Abstract: Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.

Abstract: The present invention's new calculative methodology models the motion of a seagoing vessel in six dimensions, uniquely employing a total velocity potential as the sole parameterization for taking into consideration all linear and nonlinear dynamical effects involved in interaction between the vessel and environmental water. The solid-body rotational motion of the vessel about the vessel's center of mass is determined in three dimensions (roll, pitch, yaw) by calculating the pressure torque and the buoyancy torque. The solid-body translational motion of the vessel's center of mass is determined in three dimensions (heave, surge, sway) by calculating the pressure force and the buoyancy force. The pressure torque and the pressure force are each associated with pressure (e.g., non-hydrostatic pressure) of water on the vessel's surface. The buoyancy torque and the buoyancy force are each associated with the displacement of the vessel with respect to the vessel's equilibrium position in the water.

Abstract: The hydrodynamics of a seagoing vessel are numerically modeled through the present invention's new calculative methodology, which uniquely combines vessel boundary characteristics and pseudo-spectral environmental characteristics. Solutions are obtained through mutual transformations between the vessel boundary's irregular grid and the environment's regular pseudo-spectral grid. The pressure at the vessel boundary, an important component of the vessel boundary itself, can be determined via either (i) finite element analysis (which has a Cartesian framework) or (ii) the present invention's new vessel normal vector analysis (which has a non-Cartesian framework); the latter approach avoids the singularity problem that generally besets hydrodynamics-related mathematics. Typical inventive practice implements a computer processing unit and succeeds in finding superior solutions in shorter CPU durations.

Abstract: A method to improve TCP throughput by separating TCP acknowledgment flow from TCP normal data flow in a wireless communications environment. This method creates dedicated signaling air interface link and signaling A10 link for TCP acknowledgment flow and assigns a higher priority value to TOS field of IP packets encapsulating TCP acknowledgments than those encapsulating TCP normal data.

Abstract: A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.

Abstract: Provided herein is the use of GLP-1 molecules or agonists and analogs thereof, and the use of exendin molecules or agonists and analogs thereof, including their derivatives and active fragments, for the prevention or treatment of congestive heart failure. Pharmaceutical compositions for use in the methods described herein are also disclosed. Further provided are compositions and methods for the treatment and/or prevention of diabetes mellitus, hyperglycemia, insulin resistance and obesity, and for the reduction of food intake and suppression of appetite of subjects.

Abstract: A printed circuit board includes a first signal via, a second signal via, and a first ground via. A distance between the first ground via and the first signal via is substantially equal to a distance between the first ground via and the second signal via.

Abstract: Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.

Abstract: The invention is related to a recombinant single-chain tri-specific antibody made from anti-Tumor Associated Antigen (TAA) antibody, FC interlinker, anti-CD3 antibody, HSA interlinker and anti-CD28 antibody in turn. Particularly, the invention relates to an anti-CEA, anti-CD3, anti-CD28 recombinant single-chain tri-specific antibody, CEA-scTsAb, which was constructed with three tandem antibody fragments (anti-CEA scFv, anti-CD3 scFv and anti-CD28 single-domain antibody) linked by two interlinkers (FC interlinker, HSA interlinker), and could be appended by C myc tag or histidine tag ((His)6-tag) at the C terminal. It also concerns a method for construction, expression and purification of the antibody. It also offers the encoded DNA sequence of the antibody, expression vectors and host cells for the vectors.

Abstract: The present invention relates to an arrangement for point-to-point transmission over links between first and second link (end) terminals in a system implementing time division duplex (TDD) and wherein information is sent over the links in frames divided into time slots. It is adapted to determine the lengths of the frames on a per link basis using one or more link parameters, the frame length hence being variable.

Abstract: A passive optical network (PON) system utilizing a data link layer protocol for communication is disclosed. The PON system may include an optical network unit (ONU). The PON system may also include an optical line terminal (OLT) configured to communicate with the ONU utilizing an Ethernet frame. The Ethernet frame may include at least a source application identifier and a destination application identifier. The source application identifier may represent a source application residing in at least one of the OLT and the ONU. The destination application identifier may represent one or more destination applications configured to receive data from the source application.

Abstract: An improved method for protein labeling comprising the steps of providing a synthetic small molecule tag, providing a target protein to be tagged, providing at least two enzymes for catalyzing a conjugation reaction between the tag and the target protein, incubating the tag, the protein and the enzyme, and allowing the tag to conjugate to the target protein. The tag may embody at least one structural feature of an ubiquitin C-terminus, and the structural feature may comprise a recognition sequence that is recognizable by an ubiquitin activating enzyme.

Abstract: The present invention relates to obesity related polypeptides (ORPs), related nucleic acids, expression constructs, host cells, and processes production of the obesity related polypeptides. The ORPs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.

Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.

Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.

Abstract: A method to improve TCP throughput by separating TCP acknowledgment flow from TCP normal data flow in a wireless communications environment. This method creates dedicated signaling air interface link and signaling A10 link for TCP acknowledgment flow and assigns a higher priority value to TOS field of IP packets encapsulating TCP acknowledgments than those encapsulating TCP normal data.

Abstract: A method for controlling communications traffic on an inter-access-network link includes receiving a request for transmission of a traffic flow and determining a priority queue associated with the traffic flow. If the priority queue corresponds to the one of a first plurality of priority levels, the method further includes determining whether one or more predetermined criteria for the traffic flow are satisfied. If yes, the method additionally admitting the traffic flow, storing information associated with the traffic flow in the queue, and transmitting information associated with the traffic flow from the queue based on at least a strict priority process. If the queue corresponds to the one of a second plurality of priority levels, the method further admitting the traffic flow, storing information associated with the traffic flow in the queue, and transmitting information associated with the traffic flow from the queue based on at least an arbitrated priority process.

Abstract: A modular picket fence including a pair of vertical posts positioned at suitable distance and adapted to be secured to a suitable support surface. A pair of horizontal upper and lower rails extend between and secured to the vertical posts. The upper rail has a plurality of apertures which are aligned with a plurality of apertures on the lower rail. The apertures can be of any given shape including square, narrow rectangular, wide rectangular, oval, round, narrow polygonal and wide polygonal. A plurality of vertical pickets having a cross-sectional shape corresponding to the shape of the apertures in the horizontal rails are respectively inserted through into aligned apertures of the upper and lower rails. The end portion of each vertical picket has two transverse apertures.

Abstract: Embodiments include floral picks for use with decorative foliage. One embodiment includes a floral pick including a body comprising a first body member and a second body member. The second member has a recess configured to receive the first body member. At least one wing includes a central portion positioned between the first body member and the second body member. A shaft is coupled to the body.

Abstract: A tool chest assembly includes a lower cabinet and an upper cabinet. The upper cabinet is configured to fit inside the lower cabinet during shipping or storage to save space. The tool chest assembly is configured for easy set-up and handling.