Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.

Abstract: The invention relates to compounds of Formula (1) and to processes for the preparation of intermediates used in the preparation of compositions containing and the uses of such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein.

Abstract: An apparatus and associated method characterized by an enclosure having a side member that defines a substantially orthogonally directed cavity penetrating the side member. A motor shaft in the enclosure has a distal end that is operably aligned with the cavity. A shear transfer member in the enclosure is operably affixed to the motor shaft. One of the shaft and the shear transfer member is sized for a close mating engagement with the side member in the cavity, and the shear transfer member is further sized for being simultaneously shear coupled to the side member.

Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.

Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).

Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).

Abstract: An apparatus and associated method characterized by an enclosure having a side member that defines a substantially orthogonally directed cavity penetrating the side member. A motor shaft in the enclosure has a distal end that is operably aligned with the cavity. A shear transfer member in the enclosure is operably affixed to the motor shaft. One of the shaft and the shear transfer member is sized for a close mating engagement with the side member in the cavity, and the shear transfer member is further sized for being simultaneously shear coupled to the side member.

Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.

Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).

Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).

Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.

Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.

Abstract: A thickset artificial nail tip device has two regions, including a well region that may be affixed to and blend in with a portion of a natural nail bed of a wearer, and a thicker body region that may extend beyond the natural nail bed of a wearer. The thicker body region may include a single color or multicolor design and may help to eliminate a need for applying acrylic materials on top of the artificial nail tip. In one embodiment, the well region is absent, so that the thickset artificial nail tip device may be used on a long natural nail bed. The thickset artificial nail tip device may eliminate the need for applying acrylic materials on top of an artificial nail tip and reduce the amount of filing time required after application of an artificial nail tip, thereby making the application of an artificial nail tip to a natural nail bed fast and easy.

Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.

Abstract: The counterplate and/or sleeve are modified to reduce or eliminate distortion in the counterplate in a laser welded fluid bearing design. It is known to directly weld the counterplate which lies across the end of the shaft and the thrust plate to a wall or shoulder of the sleeve in which the counterplate is fit. The radial stiffness of the sleeve is weakened by cutting grooves or the like at or near the interface between the sleeve wall and the counterplate, or on the outer diameter of the sleeve wall to essentially weaken the sleeve wall. This weakening of the sleeve wall prevents bowing or distortion of the counterplate being imposed by the sleeve.

Abstract: A fluid dynamic bearing includes a shaft and a sleeve which are supported for relative rotation by fluid in the gap therebetween. A capillary seal at one end of the bearing prevents fluid from leaking out. The seal is defined between the hub and the sleeve, which are in relative rotation, and diverge from one another in the region where the capillary seal is established. The gap which is incorporated in the capillary seal is in airway communication with the gap between the shaft and the sleeve; but the capillary seal is defined by an outer surface of the sleeve and is substantially parallel to the gap between the shaft and the sleeve. The capillary seal is radially spaced from the region where one of two journal bearing groove sets is defined. The grooves sets may be located so that they are balanced about the center of gravity of the system.