Abstract: An RF circuit for an electron beam device is formed with successive layers of fusible metal particles applied in layers and translated with respect to an electron beam. Segments of an electron device may be formed which include an open RF cavity at each end of the segment, which can be machined before the segments are brazed together. In one example, the electron beam device may have iron pole pieces assembled into the partially fused device to provide a magnetic circuit and support for subsequent layers of fused particles. The inner surfaces of the RF circuit structure may be smoothed using an etching or machining operation, and the segments may be brazed together to form a completed RF circuit structure with the magnetic pole pieces included in the monolithic structure segments.

Abstract: A subtalar plate implant (12) for correcting and/or altering the alignment of a hyperpronated foot (10) comprises a plate portion (22) and an insert portion (24) that is connected to the plate portion (22). The plate portion (22) is selectively attachable to a lateral aspect of the calcaneus (16). The insert portion (24) is positionable within the subtalar joint (18). The insert portion (24) includes a top surface (236) that is selectively positionable substantially adjacent to a base of the talus (14), the top surface (236) being angled to allow the talus (14) to articulate over the top surface (236). The insert portion (24) further includes a bottom surface (238) that is selectively positionable substantially adjacent to a dorsal surface of the calcaneus (16). The insert portion (24) can include a groove (356) that is formed along the bottom surface (238) substantially parallel to the plate portion (22).

Abstract: Provided herein is an injectable composition including, in some embodiments, a soft-tissue augmenting agent and a vehicle for the soft-tissue augmenting agent formulated for augmenting one or more soft tissues of a human or animal. Also provided herein is a soft-tissue augmenting kit including, in some embodiments, a syringe and the injectable composition formulated for augmenting one or more soft tissues of a human or animal. Also provided herein is a method for augmenting one or more soft tissues of a human or animal including, in some embodiments, injecting the injectable composition into the one or more soft tissues of the human or animal.

Abstract: Methods, associated algorithms, and systems for determining cardiac and/or cardiovascular performance from three measurements on a subject are presented, where two of the measurements are provided by plethysmographs and one measurement is provided by an electrocardiogram. The two plethysmographs are placed different distances from the subject's heart. Certain embodiments use the three measurements to calculate intermediate variables of a left ventricular ejection time and a pre-ejection period.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to throttle resource access by web crawlers. An example method disclosed herein includes obtaining, at a server, a media request message for media hosted by the server, the media request message requesting access to the media, characterizing a media-requesting source associated with the media request message, and inserting a time delay in a media response message to the media-requesting source based on the characterization.

Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Abstract: A system and method for creating a user profile and for using the user profile to order search results returned by a search engine. The user profile is based on search queries submitted by a user, the user's specific interaction with the documents identified by the search engine and personal information provided by the user. Terms for the user profile may be selected from the documents accessed by the user by performing paragraph sampling or context analysis. Generic scores associated with the search results are modulated by the user profile to measure their relevance to a user's preference and interest. The search results are re-ordered accordingly so that the most relevant results appear on the top of the list. User profiles can be created and/or stored on the client side or server side of a client-server network environment.

Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Abstract: Methods and systems for improving user search experience with a search engine by providing a way for associated users to personalize search queries and/or search results based on users' information gathered from a social network. Search personalization can be achieved through the tailoring of search methodologies or the ranking or ordering of search results in accordance with information gathered for each user.

Abstract: A coupled cavity traveling wave tube has periodic permanent magnet (PPM) RF cavity structures, each of which has a plurality of permanent magnets placed substantially equidistant from a central axis, and which are outside the extent of a plurality of electron beam tunnels arranged substantially equidistant from the central axis and within the extents of the plurality of permanent magnets. Each coupled cavity RF structure is formed by adjacent ferrous polepieces and a cylindrical wall which is beyond the extent of one or more coupling apertures which couple RF energy from one coupled cavity structure to an adjacent RF cavity.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to throttle resource access by web crawlers. An example apparatus disclosed herein includes memory including computer readable instructions. The example apparatus also includes a processor to execute the computer readable instructions to generate a media request message to obtain media hosted by a server, insert, into the media request message, a source indicator of the media requesting source, the source indicator indicating whether the media requesting source is associated with a media provider to provide audience measurement information associated with the media provided by the media provider, transmit the media request message to the server, and execute a delay tag in a media response message received from the server, the delay tag to cause a delay time period based on the source indicator.

Abstract: Focused library synthesis and medicinal chemistry on an oxadiazole-isopropylamide core proteasome inhibitor provided the lead compound that strongly inhibits CT-L activity. Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. Only para-substitution in the A-ring was important to maintain potent CT-L inhibitory activity. Hydrophobic residues in the A-ring's para-position and meta-pyridyl group at the B-ring significantly improved inhibition. The meta-pyridyl moiety improved cell permeability. The length of the aliphatic chain at the para position of the A-ring is critical with propyl yielding the most potent inhibitor, whereas shorter (i.e. ethyl, methyl or hydrogen) or longer (i.e. butyl, propyl and hexyl) chains demonstrating progressively less potency. Introduction of a stereogenic center next to the ether moiety (i.e.

Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.

Abstract: Methods and apparatus for monitoring video games are disclosed. Example video game monitors disclosed herein include a network analyzer to communicatively couple with a communication interface of a video game console, the network analyzer to detect communication packets transferred over the communication interface of the video game console. Disclosed example video game monitors also include a processor to decode the communication packets detected by the network analyzer to determine an identity of a game being played by the video game console, and report the identity of the game to a data collection facility.

Abstract: A multi-beam triode for RF amplification has plurality of electron beams generated by a thermionic cathode, each electron beam travelling through an associated grid and to a common anode electrode. An input RF energy is coupled to a grid support which is electrically common to a control grid of each electron beam, and RF is coupled out of the grid—anode gap, with suitable input RF matching cavities and output RF matching cavities provided.

Abstract: An implant that facilitates the fusion of a first bone part with a second bone part includes an implant body that extends between the first bone part and the second bone part. The implant body includes a first portion that fits within a first receiving aperture in the first bone part, and the implant body includes a second portion that fits within a second receiving aperture in the second bone part. At least one of the first portion and the second portion can be made of bone. Additionally, at least the second portion is formed to have a non-circular cross-sectional shape to inhibit relative motion between the bone parts and the implant body.

Abstract: A subtalar plate implant (12) for correcting and/or altering the alignment of a hyperpronated foot (10) comprises a plate portion (22) and an insert portion (24) that is connected to the plate portion (22). The plate portion (22) is selectively attachable to a lateral aspect of the calcaneus (16). The insert portion (24) is positionable within the subtalar joint (18). The insert portion (24) includes a top surface (236) that is selectively positionable substantially adjacent to a base of the talus (14), the top surface (236) being angled to allow the talus (14) to articulate over the top surface (236). The insert portion (24) further includes a bottom surface (238) that is selectively positionable substantially adjacent to a dorsal surface of the calcaneus (16). The insert portion (24) can include a groove (356) that is formed along the bottom surface (238) substantially parallel to the plate portion (22).

Abstract: In accordance with the teachings of the present disclosure, a method of generating a computer alarm is disclosed. The method includes determining a new instance of a characteristic of an element of a computing network to be monitored, identifying a relationship of the element to other elements of the computing network, and automatically creating an alarm threshold for the new instance of the characteristic based upon the relationship of the element to the other elements of the computing network.

Abstract: Methods and apparatus for monitoring video games are disclosed. Example methods disclosed herein monitoring a data interface between a game controller and a game port of a game console with a monitoring device. Disclosed example methods also include determining whether the game console is operating a video game in a demonstration mode or an active play mode based on data detected by the monitoring device.

Abstract: Methods and systems for correlating connections between users and links between articles to identify search and/or ad spamming are disclosed. Social networks can be used to identify connections between users for correlation with links between articles, which can be identified through searches of article contents and/or back tracing accesses to articles. One disclosed method comprises identifying first associations between a plurality of users in a network of associated users; identifying second associations between one or more users and one or more articles; identifying third associations between at least some of the articles or between some of the users and access to some of the articles; and determining at least one of the third associations is correlated with one or more of the first associations.