Abstract: This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.

Abstract: A system is disclosed for inhibiting the corrosion of ferrous and other metals by passivating the metals. The system includes novel buffered compositions which may be applied to metal products for preventing or retarding corrosion and methods for applying the buffered compositions to metal products such that corrosion protection of the products is achieved through passivation. The methods include an in-situ application to existing structures with metal reinforcement as well as applications to metal products during manufacture. Generally, the compositions may be in various forms and comprise a carrier component and one or more pH buffer components. The buffer is selected to retain the proximity of the metal at a pH at which the metal is passive to corrosion. The compositions are environmentally friendly and are capable of replacing chromates which have been traditionally used with zinc and zinc alloys to inhibit corrosion of metals but which are potentially harmful to the environment.

Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

Abstract: A circuit within a video monitor for making corrections during horizontal scan includes a data storage device containing information relating to a selected display parameter, an integrator receptive of the stored information and adapted to produce an integrated signal therefrom, and an amplifier receptive of the integrated signal for supplying signals to the video monitor based on the integrated signal. The information supplied from the data storage device to the integrator is encoded in a pulse density modulated wave form via a tri-state gate and a one-shot timer. The information stored in the data storage device is stored in bytes, each byte containing a "sign bit" and a plurality of data bits.

Abstract: CRF receptor antagonists are disclosed. Such receptor antagonists are thiadiazole-, pyrimidine-, triazine-, and triazole-containing compounds substituted with both a C3-C14 monocyclic or fused, homoaryl or heteroaryl group and a substituted amine group. The CFR receptor antagonists have utility in the treatment of a variety of disorders, including disorders associated with the hypersecretion of CRF.

Abstract: A method of etching a multicomponent alloy on a substrate, without forming etchant residue on the substrate, is described. In the method, the substrate is placed in a process chamber comprising a plasma generator and plasma electrodes. A process gas comprising a volumetric flow ratio V.sub.r of (i) a chlorine-containing gas capable of ionizing to form dissociated Cl.sup.+ plasma ions and non-dissociated Cl.sub.2.sup.+ plasma ions, and (ii) an inert gas capable of enhancing dissociation of the chlorine-containing gas, in introduced into the process chamber. The process gas is ionized to form plasma ions that energetically impinge on the substrate by (i) applying RF current at a first power level to the plasma generator, and (ii) applying RF current at a second power level to the plasma electrodes. The combination of (i) the volumetric flow ratio V.sub.r of the process gas and (ii) the power ratio P.sub.

Abstract: The invention provides a termination assembly adapted to retain an elongated, generally rigid member, such as a wire, to a mounting surface. A mounting surface is configured to define a receiving channel, which may include an aperture. A deformable sleeve member is configured to engage the generally rigid member to be retained and the channel in the mounting member. Cooperative deformation of the deformable sleeve and the mounting member will cause the two members to deform to engage one another, thereby securing the generally rigid member to the mounting surface.

Abstract: A system is disclosed for inhibiting the corrosion of ferrous and other metals by passivating the metals. The system includes novel buffered compositions which may be applied to metal products for preventing or retarding corrosion and methods for applying the buffered compositions to metal products such that corrosion protection of the products is achieved through passivation. The methods include an in-situ application to existing structures with metal reinforcement as well as applications to metal products during manufacture. Generally, the compositions may be in various forms and comprise a carrier component and one or more particulate pH buffer components. The particles of buffer are selected to retain the proximity of the metal at a pH at which the metal is passive to corrosion.

Abstract: Novel compounds having activity against trypsin are disclosed. Specifically, novel peptide aldehyde analogues that have substantial potency and specificity as inhibitors of mammalian pancreatic trypsin are presented. The compounds are useful in the prevention and treatment of the tissue damage or destruction associated with pancreatitis.

Abstract: a-Ketoamide derivatives, their pharmaceutically acceptable salts, compositions, diagnostic compositions and pharmaceutical compositions, which are useful for preventing or treating in a mammal a pathological condition characterized by thrombosis are described.a-Ketoamide derivatives, their pharmaceutically acceptable salts, compositions and diagnostic compositions, which are useful for in vivo imaging of thrombi in a mammal are also described.Methods of preventing or treating in a mammal a pathological condition characterized by thrombosis and methods of in vivo imaging of thrombi in a mammal are also disclosed.

Abstract: A pivoting gate valve assembly includes a seat plate with an orifice therethrough, a stop plate and a gate. The stop plate is mounted on the seat plate and borders a portion of the orifice. The gate is pivotably mounted to the seat plate and pivots to a closed position against the stop plate and covering the orifice. The gate and the stop plate form a substantially flush contiguous surface when in the closed position.

Abstract: A system for transforming coordinate systems in an automated video monitor alignment system includes a camera and computer to capture an image of the display bezel surrounding the cathode ray tube and of the image displayed on the CRT. Three dimensional models of the CRT tube and display bezel are used to compute and compensate for camera perspective. Camera pixel data can then be transformed to `flat plane` coordinates. When the relative orientation of the camera and CRT are corrected, the effects of parallax can be eliminated, allowing more accurate inspection, measurement, and lower cost fixturing on the production line. Thus, an accurate coordinate transformation from a camera-referenced coordinate system to a monitor-referenced coordinate system is made. Correction factors for correcting errors due to refraction can also be generated empirically in accordance with the present invention. Slope coordinate data is generated for a sample monitor for predetermined slope coordinate locations on the tube face.

Abstract: .alpha.-Ketoamide derivatives, their pharmaceutically acceptable salts, compositions, diagnostic compositions and pharmaceutical compositions, which are useful for preventing or treating in a mammal a pathological condition characterized by thrombosis are described..alpha.-Ketoamide derivatives, their pharmaceutically acceptable salts, compositions and diagnostic compositions, which are useful for in vivo imaging of thrombi in a mammal are also described.Methods of preventing or treating in a mammal a pathological condition characterized by thrombosis and methods of in vivo imaging of thrombi in a mammal are also disclosed.

Abstract: The present invention is directed to N-sulfonyl arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, disclosed are methods of using these inhibitors in their various embodiments as therapeutic agents for disease states characterized by disorders of the blood coagulation process. Further disclosed are compounds useful as intermediates in the preparation of these compounds.

Abstract: A new fiber optic connector housing and a new fiber optic receptacle, both of which conform to a new standard proposed by the X3T9.3 committee of the American National Standards Institute, are disclosed. In addition, four accessory devices for electro-optic modules, each of which includes one or more essentially conventional plug frames which fit into either one or more conventional, individual fiber optic connector housings or the new fiber optic connector housing, are disclosed.

Abstract: A termination assembly is disclosed, which termination assembly is adapted to retain an elongated, generally rigid member, such as a wire to a mounting surface. A mounting surface is configured to define a receiving channel, which may include an aperture. A deformable sleeve member is configured to engage the generally rigid member to be retained and the channel in the mounting member. Cooperative deformation of the deformable sleeve and the mounting member will cause the two members to deform to engage one another, thereby securing the generally rigid member to the mounting surface.

Abstract: Novel compounds having activity against trypsin are disclosed. Specifically, novel peptide aldehyde analogues that have substantial potency and specificity as inhibitors of mammalian pancreatic trypsin are presented. The compounds are useful in the prevention and treatment of the tissue damage or destruction associated with pancreatitis.

Abstract: This invention provides solution-phase methods for the synthesis of peptidyl argininals and to novel reagents useful therein.

Abstract: A system for transforming coordinate systems in an automated video monitor alignment system includes a camera and computer to capture an image of the display bezel surrounding the cathode ray tube and of the image displayed on the CRT. Three dimensional models of the CRT tube and display bezel are used to compute and compensate for camera perspective. Camera pixel data can then be transformed to `flat plane` coordinates. When the relative orientation of the camera and CRT are corrected for, the effects of parallax can be eliminated, allowing more accurate inspection, measurement, and lower cost fixturing on the production line. Thus, an accurate coordinate transformation from a camera-referenced coordinate system to a monitor-referenced coordinate system is made.

Abstract: A circuit within a video monitor for making corrections during horizontal scan includes a data storage device containing information relating to a selected display parameter, an integrator receptive of the stored information and adapted to produce an integrated signal therefrom, and an amplifier receptive of the integrated signal for supplying signals to the video monitor based on the integrated signal. The information supplied from the data storage device to the integrator is encoded in a pulse density modulated wave form via a tri-state gate and a one-shot timer. The information stored in the data storage device is stored in bytes, each byte containing a "sign bit" and a plurality of data bits.