Abstract: Provided herein is an apparatus, including a stationary component, a rotatable component configured to rotate relative to the stationary component, and a conical pumping seal formed between the stationary component and the rotatable component.

Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract: A device including a first axial portion, a second axial portion, and a radial portion is disclosed. A portion of the second axial portion is configured to connect to a hub. An upper surface of the second axial portion may be positioned above an upper surface of a sleeve limiter shoulder when the portion of the second axial portion is connected to the hub. The radial portion connects the first axial portion to the second axial portion. The radial portion is configured to increase stiffness by increasing surface contact between the radial portion and the sleeve limiter shoulder.

Abstract: Provided herein is an apparatus, including a first part of a data storage device and a second part of the data storage drive. The second part of the data storage device is fused to the first part substantially throughout opposing surfaces of the first part and the second part, where the opposing surfaces are in contact with each other.

Abstract: Provided herein is an apparatus, including a clamping means for clamping at least one disk onto a hub at a mounting point on the hub for the at least one disk, wherein the clamping means is configured to sit wholly above the at least one disk; a seat in an outer perimeter of the hub configured to receive the clamping means; and a locking means for locking the clamping means onto the hub.

Abstract: Provided herein is an apparatus, including a fluid dynamic bearing, wherein the fluid dynamic bearing includes a set of pressure-generating grooves, and wherein the set of pressure-generating grooves includes a plurality of chevron-shaped grooves, each chevron-shaped groove including at least two selected from a non-uniform depth, non-uniform angle, a non-uniform width, or a non-uniform length, selected to provide a predetermined spindle-motor stiffness to the journal bearing during steady-state operation and during a shock event.

Abstract: The invention relates to compounds of Formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein.

Abstract: Provided herein is an apparatus, including a plurality of disk clamp notches spaced about an outer lip of an annular disk clamp; an annular groove in an outer perimeter of a hub; and a mounting point on the hub for at least one disk, wherein the annular disk clamp occupies the annular groove of the hub, clamping the at least one disk onto the hub at the mounting point for the at least one disk.

Abstract: Provided herein is an apparatus, including a plurality of teeth extending from an outer perimeter of an annular disk clamp to an inner perimeter of the annular disk clamp and an annular groove in an outer perimeter of a hub, wherein the plurality of teeth do not engage the annular groove of the hub when the disk clamp is unlocked into an unlocked form, and wherein the plurality of teeth engage the annular groove of the hub when the annular disk clamp is locked into a locked form, clamping at least one disk onto the hub at a mounting point for the at least one disk.

Abstract: Provided herein is an apparatus, including a plurality of flanges extending to form an inner perimeter of an inner opening of an annular disk clamp; and an annular groove in an outer perimeter of a hub configured to receive the plurality of flanges of the annular disk clamp, wherein the disk clamp is seated above at least one disk when clamping the at least one disk onto the hub at a mounting point for the at least one disk.

Abstract: Provided herein is an apparatus, including a clamping means for clamping at least one disk onto a hub at a mounting point on the hub for the at least one disk, wherein the clamping means is configured to sit wholly above the at least one disk; a seat in an outer perimeter of the hub configured to receive the clamping means; and a locking means for locking the clamping means onto the hub.

Abstract: Provided herein is an apparatus, including a plurality of teeth extending from an outer perimeter of an annular disk clamp to an inner perimeter of the annular disk clamp and an annular groove in an outer perimeter of a hub, wherein the plurality of teeth do not engage the annular groove of the hub when the disk clamp is unlocked into an unlocked form, and wherein the plurality of teeth engage the annular groove of the hub when the annular disk clamp is locked into a locked form, clamping at least one disk onto the hub at a mounting point for the at least one disk.

Abstract: Provided herein is an apparatus, including a plurality of disk clamp notches spaced about an outer lip of an annular disk clamp; an annular groove in an outer perimeter of a hub; and a mounting point on the hub for at least one disk, wherein the annular disk clamp occupies the annular groove of the hub, clamping the at least one disk onto the hub at the mounting point for the at least one disk.

Abstract: Provided herein is an apparatus, including a fluid dynamic bearing, wherein the fluid dynamic bearing includes a set of pressure-generating grooves, and wherein the set of pressure-generating grooves includes a plurality of chevron-shaped grooves, each chevron-shaped groove including at least two selected from a non-uniform depth, non-uniform angle, a non-uniform width, or a non-uniform length, selected to provide a predetermined spindle-motor stiffness to the journal bearing during steady-state operation and during a shock event.

Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract: The invention is directed to an embossing assembly and methods for its preparation. The assembly comprises a drum, a non-expandable insert and an embossing sleeve and it is particularly useful for the preparation of microcups used in a display device. The assembly may also comprise only a drum and an embossing sleeve.

Abstract: An apparatus and method are provided for a robust and shock resistant fluid dynamic bearing. A fluid sealing system with fluid pumping and capillary features provides increased reliability and performance for small form factor disc drive memory systems. Concerns of motor jog are addressed, jog being the rapid and repeated opening and closing of spaces between relatively rotatable components that can dispel oil from, or draw air into, these spaces. The fluid pumping capillary sealing system includes a fluid pumping groove with a rib portion and a slot portion for pumping fluid. The fluid pumping capillary sealing system also includes a capillary seal. In an aspect, a sweeping rib sweeps fluid toward the bearing. A truncated rib is situated adjacent to the sweeping rib, the truncated rib extending a shorter radial distance as compared to the sweeping rib and forming a plenum region.

Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).

Abstract: Provided herein is an apparatus, including a stationary component; a rotatable component; a fluid dynamic bearing defined by the stationary component and the rotatable component; a first channel substantially parallel to the fluid dynamic bearing; a second channel substantially perpendicular to the first channel; and a fluid reservoir substantially parallel to the first channel, wherein the second channel fluidly connects the fluid reservoir to the first channel.