Abstract: Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.

Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.

Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.

Abstract: Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.

Abstract: Methods for making coatings on an implantable device, such as a drug-eluting stent. The coatings comprise a polymer and a drug in a crystalline or partially crystalline form. In addition, implantable devices produced by the methods and methods of using the coated implantable devices are described.

Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.

Abstract: Cross-linked proteins and peptides, and methods of making and uses of such cross-linked proteins and peptides. The cross-linked proteins and peptides have rigid, distance-matching bismethylene aryl cross-linking moieties. Compositions comprising the cross-linked proteins and peptides can be used as pharmaceutical delivery formulations. The cross-linked proteins and peptides can have improved properties, such as cell permeability, as compared to the parent protein or peptide.

Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.

Abstract: Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.

Abstract: The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Abstract: A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.

Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.

Abstract: A process of using Isatis root polysaccharide in the manufacture of medicaments for treating and/or preventing diseases induced by influenza virus and complications thereof, wherein the molecular weight of the Isatis root polysaccharide is 3000-7000 Da, and the influenza viruses include influenza virus A, influenza virus B, avian influenza virus, such as human influenza virus H1N1, H3N2, avian influenza virus H6N2, H7N3, H9N2 and INF B. The mechanism of the Isatis root polysaccharide against influenza virus is due to the ability to inhibit the attachment of influenza virus to the host cell. The present invention also discloses a pharmaceutical composition containing the above-mentioned Isatis root polysaccharides and a method for preparing the polysaccharides.

Abstract: A method for controlling operation of a resonant converter is to be implemented by a control module that generates a drive signal for controlling a power switch of the resonant converter to thereby control an output voltage and an output current provided by the resonant converter to a load. The method includes: (A) configuring the control module to determine if the load is operating in a first mode or a second mode; (B) configuring the control module to generate the drive signal according to the output voltage when the control module determines that the load is operating in the first mode; and (C) configuring the control module to generate the drive signal according to the output current when the control module determines that the load is operating in the second mode.

Abstract: Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.

Abstract: Compositions and methods for imparting stress tolerance to plants using WRKY nucleic acid and polypeptides.

Abstract: Compositions and methods for conferring drought and salt tolerance to plants using tocopherol cyclase (TC) genes, including polynucleotides, polypeptides, vectors, cells and plants.

Abstract: Provided are a plant stress tolerance related protein GmSIK1 and encoding gene and use thereof. The GmSIK1 protein has the amino acid sequence as shown in SEQ ID NO: 2. The transgenic plant with enhanced stress tolerance such as drought tolerance and/or salt tolerance can be obtained from introducing the encoding gene of GmSIK1 protein into plant cell.

Abstract: The present invention relates to novel compounds having a function of a peptide in the amylin family, related nucleic acids, expression constructs, host cells, and processes production of the compounds. The compounds of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Abstract: A method, an apparatus, and a system for automatically switching services are provided. The method includes: determining whether a switching condition is satisfied; migrating a user equipment (UE) using a first service operated on a switchable frequency point to a frequency point operating the first service, when the switching condition is satisfied; and switching the first service operated on the switchable frequency point to a second service. It is determined that a switching condition is satisfied, a UE using a first service operated on a switchable frequency point is migrated to a frequency point operating the first service, so as to switch the first service operated on the switchable frequency point to a second service, thereby improving utilization of spectrum resources and increasing a service income.