Abstract: A method for improving intracellular administration of a therapeutic agent is provided comprising: contacting cells with a compound comprising a charged derivative of a therapeutic agent having a therapeutic activity, the charged derivative being conjugated to a protein having a biological activity of being transported across a cell membrane into a cell; and having the cell transport the compound into the cell where the cell metabolizes at least a portion of the compound to form a charged metabolite product that possesses the therapeutic activity of the therapeutic agent, the charged metabolite product being less prone to being transported across the cell membrane out of the cell relative to the compound and less prone to being transported across the cell membrane out of the cell relative to the therapeutic agent.

Abstract: A disposable stabilization and applanation device for reconfiguring the cornea of an eye for ophthalmic laser surgery, includes an applanation lens that is disposed in a particular spatial position with respect to an incident laser beam. The applanation lens is inserted into the central opening of an attachment ring and applanates the eye in response to pressure from a lens cone. The attachment ring is coupled to the eye and includes a skirt which surrounds the applanation lens and extends outwardly therefrom to define a chamber. The skirt is formed with a groove which defines a suction channel between the attachment ring skirt and the corneal surface of an eye. A vacuum source is connected and fluid communication with the suction channel and is selectively activated to create a partial vacuum in the channel.

Abstract: An article is formed as a substrate having a projection extending outwardly therefrom. The article may be a magnetic recording head and the projection a write pole. The projection has a width in a thinnest dimension measured parallel to a substrate surface of no more than about 0.3 micrometers and a height measured perpendicular to the substrate of not less than about 5 times the width. The article is fabricated by forming an overlying structure on the substrate with an edge thereon, depositing a replication layer lying on the edge, depositing a filler onto the edge and the substrate, so that the filler, the replication layer, and the overlying structure in combination comprise a continuous layer on the substrate, selectively removing at least a portion of the replication layer from a free surface of the continuous layer inwardly toward the substrate, to form a defined cavity, and depositing a projection material into the defined cavity to form the projection.

Abstract: A multipurpose step stool includes two substantially parallel, congruent, triangular side support members. The triangular side support members each include first, second, and third resting edges adapted to contact a supporting surface such as a floor. The first treads are oriented parallel to the first resting edges, the second treads are oriented parallel to the second resting edges, and the platform is oriented parallel to the third resting edges.

Abstract: A pressure actuated switch assembly has a hermetically sealed electrical switch exceeding MIL-PRF-8805 requirements. A sensing element is positioned within the pressure switch housing for triggering the electrical switch at a precise pressure point(s). An electrical signal connection is positioned on the pressure switch housing. A pressure interface is also positioned on the pressure switch housing. The pressure switch housing is made of a nickel or titanium alloy for environmental protection.

Abstract: Herein, it is demonstrated that the posttranslational modification of the amino acid tyrosine to nitrotyrosine has profound consequences for immune recognition. Furthermore, it is demonstrated that self-proteins containing nitrotyrosine can be recognized by the immune systems as foreign and as such these same proteins can be converted to potential autoantigens. As such, this invention relates to compositions and methods for the prevention, diagnosis and treatment of conditions including autoimmune diseases, infectious diseases and cancer through the recognition of compounds containing nitrated tyrosine residues.

Abstract: A method of planarizing a metal conductive layer on a substrate is provided. In one embodiment, a substrate having a metal conductive layer disposed on a top surface of the substrate is provided on a substrate support. The substrate support is rotated and the top surface of the substrate is contacted with a liquid etching composition. The metal conductive layer is then exposed to an etchant gas in order to planarize the top surface of the metal conductive layer. Also provided is an apparatus for etching a metal conductive layer on a substrate. The apparatus comprises a container, a substrate support disposed in the container, a rotation actuator attached to the substrate support, and a fluid delivery assembly disposed in the container.

Abstract: The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.

Abstract: A method and apparatus used to step and correct the position of raster lines in a sinusoidal or zig-zag deflection system. By combining the magnetic flux generated with a rotation “twister” coil and a vertical deflection coil, scan lines can be uniformly spaced and separated nearly to their ends. Accordingly, the magnetic flux generated with the twister coil is adjusted going in the left to right direction then reversed in polarity and readjusted while returning from right to left. It is this controlled twister flux that combines with the linear vertical deflection flux to straighten and then step each scan line to produce an aligned raster.

Abstract: A multipurpose step stool includes two substantially parallel, congruent, triangular side support members. The triangular side support members each include first, second, and third resting edges adapted to contact a supporting surface such as a floor. The first treads are oriented parallel to the first resting edges, the second treads are oriented parallel to the second resting edges, and the platform is oriented parallel to the third resting edges.

Abstract: This invention concerns compounds of formula 1

Abstract: The invention features compounds of the general formula:

Abstract: Genetic constructs, transformation vectors and methods are taught for production of transgenic plants which can be selectively removed from a growing site by application of a chemical agent or physiological stress. The invention links a target gene for the trait of commercial interest to a conditionally lethal gene, which can be selectively expressed to cause plant death. By use of the genetic constructs, transformation vectors and methods of the present invention, invasion of environments and contamination of commercial non-engineered productions by transgenic plants can be avoided. Methods are also taught for transformation of Brassica species.

Abstract: A system for enhancing brightness and resolution while correcting certain types of convergence, geometry, color and luminance errors caused by the display device, the viewing position or both. This system involves merging images from two or more sources, overlapping and offsetting pixels, or overlapping scanning lines “merged raster” in a CRT or several (3) “merged rasters” in color CRT's, and adjusting video content and timing, to compensate for the current viewing position and/or device distortion. Display and/or viewing perspective distortion characteristics are measured from the observers viewing position for the raster or each non-converged raster and stored as correction factor data in non-volatile memory. This data is used to modify the digital addressing of video image memory, to read and to correct pixel data for each image, adjust color, modify magnitude, and to drive the displays video amplifier at the correct time with the corrected amplitude and image data.

Abstract: An apparatus for providing an electrical bias to a substrate in a processing system is described. The apparatus generally includes a conductive annular body defining a central opening. The conductive annular body may have a substrate seating surface adapted to receive the substrate and a plurality of scallops formed on a surface opposing the substrate seating surface. A plurality of electrical contacts may be formed on the substrate seating surface opposite the plurality of scallops. The electrical contacts may be adapted to engage a plating surface of the substrate.

Abstract: Method and apparatus for electrodepositing a metal onto a substrate. An oxide treatment process is performed on a substrate prior to making electrical contact between a seed layer of the substrate and a conductive contact element which provides a current. In one embodiment, the pressure at the interface between the seed layer and the conductive contact element is controlled to avoid detrimentally affecting a material(s) of the substrate.

Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

Abstract: A method and apparatus used to step and correct the position of raster lines in a sinusoidal or zig-zag deflection system. By combining the magnetic flux generated with a rotation “twister” coil and a vertical deflection coil, scan lines can be uniformly spaced and separated nearly to their ends. Accordingly, the magnetic flux generated with the twister coil is adjusted going in the left to right direction then reversed in polarity and readjusted while returning from right to left. It is this controlled twister flux that combines with the linear vertical deflection flux to straighten and then step each scan line to produce an aligned raster.

Abstract: This invention concerns compounds of formula including the stereoisomers and the pharmaceutically acceptable acid addition salt forms thereof, wherein R1 is NR4R5 or OR5; R2 is C1-6alkyl, C1-6alkyloxy or C1-6alkylthio; R3 is hydrogen, C1-6alkyl, C1-6alkylsulfonyl, C1-6alkylsulfoxy or C1-6alkylthio; R4 is hydrogen, C1-6alkyl, mono- or di(C3-6cycloalkyl)methyl, C3-6cycloalkyl, C3-6alkenyl, hydroxyC1-6alkyl, C1-6alkylcarbonyloxyC1-6alkyl or C1-6alkyloxyC1-6alkyl; R5 is C1-6alkyl, mono- or di(C3-6cycloalkyl)methyl, Ar1CH2, C1-6alkyloxyC1-6alkyl, hydroxyC1-6alkyl, C3-6alkenyl, thienylmethyl, furanylmethyl, C1-6alkylthioC1-6alkyl, morpholinyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, di(C1-6alkyl)amino, C1-6alkylcarbonylC1-6alkyl, C1-6alkyl substituted with imidazolyl; or a radical of formula —Alk—O—CO—Ar1; or R4 and R5 taken together with the nitrogen atom to which they are attached may form an optionally substituted pyrrolidinyl, piperidinyl, homopiperidinyl or morpholinyl g

Abstract: The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.