Abstract: A system for conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes a web server for receiving bid data for one or more users for basic generation service products, an application server host application software, which processes the one or more bids according to at least one auction rule, tracks the auction, monitors the auction, and/or determines when to end the auction, and a database server, which stores auction data. A method of conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes the repeating steps of receiving bids indicating desired tranche units of basic generation service products, calculating next round prices for each product, and sending round results to bidders. The system for and method of conducting a computer-based auction includes receiving and processing a withdrawal request or a switch request from at least one of the qualified bidders.

Abstract: The embodiments relate to cardiac assist devices that comprise a jacket that wraps the exterior of the heart, where the jacket comprises a left chamber and a right chamber overlaying the left and right ventricles of the heart, respectively, where the chambers are expanded pneumatically to exert pressure on the heart and thereby mechanically assist its pumping. The timing of expansion of the left and right bladders is controlled by an electrical controller to match the desired or natural timing of contraction of the left and right ventricles, where both the left and right chambers may not expand simultaneously but are timed to optimize assistance of the heart. The embodiments provide jackets that apply pneumatic pressure to the right and left ventricles separately in timing to provide mechanical cardiac resynchronization therapy, as distinct from the conventional electrical stimulation cardiac resynchronization therapy.

Abstract: The present invention discloses new catalyst systems based on trivalent metal complexes of Formula I, which can facilitate the stereospecific ring-opening polymerization of (rac)-?-Butyrolactone (rac-BBL). Also provided is a process for the stereospecific synthesis of aliphatic polyesters using the catalysts of Formula I, including alcohols and polyols as chain-transfer agents to facilitate immortal ring-opening polymerization.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

Abstract: Various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for performing predictive data analysis operations using a machine learning framework that comprises a predictive event embedding machine learning model and a network-based inference machine learning model. In some embodiments, a predictive data analysis computing entity performs a sequence of L sequential network updates on an event relationship network data object for a predictive entity to generate a cross-event classification for the predictive entity.

Abstract: Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.

Abstract: Spent catalyst (500) is removed from process microchannels (310) of a Fischer-Tropsch reactor by directing a jet of air (4) from an air knife (1) through slots of a protecting member (2). The air knife is traversed across successive rows of process microchannels (310) in direction A. The spacer member (2) protects an internal microchannel architecture (315) of the process microchannels against damage by the air jet (4) which may approach or exceed sonic velocity as it is directed into the process microchannels.

Abstract: A system for conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes a web server for receiving bid data for one or more users for basic generation service products, an application server host application software, which processes the one or more bids according to at least one auction rule, tracks the auction, monitors the auction, and/or determines when to end the auction, and a database server, which stores auction data. A method of conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes the repeating steps of receiving bids indicating desired tranche units of basic generation service products, calculating next round prices for each product, and sending round results to bidders.

Abstract: Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.

Abstract: A system which creates a durable seal between adjacent horizontal panels, including those that may be curved or subject to temperature expansion and contraction or mechanical shear. The durable seal system incorporates a plurality of ribs, a flexible member between the cover plate and the ribs and may incorporate a load transfer plate to provide support to the rib from below, and/or cores of differing compressibilities.

Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.

Abstract: A system for conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes a web server for receiving bid data for one or more users for basic generation service products, an application server host application software, which processes the one or more bids according to at least one auction rule, tracks the auction, monitors the auction, and/or determines when to end the auction, and a database server, which stores auction data. A method of conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes the repeating steps of receiving bids indicating desired tranche units of basic generation service products, calculating next round prices for each product, and sending round results to bidders.

Abstract: The present invention is related to topical ophthalmic compositions comprising one or more active components. The active components in the topical ophthalmic compositions include, but are not limited to carbachol, phospholine iodide and pharmaceutically acceptable salts thereof. Also described herein are methods for the treatment of presbyopia, methods for improving near vision in a subject with presbyopia, and methods for reducing pupil diameter in a subject with presbyopia using the topical ophthalmic compositions.

Abstract: Described herein are methods and compositions for the treatment of ocular conditions and for the improvement of vision parameters using pharmaceutically acceptable ophthalmic pilocarpine formulations. A nonlimiting example of an ocular condition that may be treated with the methods and compositions disclosed herein is presbyopia.

Abstract: Prostamide-containing intraocular implants that biodegrade in the eye and that are effective for reducing intraocular pressure in an eye for a sustained period. The implants generally contain a prostamide, such as bimatoprost, and at least three distinct biodegradable polymers selected from polylactide and poly(lactide-co-glycolide) polymers and are optimized for placement in and compatibility with the anterior chamber of the eye, particularly the anterior chamber angle. Methods for making and using the implants to reduce ocular hypertension and intraocular pressure in a patient are described.

Abstract: A coating for protecting a substrate from corrosion includes a first layer having a first composition applied on the substrate. The coating has a thickness of at least 0.5 ?m. The first composition includes an intercalated mixture of a polymer and a clay according to a formula of (Px/C1-x)v, where v comprises a volume of the intercalated mixture applied to the substrate.

Abstract: A system which creates a durable seal between adjacent horizontal panels, including those that may be curved or subject to temperature expansion and contraction or mechanical shear. The durable seal system incorporates a plurality of ribs, a flexible member between the cover plate and the ribs and may incorporate a load transfer plate to provide support to the rib from below, and/or cores of differing compressibilities.

Abstract: An expansion joint system for supporting and distributing transfer loads and for splicing adjacent systems together. The system includes an elongated core and at least three longitudinal load-transfer members with hollow cylindrical profiles within the elongated core and terminating at each face of the elongated core. The system may include splicing members sized to transition fit into each of the longitudinal load-transfer members to provide an interlocking body to join adjacent expansion joint systems.

Abstract: A toilet seat with handles is disclosed. The handles include light transmitters and light receivers. The light transmitters and receivers may be used to determine blood oxygen saturation levels and heart rate of a toilet seat user. Ultrasonic transmitters and receivers in the toilet seat handle are also disclosed for determining bone density of a toilet seat user. The handles may be retractable and may include UV sanitation.

Abstract: A system for conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes a web server for receiving bid data for one or more users for basic generation service products, an application server host application software, which processes the one or more bids according to at least one auction rule, tracks the auction, monitors the auction, and/or determines when to end the auction, and a database server, which stores auction data. A method of conducting a computer-based, simultaneous, multiple round, descending clock auction for basic generation services includes the repeating steps of receiving bids indicating desired tranche units of basic generation service products, calculating next round prices for each product, and sending round results to bidders. The system for and method of conducting a computer-based auction includes limiting the qualified bidders by a load cap to a maximum number of tranches bid during a round.