Abstract: Disclosed are compounds which may be utilized to inhibit transcription by RNA Polymerase II (Pol II), and in particular to disrupt the Super Elongation Complex (SEC). The compounds may be utilized in pharmaceutical compositions and methods for treating diseases and disorders associated with the biological activity of SEC, and in particular, diseases and disorders that are associated with high levels of expression of genes whose expression is SEC-dependent and that promote, support, or otherwise are required for the disease or disorder such as cancers.

Abstract: Systems, methods, and apparatus are described for a locking folding knife having a handle lock and a safety switch arranged around and rotatable around a pivot axis of the knife. In an engaged position the switch overlaps at least a portion of the handle lock and prevents it from moving into an unlocked position. A spring, such as a wire form spring, can be arranged within a pocket of the switch, and when the switch is moved between engaged and disengaged positions the spring can be compressed generating a rotational bias on the switch urging the switch toward either the engaged or disengaged position.

Abstract: The present invention is a bottle opener device that can be connected to an end of a handle such as a sporting equipment handle. The bottle opener device includes a sleeve having a hollow tubular shape with an open end and a closed end. The sleeve has a length and a width configured to enclose around the end of the handle. A bottle opener element is connected to the closed end of the sleeve with an opener cutout for enabling the removal of a bottle cap from a bottle. The bottle opener device also includes a magnetic element that holds on to the bottle cap against the bottle opener element after removal. A closing mechanism is integrated along a length of the sleeve which opens and closes and allows the bottle opener sleeve to be placed around the handle and tightly secure it in place by closing.

Abstract: Mechanisms are provided to perform selective deep parsing of natural language content. A targeted deep parse natural language processing system is configured to recognize one or more triggers that specify elements within natural language content that indicate a portion of natural language content that is to be targeted with a deep parse operation. A portion of natural language content is received and a pre-deep parse scan operation is performed on the natural language content based on the one or more triggers to identify one or more sub-portions of the natural language content that contain at least one of the one or more triggers. A deep parse is performed on only the one or more sub-portions of the portion of natural language content that contain at least one of the one or more triggers, while other sub-portions of the portion of natural language content are not deep parsed.

Abstract: An embodiment of the instant disclosure comprises a reversible heat pump and water heating system for conditioning a space and heating water. The system comprises a refrigerant circuit that includes a compressor, a source heat exchanger, a space heat exchanger, and an expansion device. A 4-way reversing valve alternates between heating and cooling modes of operation. The system includes a heat exchanger for heating water in the water heating loop, and a 3-way valve that either actuates the refrigerant flow through the water heater heat exchanger or bypasses at least a portion of the refrigerant flow around the water heater heat exchanger. The heat pump system is operable in at least five modes—space heating only, space cooling only, water heating only, and either space heating or space cooling combined with water heating.

Abstract: Systems and methods are described for providing power. A system comprising a generator, an inverter, and a battery can be used to provide power. The system can also comprise a transfer switch. The system can provide power to another device.

Abstract: A refrigeration system includes a refrigerated cavity, a first compression system, and a second compression system. The refrigeration system further includes a controller configured to operate the refrigeration system in a first mode in which the first compression system and the second compression system operate to cool the refrigerated cavity. The refrigeration system is further configured to selectively operate the refrigeration system in a second mode in which a refrigerant discharged from the second compressor is routed through the first evaporator to defrost the first evaporator.

Abstract: Circuit breakers with a housing with a line side and a load side and an electronically controlled lock-out lock member coupled to the housing configured to electronically controllably travel between a first position and a second position. In the second position, the lock member is in a lock-out position and prevents the handle from moving to an ON position associated with electrical current conduction and in the first position the lock member is translated to a position that allows the handle to move to the ON position.

Abstract: The present invention is a bottle opener device that can be connected to an end of a handle such as a sporting equipment handle. The bottle opener device includes a sleeve having a hollow tubular shape with an open end and a closed end. The sleeve has a length and a width configured to enclose around the end of the handle. A bottle opener element is connected to the closed end of the sleeve with an opener cutout for enabling the removal of a bottle cap from a bottle. The bottle opener device also includes a magnetic element that holds on to the bottle cap against the bottle opener element after removal. A closing mechanism is integrated along a length of the sleeve which opens and closes and allows the bottle opener sleeve to be placed around the handle and tightly secure it in place by closing.

Abstract: A mechanism is provided to implement a cognitive dictionary builder. The mechanism configures the cognitive dictionary builder with a set of selection criteria comprising a set of rules. The mechanism performs natural language processing on an input document in a corpus of information to analyze a context for each term or phrase in the input document and applies the set of rules to each term or phrase in the input document with respect to its context. The mechanism adds a term or phrase to at least one corresponding dictionary data structure based on a result of applying the set of rules.

Abstract: A priming system including a resilient chamber having flexible walls and a first check valve in a first fluid pathway between the resilient chamber and a fluid reservoir such that a fluid flows through the first check valve only in a direction from the fluid reservoir toward the resilient chamber and the fluid returns to the fluid reservoir through a second fluid pathway between the resilient chamber and the fluid reservoir upon compression of the walls of the resilient chamber.

Abstract: A suspension system includes a top mount, a bottom mount, a rigid housing, an air spring, and a linear actuator. The air spring transfers force of a first load path between the top mount and the bottom mount. The air spring includes a pressurized cavity containing pressurized gas that transfers the force of the first load path. The linear actuator transfers force of a second load path between the top mount and the bottom mount in parallel to the first load path. The rigid housing defines at least part of the pressurized cavity and transfers the force of the second load path.

Abstract: Methods of performing a rotational and translational calibrations of a print control system of an inkjet printer system having an inkjet printhead assembly with one or more inkjet printheads are disclosed. Rotational calibration is performed by printing a first rotational calibration pattern from a first standoff distance and a second rotational calibration pattern from a second standoff distance on a first calibration object. The print control system is calibrated until the rotational calibration patterns are within a direction difference tolerance of each other. Translational calibration is performed by printing a first translation calibration pattern on a second calibration object, rotating the inkjet printhead assembly 180°, and printing a second translational calibration pattern on the second calibration object. The print control system is calibrated until the translational calibration patterns are within a direction difference tolerance of each other.

Abstract: A load transporting apparatus is configured to move a load bearing frame carrying a load over a base surface. A support foot provides a first load bearing surface. A lift mechanism during a step operation raises the support foot off of the base surface, lowers the support foot onto the base surface, and raise the load off of the base surface. A first travel mechanism moves the lift mechanism and attached load along a non-linear horizontal path and a second travel mechanism moves the lift mechanism along a different horizontal path. A control system operates the first travel mechanism and the second travel mechanism to move the lift mechanism along a selected horizontal path.

Abstract: A system or method selects among multiple tuners to tune a particular channel. A request is received to tune a first channel. In response to this request, a first tuner is assigned to tune the first channel. A request is received to tune a second channel. If the program tuned by the first tuner is not being recorded, the first tuner is assigned to tune the second channel. If the program tuned by the first tuner is being recorded, the second tuner is assigned to tune the second channel.

Abstract: A patient support apparatus may include a foam frame defining a space. A bladder assembly may be positioned in the space. The bladder assembly may include a plurality of foam filled bladders. Each of the foam filled bladders may be interconnected by a manifold. A plurality of mutually exclusively selectable pressure relief valves may be provided to release air from the bladder assembly.

Abstract: A method for operating a vehicle brake system, wherein the brake system has at least one friction brake and at least one regenerative brake. A defined switching pattern is specified for switching between a self-cleaning operating mode for cleaning the friction brake and a normal operating mode of the brake system. The method includes determining information describing the state of the at least one friction brake, determining the state of the at least one friction brake from the information, determining whether the state satisfies a specific switching criterion, and, if the self-cleaning operating mode is to be activated according to the switching pattern and the state of the friction brake does not satisfy the switching criterion, suppressing activation of the self-cleaning operating mode and maintaining the normal operating mode.

Abstract: This invention relates to a process to produce an ionomer comprising: 1) contacting, in a reactor, one or more C2-C60 ?-olefins, an optional diene, and a metal alkenyl with a catalyst system comprising an activator, a catalyst compound, and a support; 2) forming a copolymer comprising one or more C2-C60 ?-olefin monomers and about 0.01 wt % to about 20 wt %, based on the weight of the copolymer, of metal alkenyl; 3) functionalizing and quenching the polymerization reaction with one or more electrophilic groups; and 4) obtaining ionomer.

Abstract: A system for providing dynamic roadside assistance coordination may include a customer mobile device or vehicle in direct, or indirect, wireless communication with an insurance provider and/or service provider remote server. The customer's device may transmit a request for roadside assistance (e.g., towing services), and a current GPS location. In response, a closest, trusted service provider vehicle may be determined, and then directed to the customer's location. For instance, a software application may receive the customer location and compare it with availability information to match the customer with a close and trusted service provider. The customer's device may receive an acknowledgement that help is on the way, and be able to track the current location of the service provider vehicle while en route. Payment for the roadside assistance may be automatically and electronically paid by the insurance provider. As a result, prompt and safe roadside assistance may be provided.

Abstract: A vibration attenuator for a rotor of an aircraft has a first ring with an eccentric weight, a coaxial second ring with an eccentric weight, and a central ring coaxial with the first and second rings and located therebetween. A first post extends from the first ring toward the central ring and is received in a first arcuate groove formed on the central ring, whereas a second post extends from the second ring toward the central ring and is received in a second groove formed on the central ring. A motor is configured for driving the central ring in rotation about the axis relative to the motor. The grooves are equal in length, and a center of the first groove is located on an opposite side from a center of the second groove. Rotation of the central ring by the motor causes rotation of the first and second rings.