Abstract: Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.

Abstract: The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Abstract: The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein A1, A2, TmR1, X, R2, R3, R9, R12, and R13 are as described in the specification. The compounds are especially useful as inhibitors of ERK2, Aurora2, GSK3, CDK2, AKT3, and ROCK protein kinases and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, neurodegenerative disorders, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein A1, A2, TmR1, X, R2, R3, R9, R12, and R13 are as described in the specification. The compounds are especially useful as inhibitors of ERK2, Aurora2, GSK3, CDK2, AKT3, and ROCK protein kinases and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, neurodegenerative disorders, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

Abstract: The present invention relates to a PSTN telephone, which is adapted to a public switched telephone network (PSTN) and is capable of communicating with a mobile phone embedded with a wireless module by a wireless manner, which comprises: a power source, capable of providing power to the telephone; a microprocessor, capable of controlling and managing electrical signals of the PSTN telephone; a keypad, capable of dialing; a telephone transceiver, further comprising a microphone, capable of receiving vocal signals of a user, and a loudspeaker, capable of amplifying vocal signals received by the telephone; a wireless module, coupled to the microprocessor, capable of matching to the wireless module of the mobile phone for enabling vocal signals to be transmitted between the same and the wireless module of the mobile phone.

Abstract: The present invention relates to a telephone, which is adapted to a public switched telephone network (PSTN) and is capable of making a call though various communication networks. As the aforesaid PSTN telephone is configured with a plurality of wireless interface modules (WIM) that one of which is activated with reference to a subscriber identity module (SIM) card being installed into the PSTN telephone by a user, the PSTN telephone is able to provide a wireless connection through the activated WIM supporting the SIM card for enabling the user to make a phone call. Therefore, the user can make a phone call simply by inserting the SIM card into the aforesaid PSTN telephone for enabling the same to access data stored in the SIM card.

Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

Abstract: The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease.

Abstract: A method of manufacturing a semiconductor device includes the steps of providing a semiconductor substrate (202), forming a dielectric layer (204) over the semiconductor substrate (202), and etching a trench or a via (206) in the dielectric layer (204) to expose a portion of the surface of the semiconductor substrate (202). The method also includes the step of forming a conductive layer (212, 220) within in the trench or the via (206). The method further includes the steps of polishing a portion of the conductive layer (220) and annealing the conductive layer (212, 220) at a predetermined temperature. Moreover, the conductive layer (212, 220) also includes a dopant, and the dopant diffuses substantially to the surface of the top side of the conductive layer (212, 220) to form a dopant oxide layer (212a, 220a) when the conductive layer (212, 220) is annealed at the predetermined temperature and the dopant is exposed to oxygen.

Abstract: Industrial robots have been widely used in industrial applications such as welding, and assembly. However, the application of the robots to precision manufacture is limited by their accuracy. As a highly non-linear system, the positioning accuracy of a robot varies with the configuration of the joints or the angular positions as well as translational positions of its joints. This results in a mechanical system of a low accuracy, but very high repeatability. This invention is about an innovative approach that will improve the accuracy of a robotic measuring system to the level of the repeatability of the robot. It is a calibration method for improving the accuracy of a robotic measuring system with joint configuration dependent performance. With such an increased measuring accuracy, the robotic measuring system can be used in many industrial applications requiring a robotic measuring system of high accuracy.

Abstract: A belt grinding machine is disclosed that includes an automatic pressure and position control systems for robotic grinding and polishing applications. The machine will be combined with off-line programming package, capable of carrying out complicated operations that cannot be performed on traditional types of machines. The multiple contact wheels of the machine give the flexibility to accommodate complicated geometry of workpieces with a large material removal rate (MRR) and great surface finishes. The basic components of this belt grinding machine consists of the followings: a power source, a drive wheel or active wheel driven by a motor, multiple contact wheels; an idler for tensioning and tracking the belt, an active force control device to keep the constant pressure on the workpiece, a proper coated abrasive belt, and a dust collection system.

Abstract: This invention is about the method for detecting the position, and orientation of holes using a robotic vision system. In certain industrial applications, there are parts with many tiny or large holes or tunnels of various shapes, and the orientation and position of each of the holes need to be inspected automatically using non-contact measuring systems such as a vision system. The relative motion of the hole being measured and the measuring system can be realized by an industrial robot or other multiaxis CNC motion systems. The method in this invention includes the approaches and algorithms to detect the hole position, size, and orientation by using a vision system mounted on the robot arms. The hole orientation is determined based on the alignment of the vision system and the hole axis. The position of the hole is the intersection between the hole axis and the surface region around the hole opening.

Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein B, R1, n, R3, Q and R4 are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

Abstract: The inventions disclosed herein relate to man-made bi-aromatic amide compounds that, when contacted with comestible food or drinks or pharmaceutical compositions at concentrations preferably on the order of about 100 ppm or lower, serve as sweet taste modifiers, sweet flavoring agents, or sweet flavor enhancers, for use in foods, beverages, and other comestible products, or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as known natural saccharide sweeteners and previously known artificial sweeteners.

Abstract: The inventions disclosed herein relate to genuses of non-naturally occurring small molecule compounds which comprise two or optionally three organic moieties of limited size “linked” by certain structurally related “linker” functional groups. Suitable linker groups include ester, amine, ether, keto, imino, thioamide, thioether, sulfonamide, sulfonate ester, sulfone, guanidine, and thiourea groups. The compounds are capable, when contacted with comestible food or drinks or pharmaceutical compositions, at concentrations preferably on the order of about 100 ppm or lower, of serving as savory (“umami”) or sweet taste modifiers, savory or sweet flavoring agents and savory or sweet flavor enhancers, for use in foods, beverages, and other comestible or orally administered medicinal products or compositions, optionally in the presence of or in mixtures with conventional flavoring agents such as monosodium glutamate or known natural or artificial sweeteners.