Abstract: The present invention provides a compound of Formula II: or a pharmaceutically acceptable salt thereof.

Abstract: A method and apparatus of clock recovery is disclosed. A communications device matches the frequency of a local clock signal with the frequency of a transmit clock signal of a transmitting device based on a first set of signals received from the transmitting device during a low-speed information exchange. The low-speed information exchange may correspond to an autonegotiation operation, wherein each of the transmitting device and the communications device declares its communication capabilities to the other device. The communications device then determines a frequency offset to be applied to the local clock signal during a high-speed data communication with the transmitting device. During the high-speed communication, the communications device may apply the frequency offset to the local clock signal and match the phase of the receive clock signal with the phase of the transmit clock signal based on a second set of signals received from the transmitting device.

Abstract: An Ethernet device is disclosed that may reduce transient currents and/or power consumption while entering and exiting a low power mode by selectively powering-on and/or powering-off a number of transceiver components at different times (e.g., in a staggered manner). The transient currents and/or power consumption may be further reduced by assigning different quiet period durations to different transceiver chains, for example, to minimize the number of transceiver components that enter and/or exit the low power mode at the same time.

Abstract: There are described ROR? modulators of the formula (I), and formula (II) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating ROR? activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of ROR? activity, for example, autoimmune and/or inflammatory disorders.

Abstract: A method for operating a receiver is disclosed. The receiver may receive, over a channel from a transmitter, a first data bit at a first period of time. The receiver may receive, over the channel, a second data bit at a second period of time subsequent to the first period of time. The first and second data bits each have either a first logical value corresponding to a voltage greater than zero volts or a second logical value corresponding to a voltage less than or equal to zero volts. The receiver performs a coefficient adaptation operation, using the first data bit, to adjust one or more coefficients of a decision feedback equalizer of the receiver only when the logical value of the first data bit is equal to the logical value of the second data bit.

Abstract: Systems and methods for producing cervical ripening in a pregnant patient. The method includes generating an electrical stimulation current between about 0.01 milliamperes and about 6 milliamperes using a current unit, coupling an electrode probe to the current unit, and inserting the electrode probe transvaginally so that at least one electrode of the electrode probe is in contact with the patient's cervix. The method also includes applying the electrical stimulation current from the current unit through the electrode probe and the at least one electrode to the patient's cervix to produce ripening of the patient's cervix.

Abstract: Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is C1 or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.

Abstract: Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.

Abstract: Methods and apparatuses for speeding the softening of the cervix (cervical ripening) by way of application of ultrasound energy. A vaginal transducer may be used to emit pulse-modulated ultrasound energy directed to the cervix. Focused ultrasound energy may be applied trans-abdominally and directed at the cervix. Ultrasound energy is widely used in medical applications such as diagnostic imaging, therapeutic heating and noninvasive surgery.

Abstract: Technologies are generally presented for employing enhanced expectation maximization (EEM) in image retrieval and authentication. Using uniform distribution as initial condition, the EEM may converge iteratively to a global optimality. If a realization of the uniform distribution is used as the initial condition, the process may also be repeatable. In some examples, a positive perturbation scheme may be used to avoid boundary overflow, often occurring with the conventional EM algorithms. To reduce computation time and resource consumption, a histogram of one dimensional Gaussian Mixture Model (GMM) with two components and wavelet decomposition of an image may be employed.

Abstract: Systems and methods for producing cervical ripening in a pregnant patient. The method includes generating an electrical stimulation current between about 0.01 milliamperes and about 6 milliamperes using a current unit, coupling an electrode probe to the current unit, and inserting the electrode probe transvaginally so that at least one electrode of the electrode probe is in contact with the patient's cervix. The method also includes applying the electrical stimulation current from the current unit through the electrode probe and the at least one electrode to the patient's cervix to produce ripening of the patient's cervix.

Abstract: Disclosed are compounds of Formula (I) wherein: the two dotted lines represent either two single or two double bonds; Q is: R1 is F, Cl, —CN, or —CH3; R2 is Cl or —CH3; R3 is —C(CH3)2OH or —CH2CH2OH; Ra is H or —CH3; each Rb is independently F, Cl, —CH3, and/or —OCH3; and n is zero, 1, or 2. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Abstract: Technologies are generally presented for employing enhanced expectation maximization (EEM) in image retrieval and authentication. Using uniform distribution as initial condition, the EEM may converge iteratively to a global optimality. If a realization of the uniform distribution is used as the initial condition, the process may also be repeatable. In some examples, a positive perturbation scheme may be used to avoid boundary overflow, often occurring with the conventional EM algorithms. To reduce computation time and resource consumption, a histogram of one dimensional Gaussian Mixture Model (GMM) with two components and wavelet decomposition of an image may be employed.

Abstract: As disclosed herein, novel compositions including steroid hormones, such as trimegestone (TMG) and progesterone (P4), provide treatments for term and preterm labor with significant effects on the delay of delivery. Delay and block of delivery occurs when both P4 and TMG are administered late in gestation in pregnant rat and guinea pig animal models. TMG exhibits remarkable drug efficacy, achieving the same inhibition as P4, but at much lower doses. These hereto unknown effects of TMG on the processes of cervical ripening and uterine contraction provide a novel approach for extending pregnancy term, including reducing a likelihood of preterm and/or term labor, along with improved methods of administration. Other diseases and/or conditions may be treated with TMG, such as dysmenorrhea or luteal insufficiency for sustaining pregnancy.

Abstract: Disclosed are nicotinamide compounds of Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. Also disclosed are methods of using such compounds in the treatment of at least one Btk associated condition, such as, for example, inflammatory disease, and pharmaceutical compositions comprising such compounds.

Abstract: Embodiments of the invention are directed toward methods for steganalysis that improve the detection of steganography in texture images. The methods combine features extracted from the image spatial representation and from a block discrete cosine transform (BDCT) representation with multiple different block sizes (i.e., N×N) to improve detection of data hidden in texture images. Image data that is to undergo steganalysis can be provided to embodiments of the invention in at least one of spatial (pixel) and JPEG format. When JPEG format is provided, the image is first decompressed to spatial representation, from which the features are extracted when the block size is at least one 2×2, 4×4, and 16×16. When the block size is 8×8, the JPEG coefficients (JPEG quantized 8×8 BDCT coefficients) derived directly from the JPEG image are used to extract features. In addition, the method is also effective as a universal steganalyzer for both texture and smooth/non-texture images.

Abstract: Implementations of the detection of double MPEG compression using digit based statistics are disclosed.

Abstract: Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, are useful as kinase modulators, including Btk modulation.