Abstract: Disclosed herein are methods of delivering implants to a target organ with an implant administration device, where the implant administration device includes a polymer retainer. Methods of making polymer retainers and methods of securing an implant within an implant administration device using a polymer retainer are also disclosed herein.

Abstract: A catalytic compound of formula I, II, or III is described; wherein M is selected from the group consisting of Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu; R1, N is an integer from 1 to 3; R2, R3, and R4 are independently selected from lower alkyl, lower alkoxy, C5-C8 aryl, and NR62, wherein R6 is —CH3 or —C2H5; and R5 is selected from —H, lower alkyl, lower alkoxy, and benzylic. Methods of using the compound to catalyze the formation of polylactides, and polylactides prepared using these methods are also described.

Abstract: Described herein are methods and compositions for the treatment of ocular conditions and for the improvement of vision parameters using pharmaceutically acceptable ophthalmic pilocarpine formulations. A nonlimiting example of an ocular condition that may be treated with the methods and compositions disclosed herein is presbyopia.

Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

Abstract: Spent catalyst (500) is removed from process microchannels (310) of a Fischer-Tropsch reactor by directing a jet of air (4) from an air knife (1) through slots of a protecting member (2). The air knife is traversed across successive rows of process microchannels (310) in direction A. The spacer member (2) protects an internal microchannel architecture (315) of the process microchannels against damage by the air jet (4) which may approach or exceed sonic velocity as it is directed into the process microchannels.

Abstract: An implant assembly may include a screw with a head having a head feature and an implant. The implant may be securable to a bone of a patient with the screw. The implant may include a bone plate, a rotatable structure having a top surface and a bottom surface. The bottom surface may include a lock feature. The lock feature may engage the head feature when the rotatable structure is in a locked orientation and disengage the head feature when the rotatable structure is in an unlocked orientation. The rotatable structure may couple to the bone plate such that the rotatable structure is rotatable between the locked orientation and the unlocked orientation. The head feature may be one of a ridge and a radial groove and the lock feature may be the other one of the ridge and the radial groove.

Abstract: Methods for treatment of increased intraocular pressure with intracameral intraocular implants are disclosed herein. The controlled and sustained release of bimatoprost to the anterior chamber of the eye may be effective to treat an eye for at least one year or longer for the reduction of TOP.

Abstract: Various embodiments of the present disclosure provide methods, apparatus, systems, computing devices, computing entities, and/or the like for revising classifier predictions, wherein classification labels are tokenized according to an index of predefined classification labels. An embedding is created for each token using an embedding model. The embeddings are provided to a machine learning model that accepts a sequence of tokens as input and produces a sequence of tokens as output. Tokens are extracted from the output of the machine learning model and a classification label corresponding to each token is retrieved according to the index of predefined classification labels.

Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

Abstract: Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.

Abstract: Methods for treatment of increased intraocular pressure with intracameral intraocular implants are disclosed herein. The controlled and sustained release of bimatoprost to the anterior chamber of the eye may be effective to treat an eye for at least one year or longer for the reduction of TOP.

Abstract: Prostamide-containing intraocular implants that biodegrade in the eye and that are effective for reducing intraocular pressure in an eye for a sustained period. The implants generally contain a prostamide, such as bimatoprost, and at least three distinct biodegradable polymers selected from polylactide and poly(lactide-co-glycolide) polymers and are optimized for placement in and compatibility with the anterior chamber of the eye, particularly the anterior chamber angle. Methods for making and using the implants to reduce ocular hypertension and intraocular pressure in a patient are described.

Abstract: The present invention is directed to syringes that can be manufactured by blow molding and can be aseptically filled and finished, i.e., Blow-Fill-Seal (“BFS”). The present invention is also directed to pen-type injectors that accommodate cartridges that can be manufactured by BFS technology.

Abstract: Lanthanide double perovskite nanocrystals are described. The nanocrystals display high energy luminescence, making them useful in a variety of light-emitting materials and devices. Methods of preparing the lanthanide double perovskite nanocrystals using a hot injection method are also described.

Abstract: Apparatus and methods for introducing a solid or semi-solid intraocular drug-containing implant into the anterior chamber of an eye are described. The drug-containing implant can be a rod-shaped biodegradable implant that may provide for the extended release of the drug and may be effective for treating a medical condition of the eye. The apparatus is ergonomically designed in the shape or style of a pen with tactile surfaces for easy gripping, a needle-rotation knob to permit orientation of the needle bevel in relation to the eye, and a spring-actuated mechanism for consistent deployment of the implant.

Abstract: A system for conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes a web server for receiving bid data for one or more users for basic generation service products, an application server host application software, which processes the one or more bids according to at least one auction rule, tracks the auction, monitors the auction, and/or determines when to end the auction, and a database server, which stores auction data. A method of conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes the repeating steps of receiving bids indicating desired tranche units of basic generation service products, calculating next round prices for each product, and sending round results to bidders. The system for and method of conducting a computer-based auction includes receiving and processing a withdrawal request or a switch request from at least one of the qualified bidders.

Abstract: The embodiments relate to cardiac assist devices that comprise a jacket that wraps the exterior of the heart, where the jacket comprises a left chamber and a right chamber overlaying the left and right ventricles of the heart, respectively, where the chambers are expanded pneumatically to exert pressure on the heart and thereby mechanically assist its pumping. The timing of expansion of the left and right bladders is controlled by an electrical controller to match the desired or natural timing of contraction of the left and right ventricles, where both the left and right chambers may not expand simultaneously but are timed to optimize assistance of the heart. The embodiments provide jackets that apply pneumatic pressure to the right and left ventricles separately in timing to provide mechanical cardiac resynchronization therapy, as distinct from the conventional electrical stimulation cardiac resynchronization therapy.

Abstract: The present invention discloses new catalyst systems based on trivalent metal complexes of Formula I, which can facilitate the stereospecific ring-opening polymerization of (rac)-?-Butyrolactone (rac-BBL). Also provided is a process for the stereospecific synthesis of aliphatic polyesters using the catalysts of Formula I, including alcohols and polyols as chain-transfer agents to facilitate immortal ring-opening polymerization.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

Abstract: Various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for performing predictive data analysis operations using a machine learning framework that comprises a predictive event embedding machine learning model and a network-based inference machine learning model. In some embodiments, a predictive data analysis computing entity performs a sequence of L sequential network updates on an event relationship network data object for a predictive entity to generate a cross-event classification for the predictive entity.