Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: An industrial integrated development environment (IDE) includes analytic features that generate control project telemetry data based on analysis of a control system design and uses this project telemetry data as the basis for control system design guidance and recommendations. The IDE system can analyze the control system design and identify industrial devices use by the control project, device features that are utilized by the control project, resource utilizations, and other such project telemetry. The IDE system can generate recommendations for improving the control system design based on this project telemetry. The project telemetry data can also be provided to product vendors, offering insights into how the vendors' products are being used by end customers.

Abstract: This disclosure relates to weldability of steel alloys that provide weld joints which retain hardness values in a heat affected zone adjacent to a fusion zone and which also have improved resistance to liquid metal embrittlement due to the presence of zinc coatings.

Abstract: A system for heating electro-optic media comprises an electro-optic device comprising: a first substrate having first and second surfaces; a second substrate having third and fourth surfaces; a chamber defined between the opposed third surface of the second substrate and the second surface of the first substrate; electro-optic medium in chamber; a first electrode associated with second surface of first substrate; and a second electrode associated with third surface of second substrate; and a circuit in communication with first and second electrodes, comprising: a first EMF source capable of producing a first voltage; a second EMF source capable of producing a second voltage different from the first voltage; a plurality of switches configured to control the application of first and second voltages to the first and second electrodes; and a controller configured to control the switches, the first EMF source, and the second EMF source.

Abstract: Various embodiments disclosed relate to a composition including a fibrous material and a binder composition. The binder composition includes at least one carbohydrate and at least one branched (poly)amine comprising a plurality of primary amines, wherein the majority of the plurality of primary amines are attached to a methylene group. Various embodiments disclosed further relate to a composition including a reaction product and a fibrous material mixed therein. The reaction product includes at least one monosaccharide and at least one branched (poly)amine comprising a plurality of primary amines, wherein each of the plurality of primary amines is attached to a methylene group. In various embodiments, the composition is used to make an engineered wood product.

Abstract: Device and method embodiments for a rotation powered vehicle are described, the rotation powered vehicle being capable of converting a rotational motion of a platform pivotally secured to the rotation powered vehicle in either of two angular directions into a linear motion of the rotation powered vehicle in a single linear direction for the purposes of conveyance. In some cases, the angular motion of the platform may be slight when compared to the resultant linear powered stroke of the rotation powered vehicle.

Abstract: A steep slope roofing panel system includes an underlayment and a plurality of roofing panels installed atop the underlayment. The panels may be installed to provide both protection from the environment and watershedding. Alternatively, the panels and the underlayment may share the watershedding functions of the roof, with one as a primary watershedding component and the other as an auxiliary watershedding component. The roofing system may be custom manufactured off-site based upon predetermined measurements and characteristics of a roof and its protrusions. Alternatively, the roofing system may be custom manufactured at the job site based upon such measurements and characteristics. Each panel may be assigned to a location on the roof and may include imprinted instructions regarding cutting and/or bending the panel to form flashing, drip edges, or other features, as well as the panel's location and installation sequence on the roof.

Abstract: A system for automated trailer weight distribution, including: A system for automated trailer weight distribution, having a tow vehicle with a hitch mount having a spring bar. The system may also include a trailer and a spring bar mount disposed on the trailer and having an initial position relative to the trailer, where the spring bar mount is configured to receive and engage the spring bar.

Abstract: The disclosure provides rotary machines that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub that defines a first gearbox disposed thereon with a plurality pivots. At least one contour also having pivots is connected to the first gearbox pivots by two linkages exterior to the first gearbox. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume. A gearbox mechanism including gears, crankshafts, bearings and connecting rods creates an oscillatory motion 2 times per revolution in the linkages such that the contour is forced to navigate about the arcuate cavity without contacting the cavity at a high rate of rotating speed.

Abstract: A system for powered trailer weight distribution having a hitch mount with a spring bar, and a trailer with a spring bar mount disposed on the trailer and having an initial position relative to the trailer, wherein the spring bar mount is configured to receive and engage the spring bar, and a weight distribution actuator configured and arranged to adjust a position of the spring bar mount relative to the spring bar while engaged with the spring bar, wherein the weight distribution actuator is connected to a power source that provides power to the weight distribution actuator, facilitating the adjustment of the position of the spring bar mount.

Abstract: A bi-directional exercise machine has a work arm, first and second cams coupled to the work arm, a resistance mechanism, and a pulley assembly that couples the resistance mechanism to the work arm via the first and second cams so that movement of the work arm is resisted by the resistance mechanism according to first and second resistance profiles provided by the first and second cams, respectfully. A primary pulley cable has a first end coupled to the first cam and a second end coupled to the second cam. When the work arm is in a rest position, the ends of the primary pulley cable extend from cable tracks of the cams, respectively, at a tangent so that the resistance mechanism applies a resistance force on the work arm via the pulley assembly immediately upon movement of the work arm out of the rest position.

Abstract: A cutting tool with a cutting region and a connecting support region where the support region is designed to connect to an external motor assembly. The cutting tool is also has a porous region that is integrated within a portion of the tool such that as the tool cuts material the porous region can allow samples of the cut material to permeate into an internal chamber of the tool. Once in the internal chamber material samples can be analyzed in-situ for direct composition analysis.

Abstract: One or more information maps are obtained by an agricultural work machine. The one or more information maps map one or more agricultural characteristic values at different geographic locations of a field. An in-situ sensor on the agricultural work machine senses an agricultural characteristic as the agricultural work machine moves through the field. A predictive map generator generates a predictive map that predicts a predictive agricultural characteristic at different locations in the field based on a relationship between the values in the one or more information maps and the agricultural characteristic sensed by the in-situ sensor. The predictive map can be output and used in automated machine control.

Abstract: The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.

Abstract: An optical fiber alignment assembly may comprise an alignment fixture including a groove configured to engage first and second optical fiber ferrules, a first clamping mechanism configured to selectively apply a force on the first optical fiber ferrule to constrain motion of the first optical fiber ferrule within the groove, and a second clamping mechanism configured to selectively apply a force on the second optical fiber ferrule to constrain motion of the second optical fiber ferrule within the groove.

Abstract: In example implementations, a printing device is provided. The printing device includes a printer module, a first driver roller, and a second drive roller. The printer module includes a single set of print bars. A first side of the single set of print bars is to print on a first side of a continuous web of print media and a second side of the single set of print bars is to print on a second side of the continuous web of print media. The continuous web of print media travels over a common set of idler rollers. The first driver roller is to control an amount of tension of the continuous web of print media on a first side. The second drive roller is to control an amount of tension of the continuous web of print media on a second side. The amount of tension of the continuous web of print media on the second side is greater than the amount of tension of the continuous web of print media on the first side.

Abstract: Described herein are single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Venezuelan equine encephalitis virus (VEEV).

Abstract: Disclosed embodiments relate to a security firewall having a security hierarchy including: secure master (SM); secure guest (SG); and non-secure (NS). There is one secure master and n secure guests. The firewall includes one secure region for secure master and one secure region for secure guests. The SM region only allows access from the secure master and the SG region allows accesses from any secure transaction. Finally, the non-secure region can be implemented two ways. In a first option, non-secure regions may be accessed only upon non-secure transactions. In a second option, non-secure regions may be accessed any processing core. In this second option, the access is downgraded to a non-secure access if the security identity is secure master or secure guest. If the two security levels are not needed the secure master can unlock the SM region to allow any secure guest access to the SM region.

Abstract: In one embodiment, a system for allocating clients between radios of an access point is disclosed. The system includes a first antenna coupled to a first radio, a second antenna coupled to a second radio, and a monitoring radio coupled to the first antenna and second antenna. The system includes computer-readable instructions that cause the system to receive at the monitoring radio, a first client attribute from each of a plurality of first client devices, and a second client attribute from each of a plurality of second client devices, and provide each aforementioned attribute to an optimization function. The system determines, with the optimization function, that one of the first radio and second radio will optimize performance for at least one device of the plurality of first client devices and second client devices and steer the at least one device accordingly.

Abstract: Roofing panels with water shedding features may be installed on the roof of a house or other structure in lieu of or as an underlayment for traditional roofing materials. The water shedding features can be built into a base of the roofing panels, as part of a frame for the roofing panels, or formed as part of a waterproofing layer applied to the base of the roofing panels, or which can be configured as a roofing panel. The roofing panels also can be installed in overlapping courses along a roof with water shedding features applied thereto or incorporated along one or more peripheral edges. The water shedding features of adjacent roofing panels will collect and divert water away from the upper surfaces and/or away from headlap and/or sidelap joints defined between the roofing panels.