Abstract: The present invention provides monoclonal IgE antibodies comprising Fc epsilon (?) constant regions and variable regions comprising at least one antigen binding region specific for binding a single epitope of a circulating, tumor-associated antigen (TAA) that is not a cell surface antigen wherein the epitope of the targeted antigen is not highly repetitive or is a non-repetitive epitope. The IgE antibodies of the invention are useful in the treatment of cancer associated with the tumor antigen. In one embodiment the TAA is prostate-specific antigen (PSA).

Abstract: Methods and substrates for laser annealing are disclosed. The substrate includes a target region to be annealed and a plurality of reflective interfaces. The reflective interfaces cause energy received by the substrate to resonate within the target region. The method includes emitting energy toward the substrate with a laser, receiving the energy with the substrate, and reflecting the received energy with a plurality of reflective interfaces embedded in the substrate to generate a resonance within the target region.

Abstract: An alignment device or jig that includes a level and a rule which is used for hanging wall supported items. The device includes locator blocks with locator pins for supporting the item and stud finder sensors for locating wall studs. The locator pins extend to protrude from the back side of the jig to allow a mark to be made into the hanging surface when the jig is pressed against the hanging surface. In the event that the item requires a stronger surface to hang onto due to excessive weight, a stud finder system can be utilized. In operation, one or more of picture frames to be mounted to a wall are hung on the device on one or more hangers. The hangers are slidingly spaced along the device scale for desired picture spacing. The device with the frames is placed against the wall and pressed to the wall, wherein the marking points mark the wall at the exact desired points where permanent hangers will be driven into the wall to support the one or more picture frames.

Abstract: A method performed and apparatus formed to fabricate an Isofix latch wire arrangement bends an elongated strip about an open profile to form an elongated tubular member, radially penetrating the member with wires across the open profile, and forming enlarged portions on the legs. The enlargements engage opposite sides of the tube to complete abutment of the strip edges to close the profile and join the wires as rivets to the tubular member formed.

Abstract: The present invention provides a system, method and apparatus for producing fire rated doors having added strength, better finishing and low cost manufacturing flexibility. The fire rated doors are made from two panels “sandwiched” together. An optional interior layer (e.g., fire resistant material, lead sheeting, steel or Kevlar) can be added between the door panels for various purposes. Splines, stiles or sticks are inserted in longitudinal channels in the door panels to provide assistance in aligning the door panels and greater hardware holding strength. An intumescent banding material concealed by a banding material around the perimeter of the door seals the door within its frame during a fire. The door design and the automated manufacturing process provide greater design choice, reduced cost and faster fabrication.

Abstract: A first optical module scans a portion of an eye with a line of light, descans reflected light from the scanned portion of the eye and confocally provides output light in a line focus configuration. A detection device detects the output light and images the portion of the eye. A second optical module detects an optical distortion and corrects the optical distortion in the line of light scanned on the portion of the eye.

Abstract: Epithelial cancer screening can include a staining tissue with a cancer targeting agent, identifying a potentially cancerous lesion using fluorescence imaging, and imaging the potentially cancerous lesion for a cancer diagnosis using optical coherence tomography.

Abstract: The invention is a decklid latch with a SMA actuator. The actuator includes a latch plate with a ratchet rotatably mounted to the latch plate and is pivotal between a released position and an engaged position operable to retain a striker. A pawl is rotatably mounted to the latch plate and is pivotal between a an engaged position operable to retain the ratchet, and a release position operable to allow the ratchet to pivot. An selectively-contractible wire is connected to the pawl by a lost motion connection and is operable to move the pawl to the release position when contracted to actuate the latch. Portions of the selectively contractible wire have been annealed to reduce brittleness. Multiple material crimps are used to further reduce strain on the selectively contractible wire.

Abstract: The present invention relates to a new tumor suppressor, designated FJX1. Also described are diagnostic, prognostic and therapeutic uses of the FJX1 protein and the FJX1 gene, alone or in combination with traditional cancer therapies.

Abstract: A method of imaging a retina of an eye includes combining an optical path of an optical coherence tomography (OCT) imager and an optical path of a line scanning laser ophthalmoscope (LSLO) imager using a system of optics. The method also includes using a single detector to switch between an OCT mode and a LSLO mode and acquiring images of the retina while switching between the OCT mode and the LSLO mode.

Abstract: An actuator is provided that uses two lengths of shape memory alloy (SMA) wire to kinematically couple a first and second lever together. The two SMA wires are routed in generally V-shaped paths around a link pin that is coaxial with the first and second levers. By selectively contracting one of the wires, the link pin slides between a locked and an unlocked position. A locking pin extending from the link pin couples the first and second levers together while the link pin is in the unlocked position.

Abstract: An anti-pinch assembly is used for a closure panel movable between open and closed positions on a motor vehicle. A controller operably connected to the closure panel controls operation thereof. A position sensor connected to the controller indicates the position of the closure panel between the open and closed positions. A capacitive sensor mounted on the vehicle and connected to the controller provides an output signal to the controller indicative of the presence of a foreign object in the path of the closure panel. The controller varies the function of the capacitive sensor through a plurality of threshold levels as a function of the position of the closure panel as indicated by the position indicator. In a critical zone of travel with the closure panel nearing the closed position, the capacitive sensor can be utilized in either a contact mode or a non-contact mode or a combination of both.

Abstract: An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.

Abstract: An optical apparatus includes a system of optical components capable of operating in a scanning laser ophthalmoscope (SLO) mode and an optical coherence tomography (OCT) mode. The system of optical components includes a first optical module for the SLO mode, a second optical module for the OCT mode, and a first scanning device. The first optical module for the SLO mode includes a first source adapted to provide a first imaging beam for the SLO mode and a first detection device configured to receive a first signal associated with a first image of a retina of an eye. The second optical module for the OCT mode includes a second source adapted to provide a second imaging beam for the OCT mode and a second detection device configured to receive a second signal associated with a second image of the retina.

Abstract: A method for lowering dark current in an image sensor pixel, the method includes the steps of providing a photosensitive area for receiving incident light which is converted into a charge; providing a gate for transferring charge from the photosensitive area; wherein the gate is held at a voltage which will accumulate majority carriers at a semiconductor-dielectric interface during integration for the photosensitive area. Alternatively, a potential profile can be provided under the gate to drain the dark current away from the photogeneration diffusion.

Abstract: A system provides an optical image of an object. A first module tracks a reference feature of the object. A second module includes a source for an imaging beam, a scanning device to move the imaging beam along a portion of the object and a detection device receives a signal associated with an image of the portion of the object. The first module controls the position of the imaging beam relative to the reference feature to correct for the motion of the object. A third module detects a distortion of the object and compensates for the distortion.

Abstract: The invention relates generally to systems, devices and methods for global disaster response, more particularly to the rapid detection, qualified assessment and monitoring of disasters and electronic triage of victims, communication, alert and evacuation systems, provision of suitable modular sensing or medical aid solutions, and their rapid deployment via delivery platforms such as disaster messaging formats and resources on client mobile phone applications or physically via remote operated vehicles (unmanned aerial sea or land systems) or targeted air delivery.

Abstract: The present invention is drawn to methods of assessing colorectal cancer prognosis by examining the expression of particular genes disregulated in this disease state. Subjects exhibiting disregulation in one or more of these genes will have a higher risk of cancer recurrence and death.

Abstract: The present invention provides monoclonal IgE antibodies comprising Fc epsilon (?) constant regions and variable regions comprising at least one antigen binding region specific for binding a single epitope of a circulating, tumor-associated antigen (TAA) that is not a cell surface antigen wherein the epitope of the targeted antigen is not highly repetitive or is a non-repetitive epitope. The IgE antibodies of the invention are useful in the treatment of cancer associated with the tumor antigen. In one embodiment the TAA is prostate-specific antigen (PSA).

Abstract: An apparatus for imaging an eye includes a housing and a system of optical components disposed in the housing. The apparatus is capable of operating in a line scanning laser ophthalmoscope (LSLO) mode and an optical coherence tomography (OCT) mode. The system of optical components can include a first source to provide a first beam of light for the OCT mode and a second source to provide a second beam of light for the LSLO mode. In the OCT mode, a first optic is used that (i) scans, using a first surface of the first optic, the first beam of light along a retina of an eye in a first dimension, and (ii) descans, using the first surface, a first light returning from the eye in the first dimension to a detection system in the OCT mode. In the LSLO mode, the first optic is used where the second beam of light passes through a second surface of the first optic.