Abstract: Described herein are methods and compositions for the treatment of ocular conditions and for the improvement of vision parameters using pharmaceutically acceptable ophthalmic pilocarpine formulations. A nonlimiting example of an ocular condition that may be treated with the methods and compositions disclosed herein is presbyopia.

Abstract: The embodiments relate to cardiac assist devices that comprise a jacket that wraps the exterior of the heart, where the jacket comprises one or more pneumatic or hydraulic bladders. The pneumatic or hydraulic bladders are linked to a pump, and the pump fills the bladders with fluid and withdraws the fluid in a cycle to match beats of the heart to assist contraction and pumping of the heart in systole or to assist expansion and filling of the heart in diastole.

Abstract: There is a need for more effectively and efficiently performing predictive data analysis to determine associations between input data objects and predictive categories This need can be addressed by, for example, solutions for performing predictive data analysis to determine associations between input data objects and predictive categories that utilize at least one of accuracy scores for predictive categories, evidentiary scores for predictive categories, and predicted certification statuses for claim data objects. In one example, a method includes: for each predictive category of one or more predictive categories associated with a claim data object, determining an accuracy score and an evidentiary score; determining a predicted certification status for the claim data object based on each accuracy score for a predictive category and each evidentiary score for a predictive category; and performing prediction-based actions based on each predicted certification status.

Abstract: Disclosed herein are methods of delivering implants to a target organ with an implant administration device, where the implant administration device includes a polymer retainer. Methods of making polymer retainers and methods of securing an implant within an implant administration device using a polymer retainer are also disclosed herein.

Abstract: An expansion joint design for supporting transfer loads. The system includes an elongated core and at least one longitudinal load-transfer member which are bonded together.

Abstract: An expansion joint design for supporting transfer loads. The system includes an elongated core and at least one longitudinal load-transfer member which are bonded together.

Abstract: A system which creates a durable seal between adjacent horizontal panels, including those that may be curved or subject to temperature expansion and contraction or mechanical shear. The durable seal system incorporates a plurality of ribs, a flexible member between the cover plate and the ribs and may incorporate a load transfer plate to provide support to the rib from below, and/or cores of differing compressibilities.

Abstract: An implant assembly may include a screw with a head having a head feature and an implant. The implant may be securable to a bone of a patient with the screw. The implant may include a bone plate, a rotatable structure having a top surface and a bottom surface. The bottom surface may include a lock feature. The lock feature may engage the head feature when the rotatable structure is in a locked orientation and disengage the head feature when the rotatable structure is in an unlocked orientation. The rotatable structure may couple to the bone plate such that the rotatable structure is rotatable between the locked orientation and the unlocked orientation. The head feature may be one of a ridge and a radial groove and the lock feature may be the other one of the ridge and the radial groove.

Abstract: The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and arc designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.

Abstract: Systems and methods enable compression of chronological data stored within a hierarchical data storage repository by identifying related data files generated at different times, wherein the related data files comprises a first data file and a second data file, and wherein the second data file was generated chronologically after the first data file; identifying duplicative data existing in both the first data file and the second data file; deleting the duplicative data from the first data file; and generating a link between the first data file and the second data file to enable retrieval of the duplicative data during display of contents of the first data file.

Abstract: The present invention discloses new catalyst systems based on trivalent metal complexes of Formula I, which can facilitate the stereospecific ring-opening polymerization of (rac)-?-Butyrolactone (rac-BBL). Also provided is a process for the stereospecific synthesis of aliphatic polyesters using the catalysts of Formula I, including alcohols and polyols as chain-transfer agents to facilitate immortal ring-opening polymerization.

Abstract: The present disclosure relates generally to systems for providing a durable water-resistant and fire-resistant foam-based seal in the joint between adjacent panels. A fire-resistant and water-resistant expansion joint seal is provided which includes one or more foam members and a plurality of intumescent members interspersed within the foam member or members to provide a spring recovery force and fire resistance.

Abstract: Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.

Abstract: The present disclosure relates generally to systems for providing a durable water-resistant and fire-resistant foam-based seal in the joint between adjacent panels. A fire-resistant and water-resistant expansion joint seal is provided which includes one or more foam members and a plurality of intumescent members interspersed within the foam member or members to provide a spring recovery force and fire resistance.

Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

Abstract: The present disclosure relates generally to systems for providing a durable water-resistant and fire-resistant foam-based seal in the joint between adjacent panels. A fire-resistant and water-resistant expansion joint seal is provided which includes one or more foam members and a plurality of intumescent members interspersed within the foam member or members to provide a spring recovery force and fire resistance.

Abstract: Apparatus and methods for introducing a solid or semi-solid intraocular drug-containing implant into the anterior chamber of an eye are described. The drug-containing implant can be a rod-shaped biodegradable implant that may provide for the extended release of the drug and may be effective for treating a medical condition of the eye. The apparatus is ergonomically designed in the shape or style of a pen with tactile surfaces for easy gripping, a needle-rotation knob to permit orientation of the needle bevel in relation to the eye, and a spring-actuated mechanism for consistent deployment of the implant.

Abstract: The present disclosure relates generally to systems for providing a durable water-resistant and fire-resistant foam-based seal in the joint between adjacent panels. A fire-resistant and water-resistant expansion joint seal is provided which includes one or more foam members and a plurality of intumescent members within the foam member or members to provide a spring recovery force and fire resistance.

Abstract: The present disclosure relates generally to systems for providing a durable water-resistant and fire-resistant foam-based seal in the joint between adjacent panels. A fire-resistant and water-resistant expansion joint seal is provided which includes one or more foam members and a plurality of intumescent members within the foam member or between members to provide a spring recovery force and fire resistance.

Abstract: Prostamide-containing biodegradable intraocular implants, prostamide compounds, prostamide-containing pharmaceutical compositions, and methods for making and using such implants and compositions for the immediate and sustained reduction of intraocular pressure and treatment of glaucoma in an eye of a patient are described.