Patents by Inventor Quy Le

Quy Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130252961
    Abstract: The invention relates to compounds of formula (?) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 26, 2013
    Applicant: PFIZER INC.
    Inventors: Simon BAILEY, Benjamin Joseph Burke, Michael Raymond Collins, Jingrong Jean Cui, Judith Gail Deal, Robert Louis Hoffman, Qinhua Huang, Ted William Johnson, Robert Steven Kania, John Charles Kath, Phuong Thi Quy Le, Michele Ann McTigue, Cynthia Louise Palmer, Paul Francis Richardson, Neal William Sach
  • Patent number: 8534919
    Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.
    Type: Grant
    Filed: September 15, 2012
    Date of Patent: September 17, 2013
    Assignee: Seagate Technology LLC
    Inventors: Lynn Bich-Quy Le, Alan Lyndon Grantz
  • Publication number: 20130196952
    Abstract: The invention relates to compounds of Formula (1) and to processes for the preparation of intermediates used in the preparation of compositions containing and the uses of such derivatives. The compounds according to the present invention are useful in numerous diseases in which ALK protein is involved or in which inhibition of ALK activity may induce benefit, especially for the treatment of cancer mediated by a mutated EML4-ALK fusion protein.
    Type: Application
    Filed: May 4, 2011
    Publication date: August 1, 2013
    Applicant: PFIZER INC.
    Inventors: Mark Edward Bunnage, Andrew Simon Cook, Jingrong Jean Cui, Kevin Nell Dack, Judith Gail Deal, Danlin Gu, Mingying He, Patrick Stephen Johnson, Ted William Johnson, Phuong Thi Quy Le, Cynthia Louise Palmer, Hong Shen
  • Patent number: 8497609
    Abstract: An apparatus and associated method characterized by an enclosure having a side member that defines a substantially orthogonally directed cavity penetrating the side member. A motor shaft in the enclosure has a distal end that is operably aligned with the cavity. A shear transfer member in the enclosure is operably affixed to the motor shaft. One of the shaft and the shear transfer member is sized for a close mating engagement with the side member in the cavity, and the shear transfer member is further sized for being simultaneously shear coupled to the side member.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: July 30, 2013
    Inventors: Alan Lyndon Grantz, Lynn Bich-Quy Le
  • Publication number: 20130064485
    Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.
    Type: Application
    Filed: September 15, 2012
    Publication date: March 14, 2013
    Applicant: SEAGATE TECHNOLOGY LLC
    Inventors: Lynn Bich-Quy Le, Alan Lyndon Grantz
  • Publication number: 20120309775
    Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).
    Type: Application
    Filed: August 16, 2012
    Publication date: December 6, 2012
    Applicant: PFIZER INC
    Inventors: Hengmiao CHENG, Dilip BHUMRALKAR, Klaus Ruprecht DRESS, Jacqui Elizabeth HOFFMAN, Mary Catherine JOHNSON, Robert Steven KANIA, Phuong Thi Quy LE, Mitchell David NAMBU, Mason Alan PAIRISH, Michael Bruno PLEWE, Khanh Tuan TRAN
  • Patent number: 8273755
    Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: September 25, 2012
    Assignee: Pfizer Inc
    Inventors: Hengmiao Cheng, Dilip Bhumralkar, Klaus Ruprecht Dress, Jacqui Elizabeth Hoffman, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Michael Bruno Plewe, Khanh Tuan Tran
  • Publication number: 20120087607
    Abstract: An apparatus and associated method characterized by an enclosure having a side member that defines a substantially orthogonally directed cavity penetrating the side member. A motor shaft in the enclosure has a distal end that is operably aligned with the cavity. A shear transfer member in the enclosure is operably affixed to the motor shaft. One of the shaft and the shear transfer member is sized for a close mating engagement with the side member in the cavity, and the shear transfer member is further sized for being simultaneously shear coupled to the side member.
    Type: Application
    Filed: October 11, 2010
    Publication date: April 12, 2012
    Applicant: SEAGATE TECHNOLOGY LLC
    Inventors: Alan Lyndon Grantz, Lynn Bich-Quy Le
  • Publication number: 20110285232
    Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.
    Type: Application
    Filed: July 29, 2011
    Publication date: November 24, 2011
    Applicant: Segate Technology LLC
    Inventors: Lynn Bich-Quy Le, Alan Lyndon Grantz
  • Patent number: 7732604
    Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: June 8, 2010
    Assignee: Pfizer Inc.
    Inventors: Hengmiao Cheng, Jingrong Jean Cui, Jacqui Elizabeth Hoffman, Lei Jia, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Bich Tran-Dubé
  • Publication number: 20100137279
    Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).
    Type: Application
    Filed: February 9, 2010
    Publication date: June 3, 2010
    Applicant: Pfizer Inc.
    Inventors: Hengmiao Cheng, Dilip Bhumralkar, Klaus Ruprecht Dress, Jacqui Elizabeth Hoffman, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Michael Bruno Plewe, Khanh Tuan Tran
  • Publication number: 20100105656
    Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Application
    Filed: January 4, 2010
    Publication date: April 29, 2010
    Inventors: Hengmiao Cheng, Jingrong Jean Cui, Jacqui Elizabeth Hoffman, Lei Jia, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Bich Tran-Dubé
  • Patent number: 7696213
    Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: April 13, 2010
    Assignee: Pfizer Inc
    Inventors: Hengmiao Cheng, Dilip Bhumralkar, Klaus Ruprecht Dress, Jacqui Elizabeth Hoffman, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Michael Bruno Plewe, Khanh Tuan Tran
  • Publication number: 20080273822
    Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.
    Type: Application
    Filed: July 19, 2008
    Publication date: November 6, 2008
    Inventors: Lynn Bich-Quy Le, Alan Lyndon Grantz
  • Patent number: 7407327
    Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: August 5, 2008
    Assignee: Seagate Technology LLC
    Inventors: Lynn Bich-Quy Le, Alan Lyndon Grantz
  • Publication number: 20080121247
    Abstract: A thickset artificial nail tip device has two regions, including a well region that may be affixed to and blend in with a portion of a natural nail bed of a wearer, and a thicker body region that may extend beyond the natural nail bed of a wearer. The thicker body region may include a single color or multicolor design and may help to eliminate a need for applying acrylic materials on top of the artificial nail tip. In one embodiment, the well region is absent, so that the thickset artificial nail tip device may be used on a long natural nail bed. The thickset artificial nail tip device may eliminate the need for applying acrylic materials on top of an artificial nail tip and reduce the amount of filing time required after application of an artificial nail tip, thereby making the application of an artificial nail tip to a natural nail bed fast and easy.
    Type: Application
    Filed: November 27, 2006
    Publication date: May 29, 2008
    Inventor: Quy Le Tran
  • Publication number: 20070265272
    Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Application
    Filed: May 8, 2007
    Publication date: November 15, 2007
    Inventors: Hengmiao Cheng, Jingrong Jean Cui, Jacqui Elizabeth Hoffman, Lei Jia, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Bich Tran-Dube
  • Publication number: 20040184688
    Abstract: A system, method and means is provided for withstanding mechanical shock for use with fluid dynamic bearings. A sealing system is provided that withstands 1000 G shock events. In an aspect, a grooved pumping seal employed between a thrust plate and a shield, a thrust plate having spiral grooves, a fluid recirculation passageway, and a reservoir creates an asymmetric pressure gradient. In an aspect, fluid is retained and air is purged utilizing an enlarged fluid reservoir, axial channels and an angled fill hole. In an aspect, a shaft is attached to a top cover supplying radial stiffness, and an enlarged single-sided thrust plate improves dynamic parallelism.
    Type: Application
    Filed: July 31, 2003
    Publication date: September 23, 2004
    Inventors: Lynn Bich-Quy Le, Alan Lyndon Grantz
  • Patent number: 6781266
    Abstract: The counterplate and/or sleeve are modified to reduce or eliminate distortion in the counterplate in a laser welded fluid bearing design. It is known to directly weld the counterplate which lies across the end of the shaft and the thrust plate to a wall or shoulder of the sleeve in which the counterplate is fit. The radial stiffness of the sleeve is weakened by cutting grooves or the like at or near the interface between the sleeve wall and the counterplate, or on the outer diameter of the sleeve wall to essentially weaken the sleeve wall. This weakening of the sleeve wall prevents bowing or distortion of the counterplate being imposed by the sleeve.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: August 24, 2004
    Assignee: Seagate Technology LLC
    Inventors: Lynn Bich-Quy Le, Donald J. Macleod, Anthony J. Aiello
  • Patent number: 6746151
    Abstract: A fluid dynamic bearing includes a shaft and a sleeve which are supported for relative rotation by fluid in the gap therebetween. A capillary seal at one end of the bearing prevents fluid from leaking out. The seal is defined between the hub and the sleeve, which are in relative rotation, and diverge from one another in the region where the capillary seal is established. The gap which is incorporated in the capillary seal is in airway communication with the gap between the shaft and the sleeve; but the capillary seal is defined by an outer surface of the sleeve and is substantially parallel to the gap between the shaft and the sleeve. The capillary seal is radially spaced from the region where one of two journal bearing groove sets is defined. The grooves sets may be located so that they are balanced about the center of gravity of the system.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: June 8, 2004
    Assignee: Seagate Technology LLC
    Inventors: Lynn Bich-Quy Le, Chris Michael Woldemar