cavity formed around a central axis thereof; the ventilation assembly is disposed in the central cavity; and an intercepting ring groove is formed at a ring seal. In this technical solution, a sealing O-ring at a sealing part of the filter element and the housing assembly is replaced with the ring seal with a self-sealing function, which has a better sealing effect under an oil pressure and can reduce a compression amount; and while oil dirt is intercepted, the disassembly of the filter element is not affected, and especially under effective exhaust of the ventilation assembly, the disassembly is more labor-saving.

Abstract: A titanium alloy product includes a titanium alloy substrate and a plurality of first holes defined in a surface of the titanium alloy substrate. The first holes have an opening on the surface of the titanium alloy substrate and an inner wall connecting with the opening, a diameter of the inner space is greater than a diameter of the opening. The product tensile strength of bonding between the titanium alloy product and a material part filled in the first holes is very high. A housing with the titanium alloy product and a method for manufacturing the titanium alloy product are also disclosed.

Abstract: The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.

Abstract: A two-step door opening mechanism for an oven is provided. A mechanical button and an electronic button are provided, the oven defining an oven cavity openable and closable by an oven door. A controller is provided. A digital valve, comprising a shaft configured to slide laterally between a first, unlocked position in which the shaft allows inward movement of the mechanical button and a second, locked position in which the shaft blocks the inward movement of the mechanical button. The electronic button, once actuated, is operable to cause the controller to direct the digital valve to move the shaft from the second, locked position into the first, unlocked position to unlock the mechanical button, and the mechanical button, once actuated, is operable to open the door when the shaft is in the first, unlocked position.

Abstract: A system and method includes soft-segment based rules optimization that can mitigate the overall false positives while maintaining 100% true positive detection. The soft clustering allows real-time re-assignment of an account to a dominate archetype behavior, as well as rule optimization based on a logical order with more relaxation on thresholds for the most inefficient rules is performed within each archetype. The rule optimization provides false positive reduction compared to a baseline rule system. The method can be used to reduce false positives for any rule-based detection system in which the same true positive detection is required.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: A mouse device includes a middle frame, a switch, a button plate, a slidable element and an elastic element. The middle frame includes an opening part and a first hook. The first hook is located beside the opening part. The switch is fixed at a position under the middle frame. The switch includes a triggering part. The button plate is located over the middle frame. The button plate includes a pressing rod. The pressing rod is penetrated downwardly through the opening part. The pressing rod includes a receiving groove and a first sleeve. The receiving groove is located over the first sleeve. The first sleeve includes a perforation. The slidable element includes a second sleeve and a second hook. The second sleeve is installed within the first sleeve. The second hook is engaged with the perforation. The elastic element is disposed within the second sleeve.

Abstract: A mouse device includes a middle frame, a switch, a button plate, a slidable element and an elastic element. The middle frame includes an opening part and a first hook. The first hook is located beside the opening part. The switch is fixed at a position under the middle frame. The switch includes a triggering part. The button plate is located over the middle frame. The button plate includes a pressing rod. The pressing rod is penetrated downwardly through the opening part. The pressing rod includes a receiving groove and a first sleeve. The receiving groove is located over the first sleeve. The first sleeve includes a perforation. The slidable element includes a second sleeve and a second hook. The second sleeve is installed within the first sleeve. The second hook is engaged with the perforation. The elastic element is disposed within the second sleeve.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: A variant AAV capsid protein, comprising an amino acid sequence corresponding to the position amino acids 585 to 597 or 598 of AAV8 or the position amino acids 583 to 595 or 596 of AAV9, and the polynucleotide, host cells, vectors, AAV virion or the pharmaceutical composition thereof. A method of treating disease, the method comprising administering to a subject in need thereof an effective amount of the recombinant AAV virion.

Abstract: A titanium alloy product includes a titanium alloy substrate and a plurality of first holes defined in a surface of the titanium alloy substrate. The first holes have an opening on the surface of the titanium alloy substrate and an inner wall connecting with the opening, a diameter of the inner space is greater than a diameter of the opening. The product tensile strength of bonding between the titanium alloy product and a material part filled in the first holes is very high. A housing with the titanium alloy product and a method for manufacturing the titanium alloy product are also disclosed.

Abstract: An AAV library, comprising AAV variants having an amino acid sequence corresponding to the position amino acids 585 to 597 or 598 of AAV8 or the position amino acids 583 to 595 or 596 of AAV9, and the polynucleotide, host cells, thereof. A method of generating and screening an AAV library and its use.

Abstract: A fence accessory includes at least two ornament bodies, each of the at least two ornament bodies including a first connecting part and a second connecting part at two opposing ends thereof. The first connecting part of one of the at least two ornament bodies and the second connecting part of an other one of the at least two ornament bodies are configured to be connected to a fence bar and clamped together as one unit. Moreover, each of the first connecting part and the second connecting part includes a hook and a slot at two opposing sides of the first connecting part and the second connecting part. The hook of the first connecting part of one ornament body is configured to connect to the slot of the second connecting part of an adjacent accessory body.

Abstract: The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.

Abstract: The present disclosure discloses a novel compound, 3,4-dihydroxyphenethyl 3-hydroxybutanoate, a method for preparing the same and use of the same, and in particular, a compound of formula I, use of the compound of formula I, optically pure isomers of the compound, a mixture of enantiomers in any ratio, or pharmaceutically acceptable salts thereof in preparing health food and drug for relieving brain fatigue, improving learning and memory abilities, and ameliorating mania mood related to brain fatigue.

Abstract: The present invention relates to the field of wound healing. More specifically, the present invention provides methods and compositions useful for improved wound healing via autologous stem cell mobilization. In one embodiment, a method for improving wound healing in a patient comprises administering to the patient a therapeutically effective amount of a stem cell mobilizer and a low dose of an immunosuppressive agent.

Abstract: The disclosure relates to a compound, 2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, for improving aortic endothelial cell function and use thereof. The compound is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The compound is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid, for example, increasing the expression of mitochondrial complex I.