Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to throttle resource access by web crawlers. An example apparatus disclosed herein includes memory including computer readable instructions. The example apparatus also includes a processor to execute the computer readable instructions to generate a media request message to obtain media hosted by a server, insert, into the media request message, a source indicator of the media requesting source, the source indicator indicating whether the media requesting source is associated with a media provider to provide audience measurement information associated with the media provided by the media provider, transmit the media request message to the server, and execute a delay tag in a media response message received from the server, the delay tag to cause a delay time period based on the source indicator.

Abstract: A data transfer system is configured to transfer data from a data transmitting site to a data receiving site. The data transfer system includes a low-side network, at least one high-side network, and a one-way data (OWD) link. The OWD link is configured to perform unidirectional data transfer from the low-side network to the at least one high-side network. The OWD link continuously synchronizes the low-side network with the at least one high-side network while continuously transferring data through the OWD link.

Abstract: Described are cancer therapies and anti-cancer compounds. In particular, disclosed are inhibitors of ACK1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new ACK1 tyrosine kinase inhibitors are also disclosed. In specific example, compound having Formula I are disclosed.

Abstract: A subtalar plate implant (12) for correcting and/or altering the alignment of a hyperpronated foot (10) comprises a plate portion (22) and an insert portion (24) that is connected to the plate portion (22). The plate portion (22) is selectively attachable to a lateral aspect of the calcaneus (16). The insert portion (24) is positionable within the subtalar joint (18). The insert portion (24) includes a top surface (236) that is selectively positionable substantially adjacent to a base of the talus (14), the top surface (236) being angled to allow the talus (14) to articulate over the top surface (236). The insert portion (24) further includes a bottom surface (238) that is selectively positionable substantially adjacent to a dorsal surface of the calcaneus (16). The insert portion (24) can include a groove (356) that is formed along the bottom surface (238) substantially parallel to the plate portion (22).

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to throttle resource access by web crawlers. An example apparatus disclosed herein includes a data interface to obtain a media request message for media hosted by a server, the media request message requesting access to the media. The example apparatus also includes a category handler to determine a source indicator of a media-requesting source associated with the media request message, the source indicator indicating whether the media-requesting source is associated with a media provider to provide audience measurement information associated with the media provided by the media provider.

Abstract: A data transfer system is configured to transfer data from a data transmitting site to a data receiving site. The data transfer system includes a low-side network, at least one high-side network, and a one-way data (OWD) link. The OWD link is configured to perform unidirectional data transfer from the low-side network to the at least one high-side network. The OWD link continuously synchronizes the low-side network with the at least one high-side network while continuously transferring data through the OWD link.

Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.

Abstract: Systems, methods, and computer-readable media are disclosed for identifying duplicate events. In one implementation, a computer-implemented method is provided that includes receiving an event based on a user interaction with a client device, and determining content and a location for the event. The method further includes calculating a duplicate value for the event using the content and the location of the even, and determining a degree of similarity by comparing the duplicate value to a table of stored duplicate values. In addition, the method includes identifying the event as a duplicate of a stored event when the degree of similarity exceeds a predetermined threshold level of similarity, and indexing the event on the client device depending on the determination of whether or not the event is a duplicate of the stored event.

Abstract: Provided herein is an injectable composition including, in some embodiments, a soft-tissue augmenting agent and a vehicle for the soft-tissue augmenting agent formulated for augmenting one or more soft tissues of a human or animal Also provided herein is a soft-tissue augmenting kit including, in some embodiments, a syringe and the injectable composition formulated for augmenting one or more soft tissues of a human or animal. Also provided herein is a method for augmenting one or more soft tissues of a human or animal including, in some embodiments, injecting the injectable composition into the one or more soft tissues of the human or animal.

Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.

Abstract: Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

Abstract: Described are cancer therapies and anti-cancer compounds. In particular, disclosed are inhibitors of ACK1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new ACK1 tyrosine kinase inhibitors are also disclosed. In specific example, compound having Formula I are disclosed.

Abstract: Focused library synthesis and medicinal chemistry on an oxadiazole-isopropylamide core proteasome inhibitor provided the lead compound that strongly inhibits CT-L activity. Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. Only para-substitution in the A-ring was important to maintain potent CT-L inhibitory activity. Hydrophobic residues in the A-ring's para-position and meta-pyridyl group at the B-ring significantly improved inhibition. The meta-pyridyl moiety improved cell permeability. The length of the aliphatic chain at the para position of the A-ring is critical with propyl yielding the most potent inhibitor, whereas shorter (i.e. ethyl, methyl or hydrogen) or longer (i.e. butyl, propyl and hexyl) chains demonstrating progressively less potency. Introduction of a stereogenic center next to the ether moiety (i.e.

Abstract: Described are cancer therapies and anti-cancer compounds. In particular, disclosed are inhibitors of Ack1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new Ack1 tyrosine kinase inhibitors are also disclosed. In specific example, compound having Formula I through IV are disclosed.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to throttle resource access by web crawlers. An example apparatus disclosed herein includes a data interface to obtain a media request message for media hosted by a server, the media request message requesting access to the media. The example apparatus also includes a category handler to determine a source indicator of a media-requesting source associated with the media request message, the source indicator indicating whether the media-requesting source is associated with a media provider to provide audience measurement information associated with the media provided by the media provider.

Abstract: Described are cancer therapies and anti-cancer compounds. In particular, disclosed are inhibitors of Ack1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new Ack1 tyrosine kinase inhibitors are also disclosed. In specific example, compound having Formula I through IV are disclosed.

Abstract: Methods and systems for improving user search experience with a search engine by providing a way for associated users to personalize search queries and/or search results based on users' information gathered from a social network. Search personalization can be achieved through the tailoring of search methodologies or the ranking or ordering of search results in accordance with information gathered for each user.

Abstract: Systems and methods for article location and retrieval are described. In one described method, the normal processing of an operating system call associated with a dialog control is interrupted, and a search dialog control is displayed. The search dialog control is associated with an index comprising a plurality of events. Each of the plurality of events may be associated with at least one of a plurality of client applications and at least some of the plurality of events can be captured in real time. Each event may be associated with one or more articles.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to throttle resource access by web crawlers. An example method disclosed herein includes obtaining, at a server, a media request message for media hosted by the server, the media request message requesting access to the media, characterizing a media-requesting source associated with the media request message, and inserting a time delay in a media response message to the media-requesting source based on the characterization.

Abstract: Focused library synthesis and medicinal chemistry on an oxadiazole-isopropylamide core proteasome inhibitor provided the lead compound that strongly inhibits CT-L activity. Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. Only para-substitution in the A-ring was important to maintain potent CT-L inhibitory activity. Hydrophobic residues in the A-ring's para-position and meta-pyridyl group at the B-ring significantly improved inhibition. The meta-pyridyl moiety improved cell permeability. The length of the aliphatic chain at the para position of the A-ring is critical with propyl yielding the most potent inhibitor, whereas shorter (i.e. ethyl, methyl or hydrogen) or longer (i.e. butyl, propyl and hexyl) chains demonstrating progressively less potency. Introduction of a stereogenic center next to the ether moiety (i.e.